{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T11:39:11Z","timestamp":1770032351573,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00431-021-04010-5","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T06:43:19Z","timestamp":1615272199000},"page":"2327-2332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Viral rashes mimicking drug reaction with eosinophilia and systemic symptoms syndrome in children after \u03b2-lactams intake: a diagnostic challenge"],"prefix":"10.1007","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-243X","authenticated-orcid":false,"given":"Arianna","family":"Dondi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Parladori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Liccioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Lanari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Patrizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iria","family":"Neri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"4010_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/pde.14044","volume":"37","author":"L Metterle","year":"2020","unstructured":"Metterle L, Hatch L, Seminario-Vidal L (2020) Pediatric drug reaction with eosinophilia and systemic symptoms: a systematic review of the literature. Pediatr Dermatol 37:124\u2013129. https:\/\/doi.org\/10.1111\/pde.14044","journal-title":"Pediatr Dermatol"},{"key":"4010_CR2","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.jaad.2019.09.036","volume":"82","author":"A Soria","year":"2020","unstructured":"Soria A, Bernier C, Veyrac G, Barbaud A, Puymirat E, Milpied B (2020) Drug reaction with eosinophilia and systemic symptoms may occur within 2 weeks of drug exposure: a retrospective study. J Am Acad Dermatol 82:606\u2013611. https:\/\/doi.org\/10.1016\/j.jaad.2019.09.036","journal-title":"J Am Acad Dermatol"},{"key":"4010_CR3","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.alit.2019.03.006","volume":"68","author":"T Shiohara","year":"2019","unstructured":"Shiohara T, Mizukawa Y (2019) Drug-induced hypersensitivity syndrome (DiHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS): an update in 2019. Allergol Int 68:301\u2013308. https:\/\/doi.org\/10.1016\/j.alit.2019.03.006","journal-title":"Allergol Int"},{"key":"4010_CR4","doi-asserted-by":"publisher","first-page":"66","DOI":"10.23750\/abm.v90i3-S.8167","volume":"90","author":"F Mori","year":"2019","unstructured":"Mori F, Caffarelli C, Caimmi S, Bottau P, Liotti L, Franceschini F, Cardinale F, Bernardini R, Crisafulli G, Saretta F, Novembre E (2019) Drug reaction with eosinophilia and systemic symptoms (DRESS) in children. Acta Biomed 90:66\u201379. https:\/\/doi.org\/10.23750\/abm.v90i3-S.8167","journal-title":"Acta Biomed"},{"key":"4010_CR5","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/j.1365-2133.2006.07704.x","volume":"156","author":"SH Kardaun","year":"2007","unstructured":"Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC (2007) Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 156:609\u2013611. https:\/\/doi.org\/10.1111\/j.1365-2133.2006.07704.x","journal-title":"Br J Dermatol"},{"key":"4010_CR6","doi-asserted-by":"publisher","first-page":"e162","DOI":"10.1111\/pde.12803","volume":"33","author":"S Sasidharanpillai","year":"2016","unstructured":"Sasidharanpillai S, Sabitha S, Riyaz N, Binitha MP, Muhammed K, Riyaz A, Jayakrishnan MP, Reyila VP (2016) Drug reaction with eosinophilia and systemic symptoms in children: a prospective study. Pediatr Dermatol 33:e162\u2013e165. https:\/\/doi.org\/10.1111\/pde.12803","journal-title":"Pediatr Dermatol"},{"key":"4010_CR7","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1056\/NEJMcp1001116","volume":"362","author":"K Luzuriaga","year":"2010","unstructured":"Luzuriaga K, Sullivan JL (2010) Infectious mononucleosis. N Engl J Med 362:1993\u20132000. https:\/\/doi.org\/10.1056\/NEJMcp1001116","journal-title":"N Engl J Med"},{"issue":"1","key":"4010_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000481988","volume":"176","author":"E Dibek Misirlioglu","year":"2018","unstructured":"Dibek Misirlioglu E, Guvenir H, Ozkaya Parlakay A, Toyran M, Tezer H, Catak AI, Kocabas CN (2018) Incidence of antibiotic-related rash in children with Epstein-Barr virus infection and evaluation of the frequency of confirmed antibiotic hypersensitivity. Int Arch Allergy Immunol 176(1):33\u201338. https:\/\/doi.org\/10.1159\/000481988","journal-title":"Int Arch Allergy Immunol"},{"key":"4010_CR9","doi-asserted-by":"publisher","unstructured":"\u00d3nodi-Nagy K, Bata-Cs\u00f6rg\u0151 Z, Varga E, Kem\u00e9ny L, Kiny\u00f3 \u00c1 (2015) Antibiotic induced cutaneous rash in infectious mononucleosis: overview of the literature. J Allergy Ther 06(05). https:\/\/doi.org\/10.4172\/2155-6121.1000222","DOI":"10.4172\/2155-6121.1000222"},{"key":"4010_CR10","doi-asserted-by":"publisher","unstructured":"Ciccarese G, Trave I, Herzum A, Parodi A, Drago F (2020) Dermatological manifestations of Epstein-Barr virus systemic infection: a case report and literature review. Int J Dermatol:1\u20138. https:\/\/doi.org\/10.1111\/ijd.14887","DOI":"10.1111\/ijd.14887"},{"key":"4010_CR11","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.jaip.2018.06.022","volume":"7","author":"F Mori","year":"2019","unstructured":"Mori F, Fili L, Barni S, Giovannini M, Capone M, Novembre EM, Parronchi P (2019) Sensitization to amoxicillin\/clavulanic acid may underlie severe rashes in children treated for infectious mononucleosis. J Allergy Clin Immunol Pract 7:728\u2013731.e1. https:\/\/doi.org\/10.1016\/j.jaip.2018.06.022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"4010_CR12","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/pde.12931","volume":"33","author":"V Descamps","year":"2016","unstructured":"Descamps V, Brunet-Possenti F (2016) Drug reaction with eosinophilia and systemic symptoms or virus reactivation with eosinophilia and systemic symptoms. Pediatr Dermatol 33:562. https:\/\/doi.org\/10.1111\/pde.12931","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"4010_CR13","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/all.12350","volume":"69","author":"P Demoly","year":"2014","unstructured":"Demoly P, Adkinson NF, Brockow K, Castells M, Chiriac AM, Greenberger PA, Khan DA, Lang DM, Park HS, Pichler W, Sanchez-Borges M, Shiohara T, Thong BY (2014) International consensus on drug allergy. Allergy 69(4):420\u2013437. https:\/\/doi.org\/10.1111\/all.12350","journal-title":"Allergy"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-021-04010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-021-04010-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-021-04010-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T01:31:37Z","timestamp":1659058297000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-021-04010-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,9]]},"references-count":13,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["4010"],"URL":"https:\/\/doi.org\/10.1007\/s00431-021-04010-5","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,9]]},"assertion":[{"value":"14 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the parents.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Patients\u2019 parents or caregivers signed informed consent regarding publishing their data and photographs.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}