{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:18:25Z","timestamp":1791497905323,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["National Research Grant #3210"],"award-info":[{"award-number":["National Research Grant #3210"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["National Research Grant #3210"],"award-info":[{"award-number":["National Research Grant #3210"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["National Research Grant #3210"],"award-info":[{"award-number":["National Research Grant #3210"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["National Research Grant #3210"],"award-info":[{"award-number":["National Research Grant #3210"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","award":["National Research Grant #3210"],"award-info":[{"award-number":["National Research Grant #3210"]}],"id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"DOI":"10.1007\/s00431-023-04954-w","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T02:02:07Z","timestamp":1681524127000},"page":"2903-2911","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prospective study of thyroid function in the first year of life in infants with Down syndrome"],"prefix":"10.1007","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7149-0225","authenticated-orcid":false,"given":"Penny M.","family":"Feldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6848-8116","authenticated-orcid":false,"given":"Nicolas","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-8945","authenticated-orcid":false,"given":"Emily","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-8895","authenticated-orcid":false,"given":"Bruce","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-4884","authenticated-orcid":false,"given":"Mary M.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"4954_CR1","unstructured":"Centers for Disease Control and Prevention (2020) Birth defects: occurrence of Down syndrome in the United States.\u00a0https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/downsyndrome\/data.html"},{"key":"4954_CR2","doi-asserted-by":"publisher","unstructured":"Amr NH (2018) Thyroid disorders in subjects with Down syndrome: an update. Acta Biomed 89(1):132\u2013139. \nhttps:\/\/doi.org\/10.23750\/abm.v89i1.7120","DOI":"10.23750\/abm.v89i1.7120"},{"key":"4954_CR3","doi-asserted-by":"publisher","unstructured":"Bull M, Trotter T, Santoro SL, Christensen C, Grout R (2022) The Council on Genetics Health supervision for children and adolescents with Down syndrome. Pediatr 149(5):e2022057010. https:\/\/doi.org\/10.1542\/peds.2022-057010","DOI":"10.1542\/peds.2022-057010"},{"key":"4954_CR4","doi-asserted-by":"publisher","unstructured":"Bull M (2011) The Committee on Genetics Clinical report-health supervision for children with Down syndrome. Pediatr 128(2):393\u2013406. https:\/\/doi.org\/10.1542\/peds.2011-1605","DOI":"10.1542\/peds.2011-1605"},{"key":"4954_CR5","unstructured":"Fisher DA (2002) Disorders of the thyroid in the newborn and infant. In: Sperling (ed) Pediatric Endocrinology, 3rd\u00a0edn. Saunders, Philadelphia 167:175\u2013176"},{"key":"4954_CR6","doi-asserted-by":"publisher","unstructured":"Cutler AT, Benezra-Obeiter R, Brink SJ (1986) Thyroid function in young children with Down syndrome. AJDC 140:479\u2013483.\u00a0https:\/\/doi.org\/10.1001\/archpedi.1986.02140190089034","DOI":"10.1001\/archpedi.1986.02140190089034"},{"key":"4954_CR7","doi-asserted-by":"publisher","unstructured":"Pierce MJ, LaFranchi SH, Pinter JD (2017) Characterization of thyroid abnormalities in a large cohort of children with Down syndrome. Horm Res Paediatr 87:170\u2013178.\u00a0https:\/\/doi.org\/10.1159\/000457952","DOI":"10.1159\/000457952"},{"key":"4954_CR8","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/jp.2014.116","volume":"34","author":"IB Purdy","year":"2014","unstructured":"Purdy IB, Singh N, Brown WL, Vangala S, Devaskar UP (2014) Revisiting early hypothyroidism screening in infants with Down syndrome. J Perinatol 34 (12):936\u2013940. https:\/\/doi.org\/10.1038\/jp.2014.116","journal-title":"J Perinatol"},{"issue":"7","key":"4954_CR9","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1089\/thy.2006.16.671","volume":"16","author":"ASP Van Trotsenburg","year":"2006","unstructured":"Van Trotsenburg ASP, Kempers MJE, Endert E, Tijssen JGP, de Vijlder JJM, Vulsma T (2006) Trisomy 21 causes persistent congenital hypothyroidism presumably of thyroidal origin. Thyroid 16(7):671\u2013680. https:\/\/doi.org\/10.1089\/thy.2006.16.671","journal-title":"Thyroid"},{"key":"4954_CR10","unstructured":"Rao LV, Snyder LM, Vallaro GM (2003) Evaluation of reference ranges for thyroid and anemia tests using the Beckman Coulter access immunoassay analyzer. Clin Chem 49(6):Suppl A53"},{"issue":"7","key":"4954_CR11","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/clinchem\/45.7.1087","volume":"45","author":"D Zurakowski","year":"1999","unstructured":"Zurakowski D, Canxio JD, Majzoub JA (1999) Pediatric reference intervals for serum thyroxine, triiodothyronine, thyrotropin, and free thyroxine. Clin Chem 45(7):1087\u20131091","journal-title":"Clin Chem"},{"key":"4954_CR12","first-page":"295","volume-title":"The Harriet Lane Book","author":"SA Ballal","year":"2009","unstructured":"Ballal SA, McIntosh P (2009) Endocrinology. In: Custer JW, Lee CK, Rau RE (eds) The Harriet Lane Book, 18th edn. Elsevier Mosby, Philadelphia, p 295","edition":"18"},{"key":"4954_CR13","first-page":"194","volume-title":"Pediatric Endocrinology","author":"DA Fisher","year":"2002","unstructured":"Fisher DA (2002) Thyroid disorders in childhood and adolescence. In: Sperling M (ed) Pediatric Endocrinology, 3rd edn. Saunders, Philadelphia, p 194","edition":"3"},{"key":"4954_CR14","doi-asserted-by":"publisher","unstructured":"Fort P, Lifshitz F, Bellisario R, Davis J, Lanes R, Pugliese M, Richman R, Post EM, David R (1984) Abnormalities of thyroid function in infants with Down syndrome. J Pediatr 104 (4):545-549. https:\/\/doi.org\/10.1016\/s0022-3476(84)80544-2","DOI":"10.1016\/s0022-3476(84)80544-2"},{"issue":"2","key":"4954_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1297\/cpe.4.115","volume":"42","author":"S Harada","year":"1995","unstructured":"Harada S, Ichihara N, Fujieda K, Okuno A (1995) Down syndrome with thyroid dysfunction detected by neonatal screening for congenital hypothyroidism. Clin Pediatr Endocrinol 42(2):115\u2013122. https:\/\/doi.org\/10.1297\/cpe.4.115","journal-title":"Clin Pediatr Endocrinol"},{"key":"4954_CR16","doi-asserted-by":"publisher","unstructured":"Erlichman I, Mimouni FB, Erlichman M, Schimmel MS (2016) Thyroxine-based screening for congenital hypothyroidism in neonates with Down syndrome. J Pediatr 173:165\u2013168. https:\/\/doi.org\/10.1016\/j.jpeds.2016.02.039","DOI":"10.1016\/j.jpeds.2016.02.039"},{"key":"4954_CR17","doi-asserted-by":"publisher","unstructured":"Salazar P, Cisternas P, Codocedo JF, Inestrosa NC (2017) Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity. Bioch Biophys Acta Mol Basis Dis 1863 (4): 870\u2013883. https:\/\/doi.org\/10.1016\/j.bbadis.2017.01.002","DOI":"10.1016\/j.bbadis.2017.01.002"},{"key":"4954_CR18","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1210\/jc.2002-021303","volume":"88","author":"ASP Van Trotsenburg","year":"2003","unstructured":"Van Trotsenburg ASP, Vulsma T, Van Santen HM, Cheung W, Vijlder JJM (2003) Lower neonatal screening thyroxine concentrations in Down syndrome newborns. J Clin Endocrinol Metab 88(4):1512\u20131515. https:\/\/doi.org\/10.1210\/jc.2002-021303","journal-title":"J Clin Endocrinol Metab"},{"key":"4954_CR19","doi-asserted-by":"publisher","unstructured":"Van Trotsenburg ASP, Vulsma T, Rutgers van Rozenburg-Marres SL, van Baar AL, Ridder JCD, Heymans HSA, Tijssen JGP, de Vijlder JJM (2005) The effect of thyroxine treatment started in the neonatal period on development and growth of two-year-old Down syndrome children: a randomized clinical trial. J Clin Endocrinol Metab 90(6):3304\u20133311. https:\/\/doi.org\/10.1210\/jc.2005-0130","DOI":"10.1210\/jc.2005-0130"},{"key":"4954_CR20","doi-asserted-by":"publisher","unstructured":"Marchal JP, Maurice-Stam H, Ikelaar NA, Klouwer FCC, Verhorstert KWJ, Witteveen ME, Houtzager BA, Grootenhuis MA, van Trotsenburg ASP (2014) Effects of early thyroxine treatment on development and growth at the age of 10.7 years: follow-up of a randomized placebo-controlled trial in children with Down's syndrome. J Clin Endocrinol Metab 99(12):E2722\u20139. https:\/\/doi.org\/10.1210\/jc.2014-2849","DOI":"10.1210\/jc.2014-2849"},{"key":"4954_CR21","doi-asserted-by":"publisher","unstructured":"Van Trotsenburg ASP, Smit BJ, Koelman JHTM, Dekker-van der Sloot M, Ridder JCD, Tijssen JGP, de Vijlder JJM,Vulsma T (2006) Median nerve conduction velocity and central conduction time measured with somatosensory evoked potentials in thyroxine-treated infants with Down syndrome. Pediatr 118(3) e825-e832. https:\/\/doi.org\/10.1542\/peds.2006-0324","DOI":"10.1542\/peds.2006-0324"},{"key":"4954_CR22","doi-asserted-by":"publisher","unstructured":"AlAaraj N, Soliman AT, Itani M, Khalil A, De Sanctis V (2019) Prevalence of thyroid dysfunctions in infants and children with Down syndrome (DS) and the effect of thyroxine treatment on linear growth and weight gain in treated subjects versus DS subjects with normal thyroid function: a controlled study. Acta Biomed 90(8-S):36\u201342. https:\/\/doi.org\/10.23750\/abm.v90i8-S.8503","DOI":"10.23750\/abm.v90i8-S.8503"},{"issue":"3","key":"4954_CR23","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1089\/thy.2020.0333","volume":"31","author":"P Van Trotsenburg","year":"2021","unstructured":"Van Trotsenburg P, Stoupa A, L\u00e9ger J, Rohrer T, Peters C, Fugazzola L, Cassio A, Heinrichs C, Beauloye V, Pohlenz J, Rodien P et al (2021) Congenital hypothyroidism: a 2020\u20132021 consensus guidelines update -an Endo-European reference network initiative endorsed by the European Society for Pediatric Endocrinology and the European Society for Endocrinology. Thyroid 31(3):387\u2013419. https:\/\/doi.org\/10.1089\/thy.2020.0333","journal-title":"Thyroid"},{"key":"4954_CR24","doi-asserted-by":"publisher","unstructured":"Salerno M, Capalbo D, Cerbone M, De Luca F (2016) Subclinical hypothyroidism in childhood \u2013 current knowledge and open issues. Nat Rev Endocrinol 12 (12): 734\u2013746.\u00a0https:\/\/doi.org\/10.1038\/nrendo.2016.100","DOI":"10.1038\/nrendo.2016.100"},{"key":"4954_CR25","doi-asserted-by":"publisher","unstructured":"Bongers-Schokking JJ, Resing WC, de Rijke YB, de Ridder Ma, de Muinck Keizer-Schrama SM (2013) Cognitive development in congenital hypothyroidism: is overtreatment a greater threat than undertreatment? J Clin Endocrinol Metab 98:4499\u20134506.\u00a0https:\/\/doi.org\/10.1210\/jc.2013-2175","DOI":"10.1210\/jc.2013-2175"},{"key":"4954_CR26","doi-asserted-by":"publisher","unstructured":"Aleksander PE, Br\u00fcckner-Spieler M, Stoehr A, Lankes E, K\u00fchnen P, Schnabel D, Ernert A, Stablein W, Craig ME, Blankenstein O et al (2018) Mean high-dose l-thyroxine treatment is efficient and safe to achieve a normal IQ in young adult patients with congenital hypothyroidism. J Clin Endocrinol Metab 103(4):1459\u20131469. https:\/\/doi.org\/10.1210\/jc.2017-01937","DOI":"10.1210\/jc.2017-01937"},{"issue":"2","key":"4954_CR27","doi-asserted-by":"publisher","first-page":"e493","DOI":"10.1542\/peds.2007-3252","volume":"122","author":"K Carroll","year":"2008","unstructured":"Carroll K, Arbogast P, Dudley J, Cooper W (2008) Increase incidence of medically-treated thyroid disease in children with Down syndrome following re-release of American Academy of Pediatrics Health Supervision Guidelines. Pediatr 122(2):e493\u2013e498. https:\/\/doi.org\/10.1542\/peds.2007-3252","journal-title":"Pediatr"},{"key":"4954_CR28","doi-asserted-by":"publisher","unstructured":"Lavigne J, Sharr C, Elsharkawi I, Ozonoff A, Baumer N, Brasington C, Cannon S, Crissman B, Davidson E, Florez JC et al (2017) Thyroid dysfunction in patients with Down syndrome: results from a multi-institutional registry study. Am J Med Genet 173(6): 1539-1545. https:\/\/doi.org\/10.1002\/ajmg.a.38219","DOI":"10.1002\/ajmg.a.38219"},{"key":"4954_CR29","doi-asserted-by":"publisher","unstructured":"Passeri E, Frigerio M, De Filippis T, Valaperta R, Capelli P, Costa E, Fugazzola L, Marelli F, Porazzi P, Arcidiacono C et al (2011) Increased risk for non-autoimmune hypothyroidism in young patients with congenital heart defects. J Clin Endocrinol Metab 96(7):E1115\u2013E1119. https:\/\/doi.org\/10.1210\/jc.2011-0057","DOI":"10.1210\/jc.2011-0057"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04954-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-023-04954-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-04954-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T08:07:37Z","timestamp":1686384457000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-023-04954-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,15]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["4954"],"URL":"https:\/\/doi.org\/10.1007\/s00431-023-04954-w","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,15]]},"assertion":[{"value":"29 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 March 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the IRB at the UMASS Chan Medical School in Worcester, MA 01655 (approval 2\/10\/2013, number: H00000722).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from the parents\/guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}