{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:02:13Z","timestamp":1781614933612,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-021-04016-z","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:03:20Z","timestamp":1616529800000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hemoglobinuria for the early identification of STEC-HUS in high-risk children: data from the ItalKid-HUS Network"],"prefix":"10.1007","author":[{"given":"Valentina","family":"Capone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Mancuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Tamburini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Montini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Ardissino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"4016_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1046\/j.1523-1755.2001.060003831.x","volume":"60","author":"P Ruggenenti","year":"2001","unstructured":"Ruggenenti P, Noris M, Remuzzi G (2001) Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int 60:831\u2013846. https:\/\/doi.org\/10.1046\/j.1523-1755.2001.060003831.x","journal-title":"Kidney Int"},{"key":"4016_CR2","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1681\/ASN.2004100861","volume":"16","author":"M Noris","year":"2005","unstructured":"Noris M, Remuzzi G (2005) Hemolytic uremic syndrome. J Am Soc Nephrol 16:1035\u20131050. https:\/\/doi.org\/10.1681\/ASN.2004100861","journal-title":"J Am Soc Nephrol"},{"key":"4016_CR3","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1016\/j.ejim.2013.12.002","volume":"25","author":"G Ardissino","year":"2014","unstructured":"Ardissino G, Possenti I, Tel F, Testa S, Paglialonga F (2014) Time to change the definition of hemolytic uremic syndrome. Eur J Intern Med 25:e29. https:\/\/doi.org\/10.1016\/j.ejim.2013.12.002","journal-title":"Eur J Intern Med"},{"key":"4016_CR4","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.290.10.1360","volume":"290","author":"AX Garg","year":"2003","unstructured":"Garg AX, Suri RS, Barrowman N, Rehman F, Matsell D, Rosas-Arellano MP, Salvadori M, Haynes RB, Clark WF (2003) Long-term renal prognosis of diarrhea-associated hemolytic uremic syndrome: a systematic review, meta-analysis, and meta-regression. J Am Med Assoc 290:1360\u20131370. https:\/\/doi.org\/10.1001\/jama.290.10.1360","journal-title":"J Am Med Assoc"},{"key":"4016_CR5","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1093\/cid\/cis531","volume":"55","author":"S Loos","year":"2012","unstructured":"Loos S, Ahlenstiel T, Kranz B, Staude H, Pape L, Hartel C, Vester U, Buchtala L, Benz K, Hoppe B, Beringer O, Krause M, Muller D, Pohl M, Lemke J, Hillebrand G, Kreuzer M, Konig J, Wigger M, Konrad M, Haffner D, Oh J, Kemper MJ (2012) An outbreak of Shiga toxin-producing Escherichia coli O104:H4 hemolytic uremic syndrome in Germany: presentation and short-term outcome in children. Clin Infect Dis 55:753\u2013759. https:\/\/doi.org\/10.1093\/cid\/cis531","journal-title":"Clin Infect Dis"},{"key":"4016_CR6","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1007\/s00467-008-0935-6","volume":"23","author":"J Scheiring","year":"2008","unstructured":"Scheiring J, Andreoli SP, Zimmerhackl LB (2008) Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS). Pediatr Nephrol 23:1749\u20131760. https:\/\/doi.org\/10.1007\/s00467-008-0935-6","journal-title":"Pediatr Nephrol"},{"key":"4016_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s00431-015-2642-1","volume":"175","author":"G Ardissino","year":"2016","unstructured":"Ardissino G, Salardi S, Colombo E, Testa S, Borsa-Ghiringhelli N, Paglialonga F, Paracchini V, Tel F, Possenti I, Belingheri M, Civitillo CF, Sardini S, Ceruti R, Baldioli C, Tommasi P, Parola L, Russo F, Tedeschi S (2016) Epidemiology of haemolytic uremic syndrome in children. Data from the North Italian HUS network. Eur J Pediatr 175:465\u2013473. https:\/\/doi.org\/10.1007\/s00431-015-2642-1","journal-title":"Eur J Pediatr"},{"key":"4016_CR8","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s00467-020-04697-y","volume":"35","author":"G Ardissino","year":"2020","unstructured":"Ardissino G, Possenti I, Vignati C, Daprai L, Capone V, Brigotti M, Luini MV, Consonni D, Montini G (2020) Is Shigatoxin 1 protective for the development of Shigatoxin 2-related hemolytic uremic syndrome in children? Data from the ItalKid-HUS Network. Pediatr Nephrol 35:1997\u20132001. https:\/\/doi.org\/10.1007\/s00467-020-04697-y","journal-title":"Pediatr Nephrol"},{"key":"4016_CR9","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1542\/peds.2005-0785","volume":"117","author":"RS Oakes","year":"2006","unstructured":"Oakes RS, Siegler RL, McReynolds MA, Pysher T, Pavia AT (2006) Predictors of fatality in postdiarrheal hemolytic uremic syndrome. Pediatrics. 117:1656\u20131662. https:\/\/doi.org\/10.1542\/peds.2005-0785","journal-title":"Pediatrics."},{"key":"4016_CR10","doi-asserted-by":"publisher","first-page":"e20152153","DOI":"10.1542\/peds.2015-2153","volume":"137","author":"G Ardissino","year":"2016","unstructured":"Ardissino G, Tel F, Possenti I, Testa S, Consonni D, Paglialonga F, Salardi S, Borsa-Ghiringhelli N, Salice P, Tedeschi S, Castorina P, Colombo RM, Arghittu M, Daprai L, Monzani A, Tozzoli R, Brigotti M, Torresani E (2016) Early volume expansion and outcomes of hemolytic uremic syndrome. Pediatrics. 137:e20152153. https:\/\/doi.org\/10.1542\/peds.2015-2153","journal-title":"Pediatrics."},{"key":"4016_CR11","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00467-012-2158-0","volume":"27","author":"A Balestracci","year":"2012","unstructured":"Balestracci A, Martin SM, Toledo I, Alvarado C, Wainsztein RE (2012) Dehydration at admission increased the need for dialysis in hemolytic uremic syndrome children. Pediatr Nephrol 27:1407\u20131410. https:\/\/doi.org\/10.1007\/s00467-012-2158-0","journal-title":"Pediatr Nephrol"},{"key":"4016_CR12","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s00431-018-3198-7","volume":"177","author":"G Ardissino","year":"2018","unstructured":"Ardissino G, Tel F, Testa S et al (2018) A simple prognostic index for Shigatoxin-related hemolytic uremic syndrome at onset: data from the ItalKid-HUS network. Eur J Pediatr 177:1667\u20131674. https:\/\/doi.org\/10.1007\/s00431-018-3198-7","journal-title":"Eur J Pediatr"},{"key":"4016_CR13","doi-asserted-by":"publisher","unstructured":"Tarr PI, Gordon CA, Chandler WL (2005) Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet. https:\/\/doi.org\/10.1016\/S0140-6736(05)71144-2","DOI":"10.1016\/S0140-6736(05)71144-2"},{"issue":"8","key":"4016_CR14","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1093\/cid\/ciz432","volume":"70","author":"RS McKee","year":"2020","unstructured":"McKee RS, Schnadower D, Tarr PI, Xie J, Finkelstein Y, Desai N, Lane RD, Bergmann KR, Kaplan RL, Hariharan S, Cruz AT, Cohen DM, Dixon A, Ramgopal S, Rominger A, Powell EC, Kilgar J, Michelson KA, Beer D, Bitzan M, Pruitt CM, Yen K, Meckler GD, Plint AC, Bradin S, Abramo TJ, Gouin S, Kam AJ, Schuh A, Balamuth F, Hunley TE, Kanegaye JT, Jones NE, Avva U, Porter R, Fein DM, Louie JP, Freedman SB, Pediatric Emergency Medicine Collaborative Research Committee and Pediatric Emergency Research Canada (2020) Predicting hemolytic uremic syndrome and renal replacement therapy in Shiga Toxin\u2013producing Escherichia coli\u2013infected children. Clin Infect Dis 70(8):1643\u20131651. https:\/\/doi.org\/10.1093\/cid\/ciz432","journal-title":"Clin Infect Dis"},{"key":"4016_CR15","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1053\/j.ajkd.2014.01.434","volume":"64","author":"G Ardissino","year":"2014","unstructured":"Ardissino G, Testa S, Possenti I, Tel F, Paglialonga F, Salardi S, Tedeschi S, Belingheri M, Cugno M (2014) Discontinuation of eculizumab maintenance treatment for atypical hemolytic uremic syndrome: a report of 10 cases. Am J Kidney Dis 64:633\u2013637. https:\/\/doi.org\/10.1053\/j.ajkd.2014.01.434","journal-title":"Am J Kidney Dis"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-021-04016-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00431-021-04016-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-021-04016-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:04:54Z","timestamp":1616529894000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00431-021-04016-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":15,"alternative-id":["4016"],"URL":"https:\/\/doi.org\/10.1007\/s00431-021-04016-z","relation":{},"ISSN":["0340-6199","1432-1076"],"issn-type":[{"value":"0340-6199","type":"print"},{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]},"assertion":[{"value":"13 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for a retrospective study has been approved by local Ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent for publication was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}