{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:11:46Z","timestamp":1790507506152,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00431-014-2366-7","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T03:19:40Z","timestamp":1405394380000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Brain imaging findings and social\/emotional problems in Israeli children with neurofibromatosis type 1"],"prefix":"10.1007","volume":"174","author":[{"given":"Rony","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liora","family":"Kornreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Aharoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayelet","family":"Halevy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinoam","family":"Shuper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"2366_CR1","doi-asserted-by":"crossref","unstructured":"[No authors listed] (1988) National Institute of Health Consensus Development Conference: Neurofibromatosis Conference Statement. Arch Neurol 45:575\u2013578","DOI":"10.1001\/archneur.1988.00520290115023"},{"key":"2366_CR2","doi-asserted-by":"crossref","unstructured":"Alkindy A, Chuzhanova N, Kini U, Cooper DN, Upadhyaya M (2012) Genotype- phenotype associations in neurofibromatosis type 1 (NF1): an increased risk of tumor complications in patients with NF1 splice-site mutations? Hum Genom 6(12):2\u20137","DOI":"10.1186\/1479-7364-6-12"},{"key":"2366_CR3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2214.2006.00717.x","volume":"33","author":"B Barton","year":"2007","unstructured":"Barton B, North K (2007) The self concept of children and adolescents with neurofibromatosis type 1. Child Care Health Dev 33:401\u2013408","journal-title":"Child Care Health Dev"},{"key":"2366_CR4","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/87565640903265137","volume":"34","author":"C Chabernaud","year":"2009","unstructured":"Chabernaud C, Sirinelli D, Barbier C, Cottier JP, Sembely C, Giraudeau B, Deseille-Turlotte G, Lorette G, Barthez MA, Castelnau P (2009) Thalamo-striatal T2-weighted hyperintensities (unidentified bright objects) correlate with cognitive impairments in neurofibromatosis type 1 during childhood. Dev Neuropsychol 34:736\u2013748","journal-title":"Dev Neuropsychol"},{"key":"2366_CR5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/088307380001500303","volume":"15","author":"LE Cutting","year":"2000","unstructured":"Cutting LE, Koth CW, Burnette CP, Abrams MT, Kaufmann WE, Denckla MB (2000) Relationship of cognitive functioning, whole brain volumes and T2 weight hyperintensities in neurofibromatosis 1. J Child Neurol 15:157\u2013160","journal-title":"J Child Neurol"},{"key":"2366_CR6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1096-8628(19960216)67:1<98::AID-AJMG17>3.0.CO;2-K","volume":"67","author":"MB Denckla","year":"1996","unstructured":"Denckla MB, Hofman K, Mazzocco MM, Melhem E, Reiss AL, Bryan RN, Harris EL, Lee J, Cox CS, Schuerholz LJ (1996) Relationship between T2-weighted hyperintensities (unidentified bright objects) and lower IQs in children with neurofibromatosis-1. Am J Med Genet 67:98\u2013102","journal-title":"Am J Med Genet"},{"key":"2366_CR7","doi-asserted-by":"crossref","unstructured":"Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH (2013) Sex is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol [Epub ahead of print]","DOI":"10.1002\/ana.24093"},{"key":"2366_CR8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/jnnp.56.5.492","volume":"56","author":"RE Ferner","year":"1993","unstructured":"Ferner RE, Chaudhuri R, Bingham J, Cox T, Huges RAC (1993) MRI in neurofibromatosis 1. The nature and evolution of increased intensity T2 weighted lesions and their relationship to intellectual impairment. J Neurol Neurosurg Psychiatry 56:492\u2013495","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2366_CR9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/dmcn.12043","volume":"55","author":"S Garg","year":"2013","unstructured":"Garg S, Lehtonen A, Huson SM, Emsley R, Trump D, Evans DG, Green J (2013) Autism and other psychiatric comorbidity in neurofibromatosis type 1: evidence from a population-based study. Dev Med Child Neurol 55:139\u2013145","journal-title":"Dev Med Child Neurol"},{"key":"2366_CR10","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s00247-006-0267-2","volume":"36","author":"DS Gill","year":"2006","unstructured":"Gill DS, Hyman SL, Steinberg A, North KN (2006) Age related findings on MRI in neurofibromatosis type 1. Pediatr Radiol 36:1048\u20131056","journal-title":"Pediatr Radiol"},{"key":"2366_CR11","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1177\/08830738040190110201","volume":"19","author":"WHS Goh","year":"2004","unstructured":"Goh WHS, Khong P-l, Leung CS, Wong VCN (2004) T2-weighted hyperintensities (unidentified bright objects) in children with neurofibromatosis 1: their impact on cognitive function. J Child Neurol 19:853\u2013858","journal-title":"J Child Neurol"},{"key":"2366_CR12","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/jnnp.2006.108134","volume":"78","author":"SL Hyman","year":"2007","unstructured":"Hyman SL, Gill DS, Shores EA, Steinberg A, North KN (2007) T2 hyperintensities in children with neurofibromatosis type 1 and their relationship to cognitive functioning. J Neurol Neurosurg Psychiatry 78:1088\u20131091","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2366_CR13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/0883073811423439","volume":"27","author":"GM Jentarra","year":"2012","unstructured":"Jentarra GM, Rice SG, Olfers S, Rajan C, Saffen DM, Narayanan V (2012) Skewed allele-specific expression of the NF1 gene in normal subjects: a possible mechanism for phenotypic variability in neurofibromatosis type 1. J Child Neurol 27:695\u2013702","journal-title":"J Child Neurol"},{"key":"2366_CR14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.pediatrneurol.2013.02.004","volume":"48","author":"JM Ko","year":"2013","unstructured":"Ko JM, Sohn YB, Jeong SY, Kim HJ, Messiaen LM (2013) Mutation spectrum of NF1 and clinical characteristics in 78 Korean patients with neurofibromatosis type 1. Pediatr Neurol 48:447\u2013453","journal-title":"Pediatr Neurol"},{"key":"2366_CR15","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1469-8749.2012.04399.x","volume":"55","author":"A Lehtonen","year":"2013","unstructured":"Lehtonen A, Howie E, Trump D, Huson SM (2013) Behaviour in children with neurofibromatosis type 1: executive function, attention, emotion and social competence. Dev Med Child Neurol 55:111\u2013125","journal-title":"Dev Med Child Neurol"},{"issue":"5","key":"2366_CR16","first-page":"VIII","volume":"164A","author":"D Levenson","year":"2014","unstructured":"Levenson D (2014) Gender plays role in predicting neuronal dysfunction for patients with neurofibromatosis 1: girls more likely to require treatment for visual decline caused by NF1-related brain tumors. Am J Med Genet A 164A(5):VIII\u2013IX","journal-title":"Am J Med Genet A"},{"key":"2366_CR17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fpsyt.2010.00151","volume":"1","author":"I Mansbach-Kleinfeld","year":"2010","unstructured":"Mansbach-Kleinfeld I, Levine SZ, Apter A, Levine SZ, Ponizovsky AM (2010) A population-based psychometric validation study of the Strengths and Difficulties Questionnaire\u2014Hebrew version. Front Psychiatry 1:151","journal-title":"Front Psychiatry"},{"key":"2366_CR18","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1212\/WNL.46.6.1660","volume":"46","author":"BD Moore III","year":"1996","unstructured":"Moore BD III, Slopis JM, Schomer D, Jackson EF, Levy BM (1996) Neuropsychological significance of areas of high signal intensity on brain MRIs of children with neurofibromatosis. Neurology 46:1660\u20131668","journal-title":"Neurology"},{"key":"2366_CR19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/jmedgenet-2012-100978","volume":"49","author":"E Pasmant","year":"2012","unstructured":"Pasmant E, Vidaud M, Vidaud D, Wolkenstein P (2012) Neurofibromatosis type 1: from genotype to phenotype. J Med Genet 49:483\u2013489","journal-title":"J Med Genet"},{"key":"2366_CR20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/jnnp.2009.179630","volume":"81","author":"JM Payne","year":"2010","unstructured":"Payne JM, Moharir MD, Webster R, North KN (2010) Brain structure and function in neurofibromatosis type1: current concepts and future directions. J Neurol Neurosurg Psychiatry 81:304\u2013309","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2366_CR21","doi-asserted-by":"crossref","unstructured":"Pride NA, Korgaonkar MS, Barton B, Payne JM, Vucic S, North KN (2013) The genetic and neuroanatomical basis of social dysfunction: lessons from neurofibromatosis type 1. Hum Brain Mapp [Epub ahead of print]","DOI":"10.1002\/hbm.22334"},{"key":"2366_CR22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00787-005-0521-4","volume":"15","author":"B Roy Van","year":"2006","unstructured":"Van Roy B, Groholt B, Heyerdahl S, Clench-Aas J (2006) Self-reported strengths and difficulties in a large Norwegian population 10\u201319 years. Eur Child Adolesc Psychiatry 15:189\u2013198","journal-title":"Eur Child Adolesc Psychiatry"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-014-2366-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-014-2366-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-014-2366-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T16:40:18Z","timestamp":1565628018000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-014-2366-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["2366"],"URL":"https:\/\/doi.org\/10.1007\/s00431-014-2366-7","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}