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The study protocol was approved by at least one ethical review board in every country (Coordinating Center Research Ethics Committee reference: 11\/LO\/1982). Written informed consent was obtained from parents or legal guardians. In the Swiss study, consent was obtained for collection of research blood, but waiver of consent for collection of anonymized epidemiological data was approved.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The funders were not involved in the design of the study, collection, analysis, interpretation of data or in writing the manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}