{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:25Z","timestamp":1791353485268,"version":"4.3.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,2,17]],"date-time":"2012-02-17T00:00:00Z","timestamp":1329436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1007\/s00431-012-1689-5","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T12:07:30Z","timestamp":1329394050000},"page":"1103-1108","source":"Crossref","is-referenced-by-count":18,"title":["Role of cytokine gene (IFN-\u03b3, TNF-\u03b1, TGF-\u03b21, IL-6, and IL-10) polymorphisms in pathogenesis of acute rheumatic fever in Turkish children"],"prefix":"10.1007","volume":"171","author":[{"given":"Nilgun","family":"Col-Araz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sacide","family":"Pehlivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Baspinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Oguzkan-Balci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugce","family":"Sever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse","family":"Balat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,17]]},"reference":[{"key":"1689_CR1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11010-011-0782-9","volume":"353","author":"MA Al-Tahhan","year":"2011","unstructured":"Al-Tahhan MA, Etewa RL, El Behery MM (2011) Association between circulating interleukin-1 beta (IL-1\u03b2) levels and IL-1\u03b2 C-511T polymorphism with cervical cancer risk in Egyptian women. Mol Cell Biochem 353:159\u2013165","journal-title":"Mol Cell Biochem"},{"key":"1689_CR2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/03009740510026760","volume":"35","author":"A Berdeli","year":"2006","unstructured":"Berdeli A, Tabel Y, Celik HA, Ozyurek R, Dogrusoz B, Aydin HH (2006) Lack of association between TNF \u03b1 gene polymorphism at position \u2212308 and risk of acute rheumatic fever in Turkish patients. Scand J Rheumatol 35:44\u201347","journal-title":"Scand J Rheumatol"},{"key":"1689_CR3","first-page":"1961","volume-title":"Nelson textbook of pediatrics","author":"D Bernstein","year":"2008","unstructured":"Bernstein D (2008) Rheumatic hearth disease. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia, pp 1961\u20131963","edition":"18"},{"key":"1689_CR4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0140-6736(05)66874-2","volume":"366","author":"JR Carapetis","year":"2005","unstructured":"Carapetis JR, McDonald M, Wilson NJ (2005) Acute rheumatic fever. Lancet 366:155\u2013168","journal-title":"Lancet"},{"key":"1689_CR5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ahj.2004.03.032","volume":"148","author":"HT Chou","year":"2004","unstructured":"Chou HT, Chen CH, Tsai CH, Tsai FJ (2004) Association between transforming growth factor-\u03b21 gene C-509T and T869C polymorphisms and rheumatic heart disease. Am Heart J 148:181\u2013186","journal-title":"Am Heart J"},{"key":"1689_CR6","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1536\/ihj.46.397","volume":"46","author":"HT Chou","year":"2005","unstructured":"Chou HT, Tsai CH, Chen WC, Tsai FJ (2005) Lack of association of genetic polymorphisms in the interleukin-1\u03b2, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 genes with risk of rheumatic heart disease in Taiwan Chinese. Int Heart J 46:397\u2013406","journal-title":"Int Heart J"},{"key":"1689_CR7","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","volume":"180","author":"KN Couper","year":"2008","unstructured":"Couper KN, Blount DG, Riley EM (2008) Il-10: the master regulator of immunity to infection. J Immunol 180:5771\u20135777","journal-title":"J Immunol"},{"key":"1689_CR8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","volume":"102","author":"D Fishman","year":"1988","unstructured":"Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S, Woo P (1988) The effect of novel polymorphism in the interleukin-6 (IL-6) gene on IL-6 transkription and plasma IL-6 levels, and an association with systemic onset juvenile chronic arthritis. J Clin Invest 102:1369\u20131376","journal-title":"J Clin Invest"},{"key":"1689_CR9","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.autrev.2009.01.012","volume":"8","author":"JE Fonseca","year":"2009","unstructured":"Fonseca JE, Santos MJ, Canhao H, Choy E (2009) Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 8:538\u2013542","journal-title":"Autoimmun Rev"},{"key":"1689_CR10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0006-2952(03)00490-8","volume":"66","author":"U Gaur","year":"2003","unstructured":"Gaur U, Aggarwal BB (2003) Regulation of proliferation, survival and apoptozis by members of the TNF superfamily. Biochem Pharmacol 66:1403\u20131408","journal-title":"Biochem Pharmacol"},{"key":"1689_CR11","first-page":"1135","volume-title":"Nelson textbook of pediatrics","author":"MA Gerber","year":"2008","unstructured":"Gerber MA (2008) Group A streptococcus. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF (eds) Nelson textbook of pediatrics, 18th edn. Saunders Elsevier, Philadelphia, pp 1135\u20131145","edition":"18"},{"key":"1689_CR12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1388-9842(02)00102-2","volume":"4","author":"Z Golbasi","year":"2002","unstructured":"Golbasi Z, Ucar O, Keles T, Sahin A, Cagli K, Camsari A, Diker E, Aydogdu S (2002) Increased levels of high sensitive C-reactive protein in patients with chronic rheumatic valve disease: evidence of ongoing inflammation. Eur J Heart Fail 4:593\u2013595","journal-title":"Eur J Heart Fail"},{"key":"1689_CR13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/jaut.2000.0487","volume":"16","author":"L Guilherme","year":"2001","unstructured":"Guilherme L, Cunha-Neto E, Tanaka AC, Dulphy N, Toubert A, Kalil J (2001) Heart-directed autoimmunity: the case of rheumatic fever. J Autoimmun 16:363\u2013367","journal-title":"J Autoimmun"},{"key":"1689_CR14","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0002-9440(10)63415-3","volume":"165","author":"L Guilherme","year":"2004","unstructured":"Guilherme L, Cury P, Demarchi LMF, Lopez AP, Oshiro SE, Aliotti S, Cunha-Neto A, Pomerantzeff PMA, Tanaka AC, Kalil J (2004) Rheumatic heart disease: proinflammatory cytokines play a role in the progression and maintenance of valvular disease. Am J Pathol 165:1583\u20131591","journal-title":"Am J Pathol"},{"key":"1689_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1196\/annals.1361.054","volume":"1051","author":"L Guilherme","year":"2005","unstructured":"Guilherme L, Fae KC, Oshiro SE, Tanaka AC, Pomerantzeff PMA, Kalil J (2005) Rheumatic fever: how S. pyogenes-primed peripheral T cells trigger heart valve lesions. Ann N Y Acad Sci 1051:132\u2013140","journal-title":"Ann N Y Acad Sci"},{"key":"1689_CR16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1568-9972(02)00062-9","volume":"1","author":"L Guilherme","year":"2002","unstructured":"Guilherme L, Kalil J (2002) Rheumatic fever: the T cell response leading to autoimmune aggression in the hearth. Autoimmun Rev 1:261\u2013266","journal-title":"Autoimmun Rev"},{"key":"1689_CR17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10875-009-9332-6","volume":"30","author":"L Guilherme","year":"2010","unstructured":"Guilherme L, Kalil J (2010) Rheumatic fever and rheumatic heart disease: cellular mechanisms leading autoimmune reactivity and disease. J Clin Immunol 30:17\u201323","journal-title":"J Clin Immunol"},{"key":"1689_CR18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-3083.2007.01974.x","volume":"66","author":"L Guilherme","year":"2007","unstructured":"Guilherme L, Ramasawmy R, Kalil J (2007) Rheumatic fever and rheumatic hearth disease: genetics and pathogenesis. Scand J Immunol 66:199\u2013207","journal-title":"Scand J Immunol"},{"issue":"2","key":"1689_CR19","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3923\/jms.2002.65.73","volume":"2","author":"M Hafez","year":"2002","unstructured":"Hafez M, El-Morsy Z, El-Shennawy F, Hawas S, Sheishaa A, Abo-El-Kheir M, Shokeir M, Al-Marsafawy H, El-Baz R, Atia G (2002) Susceptibility to over production of cytokines in acute rheumatic carditis and their role in the pathogenesis. J Med Sci 2(2):65\u201373","journal-title":"J Med Sci"},{"key":"1689_CR20","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(05)70275-0","volume":"365","author":"E Hayek","year":"2005","unstructured":"Hayek E, Gring CN, Griffin BD (2005) Mitral valve prolapse. Lancet 365:507\u2013518","journal-title":"Lancet"},{"key":"1689_CR21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0896-8411(03)00079-9","volume":"21","author":"G Hernandez-Pacheco","year":"2003","unstructured":"Hernandez-Pacheco G, Flores-Dominguez C, Rodriguez-Perez JM, Perez-Hernandez N, Fragoso JM, Saul A, Alvarez-Leon E, Granados J, Reyas PA, Vargas-Alarcon G (2003) Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease. J Autoimmun 21:59\u201363","journal-title":"J Autoimmun"},{"key":"1689_CR22","unstructured":"Terzi YK, Oguzkan-Balci S, Anlar B, Erdogan-Bakar E, Ayter S (2011) Learning disability and oligodendrocyte myelin glycoprotein (OMGP) gene in neurofibromatosis type 1. Turk J Pediatr 53:75\u201378"},{"key":"1689_CR23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","volume":"24","author":"MO Li","year":"2006","unstructured":"Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA (2006) Transforming growth factor-beta regulation in immune responses. Annu Rev Immunol 24:99\u2013146","journal-title":"Annu Rev Immunol"},{"key":"1689_CR24","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215","journal-title":"Nucleic Acids Res"},{"key":"1689_CR25","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0003-4975(03)01584-4","volume":"77","author":"JF Nasuti","year":"2004","unstructured":"Nasuti JF, Zhang PJ, Feldman MD, Pahsa T, Khurana JS, Gorman JH, Gorman RC, Narula J, Narula N (2004) Fibrillin and other matrix proteins in mitral valve prolapse syndrome. Ann Thorac Surg 77:532\u2013536","journal-title":"Ann Thorac Surg"},{"key":"1689_CR26","doi-asserted-by":"crossref","unstructured":"Pehlivan M, Okan V, Sever T, Balc\u0131 SO, Y\u0131lmaz M, Babacan T, Pehlivan S (2011) Investigation of TNF-alpha, TGF-beta1, IL-10, IL-6, IF-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic trombocytopenic purpura. Platelets. doi: 10.3109\/09537104.2011.577255","DOI":"10.3109\/09537104.2011.577255"},{"key":"1689_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2370.1999.00122.x","volume":"26","author":"V Pravica","year":"1999","unstructured":"Pravica V, Asderakis A, Perry C, Hajeer A, Sinnott PJ, Hutchinson IV (1999) In vitro production of IFN-\u03b3 correlates with CA repeat polymorphisms in the human IFN-\u03b3 gene. Eur J Immunogenet 26:1\u20133","journal-title":"Eur J Immunogenet"},{"key":"1689_CR28","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.molimm.2006.10.001","volume":"44","author":"R Ramasawmy","year":"2007","unstructured":"Ramasawmy R, Fae KC, Spina SG, Victoria GD, Tanaka AC, Palacios SA, Hounie AG, Miguel EC, Oshiro SA, Goldberg AC, Kalil J, Guilherme L (2007) Association of polymorphisms within the promoter region of the tumor necrosis factor-\u03b1 with clinical outcomes of rheumatic fever. Mol Immunol 44:1873\u20131878","journal-title":"Mol Immunol"},{"key":"1689_CR29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaut.2005.05.005","volume":"25","author":"N Sallakci","year":"2005","unstructured":"Sallakci N, Akcurin G, K\u00f6ksoy S, Kardelen F, Uguz A, Coskun M, Ertug H, Yegin O (2005) TNF-alpha G-308A polymorphism is associated with rgeumatic fever and correlates with increased TNF-alpha production. J Autoimmun 25:150\u2013154","journal-title":"J Autoimmun"},{"key":"1689_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","volume":"75","author":"K Schroder","year":"2004","unstructured":"Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004) Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163\u2013189","journal-title":"J Leukoc Biol"},{"key":"1689_CR31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00246-006-0002-7","volume":"28","author":"A Settin","year":"2007","unstructured":"Settin A, Abdel-Hady H, El-baz R, Saber I (2007) Gene polymorphisms of TNF-\u03b1 (\u2212308), IL-10 (\u22121082), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol 28:363\u2013371","journal-title":"Pediatr Cardiol"},{"issue":"Suppl 1","key":"1689_CR32","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1007\/s001340051125","volume":"26","author":"SJ Deventer Van","year":"2000","unstructured":"Van Deventer SJ (2000) Cytokine and cytokine receptor polymorphisms in infectious disease. Intensive Care Med 26(Suppl 1):S98\u2013S102","journal-title":"Intensive Care Med"},{"key":"1689_CR33","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","volume":"94","author":"AG Wilson","year":"1997","unstructured":"Wilson AG, Symons JA, McDowel TL, McDevit HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci U S A 94:3195\u20133199","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-012-1689-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-012-1689-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-012-1689-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T16:46:43Z","timestamp":1561308403000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-012-1689-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,17]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["1689"],"URL":"https:\/\/doi.org\/10.1007\/s00431-012-1689-5","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,17]]}}}