{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:54:16Z","timestamp":1791474856491,"version":"4.3.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009827","name":"Alexandria University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009827","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Unstable hemodynamics and prematurity are the main players in intraventricular hemorrhage (IVH) development. Our objective was to study 8 the use of superior vena cava flow (SVCF), left ventricular output (LVO), and right ventricular output (RVO), and anterior cerebral artery (ACA) Doppler measures in prediction of IVH in the first week of life in preterm infant\u2009\u2264\u200932\u00a0weeks and birth weight\u2009\u2264\u20091500\u00a0g. This\u00a0prospective cohort study was conducted\u00a0in 55NICU of Alexandria University\u00a0maternity hospital. Of 147 enrolled\u00a0patients, 132 infants born\u2009\u2264\u200932\u00a0weeks GA and birth weight\u2009\u2264\u20091500\u00a0g were\u00a0eligible for- the study. One hundred twenty-seven infants completed the study. Infants were scanned for ACA-RI using transfontanellar ultrasound, and SVCF, LVO, and RVO using functional echocardiography in the first 24\u00a0h after birth. Patients had another two scans on DOL3 and 7 to detect IVH development. Low SVCF and high ACA-RI significantly increased the risk of IVH using logistic regression models with OR, 3.16; 95%CI, 1.19\u20138.39; <jats:italic>P<\/jats:italic>\u2009=\u20090.02 and OR, 1.64; 95%Cl, 1.10\u20132.44; <jats:italic>P<\/jats:italic>\u2009=\u20090.02, respectively. Low SVCF and high ACA-RI significantly increased risk of catastrophic IVH <jats:italic>P<\/jats:italic>\u2009=\u20090.025 and 0.023, respectively. Combined use of low SVCF\u2009&lt;\u200955\u00a0ml\/kg\/min and ACA-RI\u2009&gt;\u20090.75 is predictor of IVH with sensitivity 40.8% and 82.1% specificity.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>: There are strong relations between both low SVCF and high ACA-RI, and IVH development in premature neonates\u2009\u2264\u200932\u00a0weeks and birth weight\u2009\u2264\u20091500\u00a0g, with more significance towards catastrophic IVH. Admission RSS and LVO are the strongest factors affecting SVCF. Maternal anemia, patent ductus arteriosus size (mm\/kg), and capillary refill time were significantly associated with high ACA-RI. These findings help in more understanding of pathophysiological factors affecting central perfusion that might affect the longer term neurodeveopmental outcome.<\/jats:p><jats:p><jats:italic>Trial registration<\/jats:italic>: This work was registered in clinical trial.gv no <jats:italic>NCT05050032<\/jats:italic>.<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022Whether SVCF and RI-ACA can predict IVH in preterm neonates is still debatable.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022Low SVC flow and high ACA-RI significantly increased risk of IVH, confirming the role of hypoperfusion-reperfusion cycle in IVH development. The most striking result that combined metrics using the cut-off value of &lt; 41 ml\/kg\/min for SVCF and &gt; 0.85 for ACA-RI \u201cin the first day of life\u201d can correctly reject the presence of IVH in 98% of patients \u201cduring the first week of life.\u201d<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04630-5","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T17:40:26Z","timestamp":1664386826000},"page":"4067-4077","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Intraventricular hemorrhage prediction in premature neonates in the era of hemodynamics monitoring: a prospective cohort study"],"prefix":"10.1007","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-9018","authenticated-orcid":false,"given":"Marwa Mohamed","family":"Farag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Hazem","family":"Gouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohamed Abd","family":"Almohsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-3333","authenticated-orcid":false,"given":"Mohammed Attia","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"issue":"11","key":"4630_CR1","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1007\/s00381-018-3897-4","volume":"34","author":"RH Han","year":"2018","unstructured":"Han RH, McKinnon A, CreveCoeur TS et al (2018) Predictors of mortality for preterm infants with intraventricular hemorrhage: a population-based study. 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