{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:00:29Z","timestamp":1794013229447,"version":"4.8.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00431-020-03744-y","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T05:04:31Z","timestamp":1595567071000},"page":"1913-1920","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Early surfactant replacement guided by lung ultrasound in preterm newborns with RDS: the ULTRASURF randomised controlled trial"],"prefix":"10.1007","volume":"179","author":[{"given":"Javier","family":"Rodriguez-Fanjul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Balaguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Batista-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ramon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bobillo-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"issue":"2","key":"3744_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/archdischild-2015-310299","volume":"102","author":"C Aldana-Aguirre","year":"2017","unstructured":"Aldana-Aguirre C, Pinto M, Featherstone RM, Kumar M (2017) Less invasive surfactant administration versus intubation for surfactant delivery in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 102(2):17\u201323","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"3744_CR2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000499361","volume":"115","author":"DG Sweet","year":"2019","unstructured":"Sweet DG, Carnielli V, Greisen G, Hallamn M, Ozek E, Te Pas A et al (2019) European consensus guidelines on the management of respiratory distress syndrome-2019 update. Neonatology 115:432\u2013451","journal-title":"Neonatology"},{"issue":"11","key":"3744_CR3","doi-asserted-by":"publisher","first-page":"CD001456","DOI":"10.1002\/14651858","volume":"11","author":"FL Bahadue","year":"2012","unstructured":"Bahadue FL, Soll R, Cochrane Neonatal group (2012) Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev 11(11):CD001456. https:\/\/doi.org\/10.1002\/14651858","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"3744_CR4","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12931-019-1040-z","volume":"20","author":"R Raschetti","year":"2019","unstructured":"Raschetti R, Centorrino R, Letamendia E, Benachi A, Marfaing-Koka A, De Luca D (2019) Estimation of early endogenous surfactant pool and CPAP failure in preterm neonates with RDS. Respir Res 20(1):75","journal-title":"Respir Res"},{"issue":"5","key":"3744_CR5","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1111\/apa.14161","volume":"107","author":"L Gortner","year":"2018","unstructured":"Gortner L, Sch\u00fcller SS, Herting E (2018) Review demonstrates that less invasive surfactant administration in preterm neonates leads to fewer complications. Acta Paediatr 107(5):736\u2013743","journal-title":"Acta Paediatr"},{"issue":"3","key":"3744_CR6","first-page":"65","volume":"2","author":"HMM Shari","year":"2014","unstructured":"Shari HMM, Naghibi S, Mahdavi E, Khademi G (2014) Diagnostic utility of chest X-rays in neonatal respiratory distress: determining the sensitivity and specificity. Int J Pediatr 2(3):65\u201372","journal-title":"Int J Pediatr"},{"key":"3744_CR7","first-page":"217","volume":"62","author":"M Roggini","year":"2010","unstructured":"Roggini M, Pepino D, D\u2019Avanzo M, Andreoli GM, Ceccanti S, Capocaccia P (2010) Respiratory distress in newborn: evaluation of chest X-rays. Minerva Pediatr 62:217\u2013219","journal-title":"Minerva Pediatr"},{"key":"3744_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14767058.2019.1605350","volume":"22","author":"A Okterm","year":"2019","unstructured":"Okterm A, Yigit S, Oguz B, Celik T, Halilogu M, Yurdakok M (2019) Accuracy of lung ultrasonography in the diagnosis of respiratory distress syndrome in newborns. J Matern Fetal Neonatal Med 22:1\u20136","journal-title":"J Matern Fetal Neonatal Med"},{"key":"3744_CR9","doi-asserted-by":"crossref","unstructured":"Liu Lung ultrasonography for the diagnosis of neonatal lung disease. J Matern Neonatal Med 27(8):856\u2013861","DOI":"10.3109\/14767058.2013.844125"},{"key":"3744_CR10","doi-asserted-by":"crossref","unstructured":"Rodriguez-Fanjul J, Balcells C, Aldecoa-Bilbao V, Moreno J, Iriondo M (2016) Lung ultrasound as a predictor of mechanical ventilation in neonates older than 32 weeks. Neonatology 110(3):198\u2013203","DOI":"10.1159\/000445932"},{"issue":"1","key":"3744_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s00431-019-03470-0","volume":"179","author":"R Gregorio-Hern\u00e1ndez","year":"2020","unstructured":"Gregorio-Hern\u00e1ndez R, Arriaga-Redondo M, P\u00e9rez-P\u00e9rez A, Ramons-Navarro C, S\u00e1nchez-Luna M (2020) Lung ultrasound in preterm infants with respiratory distress: experience in a neonatal intensive care unit. Eur J Pediatr 179(1):81\u201389","journal-title":"Eur J Pediatr"},{"key":"3744_CR12","doi-asserted-by":"crossref","unstructured":"Corsini I, Parri N, Gozzini E, Coviello C, Leonardi V, Poggi C, Giacalone M, Bianconi T, Tofani L, Raimondi F, Dani C (2019) Lung ultrasound for the differential diagnosis of respiratory distress in neonates. Neonatology 115(1):77\u201384","DOI":"10.1159\/000493001"},{"key":"3744_CR13","doi-asserted-by":"crossref","unstructured":"DeMartino L, Yousef N, Ben-Ammar R, Raimondi F, Shankar-Aguilera S, De Luca D (2018) Lung ultrasound score predicts surfactant need in extremely preterm neonates. Pediatrics 142(3)","DOI":"10.1542\/peds.2018-0463"},{"key":"3744_CR14","doi-asserted-by":"publisher","unstructured":"Brat R, Yousef N, Klifa R, Reynaud S, Shankar Aguilera S, De Luca D Lung ultrasonography score to evaluate oxygenation and surfactant need in neonates treated with continuous positive airway pressure. JAMA Pediatr 169(8):e151797. https:\/\/doi.org\/10.1001\/jamapediatrics.2015.1797","DOI":"10.1001\/jamapediatrics.2015.1797"},{"issue":"2","key":"3744_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1136\/archdischild-2019-316832","volume":"105","author":"A Razak","year":"2020","unstructured":"Razak A, Faden M (2020) Neonatal lung ultrasonography to evaluate need for surfactant or mechanical ventilation: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed 105(2):164\u2013171","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"3744_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jpeds.2019.04.020","volume":"212","author":"R Raschetti","year":"2019","unstructured":"Raschetti R, Yousef N, Vigo G, Marseglia G, Centorrino R, Ben-Ammar R (2019) Echography-guided surfactant therapy to improve timeliness of surfactant replacement: a quality improvement project. J Pediatr 212:137\u2013143","journal-title":"J Pediatr"},{"issue":"3","key":"3744_CR17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.clp.2019.05.001","volume":"46","author":"TE Tipple","year":"2019","unstructured":"Tipple TE, Ambalayanan N (2019) Oxygen toxicity in the neonate: thinking beyond the balance. Clin Perinatol 46(3):435\u2013447","journal-title":"Clin Perinatol"},{"issue":"8","key":"3744_CR18","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/S2213-2600(17)30214-X","volume":"5","author":"D De Luca","year":"2017","unstructured":"De Luca D, van Kaam AH, Tingay DG, Courtney SE, Danhaive O, Carnielli VP et al (2017) The Montreux definition of neonatal ARDS: biological and clinical background behind the description of a new entity. Lancet Respir Med 5(8):657\u2013666","journal-title":"Lancet Respir Med"},{"issue":"12","key":"3744_CR19","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1002\/ppul.24487","volume":"54","author":"V Dell\u2019Orto","year":"2019","unstructured":"Dell\u2019Orto V, Raschetti R, Centorrino R, Montane A, Tissieres P, Yousef N, Luca D (2019) Short and long-term respiratory outcomes in neonates with ventilator-associated pneumonia. Pediatr Pulmonol 54(12):1982\u20131988","journal-title":"Pediatr Pulmonol"},{"key":"3744_CR20","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jpeds.2018.01.043","volume":"197","author":"RD Higgins","year":"2018","unstructured":"Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman RI, Collaco JM, Martin CR, Woods JC, Finer NN, Raju TNK (2018) Bronchopulmonary dysplasia: executive summary of a workshop. J Pediatr 197:300\u2013308","journal-title":"J Pediatr"},{"key":"3744_CR21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/PCC.0000000000000432","volume":"16","author":"RG Khemani","year":"2015","unstructured":"Khemani RG, Smith LS, Zimmerman JJ, Erickson S, Pediatric Acute Lung Injury Consensus Conference Group (2015) Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med 16:23\u201340","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"3744_CR22","doi-asserted-by":"publisher","first-page":"510.517","DOI":"10.1007\/s00134-010-2091-2","volume":"37","author":"PE Cogo","year":"2011","unstructured":"Cogo PE, Facco M, Simonato M, De Luca D, De Terlizi F, Rizzotti U et al (2011) Pharmacokinetics and clinical predictors of surfactant redosing in respiratory distress syndrome. Intensive Care Med 37(3):510.517","journal-title":"Intensive Care Med"},{"key":"3744_CR23","doi-asserted-by":"publisher","unstructured":"Gomond-Le Goff C, Vivalda L, Foligno S, Loi B, Yousef N, De Luca D Effect of different probes and expertise on the interpretation reliability of point-of-care lung ultrasound. Chest. https:\/\/doi.org\/10.1016\/j.chest.2019","DOI":"10.1016\/j.chest.2019"},{"key":"3744_CR24","doi-asserted-by":"publisher","unstructured":"Bobillo-Perez S, Girona-Alarcon M, Rodriguez-Fanjul J, Jordan I, Balaguer GM (2019) Lung ultrasound in children: what does it give us? Paediatr Respir Rev. https:\/\/doi.org\/10.1016\/j.prrv.2019.09.006","DOI":"10.1016\/j.prrv.2019.09.006"},{"key":"3744_CR25","doi-asserted-by":"crossref","unstructured":"Vergine M, Copetti R, Brusa G, Cattarossi L (2014) Lung ultrasound accuracy in respiratory distress syndrome and transient tachypnea of the newborn. Neonatology 106(2):87\u201393","DOI":"10.1159\/000358227"},{"issue":"10","key":"3744_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0202397","volume":"13","author":"F Raimondi","year":"2018","unstructured":"Raimondi F, Migliaro F, Verdoliva L, Gragnaniello D, Poggi G, Kosova R, Sansone C, Vallone G, Capasso L (2018) Visual assessment versus computer-assisted gray scale analysis in the ultrasound evaluation of neonatal respiratory status. PLoS One 13(10):e0202397","journal-title":"PLoS One"},{"key":"3744_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.jpeds.2016.11.057","volume":"182","author":"C Autilio","year":"2017","unstructured":"Autilio C, Echaide M, Benachi A, Marfaing-Koka A, Capoluongo ED, P\u00e9rez-Gil J, de Luca D (2017) A noninvasive surfactant adsorption test predicting the need for surfactant therapy in preterm infants treated with continuous positive airway pressure. J Pediatr 182:66\u201373","journal-title":"J Pediatr"},{"key":"3744_CR28","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1097\/CCM.0000000000003340","volume":"46","author":"D Chiumello","year":"2018","unstructured":"Chiumello D, Mongodi S, Algieri I, Vergani GL, Orlando A, Via G, Crimella F, Cressoni M, Mojoli F (2018) Assessment of lung aeration and recruitment by CT scan ultrasound in acute respiratory distress syndrome patients. Crit Care Med 46:1761\u20131768","journal-title":"Crit Care Med"},{"key":"3744_CR29","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.redox.2017.03.011","volume":"12","author":"I Torres-Cuevas","year":"2017","unstructured":"Torres-Cuevas I, Parra-Llorca A, S\u00e1nchez-Illana A, Nu\u00f1ez-Ramiro A, Kuligowski J, Ch\u00e1fer-Peric\u00e1s C, Cernada M, Escobar J, Vento M (2017) Oxygen and oxidative stress in the perinatal period. Redox Biol 12:674\u2013681","journal-title":"Redox Biol"},{"key":"3744_CR30","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2019.03.034","volume":"142","author":"S Perrone","year":"2019","unstructured":"Perrone S, Laschi E, Buonocore G (2019) Biomarkers of oxidative stress in the fetus and in the newborn. Free Radic Biol Med 142:23\u201331","journal-title":"Free Radic Biol Med"},{"key":"3744_CR31","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2009.034967","volume":"19","author":"L Bookman","year":"2010","unstructured":"Bookman L, Troy R, McCaffrey M, Randolph G (2010) Using quality improvement methods to reduce variation in surfactant administration. BMJ Qual Saf 19:e23","journal-title":"BMJ Qual Saf"},{"key":"3744_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejpn.2020.04.010","volume":"26","author":"N Tusor","year":"2020","unstructured":"Tusor N, De Cunto A, Basma Y, Klein J, Meau-Petit V (2020) Ventilator-associated pneumonia in neonates: the role of point of care lung ultrasound. Eur J Pediatr 26:1\u201310","journal-title":"Eur J Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03744-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-020-03744-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-020-03744-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T22:45:22Z","timestamp":1744152322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-020-03744-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":32,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["3744"],"URL":"https:\/\/doi.org\/10.1007\/s00431-020-03744-y","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"assertion":[{"value":"1 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest or financial relationship with any organization.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the local Healthcare Ethics Committee and the institutional review board.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all the parents of the participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}