{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:30:04Z","timestamp":1790371804902,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"name":"by the National Natural Science Foundation of China","award":["81872677"],"award-info":[{"award-number":["81872677"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82073622"],"award-info":[{"award-number":["82073622"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Fundamental Research Program of Shanxi Province","award":["202303021211122"],"award-info":[{"award-number":["202303021211122"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Four \u201cBatches\u201d Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province","award":["2023XM037"],"award-info":[{"award-number":["2023XM037"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Research Project Supported by Shanxi Scholarship Council of China","award":["2023-096"],"award-info":[{"award-number":["2023-096"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]},{"name":"Scientific Research Projects on Health Funded by the Health Commission of Shanxi Province","award":["2024054"],"award-info":[{"award-number":["2024054"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Microbiol Immunol"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s00430-026-00875-1","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:28:47Z","timestamp":1776997727000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intrauterine exposure to HBsAg attenuates the immune response to hepatitis B vaccine via the miR-155-5p\/MyD88 axis of DCs in mouse pups"],"prefix":"10.1007","volume":"215","author":[{"given":"Xufeng","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangle","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bihong","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keke","family":"wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongliang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"875_CR1","unstructured":"Global hepatitis report 2024: action for access in low- and middle-income countries[EB\/OL]. -04-09). [2024-06-19]. https:\/\/www.who.int\/publications\/i\/item\/9789240091672"},{"issue":"1","key":"875_CR2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/S1473-3099(20)30586-7","volume":"21","author":"AL Funk","year":"2021","unstructured":"Funk AL, Lu Y, Yoshida K, Zhao T, Boucheron P, Van Holten J, Chou R, Bulterys M, Shimakawa Y (2021) Efficacy and safety of antiviral prophylaxis during pregnancy to prevent mother-to-child transmission of hepatitis B virus: a systematic review and meta-analysis. Lancet Infect Dis 21(1):70\u201384","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"875_CR3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/s41575-020-00361-w","volume":"18","author":"NA Terrault","year":"2021","unstructured":"Terrault NA, Levy MT, Cheung KW, Jourdain G (2021) Viral hepatitis and pregnancy. Nat Rev Gastroenterol Hepatol 18(2):117\u2013130","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"875_CR4","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.vaccine.2016.11.061","volume":"35","author":"Y Lu","year":"2017","unstructured":"Lu Y, Liang XF, Wang FZ, Yan L, Li RC, Li YP, Zhu FC, Zhai XJ, Li J, Zhuang H (2017) Hepatitis B vaccine alone may be enough for preventing hepatitis B virus transmission in neonates of HBsAg (+)\/HBeAg (-) mothers. Vaccine 35(1):40\u201345","journal-title":"Vaccine"},{"issue":"7","key":"875_CR5","first-page":"950","volume":"38","author":"XF Wang","year":"2017","unstructured":"Wang XF, Shi XH, Xu XX, Yang ZQ, Hao HY, Zhang F, Wang B, Wen HX, Fu ZD, Wang T, Feng SY, Wang B, Wang SP (2017) Effect of interleukin-6 and interleukin-12 on immune response to hepatitis B vaccination in infants of HBsAg-positive mothers. Zhonghua Liu Xing Bing Xue Za Zhi 38(7):950\u2013953","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"issue":"6","key":"875_CR6","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","volume":"180","author":"KA Fitzgerald","year":"2020","unstructured":"Fitzgerald KA, Kagan JC (2020) Toll-like receptors and the control of immunity. Cell 180(6):1044\u20131066","journal-title":"Cell"},{"issue":"7","key":"875_CR7","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.3390\/v2071394","volume":"2","author":"M Ait-Goughoulte","year":"2010","unstructured":"Ait-Goughoulte M, Lucifora J, Zoulim F, Durantel D (2010) Innate antiviral immune responses to hepatitis B virus. Viruses 2(7):1394\u20131410","journal-title":"Viruses"},{"key":"875_CR8","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.3389\/fimmu.2017.01182","volume":"8","author":"RE Drury","year":"2017","unstructured":"Drury RE, O\u2019connor D, Pollard AJ (2017) The clinical application of MicroRNAs in infectious disease. Front Immunol 8:1182","journal-title":"Front Immunol"},{"issue":"7","key":"875_CR9","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s10529-021-03115-z","volume":"43","author":"B Huang","year":"2021","unstructured":"Huang B, Chen H, Zheng Y (2021) MiR-103\/miR-107 inhibits enterovirus 71 replication and facilitates type I interferon response by regulating SOCS3\/STAT3 pathway. Biotechnol Lett 43(7):1357\u20131369","journal-title":"Biotechnol Lett"},{"issue":"7","key":"875_CR10","doi-asserted-by":"publisher","first-page":"105173","DOI":"10.1016\/j.micinf.2023.105173","volume":"25","author":"N Pandey","year":"2023","unstructured":"Pandey N, Singh SK (2023) MicroRNA-155 triggers a cellular antiviral immune response against Chandipura virus in human microglial cells. Microbes Infect 25(7):105173","journal-title":"Microbes Infect"},{"issue":"5","key":"875_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3892\/ijmm.2024.5415","volume":"54","author":"L Chen","year":"2024","unstructured":"Chen L, Liu C, Xiang X, Qiu W, Guo K (2024) miR\u2013155 promotes an inflammatory response in HaCaT cells via the IRF2BP2\/KLF2\/NF\u2013\u03baB pathway in psoriasis. Int J Mol Med 54(5):91","journal-title":"Int J Mol Med"},{"issue":"6","key":"875_CR12","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/s10620-021-07022-1","volume":"67","author":"X Yang","year":"2022","unstructured":"Yang X, Wan J, Li N, He C, Zhang Y, Ren Y, Li X, Zhu Y, Liu F, Xia L, Lu N (2022) MiR155 disrupts the intestinal barrier by inducing intestinal inflammation and altering the intestinal microecology in severe acute pancreatitis. Dig Dis Sci 67(6):2209\u20132219","journal-title":"Dig Dis Sci"},{"issue":"5","key":"875_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.micinf.2013.02.008","volume":"15","author":"Y Chen","year":"2013","unstructured":"Chen Y, Wang L, Xu Y, Liu X, Li S, Qian Q, Hu B, Zhou A, Chen T, Zhao Y (2013) Role of maternal viremia and placental infection in hepatitis B virus intrauterine transmission. Microbes Infect 15(5):409\u2013415","journal-title":"Microbes Infect"},{"issue":"2","key":"875_CR14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1515\/jpm-2014-0056","volume":"43","author":"J Wei","year":"2015","unstructured":"Wei J, Xue S, Zhang J, Wang S, Wang B (2015) Study of the relationship in pregnant women between hepatitis B markers and a placenta positive for hepatitis B surface antigen. J Perinat Med 43(2):191\u2013199","journal-title":"J Perinat Med"},{"issue":"12","key":"875_CR15","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1111\/liv.13871","volume":"38","author":"AK Vyas","year":"2018","unstructured":"Vyas AK, Ramakrishna U, Sen B, Islam M, Ramakrishna G, Patra S, Rastogi A, Sarin SK, Trehanpati N (2018) Placental expression of asialoglycoprotein receptor associated with Hepatitis B virus transmission from mother to child. Liver Int 38(12):2149\u20132158","journal-title":"Liver Int"},{"key":"875_CR16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fimmu.2020.00123","volume":"11","author":"AC Apostol","year":"2020","unstructured":"Apostol AC, Jensen KDC, Beaudin AE (2020) Training the fetal immune system through maternal inflammation-a layered hygiene hypothesis. Front Immunol 11:123","journal-title":"Front Immunol"},{"issue":"12","key":"875_CR17","doi-asserted-by":"publisher","first-page":"e571","DOI":"10.1371\/journal.pntd.0000571","volume":"3","author":"N Dauby","year":"2009","unstructured":"Dauby N, Alonso-Vega C, Suarez E, Flores A, Hermann E, C\u00f3rdova M, Tellez T, Torrico F, Truyens C, Carlier Y (2009) Maternal infection with Trypanosoma cruzi and congenital Chagas disease induce a trend to a type 1 polarization of infant immune responses to vaccines. PLoS Negl Trop Dis 3(12):e571","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"875_CR18","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/S1473-3099(11)70341-3","volume":"12","author":"N Dauby","year":"2012","unstructured":"Dauby N, Goetghebuer T, Kollmann TR, Levy J, Marchant A (2012) Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections. Lancet Infect Dis 12(4):330\u2013340","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"875_CR19","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1080\/23744235.2017.1292541","volume":"49","author":"J Wang","year":"2017","unstructured":"Wang J, He Y, Jin D, Liu J, Zheng J, Yuan N, Bai Y, Yan T, Yang Y, Liu Y, Zhang S, Zhao Y, Chen T (2017) No response to hepatitis B vaccine in infants born to HBsAg(+) mothers is associated to the transplacental transfer of HBsAg. Infect Dis (Lond) 49(8):576\u2013583","journal-title":"Infect Dis (Lond)"},{"issue":"5","key":"875_CR20","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1002\/jmv.20575","volume":"78","author":"J Ren","year":"2006","unstructured":"Ren J, Wang L, Chen Z, Ma ZM, Zhu HG, Yang DL, Li XY, Wang BI, Fei J, Wang ZG, Wen YM (2006) Gene expression profile of transgenic mouse kidney reveals pathogenesis of hepatitis B virus associated nephropathy. J Med Virol 78(5):551\u2013560","journal-title":"J Med Virol"},{"key":"875_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.3389\/fimmu.2014.00441","volume":"5","author":"A Bertoletti","year":"2014","unstructured":"Bertoletti A, Hong M (2014) Age-dependent immune events during hbv infection from birth to adulthood: an alternative interpretation. Front Immunol 5:441","journal-title":"Front Immunol"},{"issue":"5","key":"875_CR22","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1016\/j.immuni.2016.04.008","volume":"44","author":"Y Tian","year":"2016","unstructured":"Tian Y, Kuo CF, Akbari O, Ou JH (2016) Maternal-derived hepatitis B virus e antigen alters macrophage function in offspring to drive viral persistence after vertical transmission. Immunity 44(5):1204\u20131214","journal-title":"Immunity"},{"key":"875_CR23","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/j.placenta.2012.10.011","volume":"34","author":"MR Dilworth","year":"2013","unstructured":"Dilworth MR, Sibley CP, Review (2013) Transport across the placenta of mice and women. Placenta 34:S34\u2013S39","journal-title":"Placenta"},{"issue":"39","key":"875_CR24","doi-asserted-by":"publisher","first-page":"5571","DOI":"10.1016\/j.vaccine.2021.08.020","volume":"39","author":"R Wang","year":"2021","unstructured":"Wang R, Chen K, Wang Y, Liu C, Wu Z, Wang D, Qu C (2021) Booster immunization improves the generation of T follicular helper (Tfh) cells specific to hepatitis B surface antigen (HBsAg) after prenatal HBsAg exposure. Vaccine 39(39):5571\u20135579","journal-title":"Vaccine"},{"issue":"1","key":"875_CR25","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1080\/22221751.2022.2071172","volume":"11","author":"J Ning","year":"2022","unstructured":"Ning J, Wang J, Zheng H, Peng S, Mao T, Wang L, Yu G, Liu J, Liu S, Zhang T, Ding S, Lu F, Chen X (2022) Solely HBsAg intrauterine exposure accelerates HBV clearance by promoting HBs-specific immune response in the mouse pups. Emerg Microbes Infect 11(1):1356\u20131370","journal-title":"Emerg Microbes Infect"},{"issue":"8","key":"875_CR26","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s11427-009-0098-0","volume":"52","author":"X Gu","year":"2009","unstructured":"Gu X, Yang X, Wang D, Hua Z, Wu H, Chen H, Xu Y, Lu Z (2009) Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus. Sci China C Life Sci 52(8):719\u2013723","journal-title":"Sci China C Life Sci"},{"issue":"Suppl 1","key":"875_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1440-1746.2010.06541.x","volume":"26","author":"CL Lin","year":"2011","unstructured":"Lin CL, Kao JH (2011) The clinical implications of hepatitis B virus genotype: recent advances. J Gastroenterol Hepatol 26(Suppl 1):123\u2013130","journal-title":"J Gastroenterol Hepatol"},{"issue":"3","key":"875_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000319437","volume":"54","author":"HX Su","year":"2011","unstructured":"Su HX, Zhang YH, Zhang ZG, Li D, Zhang JX, Men K, Zhang L, Long Y, Xu DZ, Yan YP (2011) High conservation of hepatitis B virus surface genes during maternal vertical transmission despite active and passive vaccination. Intervirology 54(3):122\u2013130","journal-title":"Intervirology"},{"issue":"3","key":"875_CR29","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/microorganisms9030601","volume":"9","author":"H Jeong","year":"2021","unstructured":"Jeong H, Kim DH, Choi YM, Choi H, Kim D, Kim BJ (2021) rt269I Type of hepatitis B virus (HBV) polymerase versus rt269L is more prone to mutations within HBV genome in chronic patients infected with genotype C2: evidence from analysis of full HBV genotype C2 genome. Microorganisms 9(3):601","journal-title":"Microorganisms"},{"issue":"9","key":"875_CR30","first-page":"1380","volume":"115","author":"Y Yue","year":"2002","unstructured":"Yue Y, Meng J, Zhang S (2002) Mechanism of peripheral blood mononuclear cell invasion by HBV on artificial immunization in newborns. Chin Med J (Engl) 115(9):1380\u20131382","journal-title":"Chin Med J (Engl)"},{"issue":"1","key":"875_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.autrev.2008.07.016","volume":"8","author":"P Pontisso","year":"2008","unstructured":"Pontisso P, Vidalino L, Quarta S, Gatta A (2008) Biological and clinical implications of HBV infection in peripheral blood mononuclear cells. Autoimmun Rev 8(1):13\u201317","journal-title":"Autoimmun Rev"},{"issue":"4","key":"875_CR32","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1099\/jmm.0.001152","volume":"69","author":"SX Gao","year":"2020","unstructured":"Gao SX, Sun J, Li HH, Chen J, Kashif MR, Zhou P, Wei L, Zheng QW, Wu LG, Guan JC (2020) Prenatal exposure of staphylococcal enterotoxin B attenuates the development and function of blood regulatory T cells to repeated staphylococcal enterotoxin B exposure in adult offspring rats. J Med Microbiol 69(4):591\u2013599","journal-title":"J Med Microbiol"},{"key":"875_CR33","doi-asserted-by":"publisher","first-page":"6588","DOI":"10.1038\/ncomms7588","volume":"6","author":"M Hong","year":"2015","unstructured":"Hong M, Sandalova E, Low D, Gehring AJ, Fieni S, Amadei B, Urbani S, Chong YS, Guccione E, Bertoletti A (2015) Trained immunity in newborn infants of HBV-infected mothers. Nat Commun 6:6588","journal-title":"Nat Commun"},{"key":"875_CR34","first-page":"17","volume":"311","author":"RM Steinman","year":"2006","unstructured":"Steinman RM, Hemmi H (2006) Dendritic cells: translating innate to adaptive immunity. Curr Top Microbiol Immunol 311:17\u201358","journal-title":"Curr Top Microbiol Immunol"},{"issue":"9","key":"875_CR35","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S1471-4906(02)02281-0","volume":"23","author":"MB Lutz","year":"2002","unstructured":"Lutz MB, Schuler G (2002) Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?. Trends Immunol 23(9):445\u2013449","journal-title":"Trends Immunol"},{"issue":"4","key":"875_CR36","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1046\/j.1365-2567.1997.00373.x","volume":"92","author":"K Kurose","year":"1997","unstructured":"Kurose K, Akbar SM, Yamamoto K, Onji M (1997) Production of antibody to hepatitis B surface antigen (anti-HBs) by murine hepatitis B virus carriers: neonatal tolerance versus antigen presentation by dendritic cells. Immunology 92(4):494\u2013500","journal-title":"Immunology"},{"issue":"2","key":"875_CR37","first-page":"112","volume":"27","author":"HX Hao","year":"2013","unstructured":"Hao HX, Zhang YL, Li MH, Zhang LX, Yi W, Hu YH, Yi N, Cheng J, Liu SA, Xie Y (2013) Dendritic cell subsets and function in newborns from mothers of different HBV infection status. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 27(2):112\u2013114","journal-title":"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"},{"issue":"6","key":"875_CR38","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3390\/cells10061374","volume":"10","author":"J Aluri","year":"2021","unstructured":"Aluri J, Cooper MA, Schuettpelz LG (2021) Toll-like receptor signaling in the establishment and function of the immune system. Cells 10(6):1374","journal-title":"Cells"},{"issue":"2","key":"875_CR39","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s12026-021-09188-2","volume":"69","author":"KU Saikh","year":"2021","unstructured":"Saikh KU (2021) MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity. Immunol Res 69(2):117\u2013128","journal-title":"Immunol Res"},{"issue":"6","key":"875_CR40","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1007\/s12072-016-9763-0","volume":"10","author":"S Sukriti","year":"2016","unstructured":"Sukriti S, Trehanpati N, Kumar M, Pande C, Hissar SS, Sarin SK (2016) Functionally aberrant dendritic cell subsets and expression of DC-SIGN differentiate acute from chronic HBV infection. Hepatol Int 10(6):916\u2013923","journal-title":"Hepatol Int"},{"issue":"45","key":"875_CR41","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.1038\/onc.2008.274","volume":"27","author":"R Schickel","year":"2008","unstructured":"Schickel R, Boyerinas B, Park SM, Peter ME (2008) MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27(45):5959\u20135974","journal-title":"Oncogene"},{"issue":"1","key":"875_CR42","doi-asserted-by":"publisher","first-page":"70","DOI":"10.4161\/auto.26534","volume":"10","author":"G Wan","year":"2014","unstructured":"Wan G, Xie W, Liu Z, Xu W, Lao Y, Huang N, Cui K, Liao M, He J, Jiang Y, Yang BB, Xu H, Xu N, Zhang Y (2014) Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy 10(1):70\u201379","journal-title":"Autophagy"},{"issue":"2","key":"875_CR43","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1080\/08916934.2021.1891534","volume":"54","author":"LJ Chen","year":"2021","unstructured":"Chen LJ, Li JM, Zhang WD, Liu W, Li XY, Ouyang B, Tan JL, Li Y, Chen JC, Liu ZG (2021) LncRNA NEAT1 activates MyD88\/NF-\u03baB pathway in bronchopneumonia through targeting miR-155-5p. Autoimmunity 54(2):104\u2013113","journal-title":"Autoimmunity"},{"key":"875_CR44","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2147\/CCID.S350711","volume":"15","author":"J Li","year":"2022","unstructured":"Li J, Liu Y, Cao Y, Wang J, Zhao X, Jiao J, Li J, Zhang K, Yin G (2022) Inhibition of miR-155 Attenuates CD14(+) Monocyte-mediated inflammatory response and oxidative stress in psoriasis through TLR4\/MyD88\/NF-\u03baB signaling pathway. Clin Cosmet Investig Dermatol 15:193\u2013201","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"7","key":"875_CR45","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1128\/CVI.00044-13","volume":"20","author":"Y Xiong","year":"2013","unstructured":"Xiong Y, Chen S, Liu L, Zhao Y, Lin W, Ni J (2013) Increased serum microRNA-155 level associated with nonresponsiveness to hepatitis B vaccine. Clin Vaccine Immunol 20(7):1089\u20131091","journal-title":"Clin Vaccine Immunol"}],"container-title":["Medical Microbiology and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-026-00875-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00430-026-00875-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00430-026-00875-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:03:22Z","timestamp":1777003402000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00430-026-00875-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,24]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["875"],"URL":"https:\/\/doi.org\/10.1007\/s00430-026-00875-1","relation":{},"ISSN":["0300-8584","1432-1831"],"issn-type":[{"value":"0300-8584","type":"print"},{"value":"1432-1831","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,24]]},"assertion":[{"value":"25 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have seen and approved the manuscript, contributed significantly to the work. There is no conflict of interest involved in this publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"14"}}