{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:32:42Z","timestamp":1785036762759,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s00431-018-3277-9","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T16:27:58Z","timestamp":1542040078000},"page":"235-242","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinical recovery in children with uncomplicated appendicitis undergoing non-operative treatment: secondary analysis of a prospective cohort study"],"prefix":"10.1007","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0780-6395","authenticated-orcid":false,"given":"Max","family":"Knaapen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna H.","family":"van der Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Heij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst L. W.","family":"van Heurn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Bakx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon R.","family":"Gorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"3277_CR1","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jpedsurg.2007.03.049","volume":"42","author":"M Abe\u015f","year":"2007","unstructured":"Abe\u015f M, Petik B, Kazil S (2007) Nonoperative treatment of acute appendicitis in children. J Pediatr Surg 42:1439\u20131442. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2007.03.049","journal-title":"J Pediatr Surg"},{"key":"3277_CR2","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1093\/oxfordjournals.aje.a115734","volume":"132","author":"DG Addiss","year":"1990","unstructured":"Addiss DG, Shaffer N, Fowler BS, Tauxe RV (1990) The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 132:910\u2013925. \n                    https:\/\/doi.org\/10.1093\/oxfordjournals.aje.a115734","journal-title":"Am J Epidemiol"},{"key":"3277_CR3","volume-title":"Statistics with confidence: confidence intervals and statistical guidelines","author":"D Altman","year":"2000","unstructured":"Altman D, Machin D, Bryant T (2000) Statistics with confidence: confidence intervals and statistical guidelines, 2nd edn. BMJ Books, London","edition":"2"},{"key":"3277_CR4","doi-asserted-by":"publisher","first-page":"2787","DOI":"10.1007\/s00268-012-1749-z","volume":"36","author":"JE Anderson","year":"2012","unstructured":"Anderson JE, Bickler SW, Chang DC, Talamini MA (2012) Examining a common disease with unknown etiology: trends in epidemiology and surgical management of appendicitis in California, 1995-2009. World J Surg 36:2787\u20132794. \n                    https:\/\/doi.org\/10.1007\/s00268-012-1749-z","journal-title":"World J Surg"},{"key":"3277_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00268-006-0056-y","volume":"31","author":"RE Andersson","year":"2007","unstructured":"Andersson RE (2007) The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg 31:86\u201392. \n                    https:\/\/doi.org\/10.1007\/s00268-006-0056-y","journal-title":"World J Surg"},{"key":"3277_CR6","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.jpedsurg.2014.02.071","volume":"49","author":"J Armstrong","year":"2014","unstructured":"Armstrong J, Merritt N, Jones S, Scott L, B\u00fctter A (2014) Non-operative management of early, acute appendicitis in children: is it safe and effective? J Pediatr Surg 49:782\u2013785. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2014.02.071","journal-title":"J Pediatr Surg"},{"key":"3277_CR7","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1001\/jamapediatrics.2017.2937","volume":"171","author":"WA Bonadio","year":"2017","unstructured":"Bonadio WA (2017) Nonoperative treatment of appendicitis. JAMA Pediatr 171:1125. \n                    https:\/\/doi.org\/10.1001\/jamapediatrics.2017.2937","journal-title":"JAMA Pediatr"},{"key":"3277_CR8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1097\/00002508-200003000-00005","volume":"16","author":"EK Breivik","year":"2000","unstructured":"Breivik EK, Bj\u00f6rnsson GA, Skovlund E (2000) A comparison of pain rating scales by sampling from clinical trial data. Clin J Pain 16:22\u201328","journal-title":"Clin J Pain"},{"key":"3277_CR9","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S1092-9134(00)90011-X","volume":"4","author":"NJ Carr","year":"2000","unstructured":"Carr NJ (2000) The pathology of acute appendicitis. Ann Diagn Pathol 4:46\u201358. \n                    https:\/\/doi.org\/10.1053\/adpa.2000.0046","journal-title":"Ann Diagn Pathol"},{"key":"3277_CR10","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.jpedsurg.2016.08.007","volume":"52","author":"AM Caruso","year":"2017","unstructured":"Caruso AM, Pane A, Garau R, Atzori P, Podda M, Casuccio A, Mascia L (2017) Acute appendicitis in children: not only surgical treatment. J Pediatr Surg 52:444\u2013448. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.08.007","journal-title":"J Pediatr Surg"},{"key":"3277_CR11","unstructured":"Dutch Association of Pediatrics (2007) Dutch national guideline: pain measurement and management of pain in children. Utrecht. \n                    https:\/\/www.nvk.nl\/Portals\/0\/richtlijnen\/pijnmeting\/richtlijnpijnmeting.pdf\n                    \n                  . Accessed 5 May 2017"},{"key":"3277_CR12","unstructured":"Fisher J (2016) Comparison of medical and surgical treatment of uncomplicated acute appendicitis in children - \n                    ClinicalTrials.gov\n                    \n                  . In: Last Updat. December 9, 2016"},{"key":"3277_CR13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3003","volume":"139","author":"R Georgiou","year":"2017","unstructured":"Georgiou R, Eaton S, Stanton MP, Pierro A, Hall NJ (2017) Efficacy and safety of nonoperative treatment for acute appendicitis: a meta-analysis. Pediatrics 139:e20163003. \n                    https:\/\/doi.org\/10.1542\/peds.2016-3003","journal-title":"Pediatrics"},{"key":"3277_CR14","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.surg.2015.01.008","volume":"157","author":"RR Gorter","year":"2015","unstructured":"Gorter RR, van der Lee JH, Cense HA, Kneepkens CMF, Wijnen MHWA, in 't Hof KH, Offringa M, Heij HA, Ahmadi N, Bet P, Bonjer J, Galindo F, van Rijn R, Benninga MA, Hilarius D, van Veen S, Go PMNYH, Acherman Y (2015) Initial antibiotic treatment for acute simple appendicitis in children is safe: short-term results from a multicenter, prospective cohort study. Surgery 157:916\u2013923. \n                    https:\/\/doi.org\/10.1016\/j.surg.2015.01.008","journal-title":"Surgery"},{"key":"3277_CR15","doi-asserted-by":"publisher","unstructured":"Gorter RR, The S-MML, Gorter-Stam MAW et al (2017) Systematic review of nonoperative versus operative treatment of uncomplicated appendicitis. J Pediatr Surg. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.04.005","DOI":"10.1016\/j.jpedsurg.2017.04.005"},{"key":"3277_CR16","doi-asserted-by":"publisher","first-page":"e000028","DOI":"10.1136\/bmjpo-2017-000028","volume":"1","author":"NJ Hall","year":"2017","unstructured":"Hall NJ, Eaton S, Abbo O et al (2017) Appendectomy versus non-operative treatment for acute uncomplicated appendicitis in children: study protocol for a multicentre, open-label, non-inferiority, randomised controlled trial. BMJ Paediatr Open 1:e000028","journal-title":"BMJ Paediatr Open"},{"key":"3277_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jpedsurg.2015.10.024","volume":"51","author":"J Hartwich","year":"2016","unstructured":"Hartwich J, Luks FI, Watson-Smith D, Kurkchubasche AG, Muratore CS, Wills HE, Tracy TF Jr (2016) Nonoperative treatment of acute appendicitis in children: a feasibility study. J Pediatr Surg 51:111\u2013116. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2015.10.024","journal-title":"J Pediatr Surg"},{"key":"3277_CR18","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1001\/jamapediatrics.2017.2946","volume":"171","author":"L Huang","year":"2017","unstructured":"Huang L, Li Y, Zhou Z (2017) Nonoperative treatment of appendicitis\u2014reply. JAMA Pediatr 171:1125\u20131126. \n                    https:\/\/doi.org\/10.1001\/jamapediatrics.2017.2946","journal-title":"JAMA Pediatr"},{"key":"3277_CR19","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1001\/jamapediatrics.2017.0057","volume":"171","author":"L Huang","year":"2017","unstructured":"Huang L, Yin Y, Yang L, Wang C, Li Y, Zhou Z (2017) Comparison of antibiotic therapy and appendectomy for acute uncomplicated appendicitis in children. JAMA Pediatr 171:426\u2013434. \n                    https:\/\/doi.org\/10.1001\/jamapediatrics.2017.0057","journal-title":"JAMA Pediatr"},{"key":"3277_CR20","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.jpedsurg.2004.05.011","volume":"39","author":"K Kaneko","year":"2004","unstructured":"Kaneko K, Tsuda M (2004) Ultrasound-based decision making in the treatment of acute appendicitis in children. J Pediatr Surg 39:1316\u20131320","journal-title":"J Pediatr Surg"},{"key":"3277_CR21","doi-asserted-by":"publisher","unstructured":"Kessler U, Mosbahi S, Walker B et al (2017) Conservative treatment versus surgery for uncomplicated appendicitis in children: a systematic review and meta-analysis. Arch Dis Child. \n                    https:\/\/doi.org\/10.1136\/archdischild-2017-313127","DOI":"10.1136\/archdischild-2017-313127"},{"key":"3277_CR22","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-018145","volume":"7","author":"M Knaapen","year":"2017","unstructured":"Knaapen M, van der Lee JH, Bakx R, The SL, van Heurn E, Heij HA, Gorter RR, APAC collaborative study group (2017) Initial non-operative management of uncomplicated appendicitis in children: a protocol for a multicentre randomised controlled trial (APAC trial). BMJ Open 7:e018145. \n                    https:\/\/doi.org\/10.1136\/bmjopen-2017-018145","journal-title":"BMJ Open"},{"key":"3277_CR23","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jpedsurg.2014.01.003","volume":"49","author":"Y Koike","year":"2014","unstructured":"Koike Y, Uchida K, Matsushita K, Otake K, Nakazawa M, Inoue M, Kusunoki M, Tsukamoto Y (2014) Intraluminal appendiceal fluid is a predictive factor for recurrent appendicitis after initial successful non-operative management of uncomplicated appendicitis in pediatric patients. J Pediatr Surg 49:1116\u20131121. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2014.01.003","journal-title":"J Pediatr Surg"},{"key":"3277_CR24","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/01.sla.0000256391.05233.aa","volume":"245","author":"EH Livingston","year":"2007","unstructured":"Livingston EH, Woodward WA, Sarosi GA, Haley RW (2007) Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg 245:886\u2013892. \n                    https:\/\/doi.org\/10.1097\/01.sla.0000256391.05233.aa","journal-title":"Ann Surg"},{"key":"3277_CR25","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1001\/jamapediatrics.2017.2943","volume":"171","author":"ME Lopez","year":"2017","unstructured":"Lopez ME, Wesson DE (2017) Nonoperative treatment of appendicitis\u2014reply. JAMA Pediatr 171:1127. \n                    https:\/\/doi.org\/10.1001\/jamapediatrics.2017.2943","journal-title":"JAMA Pediatr"},{"key":"3277_CR26","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.jpedsurg.2016.02.056","volume":"51","author":"JB Mahida","year":"2016","unstructured":"Mahida JB, Lodwick DL, Nacion KM, Sulkowski JP, Leonhart KL, Cooper JN, Ambeba EJ, Deans KJ, Minneci PC (2016) High failure rate of nonoperative management of acute appendicitis with an appendicolith in children. J Pediatr Surg 51:908\u2013911. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2016.02.056","journal-title":"J Pediatr Surg"},{"key":"3277_CR27","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1001\/jamapediatrics.2017.2940","volume":"171","author":"PC Minneci","year":"2017","unstructured":"Minneci PC, Deans KJ (2017) Nonoperative treatment of appendicitis. JAMA Pediatr 171:1126\u20131127. \n                    https:\/\/doi.org\/10.1001\/jamapediatrics.2017.2940","journal-title":"JAMA Pediatr"},{"key":"3277_CR28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1001\/jamasurg.2015.4534","volume":"151","author":"PC Minneci","year":"2016","unstructured":"Minneci PC, Mahida JB, Lodwick DL, Sulkowski JP, Nacion KM, Cooper JN, Ambeba EJ, Moss RL, Deans KJ (2016) Effectiveness of patient choice in nonoperative vs surgical management of pediatric uncomplicated acute appendicitis. JAMA Surg 151:408\u2013415. \n                    https:\/\/doi.org\/10.1001\/jamasurg.2015.4534","journal-title":"JAMA Surg"},{"key":"3277_CR29","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.jpedsurg.2017.01.050","volume":"52","author":"M Mudri","year":"2017","unstructured":"Mudri M, Coriolano K, B\u00fctter A (2017) Cost analysis of nonoperative management of acute appendicitis in children. J Pediatr Surg 52:791\u2013794. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.01.050","journal-title":"J Pediatr Surg"},{"key":"3277_CR30","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3758\/s13428-012-0281-2","volume":"45","author":"D Oberfeld","year":"2013","unstructured":"Oberfeld D, Franke T (2013) Evaluating the robustness of repeated measures analyses: the case of small sample sizes and nonnormal data. Behav Res Methods 45:792\u2013812. \n                    https:\/\/doi.org\/10.3758\/s13428-012-0281-2","journal-title":"Behav Res Methods"},{"key":"3277_CR31","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1136\/bmj.38993.560984.BE","volume":"333","author":"JJ Oosterheert","year":"2006","unstructured":"Oosterheert JJ, Bonten MJM, Schneider MME, Buskens E, Lammers JWJ, Hustinx WMN, Kramer MHH, Prins JM, Slee PHTJ, Kaasjager K, Hoepelman AIM (2006) Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial. BMJ 333:1193","journal-title":"BMJ"},{"key":"3277_CR32","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1002\/bjs.10660","volume":"104","author":"HC Park","year":"2017","unstructured":"Park HC, Kim MJ, Lee BH (2017) Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. Br J Surg 104:1785\u20131790. \n                    https:\/\/doi.org\/10.1002\/bjs.10660","journal-title":"Br J Surg"},{"key":"3277_CR33","unstructured":"Peter Minneci NCH (2014) Multi-institutional trial of non-operative management of appendicitis - full text view - \n                    ClinicalTrials.gov\n                    \n                  . In: Last Updat. August 18, 2016"},{"key":"3277_CR34","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00384-010-0967-9","volume":"25","author":"Y Ribas","year":"2010","unstructured":"Ribas Y, Bombard\u00f3 J, Aguilar F, Jovell E, Alcantara-Moral M, Campillo F, Lleonart X, Serra-Aracil X (2010) Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis. Int J Color Dis 25:1363\u20131370. \n                    https:\/\/doi.org\/10.1007\/s00384-010-0967-9","journal-title":"Int J Color Dis"},{"key":"3277_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1111\/j.1469-0691.2006.01638.x","volume":"13","author":"BM Roede","year":"2007","unstructured":"Roede BM, Bresser P, El Moussaoui R et al (2007) Three vs. 10 days of amoxycillin\u2013clavulanic acid for type 1 acute exacerbations of chronic obstructive pulmonary disease: a randomised, double-blind study. Clin Microbiol Infect 13:284\u2013290. \n                    https:\/\/doi.org\/10.1111\/j.1469-0691.2006.01638.x","journal-title":"Clin Microbiol Infect"},{"key":"3277_CR36","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.surg.2009.09.039","volume":"147","author":"M Rub\u00e9r","year":"2010","unstructured":"Rub\u00e9r M, Andersson M, Petersson BF, Olaison G, Andersson RE, Ekerfelt C (2010) Systemic Th17-like cytokine pattern in gangrenous appendicitis but not in phlegmonous appendicitis. Surgery 147:366\u2013372. \n                    https:\/\/doi.org\/10.1016\/j.surg.2009.09.039","journal-title":"Surgery"},{"key":"3277_CR37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1097\/SLA.0000000000000835","volume":"261","author":"JF Svensson","year":"2015","unstructured":"Svensson JF, Patkova B, Almstr\u00f6m M, Naji H, Hall NJ, Eaton S, Pierro A, Wester T (2015) Nonoperative treatment with antibiotics versus surgery for acute nonperforated appendicitis in children. Ann Surg 261:67\u201371. \n                    https:\/\/doi.org\/10.1097\/SLA.0000000000000835","journal-title":"Ann Surg"},{"key":"3277_CR38","doi-asserted-by":"publisher","unstructured":"Talan DA, Saltzman DJ, Mower WR et al (2016) Antibiotics-first versus surgery for appendicitis: a US pilot randomized controlled trial allowing outpatient antibiotic management. Ann Emerg Med. \n                    https:\/\/doi.org\/10.1016\/j.annemergmed.2016.08.446","DOI":"10.1016\/j.annemergmed.2016.08.446"},{"key":"3277_CR39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/bjs.9964","volume":"103","author":"CC Rossem van","year":"2016","unstructured":"van Rossem CC, Bolmers MDM, Schreinemacher MHF, van Geloven AAW, Bemelman WA, the Snapshot Appendicitis Collaborative Study Group (2016) Prospective nationwide outcome audit of surgery for suspected acute appendicitis. Br J Surg 103:144\u2013151. \n                    https:\/\/doi.org\/10.1002\/bjs.9964","journal-title":"Br J Surg"},{"key":"3277_CR40","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.pain.2009.03.002","volume":"143","author":"CL Baeyer von","year":"2009","unstructured":"von Baeyer CL, Spagrud LJ, McCormick JC et al (2009) Three new datasets supporting use of the Numerical Rating Scale (NRS-11) for children\u2019s self-reports of pain intensity. Pain 143:223\u2013227. \n                    https:\/\/doi.org\/10.1016\/j.pain.2009.03.002","journal-title":"Pain"},{"key":"3277_CR41","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013299","volume":"6","author":"J Xu","year":"2016","unstructured":"Xu J, Liu YC, Adams S, Karpelowsky J (2016) Acute uncomplicated appendicitis study: rationale and protocol for a multicentre, prospective randomised controlled non-inferiority study to evaluate the safety and effectiveness of non-operative management in children with acute uncomplicated appendicitis. BMJ Open 6:e013299. \n                    https:\/\/doi.org\/10.1136\/bmjopen-2016-013299","journal-title":"BMJ Open"},{"key":"3277_CR42","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.jpedsurg.2017.05.003","volume":"52","author":"J Xu","year":"2017","unstructured":"Xu J, Adams S, Liu YC, Karpelowsky J (2017) Nonoperative management in children with early acute appendicitis: a systematic review. J Pediatr Surg 52:1409\u20131415. \n                    https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.05.003","journal-title":"J Pediatr Surg"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-018-3277-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-018-3277-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-018-3277-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T19:16:42Z","timestamp":1573499802000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-018-3277-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["3277"],"URL":"https:\/\/doi.org\/10.1007\/s00431-018-3277-9","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"assertion":[{"value":"9 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the medical ethics committee of the VU University medical center (Netherlands) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study and their legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}