{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:31:08Z","timestamp":1776724268658,"version":"3.51.2"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"BMBF","award":["01ER0805 and 01ER1501"],"award-info":[{"award-number":["01ER0805 and 01ER1501"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (<jats:italic>n<\/jats:italic>\u00a0=\u200995) and the control group (<jats:italic>n<\/jats:italic>\u00a0=\u200984) that received standard treatment.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: No differences in outcome were observed at 2\u00a0years. LISA seems safe in that aspect.<jats:table-wrap><jats:table><jats:tbody>\n<jats:tr>\n<jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold>\u2022 <jats:italic>LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.<\/jats:italic><\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold>\u2022 <jats:italic>Outcome data at 2\u00a0years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.<\/jats:italic><\/jats:td>\n<\/jats:tr>\n<\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-020-03572-0","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T23:32:52Z","timestamp":1581982372000},"page":"1309-1313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study"],"prefix":"10.1007","volume":"179","author":[{"name":"for the German Neonatal Network (GNN)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egbert","family":"Herting","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Kribs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"H\u00e4rtel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"von der Wense","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Weller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Hoehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Vochem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wieg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Roth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"G\u00f6pel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"issue":"11","key":"3572_CR1","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.earlhumdev.2013.08.023","volume":"89","author":"E Herting","year":"2013","unstructured":"Herting E (2013) Less invasive surfactant administration (LISA) - ways to deliver surfactant in spontaneously breathing infants. Early Hum Dev 89(11):875\u2013880","journal-title":"Early Hum Dev"},{"issue":"2","key":"3572_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s00431-016-2812-9","volume":"176","author":"D Klotz","year":"2017","unstructured":"Klotz D, Porcaro U, Fleck T, Fuchs H (2017) European perspective on less invasive surfactant administration-a survey. Eur J Pediatr 176(2):147\u2013154","journal-title":"Eur J Pediatr"},{"key":"3572_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000502610","volume":"116","author":"M Vento","year":"2019","unstructured":"Vento M, Bohlin K, Herting E, Roehr C, Dargaville P (2019) Surfactant administration via thin catheter: a practical guide. Neonatology 116:211\u2013226","journal-title":"Neonatology"},{"key":"3572_CR4","doi-asserted-by":"publisher","first-page":"F655","DOI":"10.1136\/archdischild-2018-316557","volume":"104","author":"E Herting","year":"2019","unstructured":"Herting E, H\u00e4rtel C, G\u00f6pel W (2019) Less invasive surfactant administration (LISA): chances and limitations. Arch Dis Child Fetal Neonatal Ed 104:F655\u2013F659","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"5","key":"3572_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/apa.14161","volume":"107","author":"L Gortner","year":"2018","unstructured":"Gortner L, Sch\u00fcller SS, Herting E (2018) Review demonstrates that less invasive surfactant administration in preterm neonates leads to fewer complications. Acta Paediatr 107(5):736\u2013743","journal-title":"Acta Paediatr"},{"issue":"4","key":"3572_CR6","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000499361","volume":"115","author":"DG Sweet","year":"2019","unstructured":"Sweet DG, Carnielli V, Greisen G, Hallman M, Ozek E, Te Pas A, Plavka R, Roehr CC, Saugstad OD, Simeoni U, Speer CP, Vento M, GHA V, Halliday HL (2019) European consensus guidelines on the management of respiratory distress syndrome \u2013 2019 update. Neonatology 115(4):432\u2013450","journal-title":"Neonatology"},{"issue":"6","key":"3572_CR7","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1001\/jama.2016.10708","volume":"316","author":"T Isayama","year":"2016","unstructured":"Isayama T, Iwami H, McDonald S, Beyene J (2016) Association of noninvasive ventilation strategies with mortality and bronchopulmonary dysplasia among preterm infants: a systematic review and meta-analysis. JAMA 316(6):611\u2013624","journal-title":"JAMA"},{"issue":"9803","key":"3572_CR8","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/S0140-6736(11)60986-0","volume":"378","author":"W G\u00f6pel","year":"2011","unstructured":"G\u00f6pel W, Kribs A, Ziegler A, Laux R, Hoehn T, Wieg C, Siegel J, Avenarius S, von der Wense VM, Groneck P, Weller U, M\u00f6ller J, H\u00e4rtel C, Haller S, Roth B, Herting E, German Neonatal Network (2011) Avoidance of mechanical ventilation by surfactant treatment of spontaneously breathing preterm infants (AMV): an open-label, randomised, controlled trial. Lancet 378(9803):1627\u20131634","journal-title":"Lancet"},{"issue":"4","key":"3572_CR9","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/dmcn.13675","volume":"60","author":"A Pascal","year":"2018","unstructured":"Pascal A, Govaert P, Oostra A, Naulaers G, Ortibus E, Van den Broeck C (2018) Neurodevelopmental outcome in very preterm and very-low-birthweight infants born over the past decade: a meta-analytic review. Dev Med Child Neurol 60(4):342\u2013355","journal-title":"Dev Med Child Neurol"},{"issue":"3","key":"3572_CR10","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1111\/j.1651-2227.2010.02068.x","volume":"100","author":"M Porath","year":"2011","unstructured":"Porath M, Korp L, Wendrich D, Dlugay V, Roth B, Kribs A (2011) Surfactant in spontaneous breathing with nCPAP: neurodevelopmental outcome at early school age of infants \u226427 weeks. Acta Paediatr 100(3):352\u2013359","journal-title":"Acta Paediatr"},{"issue":"6","key":"3572_CR11","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1055\/s-0035-1547295","volume":"219","author":"N Teig","year":"2015","unstructured":"Teig N, Weitk\u00e4mper A, Rothermel J, Bigge N, Lilienthal E, Rossler L, Hamelmann E (2015) Observational study on less invasive surfactant administration (LISA) in preterm infants <29 weeks - short and long-term outcomes. Z Geburtshilfe Neonatol 219(6):266\u2013273","journal-title":"Z Geburtshilfe Neonatol"},{"issue":"4","key":"3572_CR12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1159\/000346521","volume":"103","author":"K Klebermass-Schrehof","year":"2013","unstructured":"Klebermass-Schrehof K, Wald M, Schwindt J, Grill A, Prusa AR, Haiden N, Hayde M, Waldhoer T, Fuiko R, Berger A (2013) Less invasive surfactant administration in extremely preterm infants: impact on mortality and morbidity. Neonatology 103(4):252\u2013258","journal-title":"Neonatology"},{"key":"3572_CR13","first-page":"442","volume":"111","author":"E Herting","year":"2017","unstructured":"Herting E, Kribs A, G\u00f6pel W (2017) Less invasive surfactant administration \u2013 long-term pulmonary function data (abstract). Neonatology 111:442","journal-title":"Neonatology"},{"key":"3572_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1651276","volume":"12","author":"E M\u00e1rquez Isidro","year":"2019","unstructured":"M\u00e1rquez Isidro E, S\u00e1nchez Luna M, Ramos-Navarro C (2019) Long-term outcomes of preterm infants treated with less invasive surfactant technique (LISA). J Matern Fetal Neonatal Med 12:1\u20136","journal-title":"J Matern Fetal Neonatal Med"},{"key":"3572_CR15","first-page":"1","volume":"9","author":"C Ramos-Navarro","year":"2018","unstructured":"Ramos-Navarro C, S\u00e1nchez-Luna M, Zeballos-Sarrato S et al (2018) Three-year perinatal outcomes of less invasive beractant administration in preterm infants with respiratory distress syndrome. J Matern Fetal Neonatal Med 9:1\u2013171","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"8","key":"3572_CR16","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1001\/jamapediatrics.2015.0504","volume":"169","author":"A Kribs","year":"2015","unstructured":"Kribs A, Roll C, G\u00f6pel W, Wieg C, Groneck P, Laux R, Teig N, Hoehn T, B\u00f6hm W, Welzing L, Vochem M, Hoppenz M, B\u00fchrer C, Mehler K, St\u00fctzer H, Franklin J, St\u00f6hr A, Herting E, Roth B, NINSAPP Trial Investigators (2015) Nonintubated surfactant application vs conventional therapy in extremely preterm infants: a randomized clinical trial. JAMA Pediatr 169(8):723\u2013730","journal-title":"JAMA Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03572-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-020-03572-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03572-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T03:40:11Z","timestamp":1613706011000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-020-03572-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["3572"],"URL":"https:\/\/doi.org\/10.1007\/s00431-020-03572-0","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"27 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Egbert Herting, Angela Kribs, Christoph H\u00e4rtel and Wolfgang G\u00f6pel have received study support, honoraria for presentations and travel support from Chiesi Farmaceutici, a surfactant producer. Egbert Herting and Christoph H\u00e4rtel served as advisors for Draeger Medical, a company producing incubators, monitors and ventilators.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval by the local institutional review board for research in human subjects of the University of L\u00fcbeck (file number 08\u2013022) and by the local ethic committees of all participating centres has been given.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written consent from the parents for the participation in the AMV study and the follow-up in the German Neonatal Network was obtained prior to enrolment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of informed consent"}}]}}