{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:55:19Z","timestamp":1775253319639,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T00:00:00Z","timestamp":1296172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1007\/s00431-011-1400-2","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T07:23:13Z","timestamp":1296112993000},"page":"1039-1047","source":"Crossref","is-referenced-by-count":8,"title":["Study of patients with Hyper-IgM type IV phenotype who recovered spontaneously during late childhood and review of the literature"],"prefix":"10.1007","volume":"170","author":[{"given":"Neslihan Edeer","family":"Karaca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Durandy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Gulez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guzide","family":"Aksu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necil","family":"Kutukculer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,28]]},"reference":[{"key":"1400_CR1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJM198108273050905","volume":"305","author":"ME Conley","year":"1981","unstructured":"Conley ME, Cooper MD (1981) Immature IgA B cells in IgA-deficient patients. N Engl J Med 305:495\u2013497","journal-title":"N Engl J Med"},{"key":"1400_CR2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","volume":"92","author":"C Cunningham-Rundles","year":"1999","unstructured":"Cunningham-Rundles C, Bodian C (1999) Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 92:34\u201348","journal-title":"Clin Immunol"},{"key":"1400_CR3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2141.2010.08077.x","volume":"149","author":"EG Davies","year":"2010","unstructured":"Davies EG, Thrasher AJ (2010) Update on the hyper immunoglobulin M syndromes. Br J Haematol 149:167\u2013180","journal-title":"Br J Haematol"},{"key":"1400_CR4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0065-2776(04)82007-8","volume":"82","author":"A Durandy","year":"2004","unstructured":"Durandy A, Revy P, Fischer A (2004) Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (Hyper-IgM syndromes). Adv Immunol 82:295\u2013330","journal-title":"Adv Immunol"},{"key":"1400_CR5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2005.00222.x","volume":"203","author":"A Durandy","year":"2005","unstructured":"Durandy A, Revy P, Imai K, Fischer A (2005) Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects. Immunol Rev 203:67\u201379","journal-title":"Immunol Rev"},{"key":"1400_CR6","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/01.bor.0000231905.12172.b5","volume":"18","author":"A Durandy","year":"2006","unstructured":"Durandy A, Peron S, Fischer A (2006) Hyper-IgM syndromes. Curr Opin Rheumatol 18:369\u2013376","journal-title":"Curr Opin Rheumatol"},{"key":"1400_CR7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0065-2776(06)94009-7","volume":"94","author":"A Durandy","year":"2007","unstructured":"Durandy A, Taubenheim N, Peron S, Fischer A (2007) Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies. Adv Immunol 94:275\u2013306","journal-title":"Adv Immunol"},{"key":"1400_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2004.09.021","volume":"97","author":"M Erdos","year":"2005","unstructured":"Erdos M, Durandy A, Mar\u00f3di L (2005) Genetically acquired class-switch recombination defects: the multi-faced Hyper-IgM syndrome. Immunol Lett 97:1\u20136","journal-title":"Immunol Lett"},{"key":"1400_CR9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3324\/haematol.10172","volume":"92","author":"M Erdos","year":"2007","unstructured":"Erdos M, Alapi K, Mar\u00f3di L (2007) Retrospective diagnosis of X-linked hyper-IgM syndrome in a family with multiple deaths of affected males. Haematologica 92:281\u2013282","journal-title":"Haematologica"},{"key":"1400_CR10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clim.2008.08.005","volume":"129","author":"M Erdos","year":"2008","unstructured":"Erdos M, Garami M, R\u00e1k\u00f3czi E, Zalatnai A, Steinbach D, Baumann U, Kropshofer G, T\u00f3th B, Mar\u00f3di L (2008) Neuroendocrine carcinoma associated with X-linked hyper-immunoglobulin M syndrome: report of four cases and review of the literature. Clin Immunol 129:455\u2013461","journal-title":"Clin Immunol"},{"key":"1400_CR11","first-page":"406","volume":"9","author":"A Etzioni","year":"2007","unstructured":"Etzioni A, Ben-Barak A, Peron S, Durandy A (2007) Ataxia\u2013telangiectasia in twins presenting as autosomal recessive hyper-immunoglobulin M syndrome. Isr Med Assoc J 9:406\u2013407","journal-title":"Isr Med Assoc J"},{"key":"1400_CR12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jaci.2007.08.053","volume":"120","author":"RS Geha","year":"2007","unstructured":"Geha RS, Notarangelo LD, Casanova JL, Chapel H, Conley ME, Fischer A et al (2007) Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J Allergy Clin Immunol 120:776\u2013794","journal-title":"J Allergy Clin Immunol"},{"key":"1400_CR13","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/S0090-1229(05)80040-6","volume":"61","author":"LA Hanson","year":"1991","unstructured":"Hanson LA, S\u00f6derstr\u00f6m R, Nilssen DE, Theman K, Bj\u00f6rkander J, S\u00f6derstr\u00f6m T, Karlsson G, Brandtzaeg P (1991) IgG subclass deficiency with or without IgA deficiency. Clin Immunol Immunopathol 61:S70\u2013S77","journal-title":"Clin Immunol Immunopathol"},{"key":"1400_CR14","first-page":"125","volume":"46","author":"A Ikincio\u011fullari","year":"2004","unstructured":"Ikincio\u011fullari A, Kendirli T, Do\u011fu F, E\u011fin Y, Reisli I, Cin S, Babacan E (2004) Peripheral blood lymphocyte subsets in healthy Turkish children. Turk J Pediatr 46:125\u2013130","journal-title":"Turk J Pediatr"},{"key":"1400_CR15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1172\/JCI18161","volume":"112","author":"K Imai","year":"2003","unstructured":"Imai K, Catalan N, Plebani A, Mar\u00f3di L, Sanal O, Kumaki S, Nagendran V, Wood P, Glastre C, Sarrot-Reynauld F, Hermine O, Forveille M, Revy P, Fischer A, Durandy A (2003) Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination. J Clin Invest 112:136\u2013142","journal-title":"J Clin Invest"},{"key":"1400_CR16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.clim.2005.02.003","volume":"115","author":"K Imai","year":"2005","unstructured":"Imai K, Zhu Y, Revy P, Morio T, Mizutani S, Fischer A, Nonoyama S, Durandy A (2005) Analysis of class switch recombination and somatic hypermutation in patients affected with autosomal dominant Hyper-IgM syndrome type 2. Clin Immunol 115:277\u2013285","journal-title":"Clin Immunol"},{"key":"1400_CR17","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1007\/s10875-008-9171-x","volume":"28","author":"AA Jesus","year":"2008","unstructured":"Jesus AA, Duarte AJ, Oliveira JB (2008) Autoimmunity in Hyper-IgM syndrome. J Clin Immunol 28:S62\u2013S66","journal-title":"J Clin Immunol"},{"key":"1400_CR18","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2249.1997.3801278.x","volume":"108","author":"ML Johnson","year":"1997","unstructured":"Johnson ML, Keeton LG, Zhu ZB, Volanakis JE, Cooper MD, Schroeder HW Jr (1997) Age-related changes in serum immunoglobulins in patients with familial IgA deficiency and common variable immunodeficiency (CVID). Clin Exp Immunol 108:477\u2013483","journal-title":"Clin Exp Immunol"},{"key":"1400_CR19","first-page":"43","volume":"27","author":"NE Karaca","year":"2009","unstructured":"Karaca NE, Karadeniz C, Aksu G, Kutukculer N (2009) Clinical and laboratory evaluation of periodically monitored Turkish children with IgG subclass deficiencies. Asian Pac J Allergy Immunol 27:43\u201348","journal-title":"Asian Pac J Allergy Immunol"},{"key":"1400_CR20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.clim.2010.01.012","volume":"135","author":"S Kracker","year":"2010","unstructured":"Kracker S, Gardes P, Mazerolles F, Durandy A (2010) Immunoglobulin class switch recombination deficiencies. Clin Immunol 135:193\u2013203","journal-title":"Clin Immunol"},{"key":"1400_CR21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1399-3038.2006.00491.x","volume":"18","author":"N Kutukculer","year":"2007","unstructured":"Kutukculer N, Karaca NE, Demircioglu O, Aksu G (2007) Increases in serum immunoglobulins to age-related normal levels in children with IgA and\/or IgG subclass deficiency. Pediatr Allergy Immunol 18:167\u2013173","journal-title":"Pediatr Allergy Immunol"},{"key":"1400_CR22","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1182\/blood-2010-03-274241","volume":"116","author":"G Lanzi","year":"2010","unstructured":"Lanzi G, Ferrari S, Vihinen M, Caraffi S, Kutukculer N, Schiaffonati L, Plebani A, Notarangelo LD, Fra AM, Giliani S (2010) Different molecular behavior of CD40 mutants causing hyper-IgM syndrome. Blood 116:5867\u20135874","journal-title":"Blood"},{"key":"1400_CR23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0952-7915(02)00356-4","volume":"14","author":"RA Manz","year":"2002","unstructured":"Manz RA, Arce S, Cassese G, Hauser AE, Hiepe F, Radbruch A (2002) Humoral immunity and long-lived plasma cells. Curr Opin Immunol 14:517\u2013521","journal-title":"Curr Opin Immunol"},{"key":"1400_CR24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-3476(87)80286-X","volume":"110","author":"SJ McGeady","year":"1987","unstructured":"McGeady SJ (1987) Transient hypogammaglobulinemia of infancy: need to reconsider name and definition. J Pediatr 110:47\u201350","journal-title":"J Pediatr"},{"key":"1400_CR25","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1182\/blood-2008-04-153544","volume":"113","author":"HE Mei","year":"2009","unstructured":"Mei HE, Yoshida T, Sime W, Hiepe F, Thiele K, Manz RA, Radbruch A, D\u00f6rner T (2009) Blood-borne human plasma cells in steady state are derived from mucosal immune responses. Blood 113:2461\u20132469","journal-title":"Blood"},{"key":"1400_CR26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/039463200802100211","volume":"21","author":"V Moschese","year":"2008","unstructured":"Moschese V, Graziani S, Avanzini MA, Carsetti R, Marconi M, La Rocca M, Chini L, Pignata C, Soresina AR, Consolini R, Bossi G, Trizzino A, Martino S, Cardinale F, Bertolini P, Marseglia GL, Zecca M, Di Cesare S, Quinti I, Rondelli R, Pietrogrande MC, Rossi P, Plebani A (2008) A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: results from the Italian Primary Immunodeficiency Network. Int J Immunopathol Pharmacol 21:343\u2013352","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1400_CR27","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1182\/blood-2004-08-2992","volume":"105","author":"G Muehlinghaus","year":"2005","unstructured":"Muehlinghaus G, Cigliano L, Huehn S, Peddinghaus A, Leyendeckers H, Hauser AE, Hiepe F, Radbruch A, Arce S, Manz RA (2005) Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells. Blood 105:3965\u20133971","journal-title":"Blood"},{"key":"1400_CR28","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI116701","volume":"92","author":"S Nonoyama","year":"1993","unstructured":"Nonoyama S, Farrington M, Ishida H, Howard M, Ochs HD (1993) Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin. J Clin Invest 92:1282\u20131287","journal-title":"J Clin Invest"},{"key":"1400_CR29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jaci.2006.01.043","volume":"117","author":"LD Notarangelo","year":"2006","unstructured":"Notarangelo LD, Lanzi G, Peron S, Durandy A (2006) Defects of class-switch recombination. J Allergy Clin Immunol 117:855\u2013864","journal-title":"J Allergy Clin Immunol"},{"key":"1400_CR30","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1182\/blood-2004-07-2507","volume":"105","author":"M Odendahl","year":"2005","unstructured":"Odendahl M, Mei H, Hoyer BF, Jacobi AM, Hansen A, Muehlinghaus G, Berek C, Hiepe F, Manz R, Radbruch A, D\u00f6rner T (2005) Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood 105:1614\u20131621","journal-title":"Blood"},{"key":"1400_CR31","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1084\/jem.20080789","volume":"205","author":"S P\u00e9ron","year":"2008","unstructured":"P\u00e9ron S, Metin A, Gard\u00e8s P, Alyanakian MA, Sheridan E, Kratz CP, Fischer A, Durandy A (2008) Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombination. J Exp Med 205:2465\u20132472","journal-title":"J Exp Med"},{"key":"1400_CR32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/eji.1830180221","volume":"18","author":"P Vieira","year":"1988","unstructured":"Vieira P, Rajewsky K (1988) The half-lives of serum immunoglobulins in adult mice. Eur J Immunol 18:313\u2013316","journal-title":"Eur J Immunol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-011-1400-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-011-1400-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-011-1400-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T04:32:36Z","timestamp":1559968356000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-011-1400-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,28]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["1400"],"URL":"https:\/\/doi.org\/10.1007\/s00431-011-1400-2","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,28]]}}}