{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:12:58Z","timestamp":1783977178945,"version":"3.55.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Projekt DEAL"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to assess the results of primary anastomosis (PA) compared to enterostomy (ES) in infants with spontaneous intestinal perforation (SIP) and a weight below 1000\u00a0g. Between 2014 and 2016, enterostomy was routinely carried out on extremely low birth weight (ELBW) patients with SIP. From 2016 until 2019, all patients underwent anastomosis without stoma formation. We compared outcome and complications in both groups. Forty-two patients with a median gestational age of 24.3\u00a0weeks and a birth weight of 640\u00a0g with SIP were included. Thirty patients underwent PA; ES was performed in 12 patients. Overall in-hospital mortality was 11.9% (PA: 13.3%, ES: 8.3%). Reoperations due to complications became necessary in 10\/30 patients with PA and 4\/12 patients with ES. Length of stay was 110.5\u00a0days in the PA group and 124\u00a0days in the ES group. Median weight at discharge was higher in the PA group (PA: 2258\u00a0g, ES: 1880\u00a0g, <jats:italic>p<\/jats:italic>\u2009=\u2009.036).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Primary anastomosis is a feasible treatment option for SIP in infants &lt;\u20091000\u00a0g and may have a positive impact on weight gain and length of hospitalization. However, further studies on selection criteria for PA are necessary.<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Enterostomy (ES) and primary anastomosis (PA) are feasible treatment options in preterm infants with spontaneous intestinal perforation (SIP).<\/jats:italic><jats:italic>\u2022 Stomal complications or failure to thrive due to poor food utilization can pose significant problems.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Primary anastomosis in case of SIP is equal to enterostomy in terms of mortality and revision rate; however, length of stay and weight gain can be presumably positively influenced.<\/jats:italic><jats:italic>\u2022 Primary anastomosis is a valid treatment option even for patients weighing less than 1000\u00a0g.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-021-03926-2","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T18:50:13Z","timestamp":1610563813000},"page":"1529-1535","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary anastomosis as a valid alternative for extremely low birth weight infants with spontaneous intestinal perforation"],"prefix":"10.1007","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7951-1924","authenticated-orcid":false,"given":"Martin","family":"D\u00fcbbers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Holtkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigore","family":"Cernaianu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bludau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Kribs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisy","family":"Schulten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"3926_CR1","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1016\/j.jpedsurg.2016.02.086","volume":"51","author":"I de Haro Jorge","year":"2016","unstructured":"de Haro Jorge I, Prat Ortells J, Albert Cazalla A et al (2016) Long term outcome of preterm infants with isolated intestinal perforation: a comparison between primary anastomosis and ileostomy. 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