{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:10:06Z","timestamp":1790082606849,"version":"4.0.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T00:00:00Z","timestamp":1410480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1007\/s00431-014-2418-z","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T23:08:31Z","timestamp":1410390511000},"page":"459-464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Influence of hyperbilirubinemia and phototherapy on markers of genotoxicity and apoptosis in full-term infants"],"prefix":"10.1007","volume":"174","author":[{"given":"Sohier","family":"Yahia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd Elazeez","family":"Shabaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Gouida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doaa","family":"El-Ghanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Eldegla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"El-Bakary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Abdel-Hady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"2418_CR1","first-page":"30","volume":"39","author":"R Agarwal","year":"2002","unstructured":"Agarwal R, Deorari AK (2002) Unconjugated hyperbilirubinemia in newborns: current perspective. Indian Pediatr 39:30\u201342","journal-title":"Indian Pediatr"},{"key":"2418_CR2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","volume":"114","author":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia","year":"2004","unstructured":"American Academy of Pediatrics Subcommittee on Hyperbilirubinemia (2004) Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114:297\u2013316","journal-title":"Pediatrics"},{"key":"2418_CR3","first-page":"45","volume":"17","author":"NT Anitha","year":"2013","unstructured":"Anitha NT, Parkash C, Vishnu BB, Sridhar MG, Ramachandra RK (2013) Assessment of DNA damage in babies treated with phototherapy for neonatal jaundice. Curr Pediatr Res 17:45\u201347","journal-title":"Curr Pediatr Res"},{"key":"2418_CR4","first-page":"259","volume":"18","author":"A Atici","year":"2009","unstructured":"Atici A, Bozkurt A, Muslu N, Eskandari HG, Turhan AH (2009) Oxidative stress under phototherapy. Turk J Pediatr 18:259\u2013263","journal-title":"Turk J Pediatr"},{"key":"2418_CR5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1590\/S0021-75572008000200009","volume":"84","author":"A Aycicek","year":"2008","unstructured":"Aycicek A, Kocyigit A, Erel O, Senturk H (2008) Phototherapy causes DNA damage in peripheral mononuclear leukocytes in term infants. J Pediatr (Rio J) 84:141\u2013146","journal-title":"J Pediatr (Rio J)"},{"key":"2418_CR6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1651-2227.1994.tb12943.x","volume":"83","author":"T Christensen","year":"1994","unstructured":"Christensen T, Kinn G, Granli T, Amundsen I (1994) Cells, bilirubin and light. Formation of photoproducts and cellular effects at defined wavelengths. Acta Paediatr 83:7\u201312","journal-title":"Acta Paediatr"},{"key":"2418_CR7","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/1011-1344(90)85166-T","volume":"7","author":"T Christensen","year":"1990","unstructured":"Christensen T, Reitan JB, Kinn G (1990) Single-strand breaks in the DNA of human cells exposed to visible light from phototherapy lamps in the presence and absence of bilirubin. J Photochem Photobiol B 7:337\u2013346","journal-title":"J Photochem Photobiol B"},{"key":"2418_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0027-5107(94)90320-4","volume":"304","author":"J Cole","year":"1994","unstructured":"Cole J, Skopek TR (1994) International Commission for Protection Against Environmental Mutagens and Carcinogens. Working paper no. 3. Somatic mutant frequency, mutation rates and mutational spectra in the human population in vivo. Mutat Res 304:33\u2013105","journal-title":"Mutat Res"},{"key":"2418_CR9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1083\/jcb.60.2.523","volume":"60","author":"PN Dean","year":"1974","unstructured":"Dean PN, Jett JH (1974) Mathematical analysis of DNA distributions derived from flow microfluorometry. J Cell Biol 60:523\u2013527","journal-title":"J Cell Biol"},{"key":"2418_CR10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM200102223440807","volume":"344","author":"PA Dennery","year":"2001","unstructured":"Dennery PA, Seidman DS, Stevenson DK (2001) Neonatal hyperbilirubinemia. N Engl J Med 344:581\u2013590","journal-title":"N Engl J Med"},{"key":"2418_CR11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejmhg.2011.11.003","volume":"13","author":"MMYAE-SZ El-Abdin","year":"2012","unstructured":"El-Abdin MMYAE-SZ, Ibrhim MY, Koraa SSM, Mahmoud E (2012) Phototherapy and DNA changes in full-term neonates with hyperbilirubinemia. Egypt J Med Hum Genet 13:29\u201335","journal-title":"Egypt J Med Hum Genet"},{"key":"2418_CR12","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/BF02726223","volume":"67","author":"G Gathwala","year":"2000","unstructured":"Gathwala G, Sharma S (2000) Oxidative stress, phototherapy and the neonate. Indian J Pediatr 67:805\u2013808","journal-title":"Indian J Pediatr"},{"key":"2418_CR13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1383-5718(03)00090-1","volume":"538","author":"L Giovannelli","year":"2003","unstructured":"Giovannelli L, Pitozzi V, Riolo S, Dolara P (2003) Measurement of DNA breaks and oxidative damage in polymorphonuclear and mononuclear white blood cells: a novel approach using the comet assay. Mutat Res 538:71\u201380","journal-title":"Mutat Res"},{"key":"2418_CR14","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","volume":"407","author":"MO Hengartner","year":"2000","unstructured":"Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770\u2013776","journal-title":"Nature"},{"key":"2418_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/01480545.2011.653491","volume":"36","author":"H Kahveci","year":"2013","unstructured":"Kahveci H, Dogan H, Karaman A, Caner I, Tastekin A, Ikbal M (2013) Phototherapy causes a transient DNA damage in jaundiced newborns. Drug Chem Toxicol 36:88\u201392","journal-title":"Drug Chem Toxicol"},{"key":"2418_CR16","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrgentox.2009.07.016","volume":"680","author":"C Karakukcu","year":"2009","unstructured":"Karakukcu C, Ustdal M, Ozturk A, Baskol G, Saraymen R (2009) Assessment of DNA damage and plasma catalase activity in healthy term hyperbilirubinemic infants receiving phototherapy. Mutat Res 680:12\u201316","journal-title":"Mutat Res"},{"key":"2418_CR17","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.4161\/cc.10.14.16588","volume":"10","author":"K Kuribayashi","year":"2011","unstructured":"Kuribayashi K, Finnberg N, Jeffers JR, Zambetti GP, El-Deiry WS (2011) The relative contribution of pro-apoptotic p53-target genes in the triggering of apoptosis following DNA damage in vitro and in vivo. Cell Cycle 10:2380\u20132389","journal-title":"Cell Cycle"},{"key":"2418_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.chroma.2007.08.024","volume":"1167","author":"B Malayappan","year":"2007","unstructured":"Malayappan B, Garrett TJ, Segal M, Leeuwenburgh C (2007) Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2\u2032-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress. J Chromatogr A 1167:54\u201362","journal-title":"J Chromatogr A"},{"key":"2418_CR19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3233\/NPM-1261912","volume":"5","author":"WA Mohamed","year":"2012","unstructured":"Mohamed WA, Niazy WH (2012) Genotoxic effect of phototherapy in term newborn infants with hyperbilirubinemia. J Neonatal Perinatal Med 5:381\u2013387","journal-title":"J Neonatal Perinatal Med"},{"key":"2418_CR20","first-page":"1005","volume":"9","author":"P M\u00f8ller","year":"2000","unstructured":"M\u00f8ller P, Knudsen LE, Loft S, Wallin H (2000) The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol Biomarkers Prev 9:1005\u20131015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2418_CR21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0092-8674(00)81874-7","volume":"88","author":"S Nagata","year":"1997","unstructured":"Nagata S (1997) Apoptosis by death factor. Cell 88:355\u2013365","journal-title":"Cell"},{"key":"2418_CR22","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1542\/peds.2007-2215","volume":"121","author":"H Ozkan","year":"2008","unstructured":"Ozkan H, Oren H, Tatli M, Ates H, Kumral A, Duman N (2008) Erythroid apoptosis in idiopathic neonatal jaundice. Pediatrics 121:1348\u20131351","journal-title":"Pediatrics"},{"key":"2418_CR23","first-page":"599","volume":"65","author":"ML Porter","year":"2002","unstructured":"Porter ML, Dennis BL (2002) Hyperbilirubinemia in the term newborn. Am Fam Physician 65:599\u2013606","journal-title":"Am Fam Physician"},{"key":"2418_CR24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1017\/S0007114507876239","volume":"100","author":"M Renis","year":"2008","unstructured":"Renis M, Calandra L, Scifo C, Tomasello B, Cardile V, Vanella L, Bei R, La Fauci L, Galvano F (2008) Response of cell cycle\/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. Br J Nutr 100:27\u201335","journal-title":"Br J Nutr"},{"key":"2418_CR25","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1080\/08035250510032646","volume":"94","author":"EB Roll","year":"2005","unstructured":"Roll EB (2005) Bilirubin-induced cell death during continuous and intermittent phototherapy and in the dark. Acta Paediatr 94:1437\u20131442","journal-title":"Acta Paediatr"},{"key":"2418_CR26","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","volume":"175","author":"NP Singh","year":"1988","unstructured":"Singh NP, McCoy MT, Tice RR, Schneider EL (1988) A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184\u2013191","journal-title":"Exp Cell Res"},{"key":"2418_CR27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1399-0039.1972.tb00128.x","volume":"2","author":"G Sirchia","year":"1972","unstructured":"Sirchia G, Pizzi C, Scalamogna M (1972) A simple procedure for human lymphocyte isolation from peripheral blood. Tissue Antigens 2:139\u2013140","journal-title":"Tissue Antigens"},{"key":"2418_CR28","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.1073\/pnas.84.22.8130","volume":"84","author":"R Stocker","year":"1987","unstructured":"Stocker R, Ames BN (1987) Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci U S A 84:8130\u20138134","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2418_CR29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00383-008-2170-4","volume":"24","author":"K Tanaka","year":"2008","unstructured":"Tanaka K, Hashimoto H, Tachibana T, Ishikawa H, Ohki T (2008) Apoptosis in the small intestine of neonatal rat using blue light-emitting diode devices and conventional halogen-quartz devices in phototherapy. Pediatr Surg Int 24:837\u2013842","journal-title":"Pediatr Surg Int"},{"key":"2418_CR30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mrgentox.2007.06.013","volume":"654","author":"MM Tatli","year":"2008","unstructured":"Tatli MM, Minnet C, Kocyigit A, Karadag A (2008) Phototherapy increases DNA damage in lymphocytes of hyperbilirubinemic neonates. Mutat Res 654:93\u201395","journal-title":"Mutat Res"},{"key":"2418_CR31","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1651-2227.2011.02561.x","volume":"101","author":"A Tridente","year":"2012","unstructured":"Tridente A, Luca D (2012) Efficacy of light-emitting diode versus other light sources for treatment of neonatal hyperbilirubinemia: a systematic review and meta-analysis. Acta Paediatr 101:458\u2013465","journal-title":"Acta Paediatr"},{"key":"2418_CR32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1023\/B:MCBI.0000049134.69131.89","volume":"266","author":"M Valko","year":"2004","unstructured":"Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J (2004) Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 266:37\u201356","journal-title":"Mol Cell Biochem"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-014-2418-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-014-2418-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-014-2418-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T08:09:08Z","timestamp":1598256548000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-014-2418-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["2418"],"URL":"https:\/\/doi.org\/10.1007\/s00431-014-2418-z","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}