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Cross-sectional data were collected from 102 patients for a total of 344 visits. Standard growth charts for height and weight were used as reference, with age adjusted BMI calculated using the Center for Disease and Prevention Children\u2019s BMI Tool. In the 344 visits, weight ranged between 3.90 and 83\u00a0kg, and the BMI between 8.4 and 31.6 with a BMI\/age <jats:italic>z<\/jats:italic>-scores\u2009&lt;\u2009\u2009\u2212\u20092SD present in 28% and BMI\/age <jats:italic>z<\/jats:italic>-scores\u2009&gt;\u2009\u2009+\u20092SD in 9% of the measurements. The BMI\/age <jats:italic>z<\/jats:italic>-scores were relatively stable\u2009&lt;\u20095\u00a0years of age with an increasing number of patients\u2009&lt;\u2009\u2009\u2212\u20092SD after the age of 5, and a wider range of BMI\/age <jats:italic>z<\/jats:italic>-scores after the age of 13. A difference on the BMI\/age <jats:italic>z<\/jats:italic>-scores was found among the different age subgroups (&lt;\u20095, 5\u201312,\u2009\u2265\u200913\u00a0years). A multivariate analysis in 58 patients with longitudinal assessments showed that baseline BMI\/age <jats:italic>z<\/jats:italic>-scores and gender were significantly contributing to the changes while other variables were not.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Our results confirm that careful surveillance of weight and BMI\/age <jats:italic>z<\/jats:italic>-scores is needed in type 2 SMA. Further studies, including assessments of chewing and swallowing and of lean\/fat body mass, will help to better understand the possible mechanisms underlying weight issues.<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Feeding difficulties have been reported in a few studies and were invariably found in patients with type 1 SMA.<\/jats:italic><jats:italic>\u2022 Type 2 SMA patients often have low BMI with a relevant number of patients requiring tube feeding.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Reduction in BMI\/age z-score overtime appeared to depend on baseline BMI\/age z-score and gender.<\/jats:italic><jats:italic>\u2022 Patients with a low BMI\/age z-score were at higher risk of developing further reduction.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-021-04325-3","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T19:02:26Z","timestamp":1642618946000},"page":"1923-1932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body mass index in type 2 spinal muscular atrophy: a longitudinal 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