{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:45:23Z","timestamp":1790203523044,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:00:00Z","timestamp":1589760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15-31586A"],"award-info":[{"award-number":["15-31586A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences","award":["PPD2018-016\/2018"],"award-info":[{"award-number":["PPD2018-016\/2018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s00431-020-03666-9","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T07:02:40Z","timestamp":1589785360000},"page":"1739-1750","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Molecular basis and outcomes of atypical haemolytic uraemic syndrome in Czech children"],"prefix":"10.1007","volume":"179","author":[{"given":"\u0160\u00e1rka","family":"\u0160tolbov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-5853","authenticated-orcid":false,"given":"Martin","family":"Bezd\u00ed\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Seeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Proh\u00e1szka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Csuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Hrachovinov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Burkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u011b\u017eda","family":"\u0160im\u00e1nkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0160t\u011bp\u00e1nka","family":"Pr\u016fhov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Zieg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"issue":"2","key":"3666_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.amjmed.2018.08.011","volume":"132","author":"HM Tsai","year":"2019","unstructured":"Tsai HM (2019) Atypical hemolytic uremic syndrome: beyond hemolysis and uremia. Am J Med 132(2):161\u2013167. https:\/\/doi.org\/10.1016\/j.amjmed.2018.08.011","journal-title":"Am J Med"},{"issue":"4","key":"3666_CR2","doi-asserted-by":"publisher","first-page":"554","DOI":"10.2215\/CJN04760512","volume":"8","author":"V Fremeaux-Bacchi","year":"2013","unstructured":"Fremeaux-Bacchi V, Fakhouri F, Garnier A, Bienaime F, Dragon-Durey MA, Ngo S, Moulin B, Servais A, Provot F, Rostaing L, Burtey S, Niaudet P, Deschenes G, Lebranchu Y, Zuber J, Loirat C (2013) Genetics and outcome of atypical hemolytic uremic syndrome: a nationwide French series comparing children and adults. Clin J Am Soc Nephrol 8(4):554\u2013562. https:\/\/doi.org\/10.2215\/CJN04760512","journal-title":"Clin J Am Soc Nephrol"},{"issue":"10","key":"3666_CR3","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s00467-014-2817-4","volume":"29","author":"S Johnson","year":"2014","unstructured":"Johnson S, Stojanovic J, Ariceta G, Bitzan M, Besbas N, Frieling M, Karpman D, Landau D, Langman C, Licht C, Pecoraro C, Riedl M, Siomou E, van de Kar N, Walle JV, Loirat C, Taylor CM (2014) An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome. Pediatr Nephrol 29(10):1967\u20131978. https:\/\/doi.org\/10.1007\/s00467-014-2817-4","journal-title":"Pediatr Nephrol"},{"key":"3666_CR4","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/1471-2334-14-265","volume":"14","author":"GR Jenssen","year":"2014","unstructured":"Jenssen GR, Hovland E, Bjerre A, Bangstad HJ, Nygard K, Vold L (2014) Incidence and etiology of hemolytic-uremic syndrome in children in Norway, 1999-2008--a retrospective study of hospital records to assess the sensitivity of surveillance. BMC Infect Dis 14:265. https:\/\/doi.org\/10.1186\/1471-2334-14-265","journal-title":"BMC Infect Dis"},{"issue":"1","key":"3666_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00467-015-3076-8","volume":"31","author":"C Loirat","year":"2016","unstructured":"Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NC, Van de Walle J, Vivarelli M, Fremeaux-Bacchi V (2016) An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol 31(1):15\u201339. https:\/\/doi.org\/10.1007\/s00467-015-3076-8","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"3666_CR6","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1007\/s00467-012-2131-y","volume":"27","author":"LM Geerdink","year":"2012","unstructured":"Geerdink LM, Westra D, van Wijk JA, Dorresteijn EM, Lilien MR, Davin JC, Komhoff M, Van Hoeck K, van der Vlugt A, van den Heuvel LP, van de Kar NC (2012) Atypical hemolytic uremic syndrome in children: complement mutations and clinical characteristics. Pediatr Nephrol 27(8):1283\u20131291. https:\/\/doi.org\/10.1007\/s00467-012-2131-y","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"3666_CR7","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.2215\/CJN02210310","volume":"5","author":"M Noris","year":"2010","unstructured":"Noris M, Caprioli J, Bresin E, Mossali C, Pianetti G, Gamba S, Daina E, Fenili C, Castelletti F, Sorosina A, Piras R, Donadelli R, Maranta R, van der Meer I, Conway EM, Zipfel PF, Goodship TH, Remuzzi G (2010) Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin J Am Soc Nephrol 5(10):1844\u20131859. https:\/\/doi.org\/10.2215\/CJN02210310","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"3666_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1681\/ASN2012090884","volume":"24","author":"E Bresin","year":"2013","unstructured":"Bresin E, Rurali E, Caprioli J, Sanchez-Corral P, Fremeaux-Bacchi V, Rodriguez de Cordoba S, Pinto S, Goodship TH, Alberti M, Ribes D, Valoti E, Remuzzi G, Noris M (2013) Combined complement gene mutations in atypical hemolytic uremic syndrome influence clinical phenotype. J Am Soc Nephrol 24(3):475\u2013486. https:\/\/doi.org\/10.1681\/ASN2012090884","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"3666_CR9","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1007\/s00431-018-3255-2","volume":"177","author":"L Karnisova","year":"2018","unstructured":"Karnisova L, Hradsky O, Blahova K, Fencl F, Dolezel Z, Zaoral T, Zieg J (2018) Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study. Eur J Pediatr 177(12):1837\u20131844. https:\/\/doi.org\/10.1007\/s00431-018-3255-2","journal-title":"Eur J Pediatr"},{"issue":"3","key":"3666_CR10","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00431-017-3077-7","volume":"177","author":"W Keenswijk","year":"2018","unstructured":"Keenswijk W, Raes A, Vande Walle J (2018) Is eculizumab efficacious in Shigatoxin-associated hemolytic uremic syndrome? A narrative review of current evidence. Eur J Pediatr 177(3):311\u2013318. https:\/\/doi.org\/10.1007\/s00431-017-3077-7","journal-title":"Eur J Pediatr"},{"issue":"18","key":"3666_CR11","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.1093\/hmg\/ddp289","volume":"18","author":"A Tortajada","year":"2009","unstructured":"Tortajada A, Montes T, Martinez-Barricarte R, Morgan BP, Harris CL, de Cordoba SR (2009) The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. Hum Mol Genet 18(18):3452\u20133461. https:\/\/doi.org\/10.1093\/hmg\/ddp289","journal-title":"Hum Mol Genet"},{"issue":"6","key":"3666_CR12","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/jsemnephrol201308003","volume":"33","author":"D Kavanagh","year":"2013","unstructured":"Kavanagh D, Goodship TH, Richards A (2013) Atypical hemolytic uremic syndrome. Semin Nephrol 33(6):508\u2013530. https:\/\/doi.org\/10.1016\/jsemnephrol201308003","journal-title":"Semin Nephrol"},{"key":"3666_CR13","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3389\/fimmu.2019.00853","volume":"10","author":"E Valoti","year":"2019","unstructured":"Valoti E, Alberti M, Iatropoulos P, Piras R, Mele C, Breno M, Cremaschi A, Bresin E, Donadelli R, Alizzi S, Amoroso A, Benigni A, Remuzzi G, Noris M (2019) Rare functional variants in complement genes and anti-FH autoantibodies-associated aHUS. Front Immunol 10:853. https:\/\/doi.org\/10.3389\/fimmu.2019.00853","journal-title":"Front Immunol"},{"key":"3666_CR14","doi-asserted-by":"crossref","unstructured":"Delvaeye M, Noris M, De Vriese A, Esmon CT, Esmon NL, Ferrell G, Del-Favero J, Plaisance S, Claes B, Lambrechts D, Zoja C, Remuzzi G, Conway EM (2009) Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N Engl J Med 361(4):345-357. Doi: 101056\/NEJMoa0810739","DOI":"10.1056\/NEJMoa0810739"},{"issue":"12","key":"3666_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143707","volume":"10","author":"S Hyvarinen","year":"2015","unstructured":"Hyvarinen S, Jokiranta TS (2015) Minor role of plasminogen in complement activation on cell surfaces. PLoS One 10(12):e0143707. https:\/\/doi.org\/10.1371\/journal.pone.0143707","journal-title":"PLoS One"},{"issue":"2","key":"3666_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1182\/blood-2009-05-221549","volume":"115","author":"I Moore","year":"2010","unstructured":"Moore I, Strain L, Pappworth I, Kavanagh D, Barlow PN, Herbert AP, Schmidt CQ, Staniforth SJ, Holmes LV, Ward R, Morgan L, Goodship TH, Marchbank KJ (2010) Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Blood 2010 115(2):379\u2013387. https:\/\/doi.org\/10.1182\/blood-2009-05-221549","journal-title":"Blood 2010"},{"issue":"2","key":"3666_CR17","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1681\/ASN2004050380","volume":"16","author":"MA Dragon-Durey","year":"2005","unstructured":"Dragon-Durey MA, Loirat C, Cloarec S, Macher MA, Blouin J, Nivet H, Weiss L, Fridman WH, Fremeaux-Bacchi V (2005) Anti-factor H autoantibodies associated with atypical hemolytic uremic syndrome. J Am Soc Nephrol 16(2):555\u2013563. https:\/\/doi.org\/10.1681\/ASN2004050380","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"3666_CR18","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1681\/ASN2010030315","volume":"21","author":"MA Dragon-Durey","year":"2010","unstructured":"Dragon-Durey MA, Sethi SK, Bagga A, Blanc C, Blouin J, Ranchin B, Andre JL, Takagi N, Cheong HI, Hari P, Le Quintrec M, Niaudet P, Loirat C, Fridman WH, Fremeaux-Bacchi V (2010) Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome. J Am Soc Nephrol 21(12):2180\u20132187. https:\/\/doi.org\/10.1681\/ASN2010030315","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"3666_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1136\/jmg2008064766","volume":"46","author":"MA Dragon-Durey","year":"2009","unstructured":"Dragon-Durey MA, Blanc C, Marliot F, Loirat C, Blouin J, Sautes-Fridman C, Fridman WH, Fremeaux-Bacchi V (2009) The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome. J Med Genet 46(7):447\u2013450. https:\/\/doi.org\/10.1136\/jmg2008064766","journal-title":"J Med Genet"},{"issue":"3","key":"3666_CR20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1681\/ASN2012090903","volume":"24","author":"F Ozaltin","year":"2013","unstructured":"Ozaltin F, Li B, Rauhauser A, An SW, Soylemezoglu O, Gonul II, Taskiran EZ, Ibsirlioglu T, Korkmaz E, Bilginer Y, Duzova A, Ozen S, Topaloglu R, Besbas N, Ashraf S, Du Y, Liang C, Chen P, Lu D, Vadnagara K, Arbuckle S, Lewis D, Wakeland B, Quigg RJ, Ransom RF, Wakeland EK, Topham MK, Bazan NG, Mohan C, Hildebrandt F, Bakkaloglu A, Huang CL, Attanasio M (2013) DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN. J Am Soc Nephrol 24(3):377\u2013384. https:\/\/doi.org\/10.1681\/ASN2012090903","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3666_CR21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/ng2590","volume":"45","author":"M Lemaire","year":"2013","unstructured":"Lemaire M, Fremeaux-Bacchi V, Schaefer F, Choi M, Tang WH, Le Quintrec M, Fakhouri F, Taque S, Nobili F, Martinez F, Ji W, Overton JD, Mane SM, Nurnberg G, Altmuller J, Thiele H, Morin D, Deschenes G, Baudouin V, Llanas B, Collard L, Majid MA, Simkova E, Nurnberg P, Rioux-Leclerc N, Moeckel GW, Gubler MC, Hwa J, Loirat C, Lifton RP (2013) Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome. Nat Genet 45(5):531\u2013536. https:\/\/doi.org\/10.1038\/ng2590","journal-title":"Nat Genet"},{"issue":"8","key":"3666_CR22","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s00467-018-3950-2","volume":"33","author":"M Bezdicka","year":"2018","unstructured":"Bezdicka M, Stolbova S, Seeman T, Cinek O, Malina M, Simankova N, Pruhova S, Zieg J (2018) Genetic diagnosis of steroid-resistant nephrotic syndrome in a longitudinal collection of Czech and Slovak patients: a high proportion of causative variants in NUP93. Pediatr Nephrol 33(8):1347\u20131363. https:\/\/doi.org\/10.1007\/s00467-018-3950-2","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"3666_CR23","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sjki5002231","volume":"71","author":"A Akcan-Arikan","year":"2007","unstructured":"Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71(10):1028\u20131035. https:\/\/doi.org\/10.1038\/sjki5002231","journal-title":"Kidney Int"},{"issue":"8","key":"3666_CR24","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1681\/ASN2006080811","volume":"18","author":"AL Sellier-Leclerc","year":"2007","unstructured":"Sellier-Leclerc AL, Fremeaux-Bacchi V, Dragon-Durey MA, Macher MA, Niaudet P, Guest G, Boudailliez B, Bouissou F, Deschenes G, Gie S, Tsimaratos M, Fischbach M, Morin D, Nivet H, Alberti C, Loirat C (2007) Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome. J Am Soc Nephrol 18(8):2392\u20132400. https:\/\/doi.org\/10.1681\/ASN2006080811","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"3666_CR25","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/ki2013373","volume":"85","author":"A Sinha","year":"2014","unstructured":"Sinha A, Gulati A, Saini S, Blanc C, Gupta A, Gurjar BS, Saini H, Kotresh ST, Ali U, Bhatia D, Ohri A, Kumar M, Agarwal I, Gulati S, Anand K, Vijayakumar M, Sinha R, Sethi S, Salmona M, George A, Bal V, Singh G, Dinda AK, Hari P, Rath S, Dragon-Durey MA, Bagga A (2014) Prompt plasma exchanges and immunosuppressive treatment improves the outcomes of anti-factor H autoantibody-associated hemolytic uremic syndrome in children. Kidney Int 85(5):1151\u20131160. https:\/\/doi.org\/10.1038\/ki2013373","journal-title":"Kidney Int"},{"issue":"4","key":"3666_CR26","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","volume":"108","author":"J Caprioli","year":"2006","unstructured":"Caprioli J, Noris M, Brioschi S, Pianetti G, Castelletti F, Bettinaglio P, Mele C, Bresin E, Cassis L, Gamba S, Porrati F, Bucchioni S, Monteferrante G, Fang CJ, Liszewski MK, Kavanagh D, Atkinson JP, Remuzzi G (2006) Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood 108(4):1267\u20131279. https:\/\/doi.org\/10.1182\/blood-2005-10-007252","journal-title":"Blood"},{"key":"3666_CR27","doi-asserted-by":"publisher","first-page":"550","DOI":"10.12659\/aot.905917","volume":"22","author":"R Grenda","year":"2017","unstructured":"Grenda R, Durlik M (2017) Eculizumab in Renal Transplantation: a 2017 update. Ann Transplant 22:550\u2013554. https:\/\/doi.org\/10.12659\/aot.905917","journal-title":"Ann Transplant"},{"issue":"3","key":"3666_CR28","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/jtransproceed201802012","volume":"50","author":"K Vondrak","year":"2018","unstructured":"Vondrak K, Seeman T (2018) Successful 7-year eculizumab treatment of plasmapheresis-resistant recurrent atypical hemolytic-uremic syndrome due to complement factor H hybrid gene: a case report. Transplant Proc 50(3):967\u2013970. https:\/\/doi.org\/10.1016\/jtransproceed201802012","journal-title":"Transplant Proc"},{"issue":"3","key":"3666_CR29","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1371\/journalpgen0030041","volume":"3","author":"PF Zipfel","year":"2007","unstructured":"Zipfel PF, Edey M, Heinen S, Jozsi M, Richter H, Misselwitz J, Hoppe B, Routledge D, Strain L, Hughes AE, Goodship JA, Licht C, Goodship TH, Skerka C (2007) Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome. PLoS Genet 3(3):e41. https:\/\/doi.org\/10.1371\/journalpgen0030041","journal-title":"PLoS Genet"},{"key":"3666_CR30","doi-asserted-by":"crossref","unstructured":"Westland R, Bodria M, Carrea A, Lata S, Scolari F, Fremeaux-Bacchi V, D\u2019Agati VD, Lifton RP, Gharavi AG, Ghiggeri GM, Sanna-Cherchi S (2014) Phenotypic expansion of DGKE-associated diseases. J Am Soc Nephrol 25(7):1408-1414 doi: 101681\/ASN2013080886","DOI":"10.1681\/ASN.2013080886"}],"updated-by":[{"DOI":"10.1007\/s00431-021-04342-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000}}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03666-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-020-03666-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03666-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T02:05:05Z","timestamp":1641866705000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-020-03666-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,18]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["3666"],"URL":"https:\/\/doi.org\/10.1007\/s00431-020-03666-9","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,18]]},"assertion":[{"value":"27 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2022","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00431-021-04342-2","URL":"https:\/\/doi.org\/10.1007\/s00431-021-04342-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical statements"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee (Ethics Committee for Multi-Centric Clinical Trials of the Motol University Hospital and 2nd Faculty of Medicine, Charles University in Prague) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}