{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:21:55Z","timestamp":1772119315377,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1007\/s00431-015-2657-7","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T22:55:27Z","timestamp":1445468127000},"page":"399-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Attitudes of parents of Klinefelter boys and pediatricians towards neonatal screening and fertility preservation techniques in Klinefelter syndrome"],"prefix":"10.1007","volume":"175","author":[{"given":"Inge","family":"Gies","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman","family":"Tournaye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"De Schepper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"issue":"12","key":"2657_CR1","doi-asserted-by":"crossref","first-page":"e561","DOI":"10.1111\/apa.12008","volume":"101","author":"L Aksglaede","year":"2012","unstructured":"Aksglaede L, Garn I, Hollegaard M, Hougaard D, Rajpert-De Meyts E, Juul A (2012) Detection of increased gene copy number in DNA from dried blood spot samples allows efficient screening for Klinefelter syndrome. Acta Paediatr 101(12):e561\u2013e563","journal-title":"Acta Paediatr"},{"key":"2657_CR2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/humupd\/dmi039","volume":"12","author":"L Aksglaede","year":"2006","unstructured":"Aksglaede L, Wikstr\u00f6m AM, Rajpert-De Meyts E, Dunkel L, Skakkebaek NE, Juul A (2006) Natural history of seminiferous tubule degeneration in Klinefelter syndrome. Hum Reprod Update 12:39\u201348","journal-title":"Hum Reprod Update"},{"key":"2657_CR3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/jc.2002-021491","volume":"88","author":"A Bojesen","year":"2003","unstructured":"Bojesen A, Juul S, Gravholt CH (2003) Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. J Clin Endocrinol Metab 88:622\u2013626","journal-title":"J Clin Endocrinol Metab"},{"key":"2657_CR4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/ejhg.2013.102","volume":"22","author":"E Bourke","year":"2014","unstructured":"Bourke E, Snow P, Herlihy A et al (2014) A qualitative exploration of mothers\u2019 and fathers\u2019 experiences of having a child with Klinefelter syndrome and the process of reaching this diagnosis. Eur J Hum Genet 22:18\u201324, 43","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"2657_CR5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1530\/jrf.0.0250401","volume":"25","author":"GL Foss","year":"1971","unstructured":"Foss GL, Lewis FJ (1971) A study of four cases with Klinefelters\u2019 syndrome, showing motile spermatozoa in their ejaculates. J Reprod Fertil 25(3):401\u2013408","journal-title":"J Reprod Fertil"},{"key":"2657_CR6","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/humrep\/des002","volume":"27","author":"I Gies","year":"2012","unstructured":"Gies I, De Schepper J, Van Saen D, Anckaert E, Goossens E, Tournaye H (2012) Failure of a combined clinical- and hormonal-based strategy to detect early spermatogenesis and retrieve spermatogonial stem cells in 47, XXY boys by single testicular biopsy. Hum Reprod 27:998\u20131004","journal-title":"Hum Reprod"},{"key":"2657_CR7","doi-asserted-by":"crossref","unstructured":"Herlihy A, McLachlan R (2015) Screening for Klinefelter syndrome. Curr Opin Endocrinol Diabetes Obes 22(3):224\u2013229","DOI":"10.1097\/MED.0000000000000154"},{"key":"2657_CR8","first-page":"88","volume":"7","author":"M Kitamura","year":"2000","unstructured":"Kitamura M, Matsumiya K, Koga M, Nishimura K, Miura H, Tsuji T, Matsumoto M, Okamoto Y, Okuyama A (2000) Ejaculated spermatozoa in patients with non-mosaic Klinefelter\u2019s syndrome. Int J Urol 7:88\u201392","journal-title":"Int J Urol"},{"key":"2657_CR9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1210\/jcem-2-11-615","volume":"2","author":"HF Klinefelter","year":"1942","unstructured":"Klinefelter HF, Reifenstein EC, Albright F (1942) Syndrome characterized by gynecomastia, aspermatogenesis without A-Leydigism, and increased excretion of follicle-stimulating hormone. J Clin Endocrinol 2:615\u2013627","journal-title":"J Clin Endocrinol"},{"key":"2657_CR10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0140-6736(04)16678-6","volume":"364","author":"F Lanfranco","year":"2004","unstructured":"Lanfranco F, Kamschke A, Zitzmann M, Nieschlag E (2004) Klinefelter\u2019s syndrome. Lancet 364:273\u2013283","journal-title":"Lancet"},{"issue":"9076","key":"2657_CR11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(97)02174-0","volume":"350","author":"YM Lo","year":"1997","unstructured":"Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, Wainscoat JS (1997) Presence of fetal DNA in maternal plasma and serum. Lancet 350(9076):485\u2013487","journal-title":"Lancet"},{"issue":"9","key":"2657_CR12","doi-asserted-by":"crossref","first-page":"809.14","DOI":"10.1007\/s10815-011-9603-z","volume":"28","author":"M Maiburg","year":"2011","unstructured":"Maiburg M, Hoppenbrouwers A, van Stel H, Giltay J (2011) Attitudes of Klinefelter men and their relatives towards TESE-ICSI. J Assist Reprod Genet 28(9):809.14","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"2657_CR13","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.fertnstert.2013.06.010","volume":"100","author":"A Mehta","year":"2013","unstructured":"Mehta A, Bolyakov A, Roosma J, Schlegel PN, Paduch DA (2013) Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor. Fertil Steril 100(4):970\u2013974","journal-title":"Fertil Steril"},{"issue":"5","key":"2657_CR14","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4103\/1008-682X.125914","volume":"16","author":"A Mehta","year":"2014","unstructured":"Mehta A, Mielnik A, Schlegel PN, Paduch DA (2014) Novel methylation specific real-time PCR test for the diagnosis of Klinefelter syndrome. Asian J Androl 16(5):684\u2013688","journal-title":"Asian J Androl"},{"key":"2657_CR15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2605.1995.tb00386.x","volume":"18","author":"J Muller","year":"1995","unstructured":"Muller J, Skakkebaek NE, Ratcliffe SG (1995) Quantified testicular histology in boys with sex chromosome abnormalities. Int J Androl 18:57\u201362","journal-title":"Int J Androl"},{"issue":"6","key":"2657_CR16","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/humrep\/det084","volume":"28","author":"N Rives","year":"2013","unstructured":"Rives N, Milazzo JP, Perdrix A, Castanet M, Joly He\u00b4las G, Sibert L, Bironneau A, Way A, Mace B (2013) The feasibility of fertility preservation in adolescents with Klinefelter syndrome. Hum Reprod 28(6):1468\u20131479","journal-title":"Hum Reprod"},{"issue":"3","key":"2657_CR17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MED.0000000000000157","volume":"22","author":"A Skakkebaek","year":"2015","unstructured":"Skakkebaek A, Wallentin M, Gravholt C (2015) Neuropsychology and socioeconomic aspects of Klinefelter syndrome: new developments. Curr Opin Endocrinol Diabetes Obes 22(3):209\u2013216","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"2","key":"2657_CR18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/humrep\/del375","volume":"22","author":"H Berg Van den","year":"2007","unstructured":"Van den Berg H, Repping S, van der Veen F (2007) Parental desire and acceptability of spermatogonial stem cell cryopreservation in boys with cancer. Hum Reprod 22(2):594\u2013597","journal-title":"Hum Reprod"},{"key":"2657_CR19","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/ajmg.a.35709","volume":"161A","author":"J Visootsak","year":"2013","unstructured":"Visootsak J, Ayari N, Howell S et al (2013) Timing of diagnosis of 47, XXY and 48, XXYY: a survey of parent experiences. Am J Med Genet A 161A:268\u2013272","journal-title":"Am J Med Genet A"},{"issue":"3","key":"2657_CR20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1530\/REP-13-0608","volume":"147","author":"S Werler","year":"2014","unstructured":"Werler S, Demond H, Damm OS, Ehmcke J, Middendorff R, Gromoll J, Wistuba J (2014) Germ cell loss is associated with fading Lin28a expression in a mouse model for Klinefelter\u2019s syndrome. Reproduction 147(3):253\u2013264","journal-title":"Reproduction"},{"key":"2657_CR21","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1210\/jc.2003-031725","volume":"89","author":"AM Wikstr\u00f6m","year":"2004","unstructured":"Wikstr\u00f6m AM, Raivio T, Hadziselimovic F, Wikstrom S, Tuuri T, Dunkel L (2004) Klinefelter syndrome in adolescence: onset of puberty is associated with accelerated germ cell depletion. J Clin Endocrinol Metab 89:2263\u20132270","journal-title":"J Clin Endocrinol Metab"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2657-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-015-2657-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-015-2657-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T18:32:09Z","timestamp":1559068329000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-015-2657-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,22]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["2657"],"URL":"https:\/\/doi.org\/10.1007\/s00431-015-2657-7","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725873196.793520360","asserted-by":"object"}]},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,22]]}}}