{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:41:27Z","timestamp":1770504087161,"version":"3.49.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:00:00Z","timestamp":1219795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1007\/s00431-008-0816-9","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T07:03:13Z","timestamp":1219734193000},"page":"673-677","source":"Crossref","is-referenced-by-count":8,"title":["Fulminant sepsis\/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy"],"prefix":"10.1007","volume":"168","author":[{"given":"Masataka","family":"Ishimura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsumasa","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Hoshina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Baba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Urata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryutaro","family":"Kira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Takada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kusuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongchon","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,27]]},"reference":[{"key":"816_CR1","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"GR Bernard","year":"2001","unstructured":"Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A et al (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344:699\u2013709","journal-title":"N Engl J Med"},{"key":"816_CR2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00000441-200612000-00006","volume":"332","author":"AP Betrosian","year":"2006","unstructured":"Betrosian AP, Berlet T, Agarwal B (2006) Purpura fulminans in sepsis. Am J Med Sci 332:339\u2013345","journal-title":"Am J Med Sci"},{"key":"816_CR3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1177\/000313480306900119","volume":"69","author":"BJ Childers","year":"2003","unstructured":"Childers BJ, Cobanov B (2003) Acute infectious purpura fulminans: a 15-year retrospective review of 28 consecutive cases. Am Surg 69:86\u201390","journal-title":"Am Surg"},{"key":"816_CR4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0163-4453(92)94081-8","volume":"25","author":"S Dollberg","year":"1992","unstructured":"Dollberg S, Nachum Z, Klar A, Engelhard D, Ginat-Israeli T, Hurvitz H et al (1992) Haemophilus influenzae type b purpura fulminans treated with hyperbaric oxygen. J Infect 25:197\u2013200","journal-title":"J Infect"},{"key":"816_CR5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0002-9440(10)63401-3","volume":"165","author":"JG Ganopolsky","year":"2004","unstructured":"Ganopolsky JG, Castellino FJ (2004) A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol 165:1433\u20131446","journal-title":"Am J Pathol"},{"key":"816_CR6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/01.bcr.0000194269.95027.51","volume":"27","author":"T Gast","year":"2006","unstructured":"Gast T, Kowal-Vern A, An G, Hanumadass ML (2006) Purpura fulminans in an adult patient with Haemophilus influenzae sepsis: case report and review of the literature. J Burn Care Res 27:102\u2013107","journal-title":"J Burn Care Res"},{"key":"816_CR7","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/01.PCC.0000217470.68764.36","volume":"7","author":"B Goldstein","year":"2006","unstructured":"Goldstein B, Nadel S, Peters M, Barton R, Machado F, Levy H et al (2006) ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis. Pediatr Crit Care Med 7:200\u2013211","journal-title":"Pediatr Crit Care Med"},{"key":"816_CR8","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ajh.20435","volume":"80","author":"A G\u00fcrgey","year":"2005","unstructured":"G\u00fcrgey A, Aytac S, Kanra G, Secmeer G, Ceyhan M, Altay C (2005) Outcome in children with purpura fulminans: report on 16 patients. Am J Hematol 80:20\u201325","journal-title":"Am J Hematol"},{"key":"816_CR9","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1182\/blood-2003-06-1789","volume":"102","author":"BA Kerlin","year":"2003","unstructured":"Kerlin BA, Yan SB, Isermann BH, Brandt JT, Sood R, Basson BR et al (2003) Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood 102:3085\u20133092","journal-title":"Blood"},{"key":"816_CR10","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.clinbiochem.2005.05.006","volume":"38","author":"S Kinoshita","year":"2005","unstructured":"Kinoshita S, Iida H, Inoue S, Watanabe K, Kurihara M, Wada Y et al (2005) Protein S and protein C gene mutations in Japanese deep vein thrombosis patients. Clin Biochem 38:908\u2013915","journal-title":"Clin Biochem"},{"key":"816_CR11","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1182\/blood-2006-07-037945","volume":"109","author":"AJ Lay","year":"2007","unstructured":"Lay AJ, Donahue D, Tsai MJ, Castellino FJ (2007) Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood 109:1984\u20131991","journal-title":"Blood"},{"key":"816_CR12","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1182\/blood-2002-10-3254","volume":"101","author":"M Levi","year":"2003","unstructured":"Levi M, D\u00f6rffler-Melly J, Reitsma P, Buller H, Florquin S, van der Poll T et al (2003) Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice. Blood 101:4823\u20134827","journal-title":"Blood"},{"key":"816_CR13","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2006-09-003004","volume":"109","author":"LO Mosnier","year":"2007","unstructured":"Mosnier LO, Zlokovic BV, Griffin JH (2007) The cytoprotective protein C pathway. Blood 109:3161\u20133172","journal-title":"Blood"},{"key":"816_CR14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0140-6736(07)60411-5","volume":"369","author":"S Nadel","year":"2007","unstructured":"Nadel S, Goldstein B, Williams MD, Dalton H, Peters M, Macias WL et al (2007) Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet 369:836\u2013843","journal-title":"Lancet"},{"key":"816_CR15","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/BF02190684","volume":"153","author":"P Nguy\u00ean","year":"1994","unstructured":"Nguy\u00ean P, Reynaud J, Pouzol P, Munzer M, Richard O, Fran\u00e7ois P (1994) Varicella and thrombotic complications associated with transient protein C and protein S deficiencies in children. Eur J Pediatr 153:646\u2013649","journal-title":"Eur J Pediatr"},{"key":"816_CR16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-2000-9796","volume":"26","author":"T Sakata","year":"2000","unstructured":"Sakata T, Kario K, Katayama Y, Matsuyama T, Kato H, Miyata T (2000) Studies on congenital protein C deficiency in Japanese: prevalence, genetic analysis, and relevance to the onset of arterial occlusive diseases. Semin Thromb Hemost 26:11\u201316","journal-title":"Semin Thromb Hemost"},{"key":"816_CR17","first-page":"516","volume":"46","author":"JP Santamaria","year":"1985","unstructured":"Santamaria JP, Kenney S, Stiles AD (1985) Purpura fulminans associated with Haemophilus influenzae type B infection. N C Med J 46:516\u2013517","journal-title":"N C Med J"},{"key":"816_CR18","doi-asserted-by":"crossref","unstructured":"Shorr AF, Nelson DR, Wyncoll DL, Reinhart K, Brunkhorst F, Vail GM, Janes J (2008) Protein C: a potential biomarker in severe sepsis and a possible tool for monitoring treatment with drotrecogin alfa (activated). Crit Care (in press)","DOI":"10.1186\/cc6854"},{"key":"816_CR19","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/INF.0b013e3180f616f0","volume":"26","author":"S Venkataseshan","year":"2007","unstructured":"Venkataseshan S, Dutta S, Ahluwalia J, Narang A (2007) Low plasma protein C values predict mortality in low birth weight neonates with septicemia. Pediatr Infect Dis J 26:684\u2013688","journal-title":"Pediatr Infect Dis J"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-008-0816-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-008-0816-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-008-0816-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T18:52:08Z","timestamp":1684522328000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-008-0816-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,27]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["816"],"URL":"https:\/\/doi.org\/10.1007\/s00431-008-0816-9","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,27]]}}}