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In the last decades, there have been consistent advances in the understanding of pain mechanisms in newborns, and analgesia has become a fundamental part of neonatal care. MC is still often performed with inappropriate analgesic methods, and there is still great variability among the various centers about surgical and anesthethic techniques to do it. The purpose of this review is to summarize the findings in the literature about pain management and analgesia during newborn MC. We performed a systematic review of neonatal MC studies published in the last 20\u00a0years. The most effective technique appeared to be the combination of pharmacological and non-pharmacological methods of analgesia.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : Combining local anesthesia with non-pharmacological analgesic strategies appears to be effective preventing procedural pain during MC. However, a standardized protocol for analgesia during MC is yet to be determined. Sensorial saturation appeared to help when used in conjunction with the local anesthesia techniques.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 Male circumcision is a painful procedure and it is frequently performed with inappropriate analgesic methods.<\/jats:italic>\n                              <jats:italic>\u2022 A gold standard practice in analgesia during male circumcision is still lacking and there is a great variability in the modus operandi between centers.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 The combination of RB + EMLA + sucrose appears to be an analgesic strategy superior to other approaches.<\/jats:italic>\n                              <jats:italic>\u2022 We advocate for the integration of sensorial saturation during male circumcision in order to improve the efficacy of current analgesic practices.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-020-03758-6","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T16:04:43Z","timestamp":1596470683000},"page":"13-20","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Management of pain in newborn circumcision: a systematic review"],"prefix":"10.1007","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-4967","authenticated-orcid":false,"given":"Serena","family":"Rossi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Buonocore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Valerio","family":"Bellieni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"3758_CR1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12963-016-0073-5","volume":"14","author":"BJ Morris","year":"2016","unstructured":"Morris BJ, Wamai RG, Henebeng EB, Tobian AA, Klausner JD, Banerjee J, Hankins CA (2016) Estimation of country-specific and global prevalence of male circumcision. 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