{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:53:40Z","timestamp":1765486420171},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00431-020-03626-3","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T17:02:25Z","timestamp":1583600545000},"page":"1389-1394","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Urinary carbohydrate antigen 19-9 level as a biomarker in children with acute pyelonephritis"],"prefix":"10.1007","volume":"179","author":[{"given":"Abdol-Mohammad","family":"Kajbafzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Sanam","family":"Ladi Seyedian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Maryam","family":"Kameli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behnam","family":"Nabavizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Boroomand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mastaneh","family":"Moghtaderi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"issue":"11","key":"3626_CR1","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s00467-011-1801-5","volume":"26","author":"SA Saadeh","year":"2011","unstructured":"Saadeh SA, Mattoo TK (2011) Managing urinary tract infections. Pediatr Nephrol 26(11):1967\u20131976. https:\/\/doi.org\/10.1007\/s00467-011-1801-5","journal-title":"Pediatr Nephrol"},{"key":"3626_CR2","volume-title":"Urinary Tract Infection in Children: Diagnosis, Treatment and Long-term Management","author":"National Collaborating Centre for Ws, Children\u2019s H","year":"2007","unstructured":"National Collaborating Centre for Ws, Children\u2019s H (2007) National Institute for Health and Clinical Excellence: Guidance. In: Urinary Tract Infection in Children: Diagnosis, Treatment and Long-term Management. RCOG Press National Collaborating Centre for Women\u2019s and Children\u2019s Health, London"},{"key":"3626_CR3","doi-asserted-by":"publisher","first-page":"41265","DOI":"10.1038\/srep41265","volume":"7","author":"JW Lee","year":"2017","unstructured":"Lee JW, Kim SH, Park SJ, Lee KH, Park JH, Kronbichler A, Eisenhut M, Kim JH, Lee JW, Shin JI (2017) The value of delta neutrophil index in young infants with febrile urinary tract infection. Sci Rep 7:41265. https:\/\/doi.org\/10.1038\/srep41265","journal-title":"Sci Rep"},{"issue":"1","key":"3626_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s12149-010-0431-5","volume":"25","author":"E Jaksic","year":"2011","unstructured":"Jaksic E, Bogdanovic R, Artiko V, Saranovic DS, Petrasinovic Z, Petrovic M, Bojic L, Pavlovic S, Paripovic A, Antonovic O, Lezaic VD, Saranovic D, Petrovic N, Obradovic V (2011) Diagnostic role of initial renal cortical scintigraphy in children with the first episode of acute pyelonephritis. Ann Nucl Med 25(1):37\u201343. https:\/\/doi.org\/10.1007\/s12149-010-0431-5","journal-title":"Ann Nucl Med"},{"issue":"3","key":"3626_CR5","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/s00467-016-3518-y","volume":"32","author":"BK Kim","year":"2017","unstructured":"Kim BK, Yim HE, Yoo KH (2017) Plasma neutrophil gelatinase-associated lipocalin: a marker of acute pyelonephritis in children. Pediatr Nephrol 32(3):477\u2013484. https:\/\/doi.org\/10.1007\/s00467-016-3518-y","journal-title":"Pediatr Nephrol"},{"issue":"7","key":"3626_CR6","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1007\/s00467-007-0465-7","volume":"22","author":"EH Garin","year":"2007","unstructured":"Garin EH, Olavarria F, Araya C, Broussain M, Barrera C, Young L (2007) Diagnostic significance of clinical and laboratory findings to localize site of urinary infection. Pediatr Nephrol 22(7):1002\u20131006. https:\/\/doi.org\/10.1007\/s00467-007-0465-7","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"3626_CR7","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.urology.2008.10.042","volume":"73","author":"A Kotoula","year":"2009","unstructured":"Kotoula A, Gardikis S, Tsalkidis A, Mantadakis E, Zissimopoulos A, Deftereos S, Tripsianis G, Manolas K, Chatzimichael A, Vaos G (2009) Comparative efficacies of procalcitonin and conventional inflammatory markers for prediction of renal parenchymal inflammation in pediatric first urinary tract infection. Urology 73(4):782\u2013786. https:\/\/doi.org\/10.1016\/j.urology.2008.10.042","journal-title":"Urology"},{"issue":"2","key":"3626_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00431-013-2112-6","volume":"173","author":"WH Seo","year":"2014","unstructured":"Seo WH, Nam SW, Lee EH, Je BK, Yim HE, Choi BM (2014) A rapid plasma neutrophil gelatinase-associated lipocalin assay for diagnosis of acute pyelonephritis in infants with acute febrile urinary tract infections: a preliminary study. Eur J Pediatr 173(2):229\u2013232. https:\/\/doi.org\/10.1007\/s00431-013-2112-6","journal-title":"Eur J Pediatr"},{"issue":"7","key":"3626_CR9","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1507\/endocrj.EJ12-0364","volume":"60","author":"J Murai","year":"2013","unstructured":"Murai J, Soga S, Saito H, Otsuki M, Kitada T, Saisho Y, Nakamura H, Kasayama S, Koga M (2013) Study on the mechanism causing elevation of serum CA19-9 levels in diabetic patients. Endocr J 60(7):885\u2013891","journal-title":"Endocr J"},{"issue":"2","key":"3626_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/jcla.20136","volume":"21","author":"T Kodama","year":"2007","unstructured":"Kodama T, Satoh H, Ishikawa H, Ohtsuka M (2007) Serum levels of CA19-9 in patients with nonmalignant respiratory diseases. J Clin Lab Anal 21(2):103\u2013106. https:\/\/doi.org\/10.1002\/jcla.20136","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"3626_CR11","doi-asserted-by":"publisher","first-page":"2353","DOI":"10.1016\/j.juro.2010.02.031","volume":"183","author":"AM Kajbafzadeh","year":"2010","unstructured":"Kajbafzadeh AM, Elmi A, Talab SS, Emami H, Esfahani SA, Saeedi P (2010) Urinary and serum carbohydrate antigen 19-9 as a biomarker in ureteropelvic junction obstruction in children. J Urol 183(6):2353\u20132360. https:\/\/doi.org\/10.1016\/j.juro.2010.02.031","journal-title":"J Urol"},{"issue":"2","key":"3626_CR12","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/BF02388714","volume":"15","author":"RL Lebowitz","year":"1985","unstructured":"Lebowitz RL, Olbing H, Parkkulainen KV, Smellie JM, Tamminen-Mobius TE (1985) International system of radiographic grading of vesicoureteric reflux. International reflux study in children. Pediatr Radiol 15(2):105\u2013109","journal-title":"Pediatr Radiol"},{"issue":"838","key":"3626_CR13","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1259\/bjr.70.838.9404197","volume":"70","author":"EF Avni","year":"1997","unstructured":"Avni EF, Ayadi K, Rypens F, Hall M, Schulman CC (1997) Can careful ultrasound examination of the urinary tract exclude vesicoureteric reflux in the neonate? Br J Radiol 70(838):977\u2013982. https:\/\/doi.org\/10.1259\/bjr.70.838.9404197","journal-title":"Br J Radiol"},{"issue":"10","key":"3626_CR14","first-page":"1644","volume":"38","author":"GA Mandell","year":"1997","unstructured":"Mandell GA, Eggli DF, Gilday DL, Heyman S, Leonard JC, Miller JH, Nadel HR, Treves ST (1997) Procedure guideline for renal cortical scintigraphy in children. Society of Nuclear Medicine. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 38(10):1644\u20131646","journal-title":"Journal of nuclear medicine : official publication, Society of Nuclear Medicine"},{"issue":"9","key":"3626_CR15","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1007\/s00467-008-0853-7","volume":"23","author":"Z Sadeghi","year":"2008","unstructured":"Sadeghi Z, Kajbafzadeh AM, Tajik P, Monajemzadeh M, Payabvash S, Elmi A (2008) Vitamin E administration at the onset of fever prevents renal scarring in acute pyelonephritis. Pediatr Nephrol 23(9):1503\u20131510. https:\/\/doi.org\/10.1007\/s00467-008-0853-7","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"3626_CR16","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/BF00305300","volume":"19","author":"T Matsumoto","year":"1991","unstructured":"Matsumoto T, Mizunoe Y, Ogata N, Tanaka M, Kumazawa J (1991) Role of superoxide in renal scarring following infection by mannose-sensitive piliated bacteria. Urol Res 19(4):229\u2013233","journal-title":"Urol Res"},{"issue":"9","key":"3626_CR17","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s00467-016-3361-1","volume":"31","author":"A Yilmaz","year":"2016","unstructured":"Yilmaz A, Yildirim ZY, Emre S, Gedikbasi A, Yildirim T, Dirican A, Ucar EO (2016) Urine heat shock protein 70 levels as a marker of urinary tract infection in children. Pediatr Nephrol 31(9):1469\u20131476. https:\/\/doi.org\/10.1007\/s00467-016-3361-1","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"3626_CR18","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1080\/0886022x.2016.1202732","volume":"38","author":"E Amini","year":"2016","unstructured":"Amini E, Pishgar F, Hojjat A, Soleimani M, Asgari MA, Kajbafzadeh AM (2016) The role of serum and urinary carbohydrate antigen 19-9 in predicting renal injury associated with ureteral stone. Ren Fail 38(10):1626\u20131632. https:\/\/doi.org\/10.1080\/0886022x.2016.1202732","journal-title":"Ren Fail"},{"issue":"2","key":"3626_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s13193-011-0042-1","volume":"2","author":"UK Ballehaninna","year":"2011","unstructured":"Ballehaninna UK, Chamberlain RS (2011) Serum CA 19-9 as a biomarker for pancreatic cancer-a comprehensive review. Indian journal of surgical oncology 2(2):88\u2013100. https:\/\/doi.org\/10.1007\/s13193-011-0042-1","journal-title":"Indian journal of surgical oncology"},{"issue":"6","key":"3626_CR20","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1542\/peds.102.6.1422","volume":"102","author":"N Benador","year":"1998","unstructured":"Benador N, Siegrist CA, Gendrel D, Greder C, Benador D, Assicot M, Bohuon C, Girardin E (1998) Procalcitonin is a marker of severity of renal lesions in pyelonephritis. Pediatrics 102(6):1422\u20131425","journal-title":"Pediatrics"},{"issue":"1\u20132","key":"3626_CR21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0009-8981(02)00101-8","volume":"323","author":"M Meisner","year":"2002","unstructured":"Meisner M (2002) Pathobiochemistry and clinical use of procalcitonin. Clinica chimica acta; international journal of clinical chemistry 323(1\u20132):17\u201329","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"issue":"3","key":"3626_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00345-015-1630-4","volume":"34","author":"H Zhang","year":"2016","unstructured":"Zhang H, Yang J, Lin L, Huo B, Dai H, He Y (2016) Diagnostic value of serum procalcitonin for acute pyelonephritis in infants and children with urinary tract infections: an updated meta-analysis. World J Urol 34(3):431\u2013441. https:\/\/doi.org\/10.1007\/s00345-015-1630-4","journal-title":"World J Urol"},{"issue":"5","key":"3626_CR23","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1542\/peds.2012-2408","volume":"131","author":"S Leroy","year":"2013","unstructured":"Leroy S, Fernandez-Lopez A, Nikfar R, Romanello C, Bouissou F, Gervaix A, Gurgoze MK, Bressan S, Smolkin V, Tuerlinckx D, Stefanidis CJ, Vaos G, Leblond P, Gungor F, Gendrel D, Chalumeau M (2013) Association of procalcitonin with acute pyelonephritis and renal scars in pediatric UTI. Pediatrics 131(5):870\u2013879. https:\/\/doi.org\/10.1542\/peds.2012-2408","journal-title":"Pediatrics"},{"issue":"Pt 1","key":"3626_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3180001","volume":"318","author":"DR Flower","year":"1996","unstructured":"Flower DR (1996) The lipocalin protein family: structure and function. The Biochemical journal 318(Pt 1):1\u201314","journal-title":"The Biochemical journal"},{"issue":"4","key":"3626_CR25","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00467-011-1773-5","volume":"26","author":"A Wasilewska","year":"2011","unstructured":"Wasilewska A, Taranta-Janusz K, Debek W, Zoch-Zwierz W, Kuroczycka-Saniutycz E (2011) KIM-1 and NGAL: new markers of obstructive nephropathy. Pediatr Nephrol 26(4):579\u2013586. https:\/\/doi.org\/10.1007\/s00467-011-1773-5","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"3626_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.12861\/jrip.2015.09","volume":"4","author":"A Rafiei","year":"2015","unstructured":"Rafiei A, Mohammadjafari H, Bazi S, Mirabi AM (2015) Urinary neutrophil gelatinase-associated lipocalin (NGAL) might be an independent marker for anticipating scar formation in children with acute pyelonephritis. Journal of renal injury prevention 4(2):39\u201344. https:\/\/doi.org\/10.12861\/jrip.2015.09","journal-title":"Journal of renal injury prevention"},{"issue":"5","key":"3626_CR27","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1309\/lt30-bv9u-jjv9-cfhq","volume":"120","author":"MA Ansari-Lari","year":"2003","unstructured":"Ansari-Lari MA, Kickler TS, Borowitz MJ (2003) Immature granulocyte measurement using the Sysmex XE-2100. Relationship to infection and sepsis. Am J Clin Pathol 120(5):795\u2013799. https:\/\/doi.org\/10.1309\/lt30-bv9u-jjv9-cfhq","journal-title":"Am J Clin Pathol"},{"issue":"4","key":"3626_CR28","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00467-017-3843-9","volume":"33","author":"JW Lee","year":"2018","unstructured":"Lee JW, Her SM, Kim JH, Lee KH, Eisenhut M, Park SJ, Shin JI (2018) D-dimer as a marker of acute pyelonephritis in infants younger than 24 months with urinary tract infection. Pediatr Nephrol 33(4):631\u2013637. https:\/\/doi.org\/10.1007\/s00467-017-3843-9","journal-title":"Pediatr Nephrol"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03626-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-020-03626-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03626-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:16:58Z","timestamp":1615076218000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-020-03626-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,7]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["3626"],"URL":"https:\/\/doi.org\/10.1007\/s00431-020-03626-3","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,7]]},"assertion":[{"value":"17 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and the 1964 Helsinki declaration and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants\/parents included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}