{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:04:30Z","timestamp":1791497070853,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-022-04758-4","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T04:21:19Z","timestamp":1671682879000},"page":"1029-1038","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dopamine or norepinephrine for sepsis-related hypotension in preterm infants: a retrospective cohort study"],"prefix":"10.1007","volume":"182","author":[{"given":"Sagee","family":"Nissimov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Joye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Kharrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Ripstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Baczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonny","family":"Jasani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Y.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany E.","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,22]]},"reference":[{"key":"4758_CR1","unstructured":"Greenberg RG, Kandefer S, Do BT et al (2017) Late-onset sepsis in extremely premature infants: 2000\u20132011"},{"key":"4758_CR2","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1542\/PEDS.110.2.285","volume":"110","author":"BJ Stoll","year":"2002","unstructured":"Stoll BJ, Hansen N, Fanaroff AA et al (2002) Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110:285\u2013291. https:\/\/doi.org\/10.1542\/PEDS.110.2.285","journal-title":"Pediatrics"},{"key":"4758_CR3","doi-asserted-by":"publisher","first-page":"2036518","DOI":"10.1001\/jamanetworkopen.2020.36518","volume":"4","author":"N Fleiss","year":"2021","unstructured":"Fleiss N, Coggins SA, Lewis AN et al (2021) Evaluation of the neonatal sequential organ failure assessment and mortality risk in preterm infants with late-onset infection. JAMA Netw Open 4:2036518. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.36518","journal-title":"JAMA Netw Open"},{"key":"4758_CR4","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1097\/INF.0000000000003320","volume":"41","author":"FC Fitzgerald","year":"2022","unstructured":"Fitzgerald FC, Zingg W, Chimhini G et al (2022) The impact of interventions to prevent neonatal healthcare-associated infections in low- and middle-income countries: a systematic review. Pediatr Infect Dis J 41:S26\u2013S35. https:\/\/doi.org\/10.1097\/INF.0000000000003320","journal-title":"Pediatr Infect Dis J"},{"key":"4758_CR5","doi-asserted-by":"publisher","unstructured":"Lamba V, D\u2019souza S, Carafa C et al (2020) Standardizing the approach to late onset sepsis in neonates through antimicrobial stewardship: a quality improvement initiative. J Perinatol\u00a040:9 40:1433\u20131440. https:\/\/doi.org\/10.1038\/s41372-019-0577-5","DOI":"10.1038\/s41372-019-0577-5"},{"key":"4758_CR6","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1055\/S-0036-1597130","volume":"34","author":"JL Wynn","year":"2017","unstructured":"Wynn JL, Kelly MS, Clark RH et al (2017) Timing of multiorgan dysfunction among hospitalized infants with fatal fulminant sepsis. Am J Perinatol 34:633\u2013639. https:\/\/doi.org\/10.1055\/S-0036-1597130","journal-title":"Am J Perinatol"},{"key":"4758_CR7","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1111\/JPC.15606","volume":"57","author":"S Gorantiwar","year":"2021","unstructured":"Gorantiwar S, de Waal K (2021) Progression from sepsis to septic shock and time to treatments in preterm infants with late-onset sepsis. 57:1905\u20131911. https:\/\/doi.org\/10.1111\/JPC.15606","journal-title":"Progression from sepsis to septic shock and time to treatments in preterm infants with late-onset sepsis"},{"key":"4758_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/FPED.2018.00088\/FULL","volume":"6","author":"AA Garvey","year":"2018","unstructured":"Garvey AA, Kooi EMW, Dempsey EM (2018) Inotropes for preterm infants: 50 years on are we any wiser? Front Pediatr 6:88. https:\/\/doi.org\/10.3389\/FPED.2018.00088\/FULL","journal-title":"Front Pediatr"},{"key":"4758_CR9","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1097\/PCC.0000000000000898","volume":"17","author":"ML Burns","year":"2016","unstructured":"Burns ML, Stensvold HJ, Risnes K et al (2016) Inotropic therapy in newborns, a population-based national registry study. Pediatr Crit Care Med 17:948\u2013956. https:\/\/doi.org\/10.1097\/PCC.0000000000000898","journal-title":"PediatrCrit Care Med"},{"key":"4758_CR10","doi-asserted-by":"publisher","first-page":"e52","DOI":"10.1097\/PCC.0000000000002198","volume":"21","author":"SL Weiss","year":"2020","unstructured":"Weiss SL, Peters MJ, Alhazzani W et al (2020) Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med 21:e52\u2013e106. https:\/\/doi.org\/10.1097\/PCC.0000000000002198","journal-title":"Pediatr Crit Care Med"},{"key":"4758_CR11","doi-asserted-by":"publisher","first-page":"E1063","DOI":"10.1097\/CCM.0000000000005337","volume":"49","author":"L Evans","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W et al (2021) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med 49:E1063\u2013E1143. https:\/\/doi.org\/10.1097\/CCM.0000000000005337","journal-title":"Crit Care Med"},{"key":"4758_CR12","first-page":"408","volume":"107","author":"MY Rizk","year":"2018","unstructured":"Rizk MY, Lapointe A, Lefebvre F, Barrington KJK (2018) Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock. 107:408\u2013413","journal-title":"Norepinephrine infusion improves haemodynamics in the preterm infants during septic shock"},{"key":"4758_CR13","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s00431-016-2794-7","volume":"175","author":"K Rowcliff","year":"2016","unstructured":"Rowcliff K, de Waal K, Mohamed A-L, Chaudhari T (2016) Noradrenaline in preterm infants with cardiovascular compromise. Eur J Pediatr 175:1967\u20131973. https:\/\/doi.org\/10.1007\/s00431-016-2794-7","journal-title":"Eur J Pediatr"},{"key":"4758_CR14","doi-asserted-by":"publisher","unstructured":"Walsh MC, Kliegman RM (1986) Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 33 179 201.\u00a0https:\/\/doi.org\/10.1016\/S0031-3955(16)34975-6","DOI":"10.1016\/S0031-3955(16)34975-6"},{"key":"4758_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMOA043927","volume":"353","author":"KP Van Meurs","year":"2005","unstructured":"Van Meurs KP, Wright LL, Ehrenkranz RA et al (2005) Inhaled nitric oxide for premature infants with severe respiratory failure. 353:13\u201322. https:\/\/doi.org\/10.1056\/NEJMOA043927","journal-title":"Inhaled nitric oxide for premature infants with severe respiratory failure"},{"key":"4758_CR16","doi-asserted-by":"publisher","unstructured":"Dilli D, Soylu H, Tekin N (2018) Neonatal hemodynamics and management of hypotension in newborns. Turk Arch Pediatr\/T\u00fcrk Pediatri Ar\u015fivi 53:S65. https:\/\/doi.org\/10.5152\/TURKPEDIATRIARS.2018.01801","DOI":"10.5152\/TURKPEDIATRIARS.2018.01801"},{"key":"4758_CR17","first-page":"1335","volume":"177","author":"K Baske","year":"2018","unstructured":"Baske K, Saini SS, Dutta S, Sundaram V (2018) Epinephrine versus dopamine in neonatal septic shock: a double-blind randomized controlled trial. 177:1335\u20131342","journal-title":"Epinephrine versus dopamine in neonatal septic shock: a double-blind randomized controlled trial"},{"key":"4758_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1067\/MPD.2002.120834","volume":"140","author":"D Osborn","year":"2002","unstructured":"Osborn D, Evans N, Kluckow M (2002) Randomized trial of dobutamine versus dopamine in preterm infants with low systemic blood flow. J Pediatr 140:183\u2013191. https:\/\/doi.org\/10.1067\/MPD.2002.120834","journal-title":"J Pediatr"},{"key":"4758_CR19","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1002\/SIM.6607","volume":"34","author":"PC Austin","year":"2015","unstructured":"Austin PC, Stuart EA (2015) Moving towards best practice when using inverse probability of treatment weighting (IPTW) using the propensity score to estimate causal treatment effects in observational studies. Stat Med 34:3661\u20133679. https:\/\/doi.org\/10.1002\/SIM.6607","journal-title":"Stat Med"},{"key":"4758_CR20","doi-asserted-by":"publisher","unstructured":"Waal de K, Evans N (2010) Hemodynamics in preterm infants with late-onset sepsis. J Pediatr 156.\u00a0https:\/\/doi.org\/10.1016\/j.jpeds.2009.12.026","DOI":"10.1016\/j.jpeds.2009.12.026"},{"key":"4758_CR21","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/PCC.0000000000000115","volume":"15","author":"SS Saini","year":"2014","unstructured":"Saini SS, Kumar P, Kumar RM (2014) Hemodynamic changes in preterm neonates with septic shock: a prospective observational study*. PediatrCrit Care Med 15:443\u2013450. https:\/\/doi.org\/10.1097\/PCC.0000000000000115","journal-title":"PediatrCrit Care Med"},{"key":"4758_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/CC4917\/FIGURES\/2","volume":"10","author":"S Meyer","year":"2006","unstructured":"Meyer S, Gottschling S, Baghai A et al (2006) Arginine-vasopressin in catecholamine-refractory septic versus non-septic shock in extremely low birth weight infants with acute renal injury. Crit Care 10:1\u20136. https:\/\/doi.org\/10.1186\/CC4917\/FIGURES\/2","journal-title":"Crit Care"},{"key":"4758_CR23","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.clp.2010.04.002","volume":"37","author":"JL Wynn","year":"2010","unstructured":"Wynn JL, Wong HR (2010) Pathophysiology and treatment of septic shock in neonates. Clin Perinatol 37:439\u2013479","journal-title":"Clin Perinatol"},{"key":"4758_CR24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129305","volume":"10","author":"T Avni","year":"2015","unstructured":"Avni T, Lador A, Lev S et al (2015) Vasopressors for the treatment of septic shock: systematic review and meta-analysis. PLoS ONE 10:e0129305. https:\/\/doi.org\/10.1371\/journal.pone.0129305","journal-title":"PLoS ONE"},{"key":"4758_CR25","doi-asserted-by":"publisher","first-page":"196","DOI":"10.5811\/WESTJEM.2020.10.47825","volume":"22","author":"MA Ruslan","year":"2021","unstructured":"Ruslan MA, Baharuddin KA, Noor NM et al (2021) Norepinephrine in septic shock: a systematic review and meta-analysis. West J Emerg Med 22:196\u2013203. https:\/\/doi.org\/10.5811\/WESTJEM.2020.10.47825","journal-title":"West J Emerg Med"},{"key":"4758_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S13054-019-2427-4\/TABLES\/3","volume":"23","author":"L Cheng","year":"2019","unstructured":"Cheng L, Yan J, Han S et al (2019) Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials. Crit Care 23:1\u201314. https:\/\/doi.org\/10.1186\/S13054-019-2427-4\/TABLES\/3","journal-title":"Crit Care"},{"key":"4758_CR27","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1097\/CCM.0000000000001260","volume":"43","author":"AMC Ventura","year":"2015","unstructured":"Ventura AMC, Shieh HH, Bousso A et al (2015) Double-blind prospective randomized controlled trial of dopamine versus epinephrine as first-line vasoactive drugs in pediatric septic shock. Crit Care Med 43:2292\u20132302. https:\/\/doi.org\/10.1097\/CCM.0000000000001260","journal-title":"Crit Care Med"},{"key":"4758_CR28","doi-asserted-by":"publisher","first-page":"e502","DOI":"10.1097\/PCC.0000000000000954","volume":"17","author":"KN Ramaswamy","year":"2016","unstructured":"Ramaswamy KN, Singhi S, Jayashree M et al (2016) Double-blind randomized clinical trial comparing dopamine and epinephrine in pediatric fluid-refractory hypotensive septic shock\u2217. Pediatr Crit Care Med 17:e502\u2013e512. https:\/\/doi.org\/10.1097\/PCC.0000000000000954","journal-title":"Pediatr Crit Care Med"},{"key":"4758_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/sj.jp.7211774","volume":"27","author":"EM Dempsey","year":"2007","unstructured":"Dempsey EM, Barrington KJ (2007) Treating hypotension in the preterm infant: when and with what: a critical and systematic review. J Perinatol 27:469\u2013478. https:\/\/doi.org\/10.1038\/sj.jp.7211774","journal-title":"J Perinatol"},{"key":"4758_CR30","doi-asserted-by":"publisher","first-page":"e283","DOI":"10.1542\/NEO.4-10-E283","volume":"4","author":"S Noori","year":"2003","unstructured":"Noori S, Friedlich P, Seri I (2003) Pharmacology review developmentally regulated cardiovascular, renal, and neuroendocrine effects of dopamine. NeoReviews 4:e283\u2013e288. https:\/\/doi.org\/10.1542\/NEO.4-10-E283","journal-title":"NeoReviews"},{"key":"4758_CR31","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/JP.2011.2","volume":"31","author":"S Sassano-Higgins","year":"2011","unstructured":"Sassano-Higgins S, Friedlich P, Seri I (2011) A meta-analysis of dopamine use in hypotensive preterm infants: blood pressure and cerebral hemodynamics. J Perinatol 31:647\u2013655. https:\/\/doi.org\/10.1038\/JP.2011.2","journal-title":"J Perinatol"},{"key":"4758_CR32","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd001242","author":"NV Subhedar","year":"2003","unstructured":"Subhedar NV, Shaw NJ (2003) Dopamine versus dobutamine for hypotensive preterm infants. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.cd001242","journal-title":"Cochrane Database Syst Rev"},{"key":"4758_CR33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.5409\/wjcp.v5.i2.212","volume":"5","author":"SI Bhayat","year":"2016","unstructured":"Bhayat SI, Gowda HM, Eisenhut M (2016) Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence. World J Clin Pediatr 5:212. https:\/\/doi.org\/10.5409\/wjcp.v5.i2.212","journal-title":"World J Clin Pediatr"},{"key":"4758_CR34","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1038\/s41390-020-0790-0","volume":"88","author":"NS Solanki","year":"2020","unstructured":"Solanki NS, Hoffman SB (2020) Association between dopamine and cerebral autoregulation in preterm neonates. Pediatr Res 88:618\u2013622. https:\/\/doi.org\/10.1038\/s41390-020-0790-0","journal-title":"Pediatr Res"},{"key":"4758_CR35","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/FPED.2018.00086\/BIBTEX","volume":"6","author":"C Joynt","year":"2018","unstructured":"Joynt C, Cheung PY (2018) Treating hypotension in preterm neonates with vasoactive medications. Front Pediatr 6:86. https:\/\/doi.org\/10.3389\/FPED.2018.00086\/BIBTEX","journal-title":"Front Pediatr"},{"key":"4758_CR36","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1067\/mpd.2002.123100","volume":"140","author":"J-M Liet","year":"2002","unstructured":"Liet J-M, Boscher C, Gras-Leguen C et al (2002) Dopamine effects on pulmonary artery pressure in hypotensive preterm infants with patent ductus arteriosus. J Pediatr 140:373\u2013375. https:\/\/doi.org\/10.1067\/mpd.2002.123100","journal-title":"J Pediatr"},{"key":"4758_CR37","doi-asserted-by":"publisher","unstructured":"Marik PE (1994) The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA: The Journal of the American Medical Association 272:1354. https:\/\/doi.org\/10.1001\/jama.1994.03520170064037","DOI":"10.1001\/jama.1994.03520170064037"},{"key":"4758_CR38","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1097\/01.CCM.0000529509.89031.09","volume":"46","author":"E Limberg","year":"2018","unstructured":"Limberg E, Bauer S, Lam S et al (2018) 1507: Optimal norepinephrine-equivalent dose to initiate epinephrine in patients with septic shock. Crit Care Med 46:737\u2013737. https:\/\/doi.org\/10.1097\/01.CCM.0000529509.89031.09","journal-title":"Crit Care Med"},{"key":"4758_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/S12884-015-0767-X\/TABLES\/3","volume":"15","author":"H Xu","year":"2015","unstructured":"Xu H, Dai Q, Xu Y et al (2015) Time trends and risk factor associated with premature birth and infants deaths due to prematurity in Hubei Province, China from 2001 to 2012. BMC Pregnancy Childbirth 15:1\u20139. https:\/\/doi.org\/10.1186\/S12884-015-0767-X\/TABLES\/3","journal-title":"BMC Pregnancy Childbirth"},{"key":"4758_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-12-70\/TABLES\/3","volume":"12","author":"R Pirracchio","year":"2012","unstructured":"Pirracchio R, Resche-Rigon M, Chevret S (2012) Evaluation of the propensity score methods for estimating marginal odds ratios in case of small sample size. BMC Med Res Methodol 12:1\u201310. https:\/\/doi.org\/10.1186\/1471-2288-12-70\/TABLES\/3","journal-title":"BMC Med Res Methodol"},{"key":"4758_CR41","doi-asserted-by":"publisher","unstructured":"Dempsey EM, Barrington KJ, Marlow N et al (2021) Hypotension in preterm infants (HIP) randomised trial. 106:398\u2013403. https:\/\/doi.org\/10.1136\/archdischild-2020-320241","DOI":"10.1136\/archdischild-2020-320241"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-022-04758-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-022-04758-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T12:04:38Z","timestamp":1679054678000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-022-04758-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,22]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["4758"],"URL":"https:\/\/doi.org\/10.1007\/s00431-022-04758-4","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,22]]},"assertion":[{"value":"24 September 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}