{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:43:17Z","timestamp":1790419397219,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1007\/s00431-015-2527-3","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T05:39:11Z","timestamp":1429076351000},"page":"1311-1318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The clinical features of autoimmunity in 53 patients with Wiskott\u2013Aldrich syndrome in China: a single-center study"],"prefix":"10.1007","volume":"174","author":[{"given":"Nan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Mei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"issue":"2","key":"2527_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.13.2.133","volume":"13","author":"RA Aldrich","year":"1954","unstructured":"Aldrich RA, Steinberg AG, Campbell DC (1954) Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics 13(2):133\u2013139","journal-title":"Pediatrics"},{"issue":"8","key":"2527_CR2","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/PL00008395","volume":"159","author":"H Azuma","year":"2000","unstructured":"Azuma H, Oshima M, Ito K, Okuno A, Kawabata I, Banba K, Murahashi H, Sekine T, Kato Y, Ikebuchi K, Ikeda H (2000) Impaired interleukin-2 production in T-cells from a patient with Wiskott-Aldrich syndrome: basis of clinical effect of interleukin-2 replacement therapy. Eur J Pediatr 159(8):633\u2013634","journal-title":"Eur J Pediatr"},{"issue":"3","key":"2527_CR3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0049-0172(99)80026-2","volume":"29","author":"P Beauparlant","year":"1999","unstructured":"Beauparlant P, Papp K, Haraoui B (1999) The incidence of cancer associated with the treatment of rheumatoid arthritis. Semin Arthritis Rheum 29(3):148\u2013158","journal-title":"Semin Arthritis Rheum"},{"issue":"25","key":"2527_CR4","doi-asserted-by":"publisher","first-page":"6288","DOI":"10.1182\/blood-2008-12-115253","volume":"113","author":"M Bosticardo","year":"2009","unstructured":"Bosticardo M, Marangoni F, Aiuti A, Villa A, Grazia Roncarolo M (2009) Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome. Blood 113(25):6288\u20136295","journal-title":"Blood"},{"issue":"23","key":"2527_CR5","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1016\/j.febslet.2011.10.031","volume":"585","author":"SY Cleland","year":"2011","unstructured":"Cleland SY, Siegel RM (2011) Wiskott-Aldrich syndrome at the nexus of autoimmune and primary immunodeficiency diseases. FEBS Let 585(23):3710\u20133714","journal-title":"FEBS Let"},{"issue":"5 Pt 1","key":"2527_CR6","doi-asserted-by":"publisher","first-page":"e622","DOI":"10.1542\/peds.111.5.e622","volume":"111","author":"S Dupuis-Girod","year":"2003","unstructured":"Dupuis-Girod S, Medioni J, Haddad E, Quartier P, Cavazzana-Calvo M, Le Deist F, de Saint Basile G, Delaunay J, Schwarz K, Casanova JL, Blanche S, Fischer A (2003) Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics 111(5 Pt 1):e622\u2013e627","journal-title":"Pediatrics"},{"issue":"6","key":"2527_CR7","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s004670100583","volume":"16","author":"A Duzova","year":"2001","unstructured":"Duzova A, Topaloglu R, Sanal O, Kilic S, Mazza C, Besbas N, Bakkaloglu A (2001) Henoch-Sch\u00f6nlein purpura in Wiskott-Aldrich syndrome. Pediatr Nephrol 16(6):500\u2013502","journal-title":"Pediatr Nephrol"},{"key":"2527_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/nature13835","author":"KK Farh","year":"2014","unstructured":"Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N, Whitton H, Ryan RJ, Shishkin AA, Hatan M, Carrasco-Alfonso MJ, Mayer D, Luckey CJ, Patsopoulos NA, De Jager PL, Kuchroo VK, Epstein CB, Daly MJ, Hafler DA, Bernstein BE (2014) Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature. doi:10.1038\/nature13835","journal-title":"Nature"},{"issue":"1","key":"2527_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10875-013-9964-4","volume":"34","author":"A Hoshino","year":"2014","unstructured":"Hoshino A, Shimizu M, Matsukura H, Sakaki-Nakatsubo H, Nomura K, Miyawaki T, Kanegane H (2014) Allogeneic bone marrow transplantation appears to ameliorate IgA nephropathy in a patient with X-linked thrombocytopenia. J Clin Immunol 34(1):53\u201357","journal-title":"J Clin Immunol"},{"issue":"2","key":"2527_CR10","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1182\/blood-2003-05-1480","volume":"103","author":"K Imai","year":"2004","unstructured":"Imai K, Morio T, Zhu Y, Jin Y, Itoh S, Kajiwara M, Yata J, Mizutani S, Ochs HD, Nonoyama S (2004) Clinical course of patients with WASP gene mutations. Blood 103(2):456\u2013464","journal-title":"Blood"},{"issue":"1","key":"2527_CR11","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1365-2141.2007.06616.x","volume":"138","author":"JJ Kim","year":"2007","unstructured":"Kim JJ, Thrasher AJ, Jones AM, Davies EG, Cale CM (2007) Rituximab for the treatment of autoimmune cytopenias in children with immunedeficiency. Br J Haematol 138(1):94\u201396","journal-title":"Br J Haematol"},{"issue":"9","key":"2527_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1007\/BF02276716","volume":"154","author":"B Latal Hajnal","year":"1995","unstructured":"Latal Hajnal B, Lips U, Friedrich W, Zachmann M, Berthet F (1995) Addison disease 10 years after bone marrow transplantation for Wiskott-Aldrich syndrome. Eur J Pediatr 154(9):729\u2013731","journal-title":"Eur J Pediatr"},{"issue":"1","key":"2527_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000107462","volume":"145","author":"WI Lee","year":"2008","unstructured":"Lee WI, Yang CY, Jaing TH, Huang JL, Chien YH, Chang KW (2008) Clinical aspects and molecular analysis of Chinese patients with Wiskott-Aldrich syndrome in Taiwan. Int Arch Allergy Immunol 145(1):15\u201323","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"2527_CR14","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1053\/j.ajkd.2003.11.016","volume":"43","author":"H Matsukura","year":"2004","unstructured":"Matsukura H, Kanegane H, Miya K, Ohtsubo K, Higuchi A, Tanizawa T, Miyawaki T (2004) IgA nephropathy associated with X-linked thrombocytopenia. Am J Kidney Dis 43(3):e7\u2013e12","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"2527_CR15","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1084\/jem.20061338","volume":"204","author":"MH Maillard","year":"2007","unstructured":"Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK, Snapper SB (2007) The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med 204(2):381\u2013391","journal-title":"J Exp Med"},{"key":"2527_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/nyas.12049","volume":"1285","author":"MJ Massaad","year":"2013","unstructured":"Massaad MJ, Ramesh N, Geha R (2013) Wiskott-Aldrich syndrome: a comprehensive review. Ann N Y Acad Sci 1285:26\u201343","journal-title":"Ann N Y Acad Sci"},{"issue":"9","key":"2527_CR17","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1182\/blood-2012-08-448118","volume":"121","author":"N Mahlaoui","year":"2013","unstructured":"Mahlaoui N, Pellier I, Mignot C, Jais JP, Bilhou-Nab\u00e9ra C, Moshous D, Neven B, Picard C, de Saint-Basile G, Cavazzana-Calvo M, Blanche S, Fischer A (2013) Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome. Blood 121(9):1510\u20131516","journal-title":"Blood"},{"issue":"1","key":"2527_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1097\/MOH.0b013e3282f30448","volume":"15","author":"LD Notarangelo","year":"2008","unstructured":"Notarangelo LD, Miao CH, Ochs HD (2008) Wiskott-Aldrich syndrome. Curr Opin Hematol 15(1):30\u201336","journal-title":"Curr Opin Hematol"},{"issue":"3","key":"2527_CR19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1556\/AMicr.59.2012.3.5","volume":"59","author":"T Patiroglu","year":"2012","unstructured":"Patiroglu T, Gungor HE, Unal E (2012) Autoimmune diseases detected in children with primary immunodeficiency diseases: results from a reference centre at Middle Anatolia. Acta Microbiol Immunol Hung 59(3):343\u2013353","journal-title":"Acta Microbiol Immunol Hung"},{"issue":"5","key":"2527_CR20","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s11882-010-0127-x","volume":"10","author":"IM Pessach","year":"2010","unstructured":"Pessach IM (2010) The relationship of x-linked primary immune deficiencies and autoimmunity. Curr Allergy Asthma Rep 10(5):311\u2013319","journal-title":"Curr Allergy Asthma Rep"},{"issue":"4","key":"2527_CR21","first-page":"791","volume":"7","author":"S Sallah","year":"2001","unstructured":"Sallah S, Wan JY, Hanrahan LR (2001) Future development of lymphoproliferative disorders in patients with autoimmune hemolytic anemia. Clin Cancer Res 7(4):791\u2013794","journal-title":"Clin Cancer Res"},{"issue":"4","key":"2527_CR22","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1097\/00002281-200307000-00012","volume":"15","author":"SH Schurman","year":"2003","unstructured":"Schurman SH, Candotti F (2003) Autoimmunity in Wiskott-Aldrich syndrome. Curr Opin Rheumatol 15(4):446\u2013453","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"2527_CR23","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.jaci.2012.08.040","volume":"131","author":"M Shimizu","year":"2013","unstructured":"Shimizu M, Kanegane H, Wada T, Motoyoshi Y, Morio T, Candotti F, Yachie A (2013) Aberrant glycosylation of IgA in Wiskott-Aldrich syndrome and X-linked thrombocytopenia. J Allergy Clin Immunol 131(2):587\u201390.e1-3","journal-title":"J Allergy Clin Immunol"},{"issue":"11","key":"2527_CR24","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1038\/bmt.2012.31","volume":"47","author":"CR Shin","year":"2012","unstructured":"Shin CR, Kim MO, Li D, Bleesing JJ, Harris R, Mehta P, Jodele S, Jordan MB, Marsh RA, Davies SM, Filipovich AH (2012) Outcomes following hematopoietic cell transplantation for Wiskott-Aldrich syndrome. Bone Marrow Transplant 47(11):1428\u20131435","journal-title":"Bone Marrow Transplant"},{"issue":"2","key":"2527_CR25","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.clim.2011.10.001","volume":"142","author":"M Shimizu","year":"2012","unstructured":"Shimizu M, Nikolov NP, Ueno K, Ohta K, Siegel RM, Yachie A, Candotti F (2012) Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency. Clin Immunol 142(2):160\u2013166","journal-title":"Clin Immunol"},{"issue":"5","key":"2527_CR26","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0022-3476(66)80450-X","volume":"68","author":"RW ten Bensel","year":"1966","unstructured":"ten Bensel RW, Stadlan EM, Krivit W (1966) The development of malignancy in the course of the Aldrich syndrome. J Pediatr 68(5):761\u2013767","journal-title":"J Pediatr"},{"issue":"6","key":"2527_CR27","first-page":"1585","volume":"56","author":"MC Webb","year":"1993","unstructured":"Webb MC, Andrews PA, Koffman CG, Cameron JS (1993) Renal transplantation in Wiskott-Aldrich syndrome. Transplantation 56(6):1585","journal-title":"Transplantation"},{"issue":"6","key":"2527_CR28","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1097\/MOH.0b013e328365a13b","volume":"20","author":"AJ Worth","year":"2013","unstructured":"Worth AJ, Booth C, Veys P (2013) Stem cell transplantation for primary immune deficiency. Curr Opin Hematol 20(6):501\u2013508","journal-title":"Curr Opin Hematol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2527-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-015-2527-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2527-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2527-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:03:22Z","timestamp":1744149802000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-015-2527-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["2527"],"URL":"https:\/\/doi.org\/10.1007\/s00431-015-2527-3","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]},"assertion":[{"value":"19 November 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}