{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:59:22Z","timestamp":1791489562573,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-022-04583-9","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T16:03:17Z","timestamp":1660838597000},"page":"3767-3774","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Neonatal Sequential Organ Failure Assessment as a late-onset sepsis mortality predictor in very low birth weight newborns: a Brazilian cohort study"],"prefix":"10.1007","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0186-0320","authenticated-orcid":false,"given":"B\u00e1rbara B. P.","family":"Lobo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2903-6915","authenticated-orcid":false,"given":"Sergio T. M.","family":"Marba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9800-2351","authenticated-orcid":false,"given":"Helymar C.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5292-2320","authenticated-orcid":false,"given":"Jamil P. S.","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"issue":"10104","key":"4583_CR1","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","volume":"390","author":"AL Shane","year":"2017","unstructured":"Shane AL, S\u00e1nchez PJ, Stoll BJ (2017) Neonatal sepsis. Lancet 390(10104):1770\u20131780. https:\/\/doi.org\/10.1016\/S0140-6736(17)31002-4","journal-title":"Lancet"},{"key":"4583_CR2","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00431-022-04554-0","volume":"201","author":"E Giannoni","year":"2018","unstructured":"Giannoni E, Agyeman PKA, Stocker M et al  (2018) Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: a prospective population-based cohort study. J Pediatr 201:106\u2013114. https:\/\/doi.org\/10.1007\/s00431-022-04554-0","journal-title":"J Pediatr"},{"issue":"2 Pt 1","key":"4583_CR3","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/peds.110.2.285","volume":"110","author":"BJ Stoll","year":"2002","unstructured":"Stoll BJ, Hansen N, Fanaroff AA et al  (2002) Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110(2 Pt 1):285\u2013291. https:\/\/doi.org\/10.1542\/peds.110.2.285","journal-title":"Pediatrics"},{"key":"4583_CR4","doi-asserted-by":"publisher","unstructured":"Barnette BW, Schumacher BT, Armenta RF, Wynn JL, Richardson A, Bradley JS, Lazar S, Lawrence SM (2021) Contribution of concurrent comorbidities to sepsis-related mortality in preterm infants \u2264 32 weeks of gestation at an academic neonatal intensive care network. Am J Perinatol. https:\/\/doi.org\/10.1055\/a-1675-2899. Epub ahead of print. PMID: 34674193.","DOI":"10.1055\/a-1675-2899"},{"issue":"8","key":"4583_CR5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW et al  (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 315(8):801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"issue":"7","key":"4583_CR6","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1055\/s-0036-1597130","volume":"34","author":"JL Wynn","year":"2017","unstructured":"Wynn JL, Kelly MS, Benjamin DK, Clark RH, Greenberg R, Benjamin DK Jr, Smith PB (2017) Timing of multiorgan dysfunction among hospitalized Infants with fatal fulminant sepsis. Am J Perinatol 34(7):633\u2013639. https:\/\/doi.org\/10.1055\/s-0036-1597130","journal-title":"Am J Perinatol"},{"key":"4583_CR7","doi-asserted-by":"publisher","unstructured":"Vincent JL, Moreno R, Takala J, Willatts S, De Mendon\u00e7a A, Bruining H, Reinhart CK, Suter PM, Thijs LG (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22(7):707-710. https:\/\/doi.org\/10.1007\/BF01709751.","DOI":"10.1007\/BF01709751"},{"issue":"1","key":"4583_CR8","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s13054-017-1609-1","volume":"21","author":"HJ De Grooth","year":"2017","unstructured":"De Grooth HJ, Geenen IL, Girbes AR, Vincent JL, Parienti JJ, Oudemans-van Straaten HM (2017) SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis. Crit Care 21(1):38. https:\/\/doi.org\/10.1186\/s13054-017-1609-1","journal-title":"Crit Care"},{"issue":"3","key":"4583_CR9","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1001\/jama.2016.20328","volume":"317","author":"Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, Pilcher DV, for the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE)","year":"2017","unstructured":"Raith EP, Udy AA, Bailey M, McGloughlin S, MacIsaac C, Bellomo R, Pilcher DV, for the Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE) (2017) Prognostic accuracy of the SOFA score, SIRS criteria, and qSOFA score for in-hospital mortality among adults with suspected infection admitted to the intensive care unit. JAMA 317(3):290\u2013300. https:\/\/doi.org\/10.1001\/jama.2016.20328","journal-title":"JAMA"},{"issue":"10","key":"4583_CR10","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2017.2352","volume":"171","author":"TJ Matics","year":"2017","unstructured":"Matics TJ, Sanchez-Pinto LN (2017) Adaptation and validation of a pediatric Sequential Organ Failure Assessment score and evaluation of the Sepsis-3 definitions in critically ill children. JAMA Pediatr 171(10):e172352. https:\/\/doi.org\/10.1001\/jamapediatrics.2017.2352","journal-title":"JAMA Pediatr"},{"issue":"2","key":"4583_CR11","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1055\/s-0040-1714705","volume":"10","author":"AV Lalitha","year":"2021","unstructured":"Lalitha AV, Satish JK, Reddy M, Ghosh S, George J, Pujari C (2021) Sequential Organ Failure Assessment (SOFA) score as a predictor of outcome in sepsis in pediatric intensive care unit. J Pediatr Intensive Care 10(2):110\u2013117. https:\/\/doi.org\/10.1055\/s-0040-1714705","journal-title":"J Pediatr Intensive Care"},{"key":"4583_CR12","doi-asserted-by":"publisher","unstructured":"Sun J, Li J, Wu D, Deng F (2021) Accuracy of SIRS, age-adapted pSOFA, and quick SOFA scoring systems for predicting outcomes in paediatric patients with sepsis: a meta-analysis. Pediatr Neonatol 24;S1875-9572(21)00222-9. https:\/\/doi.org\/10.1016\/j.pedneo.2021.09.006.","DOI":"10.1016\/j.pedneo.2021.09.006"},{"issue":"6","key":"4583_CR13","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/PCC.0000000000000157","volume":"15","author":"JL Wynn","year":"2014","unstructured":"Wynn JL, Wong HR, Shanley TP, Bizzarro MJ, Saiman L, Polin RA (2014) Time for a neonatal\u2013specific consensus definition for sepsis. Pediatr Crit Care Med 15(6):523\u2013528. https:\/\/doi.org\/10.1097\/PCC.0000000000000157","journal-title":"Pediatr Crit Care Med"},{"issue":"1","key":"4583_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41390-019-0517-2","volume":"88","author":"JL Wynn","year":"2020","unstructured":"Wynn JL, Polin RA (2020) A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants. Pediatr Res 88(1):85\u201390. https:\/\/doi.org\/10.1038\/s41390-019-0517-2","journal-title":"Pediatr Res"},{"issue":"2","key":"4583_CR15","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.36518","volume":"4","author":"N Fleiss","year":"2021","unstructured":"Fleiss N, Coggins SA, Lewis AN et al  (2021) Evaluation of the Neonatal Sequential Organ Failure Assessment and mortality risk in preterm infants with late-onset infection. JAMA Netw Open 4(2):e2036518. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.36518","journal-title":"JAMA Netw Open"},{"issue":"1\u20131","key":"4583_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/pr.2017.224","volume":"83","author":"JL Wynn","year":"2018","unstructured":"Wynn JL, Polin RA (2018) Progress in the management of neonatal sepsis: the importance of a consensus definition. Pediatr Res 83(1\u20131):13\u201315. https:\/\/doi.org\/10.1038\/pr.2017.224","journal-title":"Pediatr Res"},{"issue":"1","key":"4583_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1067\/mpd.2001.109608","volume":"138","author":"DK Richardson","year":"2001","unstructured":"Richardson DK, Corcoran JD, Escobar GJ, Lee SK (2001) SNAP-II and SNAPPE-II: Simplified newborn illness severity and mortality risk scores. J Pediatr 138(1):92\u2013100. https:\/\/doi.org\/10.1067\/mpd.2001.109608","journal-title":"J Pediatr"},{"key":"4583_CR18","doi-asserted-by":"publisher","unstructured":"Zeigler AC, Ainsworth JE, Fairchild KD, Wynn JL, Sullivan BA (2021) Sepsis and mortality prediction in very low birth weight infants: Analysis of HeRO and nSOFA. Am J Perinatol. https:\/\/doi.org\/10.1055\/s-0041-1728829. Epub ahead of print. PMID: 33971672; PMCID: PMC8578589.","DOI":"10.1055\/s-0041-1728829"},{"issue":"6","key":"4583_CR19","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/tropej\/fmu038","volume":"60","author":"Rugolo LMSS, Bentlin MR, Mussi-Pinhata M, De Almeida MFB, Lopes JMA, Marba STM, Fiori HH, Procianoy RS, Leone CR, for the Brazilian Network on Neonatal Research","year":"2014","unstructured":"Rugolo LMSS, Bentlin MR, Mussi-Pinhata M, De Almeida MFB, Lopes JMA, Marba STM, Fiori HH, Procianoy RS, Leone CR, for the Brazilian Network on Neonatal Research (2014) Late-onset sepsis in very low birth weight infants: A Brazilian Neonatal Research Network study. J Trop Pediatr 60(6):415\u2013421. https:\/\/doi.org\/10.1093\/tropej\/fmu038","journal-title":"J Trop Pediatr"},{"issue":"4","key":"4583_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0146-0005(03)00046-6","volume":"27","author":"BJ Stoll","year":"2003","unstructured":"Stoll BJ, Hansen N (2003) Infections in VLBW infants: studies from the NICHD neonatal research network. Semin Perinatol 27(4):293\u2013301. https:\/\/doi.org\/10.1016\/S0146-0005(03)00046-6","journal-title":"Semin Perinatol"},{"key":"4583_CR21","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-2431-5-22","volume":"5","author":"K Aziz","year":"2005","unstructured":"Aziz K, McMillan DD, Andrews W, Pendray M, Qiu Z, Karuri S, Lee SK, for the Canadian Neonatal Network, (2005) Variations in rates of nosocomial infection among Canadian neonatal intensive care units may be practice-related. BMC Pediatr 5:22. https:\/\/doi.org\/10.1186\/1471-2431-5-22","journal-title":"BMC Pediatr"},{"issue":"3","key":"4583_CR22","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1097\/INF.0000000000002976","volume":"40","author":"N K\u00f6stlin-Gille","year":"2021","unstructured":"K\u00f6stlin-Gille N, H\u00e4rtel C, Haug C, G\u00f6pel W, Zemlin M, M\u00fcller A, Poets CF, Herting E, Gille C (2021) Epidemiology of early and late onset neonatal sepsis in very low birthweight infants: Data From the German Neonatal Network. Pediatr Infect Dis J 40(3):255\u2013259. https:\/\/doi.org\/10.1097\/INF.0000000000002976","journal-title":"Pediatr Infect Dis J"},{"issue":"10","key":"4583_CR23","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1097\/INF.0000000000001958","volume":"37","author":"MJ Escalante","year":"2018","unstructured":"Escalante MJ, Ceriani-Cernadas JM, D\u2019Apremont I, Bancalari A, Webb V, Genes L, Villarroel L, Munoz E, Tapia JL, for the NEOCOSUR Neonatal Network, (2018) Late onset sepsis in very low birth weight infants in the South American NEOCOSUR Network. Pediatr Infect Dis J 37(10):1022\u20131027. https:\/\/doi.org\/10.1097\/INF.0000000000001958","journal-title":"Pediatr Infect Dis J"},{"key":"4583_CR24","doi-asserted-by":"publisher","unstructured":"Hossain S, Shah PS, Ye XY, Darlow BA, Lee SK, Lui K, Network Canadian Neonatal, Australian and New Zealand Neonatal Network (2015) Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada. J Paediatr Child Health 51(9):881\u2013888. https:\/\/doi.org\/10.1111\/jpc.12863","DOI":"10.1111\/jpc.12863"},{"issue":"1","key":"4583_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1542\/peds.109.1.34","volume":"109","author":"IR Makhoul","year":"2002","unstructured":"Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B (2002) Epidemiological, clinical, and microbiological characteristics of late-onset sepsis among very low birth weight infants in Israel: A national survey. Pediatrics 109(1):34\u201339. https:\/\/doi.org\/10.1542\/peds.109.1.34","journal-title":"Pediatrics"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04583-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-022-04583-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04583-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T14:21:40Z","timestamp":1663942900000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-022-04583-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":25,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["4583"],"URL":"https:\/\/doi.org\/10.1007\/s00431-022-04583-9","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,18]]},"assertion":[{"value":"8 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the State University of Campinas.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The informed consent was waived by the Institutional Review Board since this was a retrospective analysis of existing clinical data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The informed consent was waived by the Institutional Review Board since this was a retrospective analysis of existing clinical data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}