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Bertsche reports grants from UCB Pharma GmbH and honoraria for speaking engagements from Desitin Arzneimittel GmbH, Eisai GmbH, ViroPharma Incorporated, and Shire Deutschland GmbH. The other authors declare they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. 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