{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:49:28Z","timestamp":1771296568154,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University Medical Center Utrecht"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00431-019-03391-y","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:32:55Z","timestamp":1557160375000},"page":"1033-1042","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Increasing the dose of oral vitamin K prophylaxis and its effect on bleeding risk"],"prefix":"10.1007","volume":"178","author":[{"given":"Yvette Nicole","family":"L\u00f6wensteyn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaas Johannes Georgius","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"van Heerde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard Henryk","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Christiaan Jacques","family":"Kneyber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem","family":"Kuiper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike Anne","family":"Riedijk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carin Wilhelmus Maria","family":"Verlaat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idse Hendrik Egbert","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk Adriaan","family":"van Waardenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Marin","family":"van Hasselt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"3391_CR1","unstructured":"Central Bureau of Statistics (the Netherlands). Population and population dynamics; month, quarter and year. Available from: \n                    http:\/\/statline.cbs.nl\/Statweb\/publication\/?DM=SLEN&PA=37943eng&D1=0,10-22,388,394,400,406&D2=272\u2013288&LA=EN&HDR=G1&STB=T&VW=T\n                    \n                  . Accessed 7 Jul 2018"},{"key":"3391_CR2","unstructured":"Central Bureau of Statistics (the Netherlands). Delivery and birth: 1989\u20132013. Available from: \n                    http:\/\/statline.cbs.nl\/statweb\/publication\/?vw=t&dm=slnl&pa=37422ned&d1=0%2c4-5%2c7%2c9%2c11%2c13%2c17%2c26%2c35%2c40-41&d2=0%2c10%2c20%2c30%2c40%2c(l-4)-l&hd=0\n                    \n                  . Accessed 7 Jul 2018"},{"key":"3391_CR3","unstructured":"Central Bureau of Statistics (the Netherlands). Delivery and birth: 1989\u20132013. Available from: \n                    http:\/\/statline.cbs.nl\/StatWeb\/publication\/?VW=T&DM=SLnl&PA=37302&LA=nl\n                    \n                  . Accessed 8 Jul 2018"},{"key":"3391_CR4","unstructured":"Health Council of The Netherlands. Vitamin K supplementation in infants. \n                    www.healthcouncil.nl\n                    \n                  . 2010\/11E. Reference I429\/09\/RW\/db\/862-B. Available from: \n                    https:\/\/www.gezondheidsraad.nl\/en\/task-and-procedure\/areas-of-activity\/healthy-nutrition\/advisory-letter-vitamin-k-supplementation-in\n                    \n                  . Accessed 7 Jul 2018"},{"key":"3391_CR5","unstructured":"Health Council of The Netherlands. Vitamin K for infants. NO. 2017\/04e. Available from: \n                    https:\/\/www.gezondheidsraad.nl\/sites\/default\/files\/grpublication\/vitamin_k_for_infants_201704e.pdf\n                    \n                  . Accessed 7 Jul 2018"},{"issue":"2","key":"3391_CR6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s00431-007-0443-x","volume":"167","author":"MM IJland","year":"2008","unstructured":"IJland MM, Pereira RR, Cornelissen EA (2008) Incidence of late vitamin K deficiency bleeding in newborns in the Netherlands in 2005: evaluation of the current guideline. Eur J Pediatr 167(2):165\u2013169. \n                    https:\/\/doi.org\/10.1007\/s00431-007-0443-x","journal-title":"Eur J Pediatr"},{"issue":"January","key":"3391_CR7","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1891\/0730-0832.32.3.193","volume":"31","author":"P Johnson","year":"2013","unstructured":"Johnson P, Vitamin K (2013) Prophylaxis in the newborn: indications and controversies. Neonatal Netw 31(January):193\u2013199. \n                    https:\/\/doi.org\/10.1891\/0730-0832.33.6.336","journal-title":"Neonatal Netw"},{"key":"3391_CR8","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s00431-012-1895-1","volume":"172","author":"B Laubscher","year":"2013","unstructured":"Laubscher B, B\u00e4nziger O, The Swiss Paediatric Surveillance Unit (SPSU) (2013) Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005\u20132011) surveillance in Switzerland. Eur J Pediatr 172:357\u2013360","journal-title":"Eur J Pediatr"},{"issue":"8","key":"3391_CR9","doi-asserted-by":"publisher","first-page":"e334","DOI":"10.3928\/19382359-20180709-02","volume":"47","author":"R Levin","year":"2018","unstructured":"Levin R, Jung JM, Forrey L, Glick J (2018) Refusal of vitamin K injection: survey of the current literature and practical tips for pediatricians. Pediatr Ann 47(8):e334\u2013e338. \n                    https:\/\/doi.org\/10.3928\/19382359-20180709-02","journal-title":"Pediatr Ann"},{"issue":"5","key":"3391_CR10","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s10995-016-2205-8","volume":"21","author":"LH Marcewicz","year":"2017","unstructured":"Marcewicz LH, Clayton J, Maenner M, Odom E, Okoroh E, Christensen D, Goodman A, Warren MD, Traylor J, Miller A, Jones T, Dunn J, Schaffner W, Grant A (2017) Parental refusal of vitamin K and neonatal preventive services: a need for surveillance. Matern Child Health J 21(5):1079\u20131084. \n                    https:\/\/doi.org\/10.1007\/s10995-016-2205-8","journal-title":"Matern Child Health J"},{"key":"3391_CR11","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0474-0","volume":"44","author":"MR Marchili","year":"2018","unstructured":"Marchili MR, Santoro E, Marchesi A, Bianchi S, Rotondi Aufiero L, Villani A (2018) Vitamin K deficiency: a case report and review of current guidelines. Ital J Pediatr 44:36. \n                    https:\/\/doi.org\/10.1186\/s13052-018-0474-0","journal-title":"Ital J Pediatr"},{"issue":"1","key":"3391_CR12","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/MPG.0000000000001232","volume":"63","author":"WA Mihatsch","year":"2016","unstructured":"Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domell\u00f6f M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J, ESPGHAN Committee on Nutrition (2016) Prevention of vitamin K deficiency bleeding in newborn infants: a position paper by the ESPGHAN committee on nutrition. J Pediatr Gastroenterol Nutr 63(1):123\u2013129. \n                    https:\/\/doi.org\/10.1097\/MPG.0000000000001232","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"3391_CR13","unstructured":"National Institute for Health and Care Excellence. Postnatal care up to 8 weeks after birth. Available from: \n                    https:\/\/www.nice.org.uk\/guidance\/cg37\/chapter\/1-Recommendations#maintaining-infant-health\n                    \n                  . Accessed 6 Feb 2019"},{"key":"3391_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/978-1-4899-1789-8_19","volume":"30","author":"P Newman","year":"1998","unstructured":"Newman P, Shearer MJ (1998) Vitamin K metabolism. Subcell Biochem 30:455\u2013488. \n                    https:\/\/doi.org\/10.1007\/978-1-4899-1789-8_19","journal-title":"Subcell Biochem"},{"issue":"3","key":"3391_CR15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1542\/peds.2014-1092","volume":"134","author":"V Sahni","year":"2014","unstructured":"Sahni V, Lai FY, MacDonald SE (2014) Neonatal vitamin K refusal and nonimmunization. Pediatrics 134(3):497\u2013503. \n                    https:\/\/doi.org\/10.1542\/peds.2014-1092","journal-title":"Pediatrics"},{"issue":"6","key":"3391_CR16","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.pediatrneurol.2014.02.013","volume":"50","author":"R Schulte","year":"2014","unstructured":"Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC, Sidonio R (2014) Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth. Pediatr Neurol 50(6):564\u2013568. \n                    https:\/\/doi.org\/10.1016\/j.pediatrneurol.2014.02.013","journal-title":"Pediatr Neurol"},{"issue":"2","key":"3391_CR17","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.blre.2008.06.001","volume":"23","author":"MJ Shearer","year":"2009","unstructured":"Shearer MJ (2009) Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 23(2):49\u201359. \n                    https:\/\/doi.org\/10.1016\/j.blre.2008.06.001","journal-title":"Blood Rev"},{"issue":"2","key":"3391_CR18","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s00134-002-1601-2","volume":"29","author":"A Slater","year":"2003","unstructured":"Slater A, Shann F, Pearson G (2003) PIM2: a revised version of the paediatric index of mortality. Intensive Care Med 29(2):278\u2013285. \n                    https:\/\/doi.org\/10.1007\/s00134-002-1601-2","journal-title":"Intensive Care Med"},{"issue":"9","key":"3391_CR19","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.1007\/s11095-016-1954-9","volume":"33","author":"F Sun","year":"2016","unstructured":"Sun F, Jaspers TCC, van Hasselt PM, Hennink WE, van Nostrum CF (2016) A mixed micelle formulation for oral delivery of vitamin K. Pharm Res 33(9):2168\u20132179. \n                    https:\/\/doi.org\/10.1007\/s11095-016-1954-9","journal-title":"Pharm Res"},{"key":"3391_CR20","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1055\/s-0037-1614494","volume":"81","author":"AH Sutor","year":"1999","unstructured":"Sutor AH, Von Kries R, Cornelissen EA, Mcninch AW, Andrew M (1999) Scientific and standardization committee communications Vitamin K deficiency bleeding (VKDB) in infancy* on behalf of the ISTH pediatric \/ perinatal subcommittee. Thromb Haemost 81:456\u2013461","journal-title":"Thromb Haemost"},{"key":"3391_CR21","unstructured":"Van Hasselt PM (2009) Changing attitude towards breastfeeding in infants with jaundice unveils the inefficacy of Dutch vitamin K prophylaxis. In: Vitamin K prophylaxis revisited: focus on risk factors (Thesis), 62-66"},{"key":"3391_CR22","unstructured":"Van Hasselt PM (2009) The influence of the gastric environment on the absorption of vitamin K from orally administered mixed micelles under physiological and bile deficient conditions. In: Vitamin K prophylaxis revisited: focus on risk factors (thesis), 108\u201325. Available from: \n                    https:\/\/dspace.library.uu.nl\/handle\/1874\/33563\n                    \n                  . Accessed 18 Sept 2018"},{"issue":"4","key":"3391_CR23","doi-asserted-by":"publisher","first-page":"e857","DOI":"10.1542\/peds.2007-1788","volume":"121","author":"PM Van Hasselt","year":"2008","unstructured":"Van Hasselt PM, de Koning TJ, Kvist N et al (2008) Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries. Pediatrics 121(4):e857\u2013e863. \n                    https:\/\/doi.org\/10.1542\/peds.2007-1788","journal-title":"Pediatrics"},{"issue":"1","key":"3391_CR24","doi-asserted-by":"publisher","first-page":"F456","DOI":"10.1136\/adc.2008.148239","volume":"94","author":"HPM Van","year":"2009","unstructured":"Van HPM, Kok K, Vorselaars ADM et al (2009) Vitamin K deficiency bleeding in cholestatic infants with alpha-1-antitrypsin deficiency. Arch Dis Child Fetal Neonatal Ed 94(1):F456\u2013F460. \n                    https:\/\/doi.org\/10.1136\/adc.2008.148239","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"6","key":"3391_CR25","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1007\/s00134-011-2175-7","volume":"37","author":"DY Visser","year":"2011","unstructured":"Visser DY, Jansen NJ, IJland MM, De Koning TJ, Van Hasselt PM (2011) Intracranial bleeding due to vitamin K deficiency: advantages of using a pediatric intensive care registry. Intensive Care Med 37(6):1014\u20131020. \n                    https:\/\/doi.org\/10.1007\/s00134-011-2175-7","journal-title":"Intensive Care Med"},{"key":"3391_CR26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1136\/fn.88.2.F109","volume":"88","author":"R Von Kries","year":"2003","unstructured":"Von Kries R, Hachmeister A, G\u00f6bel U (2003) Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 88:109\u2013112","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"3391_CR27","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1136\/fn.82.1.F64","volume":"82","author":"U Wariyar","year":"2000","unstructured":"Wariyar U, Hilton S, Pagan J, Tin W, Hey E, Cleveland S (2000) Six years\u2019 experience of prophylactic oral vitamin K. Arch Dis Child Fetal Neonatal Ed 82:64\u201369","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"3391_CR28","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1542\/peds.2014-2293","volume":"136","author":"M Weddle","year":"2015","unstructured":"Weddle M, Empey A, Crossen E, Green A, Green J, Phillipi CA (2015) Are pediatricians complicit in vitamin K deficiency bleeding? Pediatrics 136(4):753\u2013757. \n                    https:\/\/doi.org\/10.1542\/peds.2014-2293","journal-title":"Pediatrics"},{"issue":"5","key":"3391_CR29","doi-asserted-by":"publisher","first-page":"e20154222","DOI":"10.1542\/peds.2015-4222","volume":"137","author":"M Witt","year":"2016","unstructured":"Witt M, Kvist N, Jorgensen MH, Hulscher JBF, Verkade HJ (2016) Prophylactic dosing of vitamin K to prevent bleeding. Pediatrics 137(5):e20154222\u2013e20154222. \n                    https:\/\/doi.org\/10.1542\/peds.2015-4222","journal-title":"Pediatrics"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-019-03391-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-019-03391-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-019-03391-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T23:19:52Z","timestamp":1588634392000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-019-03391-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["3391"],"URL":"https:\/\/doi.org\/10.1007\/s00431-019-03391-y","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]},"assertion":[{"value":"11 December 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Approval for the study was obtained from the Medical Ethical Committee of the University Medical Center Utrecht.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical statements"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}