{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:52:07Z","timestamp":1792180327925,"version":"4.4.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-023-04950-0","type":"journal-article","created":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T12:19:23Z","timestamp":1680610763000},"page":"2759-2773","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["To feed or not to feed during therapeutic hypothermia in asphyxiated neonates: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0464-9689","authenticated-orcid":false,"given":"Jogender","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra Prasad","family":"Anne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Meena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkataseshan","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourabh","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4742-8787","authenticated-orcid":false,"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"4950_CR1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5409\/wjcp.v5.i1.67","volume":"5","author":"CE Ahearne","year":"2016","unstructured":"Ahearne CE, Boylan GB, Murray DM (2016) Short and long term prognosis in perinatal asphyxia: an update. World J Clin Pediatr 5:67\u201374. https:\/\/doi.org\/10.5409\/wjcp.v5.i1.67","journal-title":"World J Clin Pediatr"},{"key":"4950_CR2","doi-asserted-by":"publisher","unstructured":"Jacobs SE, Berg M, Hunt R et al (2013) Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev CD003311. https:\/\/doi.org\/10.1002\/14651858.CD003311.pub3","DOI":"10.1002\/14651858.CD003311.pub3"},{"key":"4950_CR3","doi-asserted-by":"publisher","first-page":"e1273","DOI":"10.1016\/S2214-109X(21)00264-3","volume":"9","author":"S Thayyil","year":"2021","unstructured":"Thayyil S, Pant S, Montaldo P et al (2021) Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh. Lancet Glob Health 9:e1273\u2013e1285. https:\/\/doi.org\/10.1016\/S2214-109X(21)00264-3","journal-title":"Lancet Glob Health"},{"key":"4950_CR4","doi-asserted-by":"publisher","first-page":"F230","DOI":"10.1136\/archdischild-2018-315393","volume":"104","author":"S Ojha","year":"2019","unstructured":"Ojha S, Dorling J, Battersby C et al (2019) Optimising nutrition during therapeutic hypothermia. Arch Dis Child - Fetal Neonatal Ed 104:F230\u2013F231. https:\/\/doi.org\/10.1136\/archdischild-2018-315393","journal-title":"Arch Dis Child - Fetal Neonatal Ed"},{"key":"4950_CR5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1159\/000516640","volume":"77","author":"VV Ramaswamy","year":"2021","unstructured":"Ramaswamy VV, Bandyopadhyay T, Ahmed J et al (2021) Enteral feeding strategies in preterm neonates \u226432 weeks gestational age: a systematic review and network meta-analysis. Ann Nutr Metab 77:204\u2013220. https:\/\/doi.org\/10.1159\/000516640","journal-title":"Ann Nutr Metab"},{"issue":"17","key":"4950_CR6","doi-asserted-by":"publisher","first-page":"30650","DOI":"10.1016\/j.jpedsurg.2017.10.028","volume":"S0022\u20133468","author":"CS Velazco","year":"2017","unstructured":"Velazco CS, Fullerton BS, Hong CR et al (2017) Morbidity and mortality among \u201cbig\u201d babies who develop necrotizing enterocolitis: a prospective multicenter cohort analysis. J Pediatr Surg S0022\u20133468(17):30650\u201330654. https:\/\/doi.org\/10.1016\/j.jpedsurg.2017.10.028","journal-title":"J Pediatr Surg"},{"key":"4950_CR7","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1016\/j.jpeds.2010.11.009","volume":"158","author":"CM Young","year":"2011","unstructured":"Young CM, Kingma SDK, Neu J (2011) Ischemia-reperfusion and neonatal intestinal injury. J Pediatr 158:e25-28. https:\/\/doi.org\/10.1016\/j.jpeds.2010.11.009","journal-title":"J Pediatr"},{"key":"4950_CR8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12098-014-1388-5","volume":"81","author":"H Kasivajjula","year":"2014","unstructured":"Kasivajjula H, Maheshwari A (2014) Pathophysiology and current management of necrotizing enterocolitis. Indian J Pediatr 81:489\u2013497. https:\/\/doi.org\/10.1007\/s12098-014-1388-5","journal-title":"Indian J Pediatr"},{"key":"4950_CR9","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1056\/NEJMoa0900854","volume":"361","author":"DV Azzopardi","year":"2009","unstructured":"Azzopardi DV, Strohm B, Edwards AD et al (2009) Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 361:1349\u20131358. https:\/\/doi.org\/10.1056\/NEJMoa0900854","journal-title":"N Engl J Med"},{"key":"4950_CR10","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","volume":"353","author":"S Shankaran","year":"2005","unstructured":"Shankaran S, Laptook AR, Ehrenkranz RA et al (2005) Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353:1574\u20131584. https:\/\/doi.org\/10.1056\/NEJMcps050929","journal-title":"N Engl J Med"},{"key":"4950_CR11","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1159\/000487848","volume":"113","author":"LL Chang","year":"2018","unstructured":"Chang LL, Wynn JL, Pacella MJ et al (2018) Enteral feeding as an adjunct to hypothermia in neonates with hypoxic-ischemic encephalopathy. Neonatology 113:347\u2013352. https:\/\/doi.org\/10.1159\/000487848","journal-title":"Neonatology"},{"key":"4950_CR12","doi-asserted-by":"publisher","unstructured":"Kumar J, Meena J, Ranjan A, Kumar P (2023) Oropharyngeal application of colostrum or mother\u2019s own milk in preterm infants: a systematic review and meta-analysis. Nutr Rev nuad002. https:\/\/doi.org\/10.1093\/nutrit\/nuad002","DOI":"10.1093\/nutrit\/nuad002"},{"key":"4950_CR13","doi-asserted-by":"publisher","unstructured":"Hazeldine B, Thyagarajan B, Grant M, Chakkarapani E (2017) Survey of nutritional practices during therapeutic hypothermia for hypoxic-ischaemic encephalopathy. BMJ Paediatr Open 1:e000022. https:\/\/doi.org\/10.1136\/bmjpo-2017-000022","DOI":"10.1136\/bmjpo-2017-000022"},{"key":"4950_CR14","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/apa.14979","volume":"109","author":"S Giannakis","year":"1992","unstructured":"Giannakis S, Ruhfus M, R\u00fcdiger M et al (1992) (2020) Hospital survey showed wide variations in therapeutic hypothermia for neonates in Germany. Acta Paediatr Oslo Nor 109:200\u2013201. https:\/\/doi.org\/10.1111\/apa.14979","journal-title":"Acta Paediatr Oslo Nor"},{"key":"4950_CR15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/S2352-4642(21)00026-2","volume":"5","author":"C Gale","year":"2021","unstructured":"Gale C, Longford NT, Jeyakumaran D et al (2021) Feeding during neonatal therapeutic hypothermia, assessed using routinely collected National Neonatal Research Database data: a retrospective, UK population-based cohort study. Lancet Child Adolesc Health 5:408\u2013416. https:\/\/doi.org\/10.1016\/S2352-4642(21)00026-2","journal-title":"Lancet Child Adolesc Health"},{"issue":"25","key":"4950_CR16","doi-asserted-by":"publisher","first-page":"9440","DOI":"10.1080\/14767058.2022.2041594","volume":"35","author":"W Alburaki","year":"2022","unstructured":"Alburaki W, Scringer-Wilkes M, Dawoud F et al (2022) Feeding during therapeutic hypothermia is safe and may improve outcomes in newborns with perinatal asphyxia. J Matern-Fetal Neonatal Med 35(25):9440\u20139444. https:\/\/doi.org\/10.1080\/14767058.2022.2041594","journal-title":"J Matern-Fetal Neonatal Med"},{"key":"4950_CR17","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s13052-022-01342-2","volume":"48","author":"Y Hu","year":"2022","unstructured":"Hu Y, Chen F, Xiang X et al (2022) Early versus delayed enteral nutrition for neonatal hypoxic-ischemic encephalopathy undergoing therapeutic hypothermia: a randomized controlled trial. Ital J Pediatr 48:146. https:\/\/doi.org\/10.1186\/s13052-022-01342-2","journal-title":"Ital J Pediatr"},{"key":"4950_CR18","doi-asserted-by":"publisher","unstructured":"Kulkarni T, Charki S, Biradar V et al (2021) Feasibility of minimal enteral nutrition in neonates with perinatal asphyxia during therapeutic hypothermia: a randomized controlled trial. Curr Pediatr Res 25:466\u201371. https:\/\/doi.org\/10.35841\/0971-9032.25.3.466-471","DOI":"10.35841\/0971-9032.25.3.466-471"},{"key":"4950_CR19","unstructured":"Higgins JPT, Thomas J, Chandler J et al (editors) (2022) Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane"},{"key":"4950_CR20","doi-asserted-by":"publisher","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","DOI":"10.1136\/bmj.n71"},{"key":"4950_CR21","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","volume":"283","author":"DF Stroup","year":"2000","unstructured":"Stroup DF, Berlin JA, Morton SC et al (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283:2008\u20132012. https:\/\/doi.org\/10.1001\/jama.283.15.2008","journal-title":"JAMA"},{"key":"4950_CR22","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.jclinepi.2021.11.026","volume":"142","author":"CA Cuello-Garcia","year":"2022","unstructured":"Cuello-Garcia CA, Santesso N, Morgan RL et al (2022) GRADE guidance 24 optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines. J Clin Epidemiol 142:200\u2013208. https:\/\/doi.org\/10.1016\/j.jclinepi.2021.11.026","journal-title":"J Clin Epidemiol"},{"key":"4950_CR23","unstructured":"Reeves BC, Deeks JJ, Higgins JP et al Chapter 24: including non-randomized studies on intervention effects. In: Cochrane Handbook for Systematic Reviews of Interventions version 6.3"},{"key":"4950_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","volume":"75","author":"J McGowan","year":"2016","unstructured":"McGowan J, Sampson M, Salzwedel DM et al (2016) PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement. J Clin Epidemiol 75:40\u201346. https:\/\/doi.org\/10.1016\/j.jclinepi.2016.01.021","journal-title":"J Clin Epidemiol"},{"key":"4950_CR25","doi-asserted-by":"publisher","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","DOI":"10.1136\/bmj.l4898"},{"key":"4950_CR26","doi-asserted-by":"publisher","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ i4919. https:\/\/doi.org\/10.1136\/bmj.i4919","DOI":"10.1136\/bmj.i4919"},{"key":"4950_CR27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0045-9380(87)90031-4","volume":"17","author":"RM Kliegman","year":"1987","unstructured":"Kliegman RM, Walsh MC (1987) Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness. Curr Probl Pediatr 17:213\u2013288. https:\/\/doi.org\/10.1016\/0045-9380(87)90031-4","journal-title":"Curr Probl Pediatr"},{"key":"4950_CR28","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000484197","volume":"113","author":"M Valpacos","year":"2018","unstructured":"Valpacos M, Arni D, Keir A et al (2018) Diagnosis and management of necrotizing enterocolitis: an international survey of neonatologists and pediatric surgeons. Neonatology 113:170\u2013176. https:\/\/doi.org\/10.1159\/000484197","journal-title":"Neonatology"},{"key":"4950_CR29","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1007\/s00431-022-04405-y","volume":"181","author":"J Kumar","year":"2022","unstructured":"Kumar J, Meena J, Debata P et al (2022) Three-hourly versus two-hourly feeding interval in stable preterm infants: an updated systematic review and meta-analysis of randomized controlled trials. Eur J Pediatr 181:2075\u20132086. https:\/\/doi.org\/10.1007\/s00431-022-04405-y","journal-title":"Eur J Pediatr"},{"key":"4950_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.clp.2012.12.007","volume":"40","author":"RD Christensen","year":"2013","unstructured":"Christensen RD, Lambert DK, Baer VL, Gordon PV (2013) Necrotizing enterocolitis in term infants. Clin Perinatol 40:69\u201378. https:\/\/doi.org\/10.1016\/j.clp.2012.12.007","journal-title":"Clin Perinatol"},{"key":"4950_CR31","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/sj.jp.7211135","volume":"24","author":"A Maayan-Metzger","year":"2004","unstructured":"Maayan-Metzger A, Itzchak A, Mazkereth R, Kuint J (2004) Necrotizing enterocolitis in full-term infants: case-control study and review of the literature. J Perinatol 24:494\u2013499. https:\/\/doi.org\/10.1038\/sj.jp.7211135","journal-title":"J Perinatol"},{"key":"4950_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135. https:\/\/doi.org\/10.1186\/1471-2288-14-135","journal-title":"BMC Med Res Methodol"},{"key":"4950_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/9781119536604.ch6","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"JP Higgins","year":"2019","unstructured":"Higgins JP, Li T, Deeks JJ (2019) Choosing effect measures and computing estimates of effect. In: Higgins JPT, Thomas J, Chandler J et al (eds) Cochrane Handbook for Systematic Reviews of Interventions, 1st edn. Wiley, pp 143\u2013176","edition":"1"},{"key":"4950_CR34","unstructured":"Sch\u00fcnemann H, Bro\u017cek J, Guyatt G, Oxman A (2013) GRADE handbook for grading quality of evidence and strength of recommendations. GRADE Working Group. Available from : https:\/\/gdt.gradepro.org\/app\/handbook\/handbook.html"},{"key":"4950_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jclinepi.2022.09.014","volume":"152","author":"CA Cuello","year":"2022","unstructured":"Cuello CA, Morgan RL, Brozek J et al (2022) Case studies to explore the optimal use of randomized and nonrandomized studies in evidence syntheses that use GRADE. J Clin Epidemiol 152:56\u201369. https:\/\/doi.org\/10.1016\/j.jclinepi.2022.09.014","journal-title":"J Clin Epidemiol"},{"key":"4950_CR36","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1111\/apa.12838","volume":"104","author":"B Thyagarajan","year":"1992","unstructured":"Thyagarajan B, Tillqvist E, Baral V et al (1992) (2015) Minimal enteral nutrition during neonatal hypothermia treatment for perinatal hypoxic-ischaemic encephalopathy is safe and feasible. Acta Paediatr Oslo Nor 104:146\u2013151. https:\/\/doi.org\/10.1111\/apa.12838","journal-title":"Acta Paediatr Oslo Nor"},{"key":"4950_CR37","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3390\/children8100899","volume":"8","author":"M Markus","year":"2021","unstructured":"Markus M, Giannakis S, Ruhfus M et al (2021) Fluid supply and feeding practices in cooled asphyxiated newborns. Child Basel Switz 8:899. https:\/\/doi.org\/10.3390\/children8100899","journal-title":"Child Basel Switz"},{"key":"4950_CR38","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-022-04456-x","author":"S Sharma","year":"2023","unstructured":"Sharma S, Kallesh A, Aradhya AS et al (2023) Feasibility of minimal enteral nutrition during therapeutic hypothermia for perinatal asphyxia: a five-year multicenter experience from South India. Indian J Pediatr. https:\/\/doi.org\/10.1007\/s12098-022-04456-x","journal-title":"Indian J Pediatr"},{"key":"4950_CR39","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1186\/s12887-020-02231-5","volume":"20","author":"A Alsaied","year":"2020","unstructured":"Alsaied A, Islam N, Thalib L (2020) Global incidence of necrotizing enterocolitis: a systematic review and Meta-analysis. BMC Pediatr 20:344. https:\/\/doi.org\/10.1186\/s12887-020-02231-5","journal-title":"BMC Pediatr"},{"key":"4950_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta25360","volume":"25","author":"C Gale","year":"2021","unstructured":"Gale C, Jeyakumaran D, Battersby C et al (2021) Nutritional management in newborn babies receiving therapeutic hypothermia: two retrospective observational studies using propensity score matching. Health Technol Assess Winch Engl 25:1\u2013106. https:\/\/doi.org\/10.3310\/hta25360","journal-title":"Health Technol Assess Winch Engl"},{"key":"4950_CR41","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/apa.16060","volume":"111","author":"A Havilland","year":"2022","unstructured":"Havilland A, Hariharan G (2022) Is enteral feeding safe during therapeutic hypothermia in neonates with hypoxic-ischaemic encephalopathy? Acta Paediatr 111:194\u2013195. https:\/\/doi.org\/10.1111\/apa.16060","journal-title":"Acta Paediatr"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04950-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-023-04950-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04950-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T08:06:17Z","timestamp":1686384377000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-023-04950-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,4]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["4950"],"URL":"https:\/\/doi.org\/10.1007\/s00431-023-04950-0","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,4]]},"assertion":[{"value":"25 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors consented to the publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}