{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:58:53Z","timestamp":1791874733737,"version":"4.3.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Late-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and iron deficiency. The aim of the study is to assess the positive effect of iron supplementation on psychomotor development in healthy LPT. We designed a randomized placebo-controlled double-blind trial dividing the newborns into two groups. Every patient was assessed using the Griffiths Mental Development Scales (GMDS)-II edition at 12-month post-conceptional age. The study was performed at the Neonatology Unit of our Hospital, in Italy. Sixty-six healthy LPT infants born between 34\n                    <jats:sup>0\u20447<\/jats:sup>\n                    and 36\n                    <jats:sup>6\u20447<\/jats:sup>\n                    \u00a0weeks of gestational age were enrolled in the study. One group received martial prophylaxis from the third week of life to 6\u00a0months of post-conceptional age (2\u00a0mg\/kg\/day of iron pidolate), the other received placebo. Fifty-two of the enrolled infants were assessed using the GMDS at 12-month of post-conceptional age. Statistical analysis of the mean scores of the Griffiths subscales was performed. There was a difference in the mean developmental quotient (DQ) (p\u2009&lt;\u20090.01) between the two groups: iron group mean DQ 121.45\u2009\u00b1\u200910.53 vs placebo group mean DQ 113.25\u2009\u00b1\u20099.70. Moreover, mean scores of the Griffiths subscales A, B, and D showed significant differences between the two groups (scale A p\u2009&lt;\u20090.05, scale B p\u2009&lt;\u20090.02, scale D p\u2009&lt;\u20090.01, respectively).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusions:<\/jats:italic>\n                    We recommend that all LPT neonates receive iron supplementation during the first 6\u00a0months of life in order to improve their 1-year neurodevelopmental quotient.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 Late-preterm infants (LPT) are at increased risk for long-term neurodevelopmental sequelae and also for iron deficiency.<\/jats:italic>\n                              <jats:italic>\u2022 Iron deficiency is an independent risk factor for adverse neurological outcomes.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 Healthy late-preterm who received iron supplementation during the first 6 months of life achieved better neurological outcomes at 12-month post-conceptional age than LPT who received placebo.<\/jats:italic>\n                              <jats:italic>\u2022 Our study strongly supports the need for the implementation of martial prophylaxis in LPT neonates.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-021-04181-1","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T18:02:31Z","timestamp":1626890551000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Neurological development and iron supplementation in healthy late-preterm neonates: a randomized double-blind controlled trial"],"prefix":"10.1007","volume":"181","author":[{"given":"R.","family":"Luciano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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