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Dr. Yousef and A\/Prof. De Luca have served as consultants and lecturers for Chiesi Pharmaceuticals. A\/Prof. De Luca has been a member of the advisory board for Chiesi Pharmaceuticals. A\/Prof. De Luca has received grants from and been an advisory board member of AbbVie and served as consultant and lecturer for Airway Therapeutics and AbbVie. These companies have had no role in the design, preparation, review, or approval of the manuscript or the decision to submit it for publication. Dr. Singh has served as a lecturer and received honorarium from AbbVie, Orphan Europe \/ Rorcordati Rare Diseases UK. He is Chair of Data and Safety Monitoring Board (DSMB) for a research project funded by GE. These companies have had no role in the design, preparation, review, or approval of the manuscript or the decision to submit it for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}