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We conducted a\u00a0cross-sectional study\u00a0and recruited children born less than 32\u00a0weeks\u2019 gestation between January 2006 and December 2019, in the greater Zurich area, Switzerland. Between May and December 2021, parents were invited to complete an online survey for their preterm child and for a control term born (\u2265\u200937\u00a0weeks\u2019 gestation) sibling aged 1 to 18\u00a0years. We used a validated questionnaire to assess respiratory symptoms and the\nPediatrics Quality of Life Family Impact Module (PedsQL FIM) to assess parents\u2019 HRQoL and family functioning. The survey was completed for 616 very preterm children (99 with bronchopulmonary dysplasia (BPD)) and 180 controls. Girls made up 45% (46% in controls) of the sample, and 63% (60% in controls) of participants were aged 6 to 18\u00a0years (school-age). Very preterm children reported a higher risk of respiratory symptoms than controls, especially preschoolers and those with moderate-to-severe BPD. Parents of children with \u201cmild\u201d and \u201cmoderate-severe\u201d respiratory symptoms had on average\u2009\u22123.9 (95%CI:\u2009\u22126.6 to\u2009\u22121.1) and\u2009\u22128.2 (\u221211.2 to\u2009\u22125.2) lower PedsQL FIM total score, respectively, than parents of children with no symptoms. The same pattern was observed after stratifying by age categories.<\/jats:p>\n                  <jats:p>\n                    <jats:italic>\u00a0 Conclusions<\/jats:italic>\n                    : Our study suggests that respiratory morbidity in very preterm children has a negative impact on parents\u2019 HRQoL and family functioning, even beyond the first years of life.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 The burden of respiratory morbidity associated with very premature birth is high and last far beyond the neonatal period.<\/jats:italic>\n                              <jats:italic>\u2022 Respiratory morbidity contributes to lower health-related quality of life (HRQoL) in parents of very preterm children in early infancy.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 Respiratory morbidity in very preterm children has a negative impact on parents\u2019 HRQoL and family functioning beyond the first years of life.<\/jats:italic>\n                              <jats:italic>\u2022 Parents of very preterm children with moderate and severe respiratory symptoms are the ones who report lower scores, both for preschool and school-age children.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-022-04783-3","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T04:03:37Z","timestamp":1672977817000},"page":"1201-1210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Respiratory morbidity in preschool and school-age children born very preterm and its association with parents\u2019 health-related quality of life and family functioning"],"prefix":"10.1007","volume":"182","author":[{"given":"Gabriela P.","family":"Peralta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaela","family":"Piatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah R.","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Bassler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Natalucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susi","family":"Kriemler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"4783_CR1","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","volume":"379","author":"H Blencowe","year":"2012","unstructured":"Blencowe H, Cousens S, Oestergaard MZ et al (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. 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