{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:09:22Z","timestamp":1782511762291,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Clinical Research Project of Children\u2019s Hospital of Chongqing Medical University","award":["YBXM 2019-007"],"award-info":[{"award-number":["YBXM 2019-007"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-022-04668-5","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T03:36:33Z","timestamp":1666841793000},"page":"245-254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of antibiotic stewardship among near-term and term infants admitted to a neonatal unit"],"prefix":"10.1007","volume":"182","author":[{"given":"Kun","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"4668_CR1","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1055\/s-0033-1361933","volume":"31","author":"EM Hsieh","year":"2014","unstructured":"Hsieh EM, Hornik CP, Clark RH, Laughon MM, Benjamin DK Jr, Smith BP (2014) Medication use in the neonatal intensive care unit. Am J Perinatol 31:811\u2013821. https:\/\/doi.org\/10.1055\/s-0033-1361933","journal-title":"Am J Perinatol"},{"key":"4668_CR2","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1542\/peds.2005-1707","volume":"117","author":"RH Clark","year":"2006","unstructured":"Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: data from a large national data set. Pediatrics 117:1979\u20131987. https:\/\/doi.org\/10.1542\/peds.2005-1707","journal-title":"Pediatrics"},{"key":"4668_CR3","doi-asserted-by":"publisher","first-page":"F293","DOI":"10.1136\/archdischild-2018-315024","volume":"104","author":"D Gkentzi","year":"2019","unstructured":"Gkentzi D, Kortsalioudaki C, Cailes BC, Zaoutis T, Kopsidas J, Tsolia M, Spyridis N, Siahanidou S, Sarafidis K, Heath PT et al (2019) Epidemiology of infections and antimicrobial use in Greek neonatal units. Arch Child Fetal Neonatal Ed 104:F293\u2013F297. https:\/\/doi.org\/10.1136\/archdischild-2018-315024","journal-title":"Arch Child Fetal Neonatal Ed"},{"key":"4668_CR4","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1001\/jamapediatrics.2016.2132","volume":"170","author":"JY Ting","year":"2016","unstructured":"Ting JY, Synnes A, Roberts A, Deshpandey A, Dow K, Yoon EW, Lee KS, Dobson S, Lee SK, Shah PS et al (2016) Association between antibiotic use and neonatal mortality and morbidities in very low-birth-weight infants without culture-proven sepsis or necrotizing enterocolitis. JAMA Pediatr 170:1181\u20131187. https:\/\/doi.org\/10.1001\/jamapediatrics.2016.2132","journal-title":"JAMA Pediatr"},{"key":"4668_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1542\/peds.2007-3423","volume":"123","author":"Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, S\u00e1nchez PJ, Ambalavanan N, Benjamin Jr DK, NICHD Neonatal Research Network","year":"2009","unstructured":"Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, S\u00e1nchez PJ, Ambalavanan N, Benjamin Jr DK, NICHD Neonatal Research Network (2009) Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics 123:58\u201366. https:\/\/doi.org\/10.1542\/peds.2007-3423","journal-title":"Pediatrics"},{"key":"4668_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1542\/peds.2005-2677","volume":"118","author":"CM Cotten","year":"2006","unstructured":"Cotten CM, McDonald S, Stoll B, Goldberg RN, Poole K, Benjamin DK Jr (2006) The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics 118:717\u2013722. https:\/\/doi.org\/10.1542\/peds.2005-2677","journal-title":"Pediatrics"},{"key":"4668_CR7","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1055\/s-0034-1373844","volume":"32","author":"A Novitsky","year":"2015","unstructured":"Novitsky A, Tuttle D, Locke RG, Saiman L, Mackley A, Paul DA (2015) Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants. Am J Perinatol 32:43\u201348. https:\/\/doi.org\/10.1055\/s-0034-1373844","journal-title":"Am J Perinatol"},{"key":"4668_CR8","doi-asserted-by":"publisher","first-page":"e225","DOI":"10.1542\/peds.2006-0896","volume":"119","author":"I Kummeling","year":"2007","unstructured":"Kummeling I, Stelma FF, Dagnelie PC, Snijders BEP, Penders J, Huber M, van Ree R, van den Brandt PA, Thijs C (2007) Early life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort Study. Pediatrics 119:e225-231. https:\/\/doi.org\/10.1542\/peds.2006-0896","journal-title":"Pediatrics"},{"key":"4668_CR9","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1001\/jama.2016.2395","volume":"315","author":"JS Gerber","year":"2016","unstructured":"Gerber JS, Bryan M, Ross RK, Daymont C, Parks EP, Localio AR, Grundmeier RW, Stallings VA, Zaoutis TE (2016) Antibiotic exposure during the first 6 months of life and weight gain during childhood. JAMA 315:1258\u20131265. https:\/\/doi.org\/10.1001\/jama.2016.2395","journal-title":"JAMA"},{"key":"4668_CR10","unstructured":"The President\u2019s Council of Advisors on Science and Technology (2014) Report to the president on combating antibiotic resistance. https:\/\/www.cdc.gov\/drugresistance\/pdf\/report-to-the-president-on-combating-antibiotic-resistance.pdf. Accessed 16 Apr 2021"},{"key":"4668_CR11","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1093\/cid\/ciw118","volume":"62","author":"TF Barlam","year":"2016","unstructured":"Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO et al (2016) Implementing an antibiotic stewardship program: guidelines by the infectious diseases society of america and the society for healthcare epidemiology of America. Clin Infect Dis 62:e51-77. https:\/\/doi.org\/10.1093\/cid\/ciw118","journal-title":"Clin Infect Dis"},{"key":"4668_CR12","unstructured":"World Health Organization (2015) Global action plan on antimicrobial resistance. http:\/\/www.who.int\/antimicrobial-resistance\/publications\/global-action-plan\/en\/. Accessed 16 Apr 2021"},{"key":"4668_CR13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001556","volume":"10","author":"Y Xiao","year":"2013","unstructured":"Xiao Y, Zhang J, Zheng B, Zhao L, Li S, Li L (2013) Changes in Chinese policies to promote the rational use of antibiotics. PLoS Med 10:e1001556. https:\/\/doi.org\/10.1371\/journal.pmed.1001556","journal-title":"PLoS Med"},{"key":"4668_CR14","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1093\/cid\/cix590","volume":"65","author":"N Ouldali","year":"2017","unstructured":"Ouldali N, Bell\u00eattre X, Milcent K, Guedj R, de Pontual L, Cojocaru B, Soussan-Banini V, Craiu I, Skurnik D, Gajdos V et al (2017) Impact of implementing national guidelines on antibiotic prescriptions for acute respiratory tract infections in pediatric emergency departments: an interrupted time series analysis. Clin Infect Dis 65:1469\u20131476. https:\/\/doi.org\/10.1093\/cid\/cix590","journal-title":"Clin Infect Dis"},{"key":"4668_CR15","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.1111\/apa.14337","volume":"107","author":"KN McCarthy","year":"2018","unstructured":"McCarthy KN, Hawke A, Dempsey EM (2018) Antimicrobial stewardship in the neonatal unit reduces antibiotic exposure. Acta Paediatr 107:1716\u20131721. https:\/\/doi.org\/10.1111\/apa.14337","journal-title":"Acta Paediatr"},{"key":"4668_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa962","author":"H Li","year":"2020","unstructured":"Li H, Gong Y, Han J, Zhang S, Chen S, Xu X, Lu Z, Yin X (2020) Interrupted time-series analysis to evaluate the impact of a national antimicrobial stewardship campaign on antibiotic prescribing: a typical practice in China\u2019s primary care. Clin Infect Dis. https:\/\/doi.org\/10.1093\/cid\/ciaa962","journal-title":"Clin Infect Dis"},{"key":"4668_CR17","first-page":"321","volume":"14","author":"P Fu","year":"2019","unstructured":"Fu P, Wang C, Yu H, Xu H, Jing C, Deng J, Zhao R, Hua C, Chen Y, Chen X et al (2019) Antimicrobial resistance profile of clinical isolates in pediatric hospitals in China: report from the ISPED Surveillance Program, 2018. Chin J Evid Based Pediatr 14:321\u2013326 (Chinese)","journal-title":"Chin J Evid Based Pediatr"},{"key":"4668_CR18","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3760\/cma.j.issn.0578-1310.2003.12.106.Chinese","volume":"41","author":"The Subspecialty Group of Neonatology, the Society of Pediatric, Chinese Medical Association, The Editorial Board of Chinese Journal of Pediatrics","year":"2003","unstructured":"The Subspecialty Group of Neonatology, the Society of Pediatric, Chinese Medical Association, The Editorial Board of Chinese Journal of Pediatrics (2003) Protocol for diagnosis and treatment of neonatal septicemia. Chin J Pediatr 41:897\u2013899. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1310.2003.12.106.Chinese","journal-title":"Chin J Pediatr"},{"key":"4668_CR19","volume-title":"Practice of Neonatology","author":"X Shao","year":"2010","unstructured":"Shao X, Ye H, Qiu X (2010) Practice of Neonatology, 4th edn. People\u2019s Medical Publishing House, Beijing (Chinese)","edition":"4"},{"key":"4668_CR20","first-page":"12","volume":"22","author":"Y He","year":"2020","unstructured":"He Y, Chen F, Zhang Y, Xiang L, Liu Y, Hua Z (2020) C-reactive protein-guided antibiotic treatment strategy for neonates with suspected early-onset sepsis. Chin J Contemp Pediatr 22:12\u201316 (Chinese)","journal-title":"Chin J Contemp Pediatr"},{"key":"4668_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000241296","volume":"97","author":"M Stocker","year":"2010","unstructured":"Stocker M, Fontana M, El Helou S, Wegscheider K, Berger TM (2010) Use of procalcitonin-guided decision-making to shorten antibiotic therapy in suspected neonatal early-onset sepsis: prospective randomized intervention trial. Neonatology 97:165\u2013174. https:\/\/doi.org\/10.1159\/000241296","journal-title":"Neonatology"},{"key":"4668_CR22","doi-asserted-by":"publisher","first-page":"e482","DOI":"10.1542\/peds.2015-0737","volume":"136","author":"T Ho","year":"2015","unstructured":"Ho T, Dukhovny D, Zupancic JAF, Goldmann DA, Horbar JD, Pursley DM (2015) Choosing wisely in newborn medicine: five opportunities to increase value. Pediatrics 136:e482-489. https:\/\/doi.org\/10.1542\/peds.2015-0737","journal-title":"Pediatrics"},{"key":"4668_CR23","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/S1473-3099(16)30205-5","volume":"16","author":"JB Cantey","year":"2016","unstructured":"Cantey JB, Wozniak PS, Pruszynski JE, S\u00e1nchez PJ (2016) Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study. Lancet Infect Dis 16:1178\u20131184. https:\/\/doi.org\/10.1016\/S1473-3099(16)30205-5","journal-title":"Lancet Infect Dis"},{"key":"4668_CR24","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3760\/cma.j.issn.0578-1310.2019.04.005.Chinese","volume":"57","author":"The Subspecialty Group of Neonatology, the Society of Pediatric, Professional Committee of Infectious Diseases, Neonatology Society","year":"2019","unstructured":"The Subspecialty Group of Neonatology, the Society of Pediatric, Professional Committee of Infectious Diseases, Neonatology Society (2019) Expert consensus on the diagnosis and management of neonatal sepsis (version 2019). Chin J Pediatr 57:252\u2013257. https:\/\/doi.org\/10.3760\/cma.j.issn.0578-1310.2019.04.005.Chinese","journal-title":"Chin J Pediatr"},{"key":"4668_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.idc.2014.01.006","volume":"28","author":"OM Ibrahim","year":"2014","unstructured":"Ibrahim OM, Polk RE (2014) Antimicrobial use metrics and benchmarking to improve stewardship outcomes: methodology, opportunities, and challenges. Infect Clin North Am 28:195\u2013214. https:\/\/doi.org\/10.1016\/j.idc.2014.01.006","journal-title":"Infect Clin North Am"},{"key":"4668_CR26","first-page":"796","volume":"18","author":"X Liu","year":"2016","unstructured":"Liu X, Yang J, Chen X, Hua Z (2016) Effects of antibiotic stewardship on neonatal bloodstream infections. Chin J Contemp Pediatr 18:796\u2013801 (Chinese)","journal-title":"Chin J Contemp Pediatr"},{"key":"4668_CR27","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/S0140-6736(17)31444-7","volume":"390","author":"M Stocker","year":"2017","unstructured":"Stocker M, van Herk W, El Helou S, Dutta S, Fontana MS, Schuerman FABA, van den Tooren-de Groot RK, Wieringa JW, Janota J, van der Meer-Kappelle LH et al (2017) Procalcitonin-guided decision making for duration of antibiotic therapy in neonates with suspected early-onset sepsis: a multicentre, randomised controlled trial (NeoPIns). Lancet 390:871\u2013881. https:\/\/doi.org\/10.1016\/S0140-6736(17)31444-7","journal-title":"Lancet"},{"key":"4668_CR28","volume-title":"Antibiotics for early-onset neonatal infection: antibiotics for the prevention and treatment of early-onset neonatal infection","author":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK)","year":"2012","unstructured":"National Collaborating Centre for Women\u2019s and Children\u2019s Health (UK) (2012) Antibiotics for early-onset neonatal infection: antibiotics for the prevention and treatment of early-onset neonatal infection. RCOG Press, London"},{"key":"4668_CR29","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/INF.0000000000000542","volume":"34","author":"JB Cantey","year":"2015","unstructured":"Cantey JB, Wozniak PS, S\u00e1nchez PJ (2015) Prospective surveillance of antibiotic use in the neonatal intensive care unit: results from the SCOUT study. Pediatr Infect J 34:267\u2013272. https:\/\/doi.org\/10.1097\/INF.0000000000000542","journal-title":"Pediatr Infect J"},{"key":"4668_CR30","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1542\/peds.105.3.523","volume":"105","author":"JA Garcia-Prats","year":"2000","unstructured":"Garcia-Prats JA, Cooper TR, Schneider VF, Stager CE, Hansen TN (2000) Rapid detection of microorganisms in blood cultures of newborn infants utilizing an automated blood culture system. Pediatrics 105:523\u2013527. https:\/\/doi.org\/10.1542\/peds.105.3.523","journal-title":"Pediatrics"},{"key":"4668_CR31","doi-asserted-by":"publisher","first-page":"F244","DOI":"10.1136\/archdischild-2016-310905","volume":"102","author":"D Carr","year":"2017","unstructured":"Carr D, Barnes EH, Gordon A, Isaacs D (2017) Effect of antibiotic use on antimicrobial antibiotic resistance and late-onset neonatal infections over 25 years in an Australian tertiary neonatal unit. Arch Child Fetal Neonatal Ed 102:F244\u2013F250. https:\/\/doi.org\/10.1136\/archdischild-2016-310905","journal-title":"Arch Child Fetal Neonatal Ed"},{"key":"4668_CR32","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1097\/CCM.0000000000003463","volume":"47","author":"C Lu","year":"2019","unstructured":"Lu C, Liu Q, Yuan H, Wang L (2019) Implementation of the smart use of antibiotics program to reduce unnecessary antibiotic use in a neonatal icu: a prospective interrupted time-series study in a developing country. Crit Care Med 47:e1\u2013e7. https:\/\/doi.org\/10.1097\/CCM.0000000000003463","journal-title":"Crit Care Med"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04668-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-022-04668-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04668-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T15:16:14Z","timestamp":1673622974000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-022-04668-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["4668"],"URL":"https:\/\/doi.org\/10.1007\/s00431-022-04668-5","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"26 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board of CHCMU approved the study (Approval No. 2020\u2013197-1) with a waiver of informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Patient consent was not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}