{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:21:08Z","timestamp":1770834068381,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T00:00:00Z","timestamp":1454112000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s00431-016-2694-x","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T02:57:37Z","timestamp":1454122657000},"page":"685-693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The effect of systemic corticosteroids on the innate and adaptive immune system in children with steroid responsive nephrotic syndrome"],"prefix":"10.1007","volume":"175","author":[{"given":"Hatice Ezgi","family":"Baris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safa","family":"Baris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Karakoc-Aydiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Gokce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurdan","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Cicekkoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Ogulur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harika","family":"Alpay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isil","family":"Barlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,30]]},"reference":[{"key":"2694_CR1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.immunol.18.1.309","volume":"18","author":"JD Ashwell","year":"2000","unstructured":"Ashwell JD, Lu FW, Vacchio MS (2000) Glucocorticoids in T cell development and function. Ann Rev Immunol 18:309\u2013345","journal-title":"Ann Rev Immunol"},{"key":"2694_CR2","first-page":"1","volume":"60","author":"C Baker","year":"2011","unstructured":"Baker C, Pickering L, Chilton L et al (2011) General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 60:1\u201364","journal-title":"MMWR Recomm Rep"},{"key":"2694_CR3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1191\/096120301675075008","volume":"10","author":"WW Chatham","year":"2001","unstructured":"Chatham WW, Kimberly RP (2001) Treatment of lupus with corticosteroids. Lupus 10:140\u2013147","journal-title":"Lupus"},{"key":"2694_CR4","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","volume":"335","author":"AE Coutinho","year":"2011","unstructured":"Coutinho AE, Chapman KE (2011) The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol 335:2\u201313. doi: 10.1016\/j.mce.2010.04.005","journal-title":"Mol Cell Endocrinol"},{"key":"2694_CR5","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1172\/JCI111757","volume":"75","author":"TR Cupps","year":"1985","unstructured":"Cupps TR, Gerrard TL, Falkoff RJ, Whalen G, Fauci AS (1985) Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation. J Clin Invest 75:754\u2013761","journal-title":"J Clin Invest"},{"key":"2694_CR6","first-page":"625","volume":"91","author":"PT Fan","year":"1978","unstructured":"Fan PT, Yu DT, Clements PJ, Fowlston S, Eisman J, Bluestone R (1978) Effect of corticosteroids on the human immune response: comparison of one and three daily 1 gm intravenous pulses of methylprednisolone. J Lab Clin Med 91:625\u2013634","journal-title":"J Lab Clin Med"},{"key":"2694_CR7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.7326\/0003-4819-84-3-304","volume":"84","author":"AS Fauci","year":"1976","unstructured":"Fauci AS, Dale DC, Balow JE (1976) Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med 84:304\u2013315","journal-title":"Ann Intern Med"},{"key":"2694_CR8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1081-1206(10)61380-4","volume":"97","author":"ME Fedor","year":"2006","unstructured":"Fedor ME, Rubinstein A (2006) Effects of long-term low-dose corticosteroid therapy on humoral immunity. Ann Allergy Asthma Immunol 97:113\u2013116","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2694_CR9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ki.1991.293","volume":"40","author":"RT Fiser","year":"1991","unstructured":"Fiser RT, Arnold WC, Charlton RK, Steele RW, Childress SH, Shirkey B (1991) T-lymphocyte subsets in nephrotic syndrome. Kidney Int 40:913\u2013916","journal-title":"Kidney Int"},{"key":"2694_CR10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/me.2011-0068","volume":"25","author":"JR Flammer","year":"2011","unstructured":"Flammer JR, Rogatsky I (2011) Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol 25:1075\u20131086. doi: 10.1210\/me.2011-0068","journal-title":"Mol Endocrinol"},{"key":"2694_CR11","doi-asserted-by":"crossref","first-page":"08","DOI":"10.1056\/NEJM197507032930103","volume":"293","author":"J Giangiacomo","year":"1975","unstructured":"Giangiacomo J, Cleary TG, Cole BR, Hoffstein P, Robson AM (1975) Serum immunoglobulins in the nephrotic syndrome. A possible cause of minimal change nephrotic syndrome. N Engl J Med 293:08\u201312","journal-title":"N Engl J Med"},{"key":"2694_CR12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1542\/peds.2008-1559","volume":"124","author":"DS Gipson","year":"2009","unstructured":"Gipson DS, Massengill SF, Yao L et al (2009) Management of childhood onset nephrotic syndrome. Pediatrics 124:747\u2013757. doi: 10.1542\/peds.2008-1559","journal-title":"Pediatrics"},{"key":"2694_CR13","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00467-008-0814-1","volume":"23","author":"V Guigonis","year":"2008","unstructured":"Guigonis V, Dallocchio A, Baudouin V et al (2008) Rituximab treatment for severe steroid- or cyclosporine-dependent nephrotic syndrome: a multicentric series of 22 cases. Pediatr Nephrol 23:1269\u20131279","journal-title":"Pediatr Nephrol"},{"key":"2694_CR14","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00865458","volume":"8","author":"SA Hulton","year":"1994","unstructured":"Hulton SA, Shah V, Byrne MR, Morgan G, Barratt TM, Dillon MJ (1994) Lymphocyte subpopulations, interleukin-2 and interleukin-2 receptor expression in childhood nephrotic syndrome. Pediatr Nephrol 8:135\u2013139","journal-title":"Pediatr Nephrol"},{"key":"2694_CR15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00467-008-1092-7","volume":"24","author":"A Iharada","year":"2009","unstructured":"Iharada A, Kaneko K, Tsuji S, Hasui M, Kanda S, Nishiyama T (2009) Increased nitric oxide production by T- and B-cells in idiopathic nephrotic syndrome. Pediatr Nephrol 24:1033\u20131038. doi: 10.1007\/s00467-008-1092-7","journal-title":"Pediatr Nephrol"},{"key":"2694_CR16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s10157-010-0330-z","volume":"14","author":"T Kanai","year":"2010","unstructured":"Kanai T, Shiraishi H, Yamagata T et al (2010) Th2 cells predominate in idiopathic steroid-sensitive nephrotic syndrome. Clin Exp Nephrol 14:578\u2013583","journal-title":"Clin Exp Nephrol"},{"key":"2694_CR17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12519-015-0003-9","volume":"11","author":"K Kaneko","year":"2015","unstructured":"Kaneko K, Tsuji S, Kimata T, Kitao T, Yamanouchi S, Kato S (2015) Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes. World J Pediatr 11:21\u201328. doi: 10.1007\/s12519-015-0003-9","journal-title":"World J Pediatr"},{"key":"2694_CR18","first-page":"767","volume":"146","author":"ME Kelly","year":"2010","unstructured":"Kelly ME, Juern AM, Grossman WJ, Schauer DW, Drolet BA (2010) Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Arch Dermatol 146:767\u2013774. doi: 10.1001\/archdermatol.2010.90","journal-title":"Arch Dermatol"},{"key":"2694_CR19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000085357","volume":"25","author":"MJ Kemper","year":"2005","unstructured":"Kemper MJ, Zepf K, Klaassen I, Link A, Muller-Wiefel DE (2005) Changes of lymphocyte populations in pediatric steroid-sensitive nephrotic syndrome are more pronounced in remission than in relapse. Am J Nephrol 25:132\u2013137","journal-title":"Am J Nephrol"},{"key":"2694_CR20","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2249.1996.tb08306.x","volume":"103","author":"L Lanza","year":"1996","unstructured":"Lanza L, Scudeletti M, Puppo F et al (1996) Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes. Clin Exp Immunol 103:482\u2013490","journal-title":"Clin Exp Immunol"},{"key":"2694_CR21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1001\/archneur.58.1.91","volume":"58","author":"VI Leussink","year":"2001","unstructured":"Leussink VI, Jung S, Merschdorf U, Toyka KV, Gold R (2001) High-dose methylprednisolone therapy in multiple sclerosis induces apoptosis in peripheral blood leukocytes. Arch Neurol 58:91\u201397","journal-title":"Arch Neurol"},{"key":"2694_CR22","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00467-012-2310-x","volume":"28","author":"RM Lombel","year":"2013","unstructured":"Lombel RM, Gipson DS, Hodson EM (2013) Treatment of steroid-sensitive nephrotic syndrome: new guidelines from KDIGO. Pediatr Nephrol 28:415\u2013426. doi: 10.1007\/s00467-012-2310-x","journal-title":"Pediatr Nephrol"},{"key":"2694_CR23","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.156.11.4422","volume":"156","author":"LC Meagher","year":"1966","unstructured":"Meagher LC, Cousin JM, Seckl JR, Haslett C (1966) Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes. J Immunol 156:4422\u20134428","journal-title":"J Immunol"},{"key":"2694_CR24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/intimm\/7.4.591","volume":"7","author":"EW Nijhuis","year":"1995","unstructured":"Nijhuis EW, Hinloopen B, van Lier RA, Nagelkerken L (1995) Differential sensitivity of human naive and memory CD4+ T cells for dexamethasone. Int Immunol 7:591\u2013595","journal-title":"Int Immunol"},{"key":"2694_CR25","first-page":"23","volume":"6","author":"S Nilganuwonge","year":"1988","unstructured":"Nilganuwonge S, Harisdangkul V, Rockhold L, Lewis RE, Cruse JM (1988) Lymphocyte subset T4\/T8 ratio in systemic lupus erythematosus: correlation with disease activity, laboratory abnormalities and treatment. Asian Pac J Allergy Immunol 6:23\u201328","journal-title":"Asian Pac J Allergy Immunol"},{"key":"2694_CR26","first-page":"1","volume":"63","author":"F Pereira Wde","year":"2014","unstructured":"Pereira Wde F, Brito Melo GE, Guimar\u00e3es FT, Carvalho TG, Mateo EC, Sim\u00f5es E, Silva AC (2014) The role of the immune system in idiopathic nephrotic syndrome: a review of clinical and experimental studies. Inflamm Res 63:1\u201312","journal-title":"Inflamm Res"},{"key":"2694_CR27","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0140-6736(74)91880-7","volume":"2","author":"RJ Shalhoub","year":"1974","unstructured":"Shalhoub RJ (1974) Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet 2:556\u2013560.22","journal-title":"Lancet"},{"key":"2694_CR28","first-page":"290","volume":"44","author":"KM Tornatore","year":"1995","unstructured":"Tornatore KM, Reed K, Venuto R (1995) 24-hour immunologic assessment of CD4+ and CD8+ lymphocytes in renal transplant recipients receiving chronic methylprednisolone. Clin Nephrol 44:290\u2013298","journal-title":"Clin Nephrol"},{"key":"2694_CR29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2567.2012.03570.x","volume":"136","author":"PJ Berg Van der","year":"2012","unstructured":"Van der Berg PJ, Hoevenaars EC, Yong SL et al (2012) Circulating lymphocyte subsets in different clinical situations after renal transplantation. Immunology 136:198\u2013207. doi: 10.1111\/j.1365-2567.2012.03570.x","journal-title":"Immunology"},{"key":"2694_CR30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1824-7288-39-42","volume":"39","author":"B Yildiz","year":"2013","unstructured":"Yildiz B, Cetin N, Kural N, Colak O (2013) CD19\u2009+\u2009CD23+ B cells, CD4\u2009+\u2009CD25+ T cells, E-selectin and interleukin-12 levels in children with steroid sensitive nephrotic syndrome. Ital J Pediatr 39:42. doi: 10.1186\/1824-7288-39-42","journal-title":"Ital J Pediatr"},{"key":"2694_CR31","first-page":"225","volume":"80","author":"RE Younger","year":"1987","unstructured":"Younger RE, Gerber PS, Herrod HG, Cohen RM, Crawford LV (1987) Intravenous methylprednisolone efficacy in status asthmaticus of childhood. Pediatrics 80:225\u2013230","journal-title":"Pediatrics"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2694-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-016-2694-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2694-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T17:47:19Z","timestamp":1692208039000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-016-2694-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,30]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["2694"],"URL":"https:\/\/doi.org\/10.1007\/s00431-016-2694-x","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,30]]}}}