{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T23:29:20Z","timestamp":1774308560315,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T00:00:00Z","timestamp":1455494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K08HL121182"],"award-info":[{"award-number":["K08HL121182"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR001070"],"award-info":[{"award-number":["UL1TR001070"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s00431-016-2705-y","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T05:09:52Z","timestamp":1455512992000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Nonsteroidal anti-inflammatory administration and patent ductus arteriosus ligation, a survey of practice preferences at US children\u2019s hospitals"],"prefix":"10.1007","volume":"175","author":[{"given":"Jonathan L.","family":"Slaughter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia B.","family":"Reagan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopali V.","family":"Bapat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas B.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Klebanoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"2705_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/jp.2010.3","volume":"30","author":"W Benitz","year":"2010","unstructured":"Benitz W (2010) Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis? J Perinatol 30:241\u2013252","journal-title":"J Perinatol"},{"key":"2705_CR2","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1038\/jp.2009.124","volume":"30","author":"JR Benjamin","year":"2010","unstructured":"Benjamin JR, Smith PB, Cotten CM, Jaggers J, Goldstein RF, Malcolm WF (2010) Long-term morbidities associated with vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely low birth weight infants. J Perinatol 30:408\u2013413","journal-title":"J Perinatol"},{"key":"2705_CR3","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.jpeds.2006.03.015","volume":"148","author":"CL Bose","year":"2006","unstructured":"Bose CL, Laughon M (2006) Treatment to prevent patency of the ductus arteriosus: beneficial or harmful? J Pediatr 148:713\u2013714","journal-title":"J Pediatr"},{"key":"2705_CR4","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.jpeds.2009.01.005","volume":"154","author":"R Clyman","year":"2009","unstructured":"Clyman R, Cassady G, Kirklin JK, Collins M, Philips JB 3rd (2009) The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: reexamining a randomized controlled trial. J Pediatr 154:873\u2013876","journal-title":"J Pediatr"},{"key":"2705_CR5","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.jpeds.2006.12.048","volume":"150","author":"RI Clyman","year":"2007","unstructured":"Clyman RI, Chorne N (2007) Patent ductus arteriosus: evidence for and against treatment. J Pediatr 150:216","journal-title":"J Pediatr"},{"key":"2705_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jpeds.2006.09.001","volume":"150","author":"RI Clyman","year":"2007","unstructured":"Clyman RI, Saha S, Jobe A, Oh W (2007) Indomethacin prophylaxis for preterm infants: the impact of 2 multicentered randomized controlled trials on clinical practice. J Pediatr 150:46\u201350, e42","journal-title":"J Pediatr"},{"key":"2705_CR7","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1016\/j.jpeds.2014.01.058","volume":"164","author":"RI Clyman","year":"2014","unstructured":"Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K (2014) Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones. J Pediatr 164:1449\u20131455, e1441","journal-title":"J Pediatr"},{"key":"2705_CR8","doi-asserted-by":"crossref","unstructured":"Cooke L, Steer PA, Woodgate PG (2003) Indomethacin for asymptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev (online) 2:CD003745","DOI":"10.1002\/14651858.CD003745"},{"key":"2705_CR9","unstructured":"US Federal Trade Commission v. Lundbeck Inc., Nos. 08-6379, 08-6381 (2010). Available at: https:\/\/www.gpo.gov\/fdsys\/pkg\/USCOURTS-mnd-0_08-cv-06379. Accessed 8 Feb 2016"},{"key":"2705_CR10","doi-asserted-by":"crossref","unstructured":"Fowlie PW, Davis PG, McGuire W (2010) Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev (online) 7:CD000174","DOI":"10.1002\/14651858.CD000174.pub2"},{"key":"2705_CR11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","volume":"42","author":"PA Harris","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG (2009) Research electronic data capture (REDCap)\u2014a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform 42:377\u2013381","journal-title":"J Biomed Inform"},{"key":"2705_CR12","unstructured":"American Society of Health System Pharmacists. Resolved Drug Shortage Bulletin: Ibuprofen Lysine Injection (2012). Available at: http:\/\/www.ashp.org\/menu\/DrugShortages\/ResolvedShortages\/Bulletin.aspx?Source=Resolved&Type=Rss&Id=669. Accessed 8 Feb 2016"},{"key":"2705_CR13","doi-asserted-by":"publisher","first-page":"F48","DOI":"10.1136\/adc.2007.129270","volume":"94","author":"K Herrman","year":"2009","unstructured":"Herrman K, Bose C, Lewis K, Laughon M (2009) Spontaneous closure of the patent ductus arteriosus in very low birth weight infants following discharge from the neonatal unit. Arch Dis Child Fetal Neonatal Ed 94:F48\u2013F50","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2705_CR14","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1542\/peds.2007-0184","volume":"119","author":"AH Jobe","year":"2007","unstructured":"Jobe AH (2007) Drug pricing in pediatrics: the egregious example of indomethacin. Pediatrics 119:1197\u20131198","journal-title":"Pediatrics"},{"key":"2705_CR15","doi-asserted-by":"publisher","first-page":"F45","DOI":"10.1136\/adc.2009.168682","volume":"96","author":"L Jones","year":"2010","unstructured":"Jones L, Craven P, Attia J, Thakkinstian A, Wright I (2010) Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants. Arch Dis Child Fetal Neonatal Ed 96:F45\u2013F52","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2705_CR16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.jpeds.2006.11.039","volume":"150","author":"NS Kabra","year":"2007","unstructured":"Kabra NS, Schmidt B, Roberts RS, Doyle LW, Papile L, Fanaroff A (2007) Neurosensory impairment after surgical closure of patent ductus arteriosus in extremely low birth weight infants: results from the Trial of Indomethacin Prophylaxis in Preterms. J Pediatr 150:229\u2013234","journal-title":"J Pediatr"},{"key":"2705_CR17","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1542\/peds.2008-1162","volume":"123","author":"TM Luu","year":"2009","unstructured":"Luu TM, Ment LR, Schneider KC, Katz KH, Allan WC, Vohr BR (2009) Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age. Pediatrics 123:1037\u20131044","journal-title":"Pediatrics"},{"key":"2705_CR18","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1542\/peds.2007-2781","volume":"123","author":"JC Madan","year":"2009","unstructured":"Madan JC, Kendrick D, Hagadorn JI, Frantz ID (2009) Patent ductus arteriosus therapy: impact on neonatal and 18-month outcome. Pediatrics 123:674\u2013681","journal-title":"Pediatrics"},{"key":"2705_CR19","doi-asserted-by":"crossref","unstructured":"Malviya MN, Ohlsson A, Shah SS (2013) Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants. Cochrane Database Syst Rev (online) 3:CD003951","DOI":"10.1002\/14651858.CD003951.pub3"},{"key":"2705_CR20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1542\/peds.93.4.543","volume":"93","author":"LR Ment","year":"1994","unstructured":"Ment LR, Oh W, Ehrenkranz RA, Philip AG, Vohr B, Allan W, Duncan CC, Scott DT, Taylor KJ, Katz KH, Schneider KC, Makuch RW, Oh W, Vohr B, Philip AGS, Allan W (1994) Low-dose indomethacin and prevention of intraventricular hemorrhage: a multicenter randomized trial. Pediatrics 93:543\u2013550","journal-title":"Pediatrics"},{"key":"2705_CR21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1542\/peds.105.3.485","volume":"105","author":"LR Ment","year":"2000","unstructured":"Ment LR, Vohr B, Allan W, Westerveld M, Sparrow SS, Schneider KC, Katz KH, Duncan CC, Makuch RW (2000) Outcome of children in the indomethacin intraventricular hemorrhage prevention trial. Pediatrics 105:485\u2013491","journal-title":"Pediatrics"},{"key":"2705_CR22","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jpeds.2012.05.007","volume":"161","author":"L Mirea","year":"2012","unstructured":"Mirea L, Sankaran K, Seshia M, Ohlsson A, Allen AC, Aziz K, Lee SK, Shah PS, Network CN (2012) Treatment of patent ductus arteriosus and neonatal mortality\/morbidities: adjustment for treatment selection bias. J Pediatr 161:689\u2013694, e681","journal-title":"J Pediatr"},{"key":"2705_CR23","doi-asserted-by":"crossref","unstructured":"Mosalli R, AlFaleh K (2008) Prophylactic surgical ligation of patent ductus arteriosus for prevention of mortality and morbidity in extremely low birth weight infants. Cochrane Database Syst Rev (online) 1:CD006181","DOI":"10.1002\/14651858.CD006181.pub2"},{"key":"2705_CR24","doi-asserted-by":"publisher","first-page":"e138","DOI":"10.1542\/peds.2008-2418","volume":"123","author":"S Noori","year":"2009","unstructured":"Noori S, McCoy M, Friedlich P, Bright B, Gottipati V, Seri I, Sekar K (2009) Failure of ductus arteriosus closure is associated with increased mortality in preterm infants. Pediatrics 123:e138\u2013e144","journal-title":"Pediatrics"},{"key":"2705_CR25","doi-asserted-by":"crossref","unstructured":"Ohlsson A, Walia R, Shah SS (2015) Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants. Cochrane Database Syst Rev (online) 2:CD003481","DOI":"10.1002\/14651858.CD003481.pub6"},{"key":"2705_CR26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1203\/00006450-200001000-00009","volume":"47","author":"J Patel","year":"2000","unstructured":"Patel J, Roberts I, Azzopardi D, Hamilton P, Edwards AD (2000) Randomized double-blind controlled trial comparing the effects of ibuprofen with indomethacin on cerebral hemodynamics in preterm infants with patent ductus arteriosus. Pediatr Res 47:36\u201336","journal-title":"Pediatr Res"},{"key":"2705_CR27","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S0022-3476(99)70093-4","volume":"135","author":"M Pezzati","year":"1999","unstructured":"Pezzati M, Vangi V, Biagiotti R, Bertini G, Cianciulli D, Rubaltelli FF (1999) Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus. J Pediatr 135:733\u2013738","journal-title":"J Pediatr"},{"key":"2705_CR28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/08998280.2007.11928244","volume":"20","author":"G Poon","year":"2007","unstructured":"Poon G (2007) Ibuprofen lysine (NeoProfen) for the treatment of patent ductus arteriosus. Proc Baylor Univ Med Center 20:83","journal-title":"Proc Baylor Univ Med Center"},{"key":"2705_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/BF02265403","volume":"6","author":"MD Reller","year":"1985","unstructured":"Reller MD, Lorenz JM, Kotagal UR, Meyer RA, Kaplan S (1985) Hemodynamically significant PDA: an echocardiographic and clinical assessment of incidence, natural history, and outcome in very low birth weight infants maintained in negative fluid balance. Pediatr Cardiol 6:17\u201323","journal-title":"Pediatr Cardiol"},{"key":"2705_CR30","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00246-009-9469-3","volume":"30","author":"M Roclawski","year":"2009","unstructured":"Roclawski M, Sabiniewicz R, Potaz P, Smoczynski A, Pankowski R, Mazurek T, Daibo B (2009) Scoliosis in patients with aortic coarctation and patent ductus arteriosus: does standard posterolateral thoracotomy play a role in the development of the lateral curve of the spine? Pediatr Cardiol 30:941\u2013945","journal-title":"Pediatr Cardiol"},{"key":"2705_CR31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3109\/14767058.2011.604987","volume":"24","author":"C Romagnoli","year":"2011","unstructured":"Romagnoli C, Bersani I, Rubortone SA, Lacerenza S, De Carolis MP (2011) Current evidence on the safety profile of NSAIDs for the treatment of PDA. J Matern Fetal Neonatal Med 24:10\u201313","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2705_CR32","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1056\/NEJM200106283442602","volume":"344","author":"B Schmidt","year":"2001","unstructured":"Schmidt B, Davis P, Moddemann D, Ohlsson A, Roberts RS, Saigal S, Solimano A, Vincer M, Wright LL (2001) Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants. N Engl J Med 344:1966\u20131972","journal-title":"N Engl J Med"},{"key":"2705_CR33","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1055\/s-0032-1332800","volume":"30","author":"S Sivanandan","year":"2013","unstructured":"Sivanandan S, Bali V, Soraisham AS, Harabor A, Kamaluddeen M (2013) Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. Am J Perinatol 30:745\u2013750","journal-title":"Am J Perinatol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2705-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-016-2705-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2705-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2705-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:40:00Z","timestamp":1744173600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-016-2705-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,15]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["2705"],"URL":"https:\/\/doi.org\/10.1007\/s00431-016-2705-y","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,15]]},"assertion":[{"value":"27 July 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was funded in part by the National Heart, Lung, And Blood Institute of the National Institutes of Health (USA) under Award Number K08HL121182 and REDCap support provided in part by Award Number Grant UL1TR001070 from the National Center For Advancing Translational Sciences. The content is solely the authors\u2019 responsibility and does not necessarily represent the official views of the National Institutes of Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Informed consent was obtained from all individual participants included in the study. The Nationwide Children\u2019s Hospital Institutional Review Board approved the study. The introductory page of the survey explained the purpose of the voluntary survey and informed the respondent that completing the survey would signify consent to participate. The Nationwide Children\u2019s Hospital Institutional Review Board determined that evaluation of the PHIS database was not human subjects\u2019 research, because it was an analysis of a pre-existing, de-identified dataset and involved no patient contact.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Nationwide Children\u2019s Hospital Institutional Review Board approved the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical oversight"}}]}}