{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:44:29Z","timestamp":1785498269075,"version":"3.56.0"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-023-04843-2","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T07:33:16Z","timestamp":1676619196000},"page":"1533-1554","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of food allergy in children with vitamin D insufficiency: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"182","author":[{"given":"Evdokia","family":"Psaroulaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios N.","family":"Katsaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrina","family":"Samartzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Chatziravdeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Psaroulaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Oikonomou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pelagia","family":"Tsitsani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"issue":"25","key":"4843_CR1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011030","volume":"97","author":"Y Guo","year":"2018","unstructured":"Guo Y, Ke H-J, Liu Y, Fu M, Ning J, Yu L et al (2018) Prevalence of vitamin D insufficiency among children in southern china: a cross-sectional survey. Medicine (Baltimore) 97(25):e11030","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"4843_CR2","first-page":"118","volume":"3","author":"R Nair","year":"2012","unstructured":"Nair R, Maseeh A (2012) Vitamin D: The \u2018sunshine\u2019 vitamin. J Pharmacol Pharmacother 3(2):118\u2013126","journal-title":"J Pharmacol Pharmacother"},{"key":"4843_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.mce.2017.04.008","volume":"453","author":"JC Fleet","year":"2017","unstructured":"Fleet JC (2017) The role of vitamin D in the endocrinology controlling calcium homeostasis. Mol Cell Endocrinol 453:36\u201345","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"4843_CR4","first-page":"480","volume":"8","author":"R Bouillon","year":"2014","unstructured":"Bouillon R, Suda T (2014) Vitamin D: calcium and bone homeostasis during evolution. Bonekey Rep 8(3):480","journal-title":"Bonekey Rep"},{"issue":"12","key":"4843_CR5","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/1471-2458-12-126","volume":"14","author":"Z Zhu","year":"2012","unstructured":"Zhu Z, Zhan J, Shao J, Chen W, Chen L, Li W et al (2012) High prevalence of vitamin D deficiency among children aged 1 month to 16 years in Hangzhou, China. BMC Public Health 14(12):126","journal-title":"BMC Public Health"},{"key":"4843_CR6","unstructured":"Bikle DD\u00a0 (2000) Vitamin D: production, metabolism and mechanisms of action. Endotext"},{"issue":"10","key":"4843_CR7","doi-asserted-by":"publisher","first-page":"2614","DOI":"10.21037\/tp-21-396","volume":"10","author":"T Di","year":"2021","unstructured":"Di T, Chen L (2021) A narrative review of vitamin D and food allergy in infants and children. Transl Pediatr 10(10):2614\u20132620","journal-title":"Transl Pediatr"},{"issue":"7","key":"4843_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097","journal-title":"PLoS Med"},{"key":"4843_CR9","unstructured":"Katsaras G, Psaroulaki E, Samartzi P (2022) Food allergy in children and vitamin D deficiency: a systematic review and meta-analysis [internet]. PROSPERO. Available from: https:\/\/www.crd.yorkhttps\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42022327861"},{"issue":"1","key":"4843_CR10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4065\/mcp.2010.0567","volume":"86","author":"TD Thacher","year":"2011","unstructured":"Thacher TD, Clarke BL (2011) Vitamin D insufficiency. Mayo Clin Proc 86(1):50\u201360","journal-title":"Mayo Clin Proc"},{"issue":"8","key":"4843_CR11","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1016\/j.jaip.2020.04.020","volume":"8","author":"SA Lyons","year":"2020","unstructured":"Lyons SA, Clausen M, Knulst AC, Ballmer-Weber BK, Fernandez-Rivas M, Barreales L et al (2020) Prevalence of food sensitization and food allergy in children across Europe. J Allergy Clin Immunol Pract 8(8):2736-2746.e9","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"4843_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.bpg.2005.11.010","volume":"20","author":"C Ortolani","year":"2006","unstructured":"Ortolani C, Pastorello EA (2006) Food allergies and food intolerances. Best Pract Res Clin Gastroenterol 20(3):467\u2013483","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"4843_CR13","doi-asserted-by":"crossref","unstructured":"Lo CK-L, Mertz D, Loeb M (2014) Newcastle-Ottawa Scale: comparing reviewers\u2019 to authors\u2019 assessments. BMC Med Res Methodol 14(1):45","DOI":"10.1186\/1471-2288-14-45"},{"issue":"9","key":"4843_CR14","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/S0895-4356(00)00210-9","volume":"53","author":"S Walter","year":"2000","unstructured":"Walter S (2000) Choice of effect measure for epidemiological data. J Clin Epidemiol 53(9):931\u2013939","journal-title":"J Clin Epidemiol"},{"key":"4843_CR15","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Bradburn MJ, Egger M (2008) Meta-analysis in stataTM. Syst Rev Heal Care Meta-Analysis Context Second Ed 347\u201369","DOI":"10.1002\/9780470693926.ch18"},{"issue":"3","key":"4843_CR16","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/XEB.0000000000000065","volume":"13","author":"C Tufanaru","year":"2015","unstructured":"Tufanaru C, Munn Z, Stephenson M, Aromataris E (2015) Fixed or random effects meta-analysis? Common methodological issues in systematic reviews of effectiveness. Int J Evid Based Healthc 13(3):196\u2013207","journal-title":"Int J Evid Based Healthc"},{"issue":"11","key":"4843_CR17","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JPT Higgins","year":"2002","unstructured":"Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539\u20131558","journal-title":"Stat Med"},{"issue":"1","key":"4843_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1002\/jrsm.6","volume":"1","author":"J Anzures-Cabrera","year":"2010","unstructured":"Anzures-Cabrera J, Higgins JPT (2010) Graphical displays for meta-analysis: an overview with suggestions for practice. Res Synth Methods 1(1):66\u201380","journal-title":"Res Synth Methods"},{"key":"4843_CR19","unstructured":"Series CB (2019) Cochrane handbook for systematic reviews of interventions. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al (eds) Cochrane handbook for systematic reviews of interventions. Wiley"},{"key":"4843_CR20","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Sutton AJ, Ioannidis JPA, Terrin N, Jones DR, Lau J et al (2011) Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ.\u00a0343(jul22 1):d4002\u2013d4002","DOI":"10.1136\/bmj.d4002"},{"issue":"7109","key":"4843_CR21","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629\u2013634","journal-title":"BMJ"},{"issue":"4","key":"4843_CR22","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.beem.2011.04.009","volume":"25","author":"TL Van Belle","year":"2011","unstructured":"Van Belle TL, Gysemans C, Mathieu C (2011) Vitamin D in autoimmune, infectious and allergic diseases: a vital player? Best Pract Res Clin Endocrinol Metab 25(4):617\u2013632","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"4843_CR23","doi-asserted-by":"crossref","unstructured":"Harvey NC, Cantorna MT\u00a0(2013) Vitamin D and the immune system. Diet Immun Inflamm\u00a0244\u2013263","DOI":"10.1533\/9780857095749.2.244"},{"issue":"3","key":"4843_CR24","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.4049\/jimmunol.1601213","volume":"198","author":"J James","year":"2017","unstructured":"James J, Weaver V, Cantorna MT (2017) Control of circulating IgE by the vitamin D receptor in vivo involves B cell intrinsic and extrinsic mechanisms. J Immunol 198(3):1164\u20131171","journal-title":"J Immunol"},{"issue":"9","key":"4843_CR25","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.clinbiochem.2014.01.033","volume":"47","author":"R Zakariaeeabkoo","year":"2014","unstructured":"Zakariaeeabkoo R, Allen KJ, Koplin JJ, Vuillermin P, Greaves RF (2014) Are vitamins A and D important in the development of food allergy and how are they best measured? Clin Biochem 47(9):804\u2013811","journal-title":"Clin Biochem"},{"issue":"3","key":"4843_CR26","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.arcped.2018.01.007","volume":"25","author":"C Dupont","year":"2018","unstructured":"Dupont C, Chouraqui J-P, Linglart A, Bocquet A, Darmaun D, Feillet F et al (2018) Nutritional management of cow\u2019s milk allergy in children: an update. Arch Pediatr 25(3):236\u2013243","journal-title":"Arch Pediatr"},{"issue":"3","key":"4843_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2500\/aap.2017.38.4043","volume":"38","author":"EK Willits","year":"2017","unstructured":"Willits EK, Wang Z, Jin J, Patel B, Motosue M, Bhagia A et al (2017) Vitamin D and food allergies in children: a systematic review and meta-analysis. Allergy Asthma Proc 38(3):21\u201328","journal-title":"Allergy asthma Proc"},{"issue":"1","key":"4843_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu13010177","volume":"13","author":"A Lipi\u0144ska-Opa\u0142ka","year":"2021","unstructured":"Lipi\u0144ska-Opa\u0142ka A, Tomaszewska A, Kubiak JZ, Kalicki B (2021) Vitamin d and immunological patterns of allergic diseases in children. Nutrients 13(1):1\u201312","journal-title":"Nutrients"},{"key":"4843_CR29","doi-asserted-by":"crossref","unstructured":"Chen P-J, Nakano T, Lai C-Y, Chang K-C, Chen C-L, Goto S (2021) Daily full spectrum light exposure prevents food allergy-like allergic diarrhea by modulating vitamin D3 and microbiota composition. npj Biofilms Microbiomes 7(1)","DOI":"10.1038\/s41522-021-00213-8"},{"issue":"4","key":"4843_CR30","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S1081-1206(10)63558-2","volume":"96","author":"JW Yu","year":"2006","unstructured":"Yu JW, Pekeles G, Legault L, McCusker CT (2006) Milk allergy and vitamin D deficiency rickets: a common disorder associated with an uncommon disease. Ann Allergy Asthma Immunol 96(4):615\u2013619","journal-title":"Ann Allergy Asthma Immunol"},{"key":"4843_CR31","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fped.2020.00447","volume":"8","author":"A Giannetti","year":"2020","unstructured":"Giannetti A, Bernardini L, Cangemi J, Gallucci M, Masetti R, Ricci G (2020) Role of vitamin D in prevention of food allergy in infants. Front Pediatr 8:447","journal-title":"Front Pediatr"},{"issue":"3","key":"4843_CR32","first-page":"495","volume":"14","author":"FK Alswailmi","year":"2020","unstructured":"Alswailmi FK, Sikandar MZ, Shah SIA (2020) Biological roles of vitamin D and immunoglobulin E: implications in allergic disorders. Pakistan J Med Heal Sci 14(3):495\u2013498","journal-title":"Pakistan J Med Heal Sci"},{"issue":"7","key":"4843_CR33","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1111\/pai.12295","volume":"25","author":"E Maslova","year":"2014","unstructured":"Maslova E, Hansen S, Thorne-Lyman AL, Jensen CB, Str\u00f8m M, Cohen A et al (2014) Predicted vitamin D status in mid-pregnancy and child allergic disease. Pediatr Allergy Immunol 25(7):706\u2013713","journal-title":"Pediatr Allergy Immunol"},{"issue":"6","key":"4843_CR34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/cea.12048","volume":"43","author":"PJ Vuillermin","year":"2013","unstructured":"Vuillermin PJ, Ponsonby A-L, Kemp AS, Allen KJ (2013) Potential links between the emerging risk factors for food allergy and vitamin D status. Clin Exp Allergy 43(6):599\u2013607","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"4843_CR35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2500\/aap.2011.32.3485","volume":"32","author":"M Frieri","year":"2011","unstructured":"Frieri M, Valluri A (2011) Vitamin D deficiency as a risk factor for allergic disorders and immune mechanisms. Allergy Asthma Proc 32(6):438\u2013444","journal-title":"Allergy Asthma Proc"},{"issue":"6","key":"4843_CR36","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1093\/nutrit\/nuv108","volume":"74","author":"DA Fried","year":"2016","unstructured":"Fried DA, Rhyu J, Odato K, Blunt H, Karagas MR, Gilbert-Diamond D (2016) Maternal and cord blood vitamin D status and childhood infection and allergic disease: a systematic review. Nutr Rev 74(6):387\u2013410","journal-title":"Nutr Rev"},{"issue":"6","key":"4843_CR37","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/apa.12172","volume":"102","author":"K Persson","year":"2013","unstructured":"Persson K, \u00d6hlund I, Nordstr\u00f6m L, Winberg A, R\u00f6nmark E, West CE (2013) Vitamin D deficiency at the arctic circle - a study in food-allergic adolescents and controls. Acta Paediatr 102(6):644\u2013649","journal-title":"Acta Paediatr"},{"issue":"8","key":"4843_CR38","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1111\/pai.12304","volume":"25","author":"C-Y Chiu","year":"2014","unstructured":"Chiu C-Y, Yao T-C, Chen S-H, Tsai M-H, Tu Y-L, Hua M-C et al (2014) Low cord blood vitamin D levels are associated with increased milk sensitization in early childhood. Pediatr Allergy Immunol 25(8):767\u2013772","journal-title":"Pediatr Allergy Immunol"},{"issue":"3","key":"4843_CR39","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/pr.2013.110","volume":"74","author":"X Liu","year":"2013","unstructured":"Liu X, Arguelles L, Zhou Y, Wang G, Chen Q, Tsai H-J et al (2013) Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization. Pediatr Res 74(3):321\u2013326","journal-title":"Pediatr Res"},{"issue":"8","key":"4843_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu12082418","volume":"12","author":"FC Woon","year":"2020","unstructured":"Woon FC, Chin YS, Ismail IH, Latiff AHA, Batterham M, Chan YM (2020) Maternal vitamin D levels during late pregnancy and risk of allergic diseases and sensitization during the first year of life\u2014a birth cohort study. Nutrients 12(8):1\u201312","journal-title":"Nutrients"},{"issue":"1","key":"4843_CR41","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.aller.2017.03.005","volume":"46","author":"H Guo","year":"2018","unstructured":"Guo H, Zheng Y, Cai X, Yang H, Zhang Y, Hao L et al (2018) Correlation between serum vitamin D status and immunological changes in children affected by gastrointestinal food allergy. Allergol Immunopathol (Madr) 46(1):39\u201344","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"3","key":"4843_CR42","first-page":"550","volume":"28","author":"J Li","year":"2019","unstructured":"Li J, Mei X, Cai X, Zhuo Y, Zhang L, Guo H et al (2019) Association of blood eosinophilia and vitamin D insufficiency in young infants with cow milk allergy. Asia Pac J Clin Nutr 28(3):550\u2013557","journal-title":"Asia Pac J Clin Nutr"},{"issue":"12","key":"4843_CR43","first-page":"8208","volume":"12","author":"E Dogan","year":"2020","unstructured":"Dogan E, Sevinc E (2020) The vitamin D status and serum eosinophilic cationic protein levels in infants with cow\u2019s milk protein allergy. Am J Transl Res 12(12):8208\u20138215","journal-title":"Am J Transl Res"},{"issue":"5","key":"4843_CR44","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.anai.2012.07.009","volume":"109","author":"RJ Mullins","year":"2012","unstructured":"Mullins RJ, Clark S, Wiley V, Eyles D, Camargo CA (2012) Neonatal vitamin D status and childhood peanut allergy: a pilot study. Ann Allergy Asthma Immunol 109(5):324\u2013328","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"4843_CR45","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.aller.2019.06.016","volume":"48","author":"Y Guo","year":"2020","unstructured":"Guo Y, Yu L, Deng Y-H, Ke H-J, Wu J-L (2020) Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood. Allergol Immunopathol (Madr) 48(1):84\u201389","journal-title":"Allergol Immunopathol (Madr)"},{"issue":"2","key":"4843_CR46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/all.12081","volume":"68","author":"K Weisse","year":"2013","unstructured":"Weisse K, Winkler S, Hirche F, Herberth G, Hinz D, Bauer M et al (2013) Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. Allergy 68(2):220\u2013228","journal-title":"Allergy"},{"issue":"11","key":"4843_CR47","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1111\/j.1398-9995.2011.02681.x","volume":"66","author":"X Liu","year":"2011","unstructured":"Liu X, Wang G, Hong X, Wang D, Tsai H-J, Zhang S et al (2011) Gene-vitamin D interactions on food sensitization: a prospective birth cohort study. Allergy 66(11):1442\u20131448","journal-title":"Allergy"},{"issue":"5","key":"4843_CR48","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1016\/j.jaci.2011.01.017","volume":"127","author":"S Sharief","year":"2011","unstructured":"Sharief S, Jariwala S, Kumar J, Muntner P, Melamed ML (2011) Vitamin D levels and food and environmental allergies in the United States: results from the National Health and Nutrition Examination Survey 2005\u20132006. J Allergy Clin Immunol 127(5):1195\u20131202","journal-title":"J Allergy Clin Immunol"},{"key":"4843_CR49","doi-asserted-by":"crossref","unstructured":"Allen KJ, Koplin JJ, Ponsonby A-L, Gurrin LC, Wake M, Vuillermin P et al (2013) Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol 131(4):1109\u201316\u20131116.e1\u20136","DOI":"10.1016\/j.jaci.2013.01.017"},{"key":"4843_CR50","unstructured":"Warren C, Aktas ON, Manalo L, Bartell TR, Gupta R (2022) The epidemiology of multi-food allergy in the United States-a population-based study. Ann Allergy Asthma Immuno 31"},{"issue":"3","key":"4843_CR51","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.cyto.2008.12.009","volume":"45","author":"C Almerighi","year":"2009","unstructured":"Almerighi C, Sinistro A, Cavazza A, Ciaprini C, Rocchi G, Bergamini A (2009) 1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes. Cytokine 45(3):190\u2013197","journal-title":"Cytokine"},{"issue":"4","key":"4843_CR52","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1001\/archinternmed.2008.560","volume":"169","author":"AA Ginde","year":"2009","unstructured":"Ginde AA, Mansbach JM, Camargo CA (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 169(4):384\u2013390","journal-title":"Arch Intern Med"},{"issue":"2","key":"4843_CR53","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.diabres.2008.09.046","volume":"83","author":"T Du","year":"2009","unstructured":"Du T, Zhou Z-G, You S, Huang G, Lin J, Yang L et al (2009) Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Diabetes Res Clin Pract 83(2):208\u2013214","journal-title":"Diabetes Res Clin Pract"},{"issue":"6","key":"4843_CR54","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2310\/JIM.0b013e31821b8755","volume":"59","author":"C Aranow","year":"2011","unstructured":"Aranow C (2011) Vitamin D and the immune system. J Investig Med 59(6):881\u2013886","journal-title":"J Investig Med"},{"key":"4843_CR55","doi-asserted-by":"crossref","unstructured":"Gombart AF, Pierre A, Maggini S (2020) A review of micronutrients and the immune system-working in harmony to reduce the risk of infection. Nutrients\u00a016;12(1)","DOI":"10.3390\/nu12010236"},{"issue":"5","key":"4843_CR56","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.4049\/jimmunol.173.5.2909","volume":"173","author":"T-T Wang","year":"2004","unstructured":"Wang T-T, Nestel FP, Bourdeau V, Nagai Y, Wang Q, Liao J et al (2004) Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J Immunol 173(5):2909\u20132912","journal-title":"J Immunol"},{"key":"4843_CR57","doi-asserted-by":"publisher","first-page":"205031212110140","DOI":"10.1177\/20503121211014073","volume":"9","author":"L Bui","year":"2021","unstructured":"Bui L, Zhu Z, Hawkins S, Cortez-Resendiz A, Bellon A (2021) Vitamin D regulation of the immune system and its implications for COVID-19: a mini review. SAGE open Med 9:20503121211014070","journal-title":"SAGE open Med"},{"issue":"2","key":"4843_CR58","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000447692","volume":"170","author":"D Bagnasco","year":"2016","unstructured":"Bagnasco D, Ferrando M, Varricchi G, Passalacqua G, Canonica GW (2016) A critical evaluation of anti-IL-13 and anti-IL-4 strategies in severe asthma. Int Arch Allergy Immunol 170(2):122\u2013131","journal-title":"Int Arch Allergy Immunol"},{"issue":"1","key":"4843_CR59","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1172\/JCI21759","volume":"116","author":"E Xystrakis","year":"2006","unstructured":"Xystrakis E, Kusumakar S, Boswell S, Peek E, Urry Z, Richards DF et al (2006) Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 116(1):146\u2013155","journal-title":"J Clin Invest"},{"issue":"9","key":"4843_CR60","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3345\/kjp.2015.58.9.325","volume":"58","author":"SJ Lee","year":"2015","unstructured":"Lee SJ, Kang BH, Choi BS (2015) Vitamin D serum levels in children with allergic and vasomotor rhinitis. Korean J Pediatr 58(9):325\u2013329","journal-title":"Korean J Pediatr"},{"issue":"2","key":"4843_CR61","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jaci.2010.06.011","volume":"126","author":"MF Vassallo","year":"2010","unstructured":"Vassallo MF, Camargo CA (2010) Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children. J Allergy Clin Immunol 126(2):217\u2013222","journal-title":"J Allergy Clin Immunol"},{"key":"4843_CR62","doi-asserted-by":"crossref","unstructured":"van der Aar AMG, Sibiryak DS, Bakdash G, van Capel TMM, van der Kleij HPM, Opstelten D-JE et al (2011) Vitamin D3 targets epidermal and dermal dendritic cells for induction of distinct regulatory T cells. J Allergy Clin Immunol 127(6):1532\u201340.e7","DOI":"10.1016\/j.jaci.2011.01.068"},{"issue":"3","key":"4843_CR63","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/mi.2016.93","volume":"10","author":"J Strandmark","year":"2017","unstructured":"Strandmark J, Steinfelder S, Berek C, K\u00fchl AA, Rausch S, Hartmann S (2017) Eosinophils are required to suppress Th2 responses in Peyer\u2019s patches during intestinal infection by nematodes. Mucosal Immunol 10(3):661\u2013672","journal-title":"Mucosal Immunol"},{"issue":"8","key":"4843_CR64","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1084\/jem.20131800","volume":"211","author":"DK Chu","year":"2014","unstructured":"Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A et al (2014) Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo. J Exp Med 211(8):1657\u20131672","journal-title":"J Exp Med"},{"issue":"3","key":"4843_CR65","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00281-021-00856-x","volume":"43","author":"A Gurtner","year":"2021","unstructured":"Gurtner A, Gonzalez-Perez I, Arnold IC (2021) Intestinal eosinophils, homeostasis and response to bacterial intrusion. Semin Immunopathol 43(3):295\u2013306","journal-title":"Semin Immunopathol"},{"key":"4843_CR66","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cellimm.2017.10.003","volume":"322","author":"H Lu","year":"2017","unstructured":"Lu H, Xie R-D, Lin R, Zhang C, Xiao X-J, Li L-J et al (2017) Vitamin D-deficiency induces eosinophil spontaneous activation. Cell Immunol 322:56\u201363","journal-title":"Cell Immunol"},{"issue":"1","key":"4843_CR67","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ijgo.2010.07.034","volume":"112","author":"SA Karim","year":"2011","unstructured":"Karim SA, Nusrat U, Aziz S (2011) Vitamin D deficiency in pregnant women and their newborns as seen at a tertiary-care center in Karachi. Pakistan Int J Gynaecol Obstet 112(1):59\u201362","journal-title":"Pakistan Int J Gynaecol Obstet"},{"issue":"1","key":"4843_CR68","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jada.2010.10.002","volume":"111","author":"DK Dror","year":"2011","unstructured":"Dror DK, King JC, Durand DJ, Allen LH (2011) Association of modifiable and nonmodifiable factors with vitamin D status in pregnant women and neonates in Oakland. CA J Am Diet Assoc 111(1):111\u2013116","journal-title":"CA J Am Diet Assoc"},{"issue":"6","key":"4843_CR69","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1111\/j.1365-2222.2011.03712.x","volume":"41","author":"A Chi","year":"2011","unstructured":"Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M et al (2011) Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study. Clin Exp Allergy 41(6):842\u2013850","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"4843_CR70","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1398-9995.2011.02767.x","volume":"67","author":"D Hinz","year":"2012","unstructured":"Hinz D, Bauer M, R\u00f6der S, Olek S, Huehn J, Sack U et al (2012) Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy 67(3):380\u2013389","journal-title":"Allergy"},{"issue":"1 Pt 1","key":"4843_CR71","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1399-3038.2009.00949.x","volume":"21","author":"BI Nwaru","year":"2010","unstructured":"Nwaru BI, Ahonen S, Kaila M, Erkkola M, Haapala A-M, Kronberg-Kippil\u00e4 C et al (2010) Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 21(1 Pt 1):29\u201337","journal-title":"Pediatr Allergy Immunol"},{"issue":"11","key":"4843_CR72","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00431-016-2785-8","volume":"175","author":"C Grant","year":"2016","unstructured":"Grant C, Knight J, Milne T, Sinclair J, Camargo C (2016) EAPS-0711 Vitamin D supplementation during pregnancy and infancy reduces food allergen sensitisation and parental-reported food allergy: a randomised controlled trial; EAPS Congress 2016. Eur J Pediatr 175(11):1393\u20131880","journal-title":"Eur J Pediatr"},{"issue":"1","key":"4843_CR73","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/ped.12207","volume":"56","author":"C Norizoe","year":"2014","unstructured":"Norizoe C, Akiyama N, Segawa T, Tachimoto H, Mezawa H, Ida H et al (2014) Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial. Pediatr Int 56(1):6\u201312","journal-title":"Pediatr Int"},{"key":"4843_CR74","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.jpeds.2019.02.021","volume":"209","author":"J Rosendahl","year":"2019","unstructured":"Rosendahl J, Pelkonen AS, Helve O, Hauta-alus H, Holmlund-Suila E, Valkama S et al (2019) High-dose vitamin D supplementation does not prevent allergic sensitization of infants. J Pediatr 209:139-145.e1","journal-title":"J Pediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04843-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-023-04843-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04843-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T01:47:15Z","timestamp":1701913635000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-023-04843-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["4843"],"URL":"https:\/\/doi.org\/10.1007\/s00431-023-04843-2","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"16 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2023","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Supplementary material was replaced with the clean version of material.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All analyses were based on previously published studies; thus, no ethical approval was required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}