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The objective of this study is to expand and provide a detailed definition of the sensory profile of patients with PMS. The secondary objective was to examine the relationship between sensory patterns and adaptive behavior. A cross-sectional study was carried out among 51 Spanish patients with a confirmed genetic diagnosis of PMS. All the participants\u2019 parents completed the Short Sensory Profile-Spanish (SSP-S) and the <jats:italic>Adaptive Behavior Assessment System II<\/jats:italic> (ABAS-II). Correlational, multiple regression and hierarchical cluster analyses were performed. An atypical sensory profile was identified in almost 75% of PMS patients. Definite differences were found among scores; nonetheless, sub-threshold values were observed in tactile sensitivity, underresponsive\/seeks sensation, auditory filtering, and low energy\/weak sensory categories. Conceptual, social, and practical domains, as well as the General Adaptive Composite (GAC) of the ABAS-II showed extremely low scores (i.e., &lt;70). Significant correlations were found (<jats:italic>p<\/jats:italic>&lt;0.005) between SSP-S scores and the conceptual, social, practical, and GAC index of the ABAS-II, whereby higher SSP-S scores were associated with better skills and higher adaptive performance. The cluster analysis indicated that the group with the largest mutation size (7.23 Mb) showed the greatest sensory processing difficulties and very low adaptive skills.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: Patients with PMS show an atypical sensory profile, which correlates with limitations in general adaptive behaviors.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022\u00a0PMS sensory processing difficulties were associated with a pattern of underresponsive\/seeks sensation, low energy\/weak, and tactile\nhyporeactivity.<\/jats:italic><jats:italic>\u2022\u00a0Sensory processing difficulties have been associated with limitations in the development of appropriate adaptive communication and\ninteraction behaviors.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022\u00a0Sensory definite differences associated with tactile hyperreactivity, as well as significant effects of\u00a0<\/jats:italic><jats:italic>underresponsiveness\/seeks sensation and auditory filtering categories on the adaptive abilities were found in\u00a0<\/jats:italic><jats:italic>SHANK3<\/jats:italic><jats:sub><jats:italic>deletion<\/jats:italic><\/jats:sub><jats:italic>patients.<\/jats:italic><jats:italic>\u2022 Cluster analysis suggests that smaller mutation sizes were related to better sensory processing and higher adaptive skills, while patients with larger deletion sizes have greater adaptive difficulties and worse sensory processing skills.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04564-y","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T22:02:18Z","timestamp":1657922538000},"page":"3141-3152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sensory processing and adaptive behavior in Phelan-McDermid syndrome: a cross-sectional study"],"prefix":"10.1007","volume":"181","author":[{"given":"Sergio","family":"Serrada-Tejeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Luz","family":"Cuadrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9684-6876","authenticated-orcid":false,"given":"Rosa M\u00aa","family":"Mart\u00ednez-Pi\u00e9drola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"M\u00e1ximo-Bocanegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"S\u00e1nchez-Herrera-Baeza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda Roc\u00edo","family":"Camacho-Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"P\u00e9rez-de-Heredia-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,15]]},"reference":[{"issue":"7","key":"4564_CR1","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1080\/13854046.2017.1413211","volume":"32","author":"L Soorya","year":"2018","unstructured":"Soorya L, Leon J, Trelles MP, Thurm A (2018) Framework for assessing individuals with rare genetic disorders associated with profound intellectual and multiple disabilities (PIMD): the example of Phelan McDermid Syndrome. 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