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However, data is sparse in children. The aim of this study was to describe the prevalence and risk factors for lactic acidosis in children hospitalised for acute moderate or severe asthma. A total of 154 children 2\u201317 years of age were enrolled in a prospective observational study conducted in a tertiary hospital. All had capillary blood gas assessment 4 h after the first dose of salbutamol in hospital. The primary endpoint was the prevalence of lactic acidosis. Potential contributing factors such as age, sex, BMI, initial degree of asthma severity, type of salbutamol administration (nebuliser or inhaler), steroids, ipratropium bromide, and glucose-containing maintenance fluid represented secondary endpoints. All in all, 87% of patients had hyperlactatemia (lactate concentration &gt; 2.2 mmol\/l). Lactic acidosis (lactate concentration &gt; 5 mmol\/l and anion gap \u2265 16 mmol\/l) was observed in 26%. In multivariate analysis, age more than 6 years (OR = 2.8, 95% CI 1.2\u20136.6), glycemia above 11 mmol\/l (OR = 3.2 95% CI 1.4\u20137.4), and salbutamol administered by nebuliser (OR = 10, 95% CI 2.7\u201347) were identified as risk factors for lactic acidosis in children with moderate or severe asthma.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Lactic acidosis is a frequent and early complication of acute moderate or severe asthma in children.<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Lactic acidosis during acute asthma is associated with b2-mimetics administration.<\/jats:italic><jats:italic>\u2022 Salbutamol-related lactic acidosis is self-limited but important to recognise, as compensatory hyperventilation of lactic acidosis can be mistaken for respiratory worsening and lead to inappropriate supplemental bronchodilator administration.<\/jats:italic><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Lactic acidosis is a frequent complication of acute asthma in the paediatric population.<\/jats:italic><jats:italic>\u2022 Age older than 6 years, hyperglycaemia, and nebulised salbutamol are risk factors for lactic acidosis during asthma.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-020-03834-x","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T03:43:52Z","timestamp":1603338232000},"page":"1125-1131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study"],"prefix":"10.1007","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-5956","authenticated-orcid":false,"given":"Marta","family":"Ruman-Colombier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Rochat Guignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermindo R.","family":"Di Paolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Gehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Pauchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"issue":"5","key":"3834_CR1","doi-asserted-by":"publisher","first-page":"L998","DOI":"10.1152\/ajplung.00075.2020","volume":"318","author":"LP Boulet","year":"2020","unstructured":"Boulet LP, Reddel HK, Brightling C, Brusselle G (2020) GINA fosters World Asthma Day 2020 to prevent asthma deaths. 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