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Yet, the interpretation of exercise capacity is challenged by changes in body composition during growth. Our aim was to create an overview of disease-specific exercise capacity in children with CHD. We performed a multicentre retrospective study of exercise capacity of CHD patients, aged 6\u201318\u00a0years, tested between January 2001 and October 2018. Sex-specific distribution graphs were made using the LMS method and height to relate to body size. We included all CHD with <jats:italic>N<\/jats:italic>\u2009&gt;\u200950, including severe defects (e.g., univentricular heart, tetralogy of Fallot) and \u201csimple\u201d lesions as ventricular septum defect and atrial septum defect. We included 1383 tests of 1208 individual patients for analysis. The peak oxygen uptake (VO<jats:sub>2<\/jats:sub>peak, 37.3\u00a0ml\/min\/kg (25th\u201375th percentile 31.3\u201343.8)) varied between specific defects; patients with univentricular hearts had lower VO<jats:sub>2peak<\/jats:sub> compared with other CHD. All groups had lower VO<jats:sub>2peak<\/jats:sub> compared to healthy Dutch children. Males had higher VO<jats:sub>2peak<\/jats:sub>, W<jats:sub>peak<\/jats:sub> and O<jats:sub>2<\/jats:sub>pulse<jats:sub>peak<\/jats:sub> than females. Sex- and disease-specific distribution graphs for VO<jats:sub>2peak<\/jats:sub>, W<jats:sub>peak<\/jats:sub> and O2pulse<jats:sub>peak<\/jats:sub> showed increase in variation with increase in height.\u00a0<\/jats:p><jats:p>\u00a0 <jats:italic>Conclusion<\/jats:italic>: Disease-specific distribution graphs for exercise capacity in children with CHD from a large multicentre cohort demonstrated varying degrees of reduced VO<jats:sub>2peak<\/jats:sub> and W<jats:sub>peak<\/jats:sub>. The distribution graphs can be used in the structured follow-up of patients with CHD to predict outcome and identify patients at risk.<\/jats:p><jats:p><jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold>\u2022\u00a0<jats:italic>Children with congenital heart disease (COnHD) are at risk to develop heart failure, arrhytmia\u2019s and other complications. Exercise capacity may be an important predictor for outcome in children with ConHD. In children, the interpretation of exercise capacity poses an additional challenge related to physical changes during growth.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold>\u2022\u00a0<jats:italic>In this report of a multi-center cohort &gt;1300 childrewn with ConHD, we related the changes in exercise capacity to length. We demonstrated that exercise capacity was reduced as compared with healthy children and we observed variation between disease groups. Patients with a univentricular circulation (Fontan) had worse exercise capacity. We constructed disease specific charts of development of exercise capacity throughout childhood, accessible via a web-site. These graphs may help practitioner to guide children with ConHD.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-022-04648-9","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T06:02:31Z","timestamp":1667628151000},"page":"295-306","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Exercise capacity in a cohort of children with congenital heart disease"],"prefix":"10.1007","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7882-1162","authenticated-orcid":false,"given":"Wouter J.","family":"van Genuchten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem A.","family":"Helbing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend D. 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The Research Ethics Committee of the i) Erasmus Medical Centre\u2014Sophia Children\u2019s Hospital, ii) University Medical Centre Utrecht\u2014Wilhelmina Children\u2019s Hospital, iii) Leiden University Medical Centre\u2014Willem-Alexander Children\u2019s Hospital, and iv) Radboud University Medical Centre\u2014Amalia Children\u2019s Hospital have confirmed that no ethical approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Because of the retrospective nature of this study on existing data no informed consent was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Because of the retrospective nature of this study on existing data no informed consent was obtained.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}