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Volume targeted ventilation (VTV) is a lung protective strategy but the optimal target tidal volume in CDH infants has not previously been studied. The aim of this study was to test the hypothesis that low targeted volumes would be better in CDH infants as determined by measuring the work of breathing (WOB) in CDH infants, at three different targeted tidal volumes. A randomised cross-over study was undertaken. Infants were eligible for inclusion in the study after surgical repair of their diaphragmatic defect. Targeted tidal volumes of 4, 5, and 6\u00a0ml\/kg were each delivered in random order for 20-min periods with 20-min periods of baseline ventilation between. WOB was assessed and measured by using the pressure\u2013time product of the diaphragm (PTPdi). Nine infants with a median gestational age at birth of 38\u2009+\u20094 (range 36\u2009+\u20094\u201340\u2009+\u20096) weeks and median birth weight 3202 (range 2855\u20133800) g were studied. The PTPdi was higher at 4\u00a0ml\/kg than at both 5, <jats:italic>p<\/jats:italic>\u2009=\u20090.008, and 6\u00a0ml\/kg, <jats:italic>p<\/jats:italic>\u2009=\u20090.012.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: VTV of 4\u00a0ml\/kg demonstrated an increased PTPdi compared to other VTV levels studied and should be avoided in post-surgical CDH infants.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Lung injury secondary to mechanical ventilation increases the mortality and morbidity of infants with CDH.<\/jats:italic><jats:italic>\u2022 Volume targeted ventilation (VTV) reduces \u2018volutrauma\u2019 and ventilator-induced lung injury in other neonatal intensive care populations.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 A randomised cross-over trial was carried out investigating the response to different VTV levels in infants with CDH.<\/jats:italic><jats:italic>\u2022 Despite pulmonary hypoplasia being a common finding in CDH, a VTV of 5ml\/kg significantly reduced the work of breathing in infants with CDH compared to a lower VTV level.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04413-y","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T18:02:33Z","timestamp":1647626553000},"page":"2453-2458","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Work of breathing at different tidal volume targets in newborn infants with congenital diaphragmatic hernia"],"prefix":"10.1007","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5310-3172","authenticated-orcid":false,"given":"Rebecca","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-193X","authenticated-orcid":false,"given":"Katie A.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6480-468X","authenticated-orcid":false,"given":"Emma E.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5258-5301","authenticated-orcid":false,"given":"Theodore","family":"Dassios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8672-5349","authenticated-orcid":false,"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,18]]},"reference":[{"key":"4413_CR1","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1016\/j.jpedsurg.2020.06.022","volume":"55","author":"M Paoletti","year":"2020","unstructured":"Paoletti M, Raffler G, Gaffi MS, Antounians L, Lauriti G, Zani A (2020) Prevalence and risk factors for congenital diaphragmatic hernia: a global view. 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