{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T02:06:48Z","timestamp":1785290808899,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:00:00Z","timestamp":1470700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:00:00Z","timestamp":1470700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Alma and K.A. Snellman Foundation, Oulu, Finland"},{"name":"The Foundation for Pediatric Research, Finland"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00431-016-2758-y","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T04:10:13Z","timestamp":1470715813000},"page":"1175-1183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Neurally adjusted ventilatory assist (NAVA) in preterm newborn infants with respiratory distress syndrome\u2014a randomized controlled trial"],"prefix":"10.1007","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-344X","authenticated-orcid":false,"given":"Merja","family":"Kallio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Koskela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Peltoniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tero","family":"Kontiokari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Suo-Palosaari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Saarela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,9]]},"reference":[{"key":"2758_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1651-2227.2012.02830.x","volume":"102","author":"M Alander","year":"2013","unstructured":"Alander M, Peltoniemi O, Saarela T, Anttila E, Pokka T, Kontiokari T (2013) Current trends in paediatric and neonatal ventilatory care\u2014a nationwide survey. Acta Paediatr 102:123\u2013128","journal-title":"Acta Paediatr"},{"key":"2758_CR2","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1002\/ppul.21519","volume":"47","author":"M Alander","year":"2012","unstructured":"Alander M, Peltoniemi O, Pokka T, Kontiokari T (2012) Comparison of pressure-, flow-, and NAVA-triggering in pediatric and neonatal ventilatory care. Pediatr Pulmonol 47:76\u201383","journal-title":"Pediatr Pulmonol"},{"key":"2758_CR3","first-page":"157","volume":"16","author":"P Bendapudi","year":"2015","unstructured":"Bendapudi P, Rao GG, Greenough A (2015) Diagnosis and management of persistent pulmonary hypertension of the newborn. Paediatr Respir Rev 16:157\u2013161","journal-title":"Paediatr Respir Rev"},{"key":"2758_CR4","doi-asserted-by":"publisher","DOI":"10.1002\/0470023589","volume-title":"Applied mixed models in medicine","author":"H Brown","year":"2006","unstructured":"Brown H, Prescott R (2006) Applied mixed models in medicine. John Wiley & Sons Ltd, Chichester England"},{"key":"2758_CR5","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.4187\/respcare.01429","volume":"56","author":"MK Brown","year":"2011","unstructured":"Brown MK, DiBlasi RM (2011) Mechanical ventilation of the premature neonate. Respir Care 56:1298\u20131311 discussion 1311-3","journal-title":"Respir Care"},{"key":"2758_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-4271","volume":"137","author":"COMMITTEE ON FETUS AND NEWBORN and SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE","year":"2016","unstructured":"COMMITTEE ON FETUS AND NEWBORN and SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE (2016) Prevention and management of procedural pain in the neonate: an update. Pediatrics 137:1\u201313","journal-title":"Pediatrics"},{"key":"2758_CR7","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1148\/radiology.157.2.3840268","volume":"157","author":"DK Edwards","year":"1985","unstructured":"Edwards DK, Hilton SV, Merritt TA, Hallman M, Mannino F, Boynton BR (1985) Respiratory distress syndrome treated with human surfactant: radiographic findings. Radiology 157:329\u2013334","journal-title":"Radiology"},{"key":"2758_CR8","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0034-5687(00)00184-5","volume":"124","author":"S Hannam","year":"2001","unstructured":"Hannam S, Ingram DM, Rabe-Hesketh S, Milner AD (2001) Characterisation of the Hering-Breuer deflation reflex in the human neonate. Respir Physiol 124:51\u201364","journal-title":"Respir Physiol"},{"key":"2758_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jpeds.2015.08.003","volume":"168","author":"A Harma","year":"2016","unstructured":"Harma A, Aikio O, Hallman M, Saarela T (2016) Intravenous paracetamol decreases requirements of morphine in very preterm infants. J Pediatr 168:36\u201340","journal-title":"J Pediatr"},{"key":"2758_CR10","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.siny.2015.03.001","volume":"20","author":"A Jain","year":"2015","unstructured":"Jain A, McNamara PJ (2015) Persistent pulmonary hypertension of the newborn: advances in diagnosis and treatment. Semin Fetal Neonatal Med 20:262\u2013271","journal-title":"Semin Fetal Neonatal Med"},{"key":"2758_CR11","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/bdra.23235","volume":"100","author":"EA Jensen","year":"2014","unstructured":"Jensen EA, Schmidt B (2014) Epidemiology of bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol 100:145\u2013157","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2758_CR12","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1164\/ajrccm.163.7.2011060","volume":"163","author":"AH Jobe","year":"2001","unstructured":"Jobe AH, Bancalari E (2001) Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163:1723\u20131729","journal-title":"Am J Respir Crit Care Med"},{"key":"2758_CR13","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1016\/S0140-6736(06)68615-7","volume":"367","author":"JP Kinsella","year":"2006","unstructured":"Kinsella JP, Greenough A, Abman SH (2006) Bronchopulmonary dysplasia. Lancet 367:1421\u20131431","journal-title":"Lancet"},{"key":"2758_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.earlhumdev.2015.11.001","volume":"92","author":"M Kocek","year":"2016","unstructured":"Kocek M, Wilcox R, Crank C, Patra K (2016) Evaluation of the relationship between opioid exposure in extremely low birth weight infants in the neonatal intensive care unit and neurodevelopmental outcome at 2\u00a0years. Early Hum Dev 92:29\u201332","journal-title":"Early Hum Dev"},{"key":"2758_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1651-2227.2004.tb00702.x","volume":"93","author":"M Koivisto","year":"2004","unstructured":"Koivisto M, Marttila R, Kurkinen-Raty M, Saarela T, Pokela ML, Jouppila P, Hallman M (2004) Changing incidence and outcome of infants with respiratory distress syndrome in the 1990s: a population-based survey. Acta Paediatr 93:177\u2013184","journal-title":"Acta Paediatr"},{"key":"2758_CR16","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.jpeds.2012.04.040","volume":"161","author":"J Lee","year":"2012","unstructured":"Lee J, Kim HS, Sohn JA, Lee JA, Choi CW, Kim EK, Kim BI, Choi JH (2012) Randomized crossover study of neurally adjusted ventilatory assist in preterm infants. J Pediatr 161:808\u2013813","journal-title":"J Pediatr"},{"key":"2758_CR17","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1159\/000367886","volume":"107","author":"F Longhini","year":"2015","unstructured":"Longhini F, Ferrero F, De Luca D, Cosi G, Alemani M, Colombo D, Cammarota G, Berni P, Conti G, Bona G, Della Corte F, Navalesi P (2015) Neurally adjusted ventilatory assist in preterm neonates with acute respiratory failure. Neonatology 107:60\u201367","journal-title":"Neonatology"},{"key":"2758_CR18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.clp.2013.10.002","volume":"41","author":"C McPherson","year":"2014","unstructured":"McPherson C, Grunau RE (2014) Neonatal pain control and neurologic effects of anesthetics and sedatives in preterm infants. Clin Perinatol 41:209\u2013227","journal-title":"Clin Perinatol"},{"key":"2758_CR19","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1056\/NEJMoa072788","volume":"358","author":"CJ Morley","year":"2008","unstructured":"Morley CJ, Davis PG, Doyle LW, Brion LP, Hascoet JM, Carlin JB, Trial Investigators COIN (2008) Nasal CPAP or intubation at birth for very preterm infants. N Engl J Med 358:700\u2013708","journal-title":"N Engl J Med"},{"key":"2758_CR20","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s00134-012-2535-y","volume":"38","author":"O Pdl","year":"2012","unstructured":"Pdl O, Schuffelmann C, Gomez-Zamora A, Villar J, Kacmarek RM (2012) Asynchrony, neural drive, ventilatory variability and COMFORT: NAVA versus pressure support in pediatric patients. A non-randomized cross-over trial. Intensive Care Med 38:838\u2013846","journal-title":"Intensive Care Med"},{"key":"2758_CR21","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1016\/j.ijnurstu.2014.04.001","volume":"51","author":"T Polkki","year":"2014","unstructured":"Polkki T, Korhonen A, Axelin A, Saarela T, Laukkala H (2014) Development and preliminary validation of the neonatal infant acute pain assessment scale (NIAPAS). Int J Nurs Stud 51:1585\u20131594","journal-title":"Int J Nurs Stud"},{"key":"2758_CR22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1097\/01.ccx.0000198994.37319.60","volume":"12","author":"C Putensen","year":"2006","unstructured":"Putensen C, Muders T, Varelmann D, Wrigge H (2006) The impact of spontaneous breathing during mechanical ventilation. Curr Opin Crit Care 12:13\u201318","journal-title":"Curr Opin Crit Care"},{"key":"2758_CR23","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1038\/71012","volume":"5","author":"C Sinderby","year":"1999","unstructured":"Sinderby C, Navalesi P, Beck J, Skrobik Y, Comtois N, Friberg S, Gottfried SB, Lindstrom L (1999) Neural control of mechanical ventilation in respiratory failure. Nat Med 5:1433\u20131436","journal-title":"Nat Med"},{"key":"2758_CR24","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/jp.2012.136","volume":"33","author":"H Stein","year":"2013","unstructured":"Stein H, Alosh H, Ethington P, White DB (2013) Prospective crossover comparison between NAVA and pressure control ventilation in premature neonates less than 1500 grams. J Perinatol 33:452\u2013456","journal-title":"J Perinatol"},{"key":"2758_CR25","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jpeds.2011.10.014","volume":"160","author":"H Stein","year":"2012","unstructured":"Stein H, Howard D (2012) Neurally adjusted ventilatory assist in neonates weighing <1500 grams: a retrospective analysis. J Pediatr 160:786\u20139.e1","journal-title":"J Pediatr"},{"key":"2758_CR26","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1586\/17476348.2014.899907","volume":"8","author":"L Strueby","year":"2014","unstructured":"Strueby L, Thebaud B (2014) Advances in bronchopulmonary dysplasia. Expert Rev Respir Med 8:327\u2013338","journal-title":"Expert Rev Respir Med"},{"key":"2758_CR27","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1159\/000326843","volume":"99","author":"A van Kaam","year":"2011","unstructured":"van Kaam A (2011) Lung-protective ventilation in neonatology. Neonatology 99:338\u2013341","journal-title":"Neonatology"},{"key":"2758_CR28","doi-asserted-by":"crossref","unstructured":"van Kaam AH, Rimensberger PC, Borensztajn D, De Jaegere AP, Neovent Study Group (2010) Ventilation practices in the neonatal intensive care unit: a cross-sectional study. J Pediatr 157:767\u201371.e1-3","DOI":"10.1016\/j.jpeds.2010.05.043"},{"key":"2758_CR29","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1097\/PCC.0b013e31828a8606","volume":"14","author":"L Vignaux","year":"2013","unstructured":"Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Jaecklin T, Levy-Jamet Y, Tourneux P, Jolliet P, Rimensberger PC (2013) Optimizing patient-ventilator synchrony during invasive ventilator assist in children and infants remains a difficult task*. Pediatr Crit Care Med 14:e316\u2013e325","journal-title":"Pediatr Crit Care Med"},{"key":"2758_CR30","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/sj.jp.7210963","volume":"23","author":"MC Walsh","year":"2003","unstructured":"Walsh MC, Wilson-Costello D, Zadell A, Newman N, Fanaroff A (2003) Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia. J Perinatol 23:451\u2013456","journal-title":"J Perinatol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-016-2758-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2758-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-016-2758-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:46:47Z","timestamp":1744174007000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-016-2758-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["2758"],"URL":"https:\/\/doi.org\/10.1007\/s00431-016-2758-y","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,9]]},"assertion":[{"value":"18 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work was funded by the Alma and K.A. Snellman Foundation, Oulu, Finland, and the Foundation for Pediatric Research, Finland.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"All procedures performed in this trial were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from a parent or legal guardian for every individual participant included in the trial.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Dr. Kallio has participated as a speaker in scientific meetings and symposia organized and financed by Maquet Critical Care. The other authors declare that they have no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}