{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:38:15Z","timestamp":1790401095101,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007195","name":"Universit\u00e0 degli Studi di Napoli Federico II","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The resurgence of syphilis and subsequent risk for newborns has been described worldwide; however, European data on this congenital infection is lacking. We report the activity of a multidisciplinary specialized unit assisting a large area in the Southern Italy. A retrospective cohort study has been conducted at the Perinatal and Pediatric Infectious Diseases Units of the Federico II University of Naples, enrolling all newborns and children referred from January 2010 to June 2022 exposed to\n                    <jats:italic>Treponema pallidum<\/jats:italic>\n                    in utero and\/or congenitally infected. A total of 323 patients were included in the analysis. Twenty (6.2%) received a diagnosis of confirmed congenital syphilis (CS) and one died. Fifteen CS cases had typical clinical features. Since 2017, the number of referred neonates tripled while the rate of late maternal diagnoses did not significantly differ. When compared with mothers of exposed infants, mothers of CS cases were younger (25\u2009\u00b1\u20097.2 vs 29.9\u2009\u00b1\u20096\u00a0years,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009\n                    <jats:italic>0.041<\/jats:italic>\n                    ), had less previous pregnancies (0.64 vs 1.11,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009\n                    <jats:italic>0.044<\/jats:italic>\n                    ), and received a diagnosis of syphilis at a later stage of pregnancy (86% vs 20%, from third trimester or later on;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Appropriate maternal therapy was protective against vertical transmission (\u2212\u20091.2;\u2009\u2212\u20091.4,\u2009\u2212\u20091 95% CI;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Paternal syphilis status was known in 36% of cases.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : CS has still a significant impact. Prevention should be implemented towards specific maternal risk profiles. A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022\u00a0The resurgence of syphilis and subsequent risk for newborns has been described worldwide.<\/jats:italic>\n                              <jats:italic>\u2022 European data on this congenital infection is lacking.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022\u00a0Congenital syphilis has a significant impact still in Europe\u00a0and prevention should be implemented towards specific maternal risk profiles.\u00a0<\/jats:italic>\n                              <jats:italic>\u2022 A specialized unit is the preferable model to improve surveillance and healthcare for this neglected population.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-022-04703-5","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T17:07:57Z","timestamp":1668445677000},"page":"41-51","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Congenital syphilis in the twenty-first century: an area-based study"],"prefix":"10.1007","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6014-9374","authenticated-orcid":false,"given":"Serena","family":"Salom\u00e8","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Donata","family":"Cambriglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Maria","family":"Scarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Betts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pacella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Sansone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Letizia","family":"Mazzarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lo Vecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giusy","family":"Ranucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremia Zito","family":"Marinosci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Capasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"issue":"5","key":"4703_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/bdra.23562","volume":"109","author":"ME Tsimis","year":"2017","unstructured":"Tsimis ME, Sheffield JS (2017) Update on syphilis and pregnancy. Birth Defects Res 109(5):347\u2013352. https:\/\/doi.org\/10.1002\/bdra.23562","journal-title":"Birth Defects Research"},{"key":"4703_CR2","doi-asserted-by":"publisher","unstructured":"Committee on Infectious Diseases AA of P, Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH (2021) Red Book: 2021\u20132024 Report of the Committee on Infectious\u00a0Diseases. https:\/\/doi.org\/10.1542\/9781610025782","DOI":"10.1542\/9781610025782"},{"key":"4703_CR3","doi-asserted-by":"publisher","unstructured":"Schlueter A, Doshi U, Garg B, Hersh AR, Caughey AB (2021) Adverse pregnancy outcomes associated with maternal syphilis infection. 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