{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:53:38Z","timestamp":1792155218261,"version":"4.4.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009448","name":"Universit\u00e0 degli Studi della Campania Luigi Vanvitelli","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009448","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We investigated prevalence of and factors associated with acute kidney injury (AKI) in a group of patients hospitalized with viral bronchiolitis. We retrospectively enrolled 139 children (mean age\u2009=\u20093.2\u2009\u00b1\u20092.1\u00a0months; males\u2009=\u200958.9%) hospitalized for viral bronchiolitis in a non-pediatric intensive care unit (PICU) setting. The Kidney Disease\/Improving Global Outcomes creatinine criterion was used to diagnose AKI. We estimated basal serum creatinine by back-calculating it by Hoste (age) equation assuming that basal eGFR were the median age-based eGFR normative values. Univariate and multivariate logistic regression models were used to explore associations with AKI. Out of 139 patients, AKI was found in 15 (10.8%). AKI was found in 13 out of 74 (17.6%) patients with and in 2 out of 65 (3.1%) without respiratory syncytial virus (RSV) infection (<jats:italic>p<\/jats:italic>\u2009=\u20090.006). No patient required renal replacement therapies, while 1 out of 15 (6.7%) developed AKI stage 3, 1 (6.7%) developed AKI stage 2, and 13 (86.6%) developed AKI stage 1. Among the 15 patients with AKI, 13 (86.6%) reached the maximum AKI stage at admission, 1 (6.7%) at 48\u00a0h, and 1 (6.7%) at 96\u00a0h. At multivariate analysis, birth weight\u2009&lt;\u200910th percentile (odds ratio, OR\u2009=\u200934.1; 95% confidence interval, CI\u2009=\u20093.6\u2013329.4; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), preterm birth (OR\u2009=\u200920.3; 95% CI\u2009=\u20093.1\u2013129.5; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), RSV infection (OR\u2009=\u200927.0; 95% CI\u2009=\u20092.6\u2013279.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.006), and hematocrit levels\u2009&gt;\u20092 standard deviation score (SDS) (OR\u2009=\u200922.4; 95% CI\u2009=\u20092.8\u2013183.6; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) were significantly associated with AKI.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: About 11% of patients hospitalized with viral bronchiolitis in a non-PICU setting develop an AKI (frequently mild in degree). Preterm birth, birth weight\u2009&lt;\u200910th percentile, hematocrit levels\u2009&gt;\u20092SDS, and RSV infection are significantly associated with AKI in the setting of viral bronchiolitis.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Viral bronchiolitis affects children in the first months of life and in 7.5% of cases it can be complicated by acute\u00a0kidney injury (AKI).<\/jats:italic><jats:italic>\u2022\u00a0<\/jats:italic><jats:italic>No studies investigated associations with AKI in infants hospitalized for viral bronchiolitis<\/jats:italic>.<\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 About 11% of patients hospitalized with viral bronchiolitis can develop an AKI (frequently mild in degree).<\/jats:italic><jats:italic>\u2022 Preterm birth, birth weight &lt;10th percentile, hematocrit levels &gt; 2 standard deviation score, and respiratory\u00a0syncytial virus infection are associated with AKI development in infants with viral bronchiolitis.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-023-05029-6","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T05:02:40Z","timestamp":1684904560000},"page":"3569-3576","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Acute kidney injury in infants hospitalized for viral bronchiolitis"],"prefix":"10.1007","volume":"182","author":[{"given":"Pierluigi","family":"Marzuillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Di Sessa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Golino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Tirelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"De Lucia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Rivetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Miraglia del Giudice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Guarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Nunziata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"5029_CR1","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMRA1413456","volume":"374","author":"HC Meissner","year":"2016","unstructured":"Meissner HC (2016) Viral bronchiolitis in children. 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The study was conducted accordingly with the principles outlined in the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study before any clinical procedure. This is a retrospective study, and a specific consent to be enrolled in the study was waived due to the nature of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}