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The purpose of this paper is the assessment of the evolution of three of the most relevant parameters, before and after IVH: mean arterial pressure (MAP), arterial carbon dioxide pressure (pCO<jats:sub>2<\/jats:sub>), and cerebral blood flow (CBF). Clinical records of 254 preterm infants with a gestational age of 23\u201330\u00a0weeks, with and without a diagnosis of IVH, were reviewed for MAP and arterial pCO<jats:sub>2<\/jats:sub>in the period up to 7\u00a0days before and 3\u00a0days after IVH or during the first 10\u00a0days of life in cases without IVH.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: A statistically significant increase in pCO<jats:sub>2<\/jats:sub>and decrease in MAP in patients with IVH compared with those without were detected. Both the mean values and the mean absolute deviations of CBF were computed in this study, and the latter was significantly higher than in control group. High deviations of CBF, as well as hypercapnia and hypotension, are likely to contribute to the rupture of cerebral blood vessels in preterm infants, and consequently, to the development of IVH.<jats:table-wrap><jats:table><jats:tbody><jats:tr><jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold>\u2022<jats:italic>The origin of IVH is multifactorial, but mean arterial pressure, carbon dioxide partial pressure, and cerebral blood flow are recognized as the most important parameters.<\/jats:italic><jats:italic>\u2022 In premature infants, the autoregulation mechanisms are still underdeveloped and cannot compensate for cerebral blood flow fluctuations.<\/jats:italic><\/jats:td><\/jats:tr><jats:tr><jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold>\u2022<jats:italic>The numerical simulation of CBF is shown to be a promising approach that may be useful in the care of preterm infants.<\/jats:italic><jats:italic>\u2022 The mean values of CBF before and after IVH in the affected group were similar to those in the control group, but the mean absolute deviations of CBF in the affected group before and after IVH were significantly higher than that in the control group.<\/jats:italic><\/jats:td><\/jats:tr><\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-020-03585-9","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T10:02:21Z","timestamp":1580205741000},"page":"929-937","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Assessing key clinical parameters before and after intraventricular hemorrhage in very preterm infants"],"prefix":"10.1007","volume":"179","author":[{"given":"Ren\u00e9e","family":"Lampe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rieger-Fackeldey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Sidorenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varvara","family":"Turova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Botkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Alves-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Kovtanyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00fcndeln","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Felderhoff-M\u00fcser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"3585_CR1","doi-asserted-by":"crossref","unstructured":"Ballabh P (2010) Intraventricular hemorrhage in premature infants: mechanism of disease. 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