{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:46:59Z","timestamp":1777355219924,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T00:00:00Z","timestamp":1425945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1007\/s00431-015-2508-6","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T02:44:47Z","timestamp":1425869087000},"page":"1069-1076","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Non-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency"],"prefix":"10.1007","volume":"174","author":[{"given":"Monica","family":"Piquer Gibert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Giner Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofelia","family":"Cruz Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Ruiz Echevarria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Plaza Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan I.","family":"Arostegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillem","family":"de Valles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Juan Otero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Anunciacion","family":"Martin-Mateos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"issue":"2","key":"2508_CR1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/10428190500285285","volume":"47","author":"A Aghamohammadi","year":"2006","unstructured":"Aghamohammadi A, Parvaneh N, Tirgari F, Mahjoob F, Movahedi M, Gharagozlou M et al (2006) Lymphoma of mucosa-associated lymphoid tissue in common variable immunodeficiency. Leuk Lymphoma 47(2):343\u2013346. doi: 10.1080\/10428190500285285","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"2508_CR2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0301-0546(09)70254-X","volume":"37","author":"I Baron-Ruiz","year":"2009","unstructured":"Baron-Ruiz I, Martin-Mateos MA, Plaza-Martin AM, Giner-Munoz MT, Piquer M (2009) Lymphoma as presentation of common variable immunodeficiency. Allergol Immunopathol 37(1):51\u201353","journal-title":"Allergol Immunopathol"},{"issue":"6","key":"2508_CR3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2002.124999","volume":"109","author":"PJ Busse","year":"2002","unstructured":"Busse PJ, Razvi S, Cunningham-Rundles C (2002) Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency. J Allergy Clin Immunol 109(6):1001\u20131004. doi: 10.1067\/mai.2002.124999","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"2508_CR4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","volume":"112","author":"H Chapel","year":"2008","unstructured":"Chapel H, Lucas M, Lee M, Bjorkander J, Webster D, Grimbacher B et al (2008) Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 112(2):277\u2013286. doi: 10.1182\/blood-2007-11-124545","journal-title":"Blood"},{"issue":"5","key":"2508_CR5","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jaci.2012.05.046","volume":"130","author":"H Chapel","year":"2012","unstructured":"Chapel H, Lucas M, Patel S, Lee M, Cunningham-Rundles C, Resnick E et al (2012) Confirmation and improvement of criteria for clinical phenotyping in common variable immunodeficiency disorders in replicate cohorts. J Allergy Clin Immunol 130(5):1197\u20131198.e9. doi: 10.1016\/j.jaci.2012.05.046","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"2508_CR6","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MOH.0b013e328302c7b6","volume":"15","author":"I Chua","year":"2008","unstructured":"Chua I, Quinti I, Grimbacher B (2008) Lymphoma in common variable immunodeficiency: interplay between immune dysregulation, infection and genetics. Curr Opin Hematol 15(4):368\u2013374. doi: 10.1097\/MOH.0b013e328302c7b6","journal-title":"Curr Opin Hematol"},{"issue":"3","key":"2508_CR7","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","volume":"93","author":"ME Conley","year":"1999","unstructured":"Conley ME, Notarangelo LD, Etzioni A (1999) Diagnostic criteria for primary immunodeficiencies. Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies). Clin Immunol 93(3):190\u2013197. doi: 10.1006\/clim.1999.4799","journal-title":"Clin Immunol"},{"issue":"3","key":"2508_CR8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ajh.10050","volume":"69","author":"C Cunningham-Rundles","year":"2002","unstructured":"Cunningham-Rundles C, Cooper DL, Duffy TP, Strauchen J (2002) Lymphomas of mucosal-associated lymphoid tissue in common variable immunodeficiency. Am J Hematol 69(3):171\u2013178","journal-title":"Am J Hematol"},{"issue":"4","key":"2508_CR9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00915550","volume":"7","author":"C Cunningham-Rundles","year":"1987","unstructured":"Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, Lieberman P (1987) Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol 7(4):294\u2013299","journal-title":"J Clin Immunol"},{"issue":"5","key":"2508_CR10","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1007\/s10875-011-9565-z","volume":"31","author":"SP Silva Da","year":"2011","unstructured":"Da Silva SP, Resnick E, Lucas M, Lortan J, Patel S, Cunningham-Rundles C et al (2011) Lymphoid proliferations of indeterminate malignant potential arising in adults with common variable immunodeficiency disorders: unusual case studies and immunohistological review in the light of possible causative events. J Clin Immunol 31(5):784\u2013791. doi: 10.1007\/s10875-011-9565-z","journal-title":"J Clin Immunol"},{"issue":"6","key":"2508_CR11","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.intimp.2004.02.011","volume":"4","author":"J Gracia De","year":"2004","unstructured":"De Gracia J, Vendrell M, Alvarez A, Pallisa E, Rodrigo MJ, de la Rosa D et al (2004) Immunoglobulin therapy to control lung damage in patients with common variable immunodeficiency. Int Immunopharmacol 4(6):745\u2013753. doi: 10.1016\/j.intimp.2004.02.011","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2508_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04384.x","volume":"165","author":"F Dhalla","year":"2011","unstructured":"Dhalla F, da Silva SP, Lucas M, Travis S, Chapel H (2011) Review of gastric cancer risk factors in patients with common variable immunodeficiency disorders, resulting in a proposal for a surveillance programme. Clin Exp Immunol 165(1):1\u20137. doi: 10.1111\/j.1365-2249.2011.04384.x","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"2508_CR13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2249.2003.02253.x","volume":"134","author":"MM Gompels","year":"2003","unstructured":"Gompels MM, Hodges E, Lock RJ, Angus B, White H, Larkin A et al (2003) Lymphoproliferative disease in antibody deficiency: a multi-centre study. Clin Exp Immunol 134(2):314\u2013320","journal-title":"Clin Exp Immunol"},{"issue":"8423","key":"2508_CR14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(85)91037-2","volume":"1","author":"LJ Kinlen","year":"1985","unstructured":"Kinlen LJ, Webster AD, Bird AG, Haile R, Peto J, Soothill JF, Thompson RA (1985) Prospective study of cancer in patients with hypogammaglobulinaemia. Lancet 1(8423):263\u2013266","journal-title":"Lancet"},{"issue":"3","key":"2508_CR15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","volume":"130","author":"L Mellemkjaer","year":"2002","unstructured":"Mellemkjaer L, Hammarstrom L, Andersen V, Yuen J, Heilmann C, Barington T et al (2002) Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study. Clin Exp Immunol 130(3):495\u2013500. doi: 10.1046\/j.1365-2249.2002.02004.x","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"2508_CR16","first-page":"208","volume":"22","author":"P Mohammadinejad","year":"2012","unstructured":"Mohammadinejad P, Aghamohammadi A, Abolhassani H, Sadaghiani MS, Abdollahzade S, Sadeghi B et al (2012) Pediatric patients with common variable immunodeficiency: long-term follow-up. J Investig Allergol Clin Immunol 22(3):208\u2013214","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"5","key":"2508_CR17","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1081-1206(10)61096-4","volume":"97","author":"PR Ogershok","year":"2006","unstructured":"Ogershok PR, Hogan MB, Welch JE, Corder WT, Wilson NW (2006) Spectrum of illness in pediatric common variable immunodeficiency. Ann Allergy Asthma Immunol 97(5):653\u2013656. doi: 10.1016\/S1081-1206(10)61096-4","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"3","key":"2508_CR18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","volume":"27","author":"I Quinti","year":"2007","unstructured":"Quinti I, Soresina A, Spadaro G, Martino S, Donnanno S, Agostini C et al (2007) Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency. J Clin Immunol 27(3):308\u2013316. doi: 10.1007\/s10875-007-9075-1","journal-title":"J Clin Immunol"},{"issue":"2","key":"2508_CR19","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1365-2249.2006.03209.x","volume":"146","author":"M Raeiszadeh","year":"2006","unstructured":"Raeiszadeh M, Kopycinski J, Paston SJ, Diss T, Lowdell M, Hardy GAD et al (2006) The T cell response to persistent herpes virus infections in common variable immunodeficiency. Clin Exp Immunol 146(2):234\u2013242. doi: 10.1111\/j.1365-2249.2006.03209.x","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"2508_CR20","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","volume":"119","author":"ES Resnick","year":"2012","unstructured":"Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C (2012) Morbidity and mortality in common variable immune deficiency over 4 decades. Blood 119(7):1650\u20131657. doi: 10.1182\/blood-2011-09-377945","journal-title":"Blood"},{"issue":"5","key":"2508_CR21","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/pbc.21808","volume":"52","author":"S Shabbat","year":"2009","unstructured":"Shabbat S, Aharoni J, Sarid L, Ben-Harush M, Kapelushnik J (2009) Rituximab as monotherapy and in addition to reduced CHOP in children with primary immunodeficiency and non-Hodgkin lymphoma. Pediatr Blood Cancer 52(5):664\u2013666. doi: 10.1002\/pbc.21808","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"2508_CR22","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.jpeds.2008.12.020","volume":"154","author":"S Urschel","year":"2009","unstructured":"Urschel S, Kayikci L, Wintergerst U, Notheis G, Jansson A, Belohradsky BH (2009) Common variable immunodeficiency disorders in children: delayed diagnosis despite typical clinical presentation. J Pediatr 154(6):888\u2013894. doi: 10.1016\/j.jpeds.2008.12.020","journal-title":"J Pediatr"},{"issue":"8","key":"2508_CR23","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood-2010-03-272351","volume":"116","author":"CM Vajdic","year":"2010","unstructured":"Vajdic CM, Mao L, van Leeuwen MT, Kirkpatrick P, Grulich AE, Riminton S (2010) Are antibody deficiency disorders associated with a narrower range of cancers than other forms of immunodeficiency? Blood 116(8):1228\u20131234. doi: 10.1182\/blood-2010-03-272351","journal-title":"Blood"},{"issue":"3","key":"2508_CR24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1399-3038.2010.01085.x","volume":"22","author":"AA Ven Van de","year":"2011","unstructured":"Van de Ven AA, van Montfrans JM (2011) Clinical complications in pediatric CVID are not restricted to patients with severely reduced class-switched memory B cells. Pediatr Allergy Immunol 22(3):347\u2013348. doi: 10.1111\/j.1399-3038.2010.01085.x","journal-title":"Pediatr Allergy Immunol"},{"issue":"1","key":"2508_CR25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood-2007-06-091744","volume":"111","author":"C Wehr","year":"2008","unstructured":"Wehr C, Kivioja T, Schmitt C, Ferry B, Witte T, Eren E et al (2008) The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 111(1):77\u201385. doi: 10.1182\/blood-2007-06-091744","journal-title":"Blood"},{"issue":"4","key":"2508_CR26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1084\/jem.20050381","volume":"202","author":"WH Wheat","year":"2005","unstructured":"Wheat WH, Cool CD, Morimoto Y, Rai PR, Kirkpatrick CH, Lindenbaum BA et al (2005) Possible role of human herpesvirus 8 in the lymphoproliferative disorders in common variable immunodeficiency. J Exp Med 202(4):479\u2013484. doi: 10.1084\/jem.20050381","journal-title":"J Exp Med"},{"issue":"5","key":"2508_CR27","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/j.1399-3038.2010.01004.x","volume":"21","author":"PL Yong","year":"2010","unstructured":"Yong PL, Orange JS, Sullivan KE (2010) Pediatric common variable immunodeficiency: immunologic and phenotypic associations with switched memory B cells. Pediatr Allergy Immunol 21(5):852\u2013858. doi: 10.1111\/j.1399-3038.2010.01004.x","journal-title":"Pediatr Allergy Immunol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2508-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-015-2508-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2508-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T22:32:05Z","timestamp":1559082725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-015-2508-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["2508"],"URL":"https:\/\/doi.org\/10.1007\/s00431-015-2508-6","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]}}}