{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T05:13:24Z","timestamp":1663996404602},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Alma Mater Studiorum - Universit\u00e0 di Bologna"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This observational study aimed to investigate whether predischarge cerebral oxygenation (CrSO<jats:sub>2<\/jats:sub>), monitored by near-infrared spectroscopy, correlates with later psychomotor outcome in very preterm infants. Infants &lt;32 weeks\u2019 gestation or &lt;1500 g without evidence of major brain lesions underwent a 3-h continuous CrSO<jats:sub>2<\/jats:sub> monitoring before hospital discharge. Psychomotor development was assessed at 6, 12, 18, and 24 months using the Griffiths Mental Developmental Scales. The developmental quotients (DQ) at each follow-up appointment were correlated with predischarge CrSO<jats:sub>2<\/jats:sub>. Significant correlations were adjusted for possible confounders. Sixty-three infants were enrolled. A significant correlation between CrSO<jats:sub>2<\/jats:sub> and DQ was observed at 6 months ca (<jats:italic>p<\/jats:italic>=0.010), but not at later psychomotor assessments. This correlation was confirmed significant (<jats:italic>b<\/jats:italic>=0.274, <jats:italic>p<\/jats:italic>=0.038) even after the adjustment for relevant covariates.<\/jats:p><jats:p><jats:italic>\u00a0 \u00a0Conclusion<\/jats:italic>: According to these preliminary findings, the association between predischarge CrSO<jats:sub>2<\/jats:sub> and psychomotor development over the first 24 months in preterm infants without major brain lesions is time-limited. Hence, this parameter may not represent an effective predictor for medium-term neurodevelopment.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022\u00a0Prematurity is a major risk factor for adverse neurodevelopment. <\/jats:italic><jats:italic>\u2022\u00a0The validation of clinical tools for psychomotor outcome prediction may aid to identify high-risk preterm infants who might benefit from early interventions.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022\u00a0In infants without major brain lesions, predischarge CrSO<\/jats:italic><jats:sub><jats:italic>2<\/jats:italic><\/jats:sub><jats:italic>correlates with psychomotor outcome at 6 months ca but not later, indicating a short time predictability.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04578-6","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T21:02:27Z","timestamp":1659646947000},"page":"3711-3714","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predischarge cerebral oxygenation and psychomotor outcome in very preterm infants: is there an association?"],"prefix":"10.1007","volume":"181","author":[{"given":"Silvia","family":"Martini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Savini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Sansavini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Corvaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"4578_CR1","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1542\/peds.2004-0221","volume":"115","author":"D Wilson-Costello","year":"2005","unstructured":"Wilson-Costello D, Friedman H, Minich N, Fanaroff AA, Hack M (2005) Improved survival rates with increased neurodevelopmental disability for extremely low birth weight infants in the 1990s. 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Am J Perinatol 33:1093\u20131098","journal-title":"Am J Perinatol"},{"key":"4578_CR4","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/dmcn.12622","volume":"57","author":"EA Verhagen","year":"2015","unstructured":"Verhagen EA, Van Braeckel KN, van der Veere CN, Groen H, Dijk PH, Hulzebos CV, Bos AF (2015) Cerebral oxygenation is associated with neurodevelopmental outcome of preterm children at age 2 to 3 years. Dev Med Child Neurol 57:449\u2013455","journal-title":"Dev Med Child Neurol"},{"key":"4578_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jpeds.2018.11.038","volume":"207","author":"T Alderliesten","year":"2019","unstructured":"Alderliesten T, van Bel F, van der Aa NE, Steendijk P, van Haastert IC, de Vries LS, Groenendaal F, Lemmers P (2019) Low cerebral oxygenation in preterm infants is associated with adverse neurodevelopmental outcome. 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Orsola-Malpighi Hospital, Bologna (Italy).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The consent for participation was obtained from the parents or legal guardians of the enrolled infants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}