{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T08:21:02Z","timestamp":1772526062777,"version":"3.50.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T00:00:00Z","timestamp":1174003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2007,3,16]],"date-time":"2007-03-16T00:00:00Z","timestamp":1174003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2007,6]]},"DOI":"10.1007\/s00431-007-0461-8","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T14:00:51Z","timestamp":1173967251000},"page":"511-519","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["What is new in otitis media?"],"prefix":"10.1007","volume":"166","author":[{"given":"Lucien","family":"Corbeel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,3,16]]},"reference":[{"key":"461_CR1","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1542\/peds.113.5.1412","volume":"113","author":"American Academy of Family Physicians","year":"2004","unstructured":"American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery, American Academy of Pediatrics Subcommittee on Otitis Media With Effusion (2004) Otitis media with effusion. Pediatrics 113:1412\u20131429","journal-title":"Pediatrics"},{"key":"461_CR2","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1542\/peds.101.4.617","volume":"101","author":"MA Andrade","year":"1998","unstructured":"Andrade MA, Hoberman A, Glustein J, Paradise JL, Wald ER (1998) Acute otitis media in children with bronchiolitis. Pediatrics 101:617\u2013619","journal-title":"Pediatrics"},{"key":"461_CR3","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1542\/peds.2005-2172","volume":"117","author":"H Bauchner","year":"2006","unstructured":"Bauchner H, Marchant CD, Bisbee A, Heeren T, Wang B, McCabe M, Pelton S, Boston-Based Pediatric Research Group (2006) Effectiveness of Centers for Disease Control and Prevention recommendations for outcomes of acute otitis media. Pediatrics 117:1009\u20131017","journal-title":"Pediatrics"},{"key":"461_CR4","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/01.inf.0000172939.13159.3b","volume":"24","author":"E Bingen","year":"2005","unstructured":"Bingen E, Cohen R, Jourenkova N, Gehanno P (2005) Epidemiologic study of conjunctivitis-otitis syndrome. Pediatr Infect Dis J 24:731\u2013732","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR5","first-page":"356","volume-title":"Pediatric otolaryngology","author":"CD Bluestone","year":"1983","unstructured":"Bluestone CD, Klein JO (1983) Otitis media with effusion, atelectasis, and Eustachian tube dysfunction. In: Bluestone CD, Stool SE (eds) Pediatric otolaryngology. Saunders, Philadelphia, pp 356\u2013512"},{"key":"461_CR6","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1542\/peds.2004-0778","volume":"115","author":"CN Brouwer","year":"2005","unstructured":"Brouwer CN, Maille AR, Rovers MM, Veenhoven RH, Grobbee DE, Sanders EA, Schilder AG (2005) Effect of pneumococcal vaccination on quality of life in children with recurrent acute otitis media: a randomized, controlled trial. Pediatrics 115:273\u2013279","journal-title":"Pediatrics"},{"key":"461_CR7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.clinthera.2006.01.011","volume":"28","author":"S Brunton","year":"2006","unstructured":"Brunton S (2006) Current face of acute otitis media: microbiology and prevalence resulting from widespread use of heptavalent pneumococcal conjugate vaccine. Clin Ther 28:118\u2013123","journal-title":"Clin Ther"},{"key":"461_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00431-006-0233-x","volume":"166","author":"Y Bulut","year":"2007","unstructured":"Bulut Y, G\u00fcven M, Otlu B, Yenisehirli G, Aladag I, Eyibilen A, Dogru S (2007) Acute otitis media and respiratory viruses. Eur J Pediatr 166:223\u2013228. DOI 10.1007\/s00431-006-0233-x","journal-title":"Eur J Pediatr"},{"key":"461_CR9","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1097\/01.inf.0000178066.24569.98","volume":"24","author":"N Buznach","year":"2005","unstructured":"Buznach N, Dagan R, Greenberg D (2005) Clinical and bacterial characteristics of acute bacterial conjunctivitis in children in the antibiotic resistance era. Pediatr Infect Dis J 24:823\u2013828","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR10","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/00006454-199802000-00014","volume":"17","author":"DM Canafax","year":"1998","unstructured":"Canafax DM, Yuan Z, Chonmaitree T, Deka K, Russlie HQ, Giebink GS (1998) Amoxicillin middle ear fluid penetration and pharmacokinetics in children with acute otitis media. Pediatr Infect Dis J 17:149\u2013156","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00431-005-0024-9","volume":"165","author":"J Casado-Flores","year":"2006","unstructured":"Casado-Flores J, Aristegui J, de Liria CR, Martinon JM, Fernandez C; Spanish Pneumococcal Meningitis Study Group (2006) Clinical data and factors associated with poor outcome in pneumococcal meningitis. Eur J Pediatr 165:285\u2013289","journal-title":"Eur J Pediatr"},{"key":"461_CR12","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/S0022-3476(05)81950-X","volume":"120","author":"T Chonmaitree","year":"1992","unstructured":"Chonmaitree T, Owen MJ, Patel JA, Hedgpeth D, Horlick D, Howie VM (1992) Effect of viral respiratory tract infection on outcome of acute otitis media. J Pediatr 120:856\u2013862","journal-title":"J Pediatr"},{"key":"461_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00431-004-1565-z","volume":"164","author":"L Corbeel","year":"2005","unstructured":"Corbeel L (2005) The \u2018wait and see\u2019 approach of acute otitis media. Eur J Pediatr 164:1\u20132","journal-title":"Eur J Pediatr"},{"key":"461_CR14","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s00431-005-0025-8","volume":"165","author":"L Corbeel","year":"2006","unstructured":"Corbeel L (2006) Pneumococcal meningitis and otitis media. Eur J Pediatr 165:283\u2013284","journal-title":"Eur J Pediatr"},{"key":"461_CR15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1136\/bmj.320.7231.350","volume":"320","author":"RA Damoiseaux","year":"2000","unstructured":"Damoiseaux RA, van Balen FA, Hoes AW, Verheij TJ, de Melker RA (2000) Primary care based randomised, double blind trial of amoxicillin versus placebo for acute otitis media in children aged under 2\u00a0years. BMJ 320:350\u2013354","journal-title":"BMJ"},{"key":"461_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/fampra\/cmi083","volume":"23","author":"RA Damoiseaux","year":"2006","unstructured":"Damoiseaux RA, Rovers MM, Van Balen FA, Hoes AW, de Melker RA (2006) Long-term prognosis of acute otitis media in infancy: determinants of recurrent acute otitis media and persistent middle ear effusion. Fam Pract 23:40\u201345","journal-title":"Fam Pract"},{"key":"461_CR17","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0165-5876(00)00462-6","volume":"57","author":"J Engel","year":"2001","unstructured":"Engel J, Mahler E, Anteunis L, Marres E, Zielhuis G (2001) Why are NICU infants at risk for chronic otitis media with effusion? Int J Pediatr Otorhinolaryngol 57:137\u2013144","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"461_CR18","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1136\/adc.2004.063461","volume":"90","author":"DM Fleming","year":"2005","unstructured":"Fleming DM, Pannell RS, Elliot AJ, Cross KW (2005) Respiratory illness associated with influenza and respiratory syncytial virus infection. Arch Dis Child 90:741\u2013746","journal-title":"Arch Dis Child"},{"key":"461_CR19","unstructured":"Fletcher MA, Fritzell B (2006) Brief review of the clinical effectiveness of PREVENAR(\u00ae) against otitis media. Vaccine Sep 20 (epub ahead of print)"},{"key":"461_CR20","doi-asserted-by":"publisher","first-page":"e1087","DOI":"10.1542\/peds.2005-2651","volume":"117","author":"J Garbutt","year":"2006","unstructured":"Garbutt J, Rosenbloom I, Wu J, Storch GA (2006) Empiric first-line antibiotic treatment of acute otitis in the era of the heptavalent pneumococcal conjugate vaccine. Pediatrics 117:e1087\u2013e1094","journal-title":"Pediatrics"},{"key":"461_CR21","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1056\/NEJM199901283400402","volume":"340","author":"T Heikkinen","year":"1999","unstructured":"Heikkinen T, Thint M, Chonmaitree T (1999) Prevalence of various respiratory viruses in the middle ear during acute otitis media. N Engl J Med 340:260\u2013264","journal-title":"N Engl J Med"},{"key":"461_CR22","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1056\/NEJMcp010944","volume":"347","author":"JO Hendley","year":"2002","unstructured":"Hendley JO (2002) Otitis media. N Engl J Med 347:1169\u20131174","journal-title":"N Engl J Med"},{"key":"461_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00431-004-1564-0","volume":"164","author":"M Hotomi","year":"2005","unstructured":"Hotomi M, Yamanaka N, Samukawa T, Suzumot M, Sakai A, Shimada J, Ikeda Y, Faden H (2005) Treatment and outcome of severe and non-severe acute otitis media. Eur J Pediatr 164:3\u20138","journal-title":"Eur J Pediatr"},{"key":"461_CR24","first-page":"173","volume":"1","author":"K Ingels","year":"2005","unstructured":"Ingels K, Rovers MM, van der Wilt GJ, Zielhuis GA (2005) Ventilation tubes in infants increase the risk of otorrhoea and antibiotic usage. B-ENT 1:173\u2013176","journal-title":"B-ENT"},{"key":"461_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1046\/j.1365-2273.2000.00350.x","volume":"25","author":"H Kubba","year":"2000","unstructured":"Kubba H, Pearson JP, Birchall JP (2000) The aetiology of otitis media with effusion: a review. Clin Otolaryngol Allied Sci 25:181","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"461_CR26","first-page":"CD004401","volume":"18","author":"AJ Leach","year":"2006","unstructured":"Leach AJ, Morris PS (2006) Antibiotics for the prevention of acute and chronic suppurative otitis media in children. Cochrane Database Syst Rev 18:CD004401","journal-title":"Cochrane Database Syst Rev"},{"key":"461_CR27","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00006454-200306000-00006","volume":"22","author":"E Leibovitz","year":"2003","unstructured":"Leibovitz E, Satran R, Piglansky L, Raiz S, Press J, Leiberman A, Dagan R (2003) Can acute otitis media caused by Haemophilus influenzae be distinguished from that caused by Streptococcus pneumoniae? Pediatr Infect Dis J 22:509\u2013515","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR28","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1086\/429918","volume":"191","author":"S Libson","year":"2005","unstructured":"Libson S, Dagan R, Greenberg D, Porat N, Trepler R, Leiberman A, Leibovitz E (2005) Nasopharyngeal carriage of Streptococcus pneumoniae at the completion of successful antibiotic treatment of acute otitis media predisposes to early clinical recurrence. J Infect Dis 191:1869\u20131875","journal-title":"J Infect Dis"},{"key":"461_CR29","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.ijporl.2005.08.019","volume":"70","author":"M Lilja","year":"2006","unstructured":"Lilja M, Palva T, Ramsay H, Laitinen K, Andersson S (2006) Meconium contaminated amniotic fluid and infant otitis media. Is it a risk factor in children surviving aspiration and initial distress of respiration? Int J Pediatr Otorhinolaryngol 70:655\u2013662","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"461_CR30","first-page":"CD001801","volume":"1","author":"J Lous","year":"2005","unstructured":"Lous J, Burton MJ, Felding JU, Ovesen T, Rovers MM, Williamson I (2005) Grommets (ventilation tubes) for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev 1:CD001801","journal-title":"Cochrane Database Syst Rev"},{"key":"461_CR31","first-page":"123","volume":"1","author":"S McLinn","year":"1978","unstructured":"McLinn S (1978) Comparative study of cefaclor, a new cephalosporin, and amoxicillin in the treatment of acute otitis media in children. Curr Chemother 1:123\u2013125","journal-title":"Curr Chemother"},{"key":"461_CR32","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0165-5876(03)00124-1","volume":"67","author":"H Monobe","year":"2003","unstructured":"Monobe H, Ishibashi T, Normura Y, Shinogami M, Yano J (2003) Role of respiratory viruses in children with acute otitis media. Int J Pediatr Otorhinolaryngol 67:801\u2013806","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"461_CR33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/jmv.10581","volume":"72","author":"J Nokso-Koivisto","year":"2004","unstructured":"Nokso-Koivisto J, Raty R, Blomqvist S, Kleemola M, Syrjanen R, Pitkaranta A, Kilpi T, Hovi T (2004) Presence of specific viruses in the middle ear fluids and respiratory secretions of young children with acute otitis media. J Med Virol 72:241\u2013248","journal-title":"J Med Virol"},{"key":"461_CR34","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1056\/NEJM200104193441601","volume":"344","author":"JL Paradise","year":"2001","unstructured":"Paradise JL, Feldman HM, Campbell TF, Dollaghan CA, Colburn DK, Bernard BS, Rockette HE, Janosky JE, Pitcairn DL, Sabo DL, Kurs-Lasky M, Smith CG (2001) Effects of early or delayed insertion of tympanostomy tubes for persistent otitis media on developmental outcomes at the age of three years. N Engl J Med 344:1179\u20131187","journal-title":"N Engl J Med"},{"key":"461_CR35","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1542\/peds.65.5.917","volume":"65","author":"JL Paradise","year":"1980","unstructured":"Paradise JL (1980) Otitis media in infants and children. Pediatrics 65:917\u2013943","journal-title":"Pediatrics"},{"key":"461_CR36","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/00006454-199505001-00005","volume":"14","author":"JL Paradise","year":"1995","unstructured":"Paradise JL (1995) Treatment guidelines for otitis media: the need for breadth and flexibility. Pediatr Infect Dis J 14:429\u2013435","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1542\/peds.99.3.318","volume":"99","author":"JL Paradise","year":"1997","unstructured":"Paradise JL, Rockette HE, Colborn DK, Bernard BS, Smith CG, Kurs-Lasky M, Janosky JE (1997) Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics 99:318\u2013333","journal-title":"Pediatrics"},{"key":"461_CR38","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1542\/peds.112.2.265","volume":"112","author":"JL Paradise","year":"2003","unstructured":"Paradise JL, Dollaghan CA, Campbell TF, Feldman HM, Bernard BS, Colborn DK, Rockette HE, Janosky JE, Pitcairn DL, Kurs-Lasky M, Sabo DL, Smith CG (2003) Otitis media and tympanostomy tube insertion during the first three years of life: developmental outcomes at the age of four years. Pediatrics 112:265\u2013277","journal-title":"Pediatrics"},{"key":"461_CR39","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1542\/peds.2005-0064","volume":"115","author":"H Pellman","year":"2005","unstructured":"Pellman H (2005) Thoughts on the American Academy of Pediatrics\/American Academy of Family Physicians Clinical Practice Guideline on acute otitis media: a different perspective. Pediatrics 115:1443\u20131444","journal-title":"Pediatrics"},{"key":"461_CR40","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.pcl.2005.02.013","volume":"52","author":"SI Pelton","year":"2005","unstructured":"Pelton SI (2005) Otitis media: re-evaluation of diagnosis and treatment in the era of antimicrobial resistance, pneumococcal conjugate vaccine, and evolving morbidity. Pediatr Clin North Am 52:711\u2013728","journal-title":"Pediatr Clin North Am"},{"key":"461_CR41","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1056\/NEJM199906243402513","volume":"340","author":"A Pitkaranta","year":"1999","unstructured":"Pitkaranta A, Hayden FG (1999) Respiratory viruses and otitis media. N Engl J Med 340:2001\u20132002","journal-title":"N Engl J Med"},{"key":"461_CR42","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.diagmicrobio.2005.02.012","volume":"53","author":"S Pottumarthy","year":"2005","unstructured":"Pottumarthy S, Sader HS, Fritsche TR, Jones RN (2005) Susceptibility patterns for amoxicillin\/clavulanate tests mimicking the licensed formulations and pharmacokinetic relationships: do the MIC obtained with 2:1 ratio testing accurately reflect activity against beta-lactamase-producing strains of Haemophilus influenzae and Moraxella catarrhalis? Diagn Microbiol Infect Dis 53:225\u2013231","journal-title":"Diagn Microbiol Infect Dis"},{"key":"461_CR43","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1080\/08035250500437531","volume":"95","author":"M Renko","year":"2006","unstructured":"Renko M, Kontiokari T, Jounio-Ervasti K, Rantala H, Uhari M (2006) Disappearance of middle ear effusion in acute otitis media monitored daily with tympanometry. Acta Paediatr 95:359\u2013363","journal-title":"Acta Paediatr"},{"key":"461_CR44","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1542\/peds.2005-1983","volume":"117","author":"K Revai","year":"2006","unstructured":"Revai K, McCormick DP, Patel J, Grady JJ, Saeed K, Chonmaitree T (2006) Effect of pneumococcal conjugate vaccine on nasopharyngeal bacterial colonization during acute otitis media. Pediatrics 117:1823\u20131829","journal-title":"Pediatrics"},{"key":"461_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/S0022-3476(94)70356-6","volume":"124","author":"RM Rosenfeld","year":"1994","unstructured":"Rosenfeld RM, Vertrees JE, Carr J, Cipolle RJ, Uden DL, Giebink GS, Canafax DM (1994) Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials. J Pediatr 124:355\u2013367","journal-title":"J Pediatr"},{"key":"461_CR46","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1016\/j.otohns.2004.02.002","volume":"130","author":"RM Rosenfeld","year":"2004","unstructured":"Rosenfeld RM, Culpepper L, Doyle KJ, Grundfast KM, Hoberman A, Kenna MA, Lieberthal AS, Mahoney M, Wahl RA, Woods CR Jr, Yawn B, American Academy of Pediatrics Subcommittee on Otitis Media with Effusion, American Academy of Family Physicians, American Academy of Otolaryngology-Head and Neck Surgery (2004) Clinical practice guideline: otitis media with effusion. Otolaryngol Head Neck Surg 130:S95\u2013S118","journal-title":"Otolaryngol Head Neck Surg"},{"key":"461_CR47","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S0140-6736(04)15495-0","volume":"363","author":"MM Rovers","year":"2004","unstructured":"Rovers MM, Schilder AG, Zielhuis GA, Rosenfeld RN (2004) Otitis media. Lancet 363:465\u2013473","journal-title":"Lancet"},{"key":"461_CR48","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/adc.2004.059444","volume":"90","author":"MM Rovers","year":"2005","unstructured":"Rovers MM, Black N, Browning GG, Maw R, Zielhuis GA, Haggard MP (2005) Grommets in otitis media with effusion: an individual patient data meta-analysis. Arch Dis Child 90:480\u2013485","journal-title":"Arch Dis Child"},{"key":"461_CR49","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1016\/S0140-6736(06)69606-2","volume":"368","author":"MM Rovers","year":"2006","unstructured":"Rovers MM, Glasziou P, Appelman CL, Burke P, McCormick DP, Damoiseaux RA, Gaboury I, Little P, Hoes AW (2006) Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet 368:1429\u20131435","journal-title":"Lancet"},{"key":"461_CR50","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.anl.2004.07.005","volume":"31","author":"S Sagai","year":"2004","unstructured":"Sagai S, Suetake M, Yano H, Yoshida M, Ohyama K, Endo H, Takayanagi R, Nishimura H, Kobayashi T (2004) Relationship between respiratory syncytial virus infection and acute otitis media in children. Auris Nasus Larynx 31:341\u2013345","journal-title":"Auris Nasus Larynx"},{"key":"461_CR51","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/jcm.33.8.2027-2031.1995","volume":"33","author":"A Samuelson","year":"1995","unstructured":"Samuelson A, Freijd A, Jonasson J, Lindberg AA (1995) Turnover of nonencapsulated Haemophilus influenzae in the nasopharynges of otitis-prone children. J Clin Microbiol 33:2027\u20132031","journal-title":"J Clin Microbiol"},{"key":"461_CR52","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1046\/j.1365-2125.1999.00887.x","volume":"47","author":"F Scaglione","year":"1999","unstructured":"Scaglione F, Demartini G, Dugnani S, Arcidiacono MM, Pintucci JP, Fraschini F (1999) Interpretation of middle ear fluid concentrations of antibiotics: comparison between ceftibuten, cefixime and azithromycin. Br J Clin Pharmacol 47:267\u2013271","journal-title":"Br J Clin Pharmacol"},{"key":"461_CR53","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s00431-005-1655-6","volume":"164","author":"O Schildgen","year":"2005","unstructured":"Schildgen O, Gelkowski T, Glatzel T, Schuster J, Simon A (2005) Frequency of human metapneumovirus in the upper respiratory tract of children with symptoms of an acute otitis media. Eur J Pediatr 164:400\u2013401","journal-title":"Eur J Pediatr"},{"key":"461_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2005-1879","volume":"118","author":"CG Smith","year":"2006","unstructured":"Smith CG, Paradise JL, Sabo DL, Rockette HE, Kurs-Lasky M, Bernard BS, Colborn DK (2006) Tympanometric findings and the probability of middle-ear effusion in 3686 infants and young children. Pediatrics 118:1\u201313","journal-title":"Pediatrics"},{"key":"461_CR55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/infdis\/154.1.100","volume":"154","author":"SM Spinola","year":"1986","unstructured":"Spinola SM, Peacock J, Denny FW, Smith DL, Cannon JG (1986) Epidemiology of colonization by nontypable Haemophilus influenzae in children: a longitudinal study. J Infect Dis 154:100\u2013109","journal-title":"J Infect Dis"},{"key":"461_CR56","first-page":"CD001480","volume":"1","author":"M Straetemans","year":"2004","unstructured":"Straetemans M, Sanders EA, Veenhoven RH, Schilder AG, Damoiseaux RA, Zielhuis GA (2004) Pneumococcal vaccines for preventing otitis media. Cochrane Database Syst Rev 1:CD001480","journal-title":"Cochrane Database Syst Rev"},{"key":"461_CR57","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/01.inf.0000178072.83531.4f","volume":"24","author":"RK Syrjanen","year":"2005","unstructured":"Syrjanen RK, Auranen KJ, Leino TM, Kilpi TM, Makela PH (2005) Pneumococcal acute otitis media in relation to pneumococcal nasopharyngeal carriage. Pediatr Infect Dis J 24:801\u2013806","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR58","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1097\/01.inf.0000241097.37428.1d","volume":"25","author":"RK Syrjanen","year":"2006","unstructured":"Syrjanen RK, Herva EE, Makela PH, Puhakka HJ, Auranen KJ, Takala AK, Kilpi TM (2006) The value of nasopharyngeal culture in predicting the etiology of acute otitis media in children less than two years of age. Pediatr Infect Dis J 25:1032\u20131036","journal-title":"Pediatr Infect Dis J"},{"key":"461_CR59","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.idc.2005.05.008","volume":"19","author":"P Toltzis","year":"2005","unstructured":"Toltzis P, Jacobs MR (2005) The epidemiology of childhood pneumococcal disease in the United States in the era of conjugate vaccine use. Infect Dis Clin North Am 19:629\u2013645","journal-title":"Infect Dis Clin North Am"},{"key":"461_CR60","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1097\/01.mlg.0000172207.59888.a2","volume":"115","author":"H Valtonen","year":"2005","unstructured":"Valtonen H, Dietz A, Qvarnberg Y (2005) Long-term clinical, audiologic, and radiologic outcomes in palate cleft children treated with early tympanostomy for otitis media with effusion: a controlled prospective study. Laryngoscope 115:1512\u20131516","journal-title":"Laryngoscope"},{"key":"461_CR61","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s00431-004-1475-0","volume":"163","author":"MJ van Kempen","year":"2004","unstructured":"van Kempen MJ, Vaneechoutte M, Claeys G, Verschraegen GL, Vermeiren J, Dhooge IJ (2004) Antibiotic susceptibility of acute otitis media pathogens in otitis-prone Belgian children. Eur J Pediatr 163:524\u2013529","journal-title":"Eur J Pediatr"},{"key":"461_CR62","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.ijporl.2005.06.022","volume":"70","author":"MJ van Kempen","year":"2006","unstructured":"van Kempen MJ, Vermeiren JS, Vaneechoutte M, Claeys G, Veenhoven RH, Rijkers GT, Sanders EA, Dhooge IJ (2006) Pneumococcal conjugate vaccination in children with recurrent acute otitis media: a therapeutic alternative? Int J Pediatr Otorhinolaryngol 70:275\u2013285","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"461_CR63","doi-asserted-by":"publisher","unstructured":"Vlastarakos PV, Nikolopoulos TP, Korres S, Tavoulari E, Tzagaroulakis A, Ferekidis E (2007) Grommets in otitis media with effusion: the most frequent operation in children. But does it have significant complications? Eur J Pediatr. DOI 10.1007\/s00431-006-0367-x","DOI":"10.1007\/s00431-006-0367-x"},{"key":"461_CR64","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1016\/j.jinf.2004.09.002","volume":"51","author":"H Yano","year":"2005","unstructured":"Yano H, Suetake M, Endo H, Takayanagi R, Numata M, Ohyama K, Sagai S, Okitsu N, Okamoto M, Nishimura H, Kobayashi T (2005) Isolation of measles virus from middle ear fluid of infants with acute otitis media. J Infect 51:e237\u2013e240","journal-title":"J Infect"},{"key":"461_CR65","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.ijporl.2005.12.002","volume":"70","author":"D Zanetti","year":"2006","unstructured":"Zanetti D, Nassif N (2006) Indications for surgery in acute mastoiditis and their complications in children. Int J Pediatr Otorhinolaryngol 70:1175\u20131182","journal-title":"Int J Pediatr Otorhinolaryngol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-007-0461-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-007-0461-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-007-0461-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T02:45:14Z","timestamp":1707705914000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-007-0461-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,16]]},"references-count":65,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["461"],"URL":"https:\/\/doi.org\/10.1007\/s00431-007-0461-8","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,16]]},"assertion":[{"value":"16 January 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}