{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:49:13Z","timestamp":1792464553259,"version":"4.5.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To compare the incidence of respiratory symptoms and short-term consequences between children with Down syndrome and children from the general population, we conducted a prospective parent-reported observational study. Children with Down syndrome (\u2264\u200918\u00a0years) were included between March 2012 and June 2014. Caregivers received a baseline questionnaire with follow-up 1\u20132\u00a0years after inclusion. Caregivers received a weekly questionnaire about respiratory symptoms, fever, antibiotic prescriptions, doctor\u2019s visits, and consequences for school and work attendance. Children with Down syndrome were compared to a cohort of the general population (\u201cKind en Ziek\u201d study) with similar weekly questionnaires. A total of 9,011 childweeks were reported for 116 participants with Down syndrome (75% response rate). The frequency of respiratory symptoms was higher in children with Down syndrome than in children from the general population (30% vs 15.2%). In addition, symptoms subsided later (around 8 vs 5\u00a0years of age). The seasonal influence was limited, both in children with Down syndrome and children from the general population. Consequences of respiratory disease were significant in children with Down syndrome compared to children from the general population, with a higher rate of doctor\u2019s visits (21.3% vs 11.8%), antibiotic prescriptions (47.8% vs 26.3%), and absenteeism from school (55.5% vs 25.4%) and work (parents, 9.4% vs 8.1%).<\/jats:p><jats:p><jats:italic>\u00a0 Conclusion<\/jats:italic>: Children with Down syndrome have a higher frequency of respiratory symptoms and symptoms last until a later age, confirming the impression of professionals and caregivers. Individualized treatment plans might prevent unfavorable consequences of chronic recurrent respiratory disease in children with Down syndrome.<jats:table-wrap><jats:table><jats:tbody><jats:tr><jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Children with Down syndrome have an altered immune system and are prone to a more severe course of respiratory tract infections<\/jats:italic>.<jats:italic>\u2022 The overall conception is that patients with Down syndrome suffer from respiratory tract infections more often<\/jats:italic>.<\/jats:td><\/jats:tr><jats:tr><jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Children with Down syndrome suffer from respiratory symptoms more frequently than children from the general population<\/jats:italic>.<jats:italic>\u2022 The respiratory symptoms in children with Down syndrome subside at a later age compared to children from the general population<\/jats:italic>.<\/jats:td><\/jats:tr><\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04634-1","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T23:04:36Z","timestamp":1664838276000},"page":"4079-4089","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Increased rate of respiratory symptoms in children with Down syndrome: a 2-year web-based parent-reported prospective study"],"prefix":"10.1007","volume":"181","author":[{"given":"Noortje B.","family":"Eijsvoogel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruud H. 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