{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:49:00Z","timestamp":1790628540200,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:00:00Z","timestamp":1686960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010763","name":"National Health Care Institute","doi-asserted-by":"crossref","award":["2017045964"],"award-info":[{"award-number":["2017045964"]}],"id":[{"id":"10.13039\/501100010763","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to examine whether therapeutic communication improves children\u2019s comfort during venipuncture compared to standard communication. This study was registered in the Dutch trial register (NL8221), December 10, 2019. This single-blinded interventional study was carried out in an outpatient clinic of a tertiary hospital. Inclusion criteria were age between 5 and 18\u00a0years, use of topical anesthesia (EMLA) and sufficient understanding of the Dutch language. 105 children were included, 51 assigned to the standard communication group (SC group) and 54 patients to the therapeutic communication group (TC group). The primary outcome measure was self-reported pain based on the Faces Pain Scale Revised (FPS-R). Secondary outcome measures were observed pain (numeric rating scale (NRS)), self-reported\/observed anxiety in child and parent (NRS), self-reported satisfaction in child, parent and medical personnel (NRS), and procedural time. No difference was found for self-reported pain. Self-reported and observed anxiety (by parents and medical personnel) was lower in the TC group (<jats:italic>p<\/jats:italic>-values ranged from <jats:italic>p<\/jats:italic>\u2009=\u20090.005 to <jats:italic>p<\/jats:italic>\u2009=\u20090.048). Procedural time was lower in the TC group (<jats:italic>p<\/jats:italic>\u2009=\u20090.011). Satisfaction level of medical personnel was higher in the TC group (<jats:italic>p<\/jats:italic>\u2009=\u20090.014).<\/jats:p><jats:p>\u00a0 \u00a0<jats:italic>Conclusion<\/jats:italic>: TC during venipuncture did not result in lower self-reported pain. However, secondary outcomes (observed pain, anxiety and procedural time) were significantly improved in the TC group.<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Medical procedures, especially needle related procedures, cause anxiety and fear in children and adults.<\/jats:italic><jats:italic>\u2022 In adults communication techniques based on hypnosis are effective in reducing pain and anxiety during medical procedures.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Our study found that with a small change in communication technique (called therapeutic communication or TC), the comfort of children during venipuncture improves.<\/jats:italic><jats:italic>\u2022 This improved comfort was mainly reflected by reduced anxiety scores and shorter procedural time. This makes TC\u00a0suitable for the outpatient setting.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-023-05036-7","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T21:01:17Z","timestamp":1687035677000},"page":"3871-3881","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Therapeutic communication improves patient comfort during venipuncture in children: a single-blinded intervention study"],"prefix":"10.1007","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0201-2327","authenticated-orcid":false,"given":"Lonneke A. M.","family":"Aarts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-124X","authenticated-orcid":false,"given":"Geert-Jan","family":"van Geffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5315-5134","authenticated-orcid":false,"given":"Eva A. L.","family":"Smedema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2682-2654","authenticated-orcid":false,"given":"Rosanne M.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,17]]},"reference":[{"key":"5036_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/children8010034","volume":"8","author":"JS Dalley","year":"2021","unstructured":"Dalley JS, Morrongiello BA, McMurtry CM (2021) Children\u2019s Perspectives on Outpatient Physician Visits: Capturing a Missing Voice in Patient-Centered Care. Children 8:1\u201315. https:\/\/doi.org\/10.3390\/children8010034","journal-title":"Children"},{"key":"5036_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/14651858.CD005179.pub4","volume":"10","author":"KA Birnie","year":"2018","unstructured":"Birnie KA, Noel M, Chambers CT, Uman LS, Parker JA (2018) Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev 10:1\u2013165. https:\/\/doi.org\/10.1002\/14651858.CD005179.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"5036_CR3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/jan.13818","volume":"75","author":"J McLenon","year":"2019","unstructured":"McLenon J, Rogers MA (2019) The fear of needles: A systematic review and meta-analysis. J Adv Nurs 75:30\u201342. https:\/\/doi.org\/10.1111\/jan.13818","journal-title":"J Adv Nurs"},{"key":"5036_CR4","doi-asserted-by":"publisher","unstructured":"McMurtry CM, Riddell RP, Taddio A, Racine N, Asmundson GJ, Noel M, Chambers CT, Psych R, Shah V, HelpinKids&Adults Team (2015) Far From \"Just a Poke\": Common Painful Needle Procedures and the Development of Needle Fear. Clin J Pain 32:S3-S11. https:\/\/doi.org\/10.1097\/AJP.0000000000000272","DOI":"10.1097\/AJP.0000000000000272"},{"key":"5036_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1089\/g4h.2018.0111","volume":"8","author":"S Dumoulin","year":"2019","unstructured":"Dumoulin S, Bouchard S, Ellis J, Lavoie KL, V\u00e9zina M-P, Charbonneau P, Tardif J, Hajjar A (2019) A randomized controlled trial on the use of virtual reality for needle-related procedures in children and adolescents in the emergency department. Games Healt J 8:285\u2013293. https:\/\/doi.org\/10.1089\/g4h.2018.0111","journal-title":"Games Healt J"},{"key":"5036_CR6","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.1542\/peds.2008-1055d","volume":"122","author":"GA Walco","year":"2008","unstructured":"Walco GA (2008) Needle pain in children: contextual factors. Pediatrics 122:S125-129. https:\/\/doi.org\/10.1542\/peds.2008-1055d","journal-title":"Pediatrics"},{"key":"5036_CR7","doi-asserted-by":"publisher","first-page":"S130","DOI":"10.1542\/peds.2008-1055e","volume":"122","author":"RM Kennedy","year":"2008","unstructured":"Kennedy RM, Luhmann J, Zempsky WT (2008) Clinical implications of unmanaged needle-insertion pain and distress in children. Pediatrics 122:S130\u2013S133. https:\/\/doi.org\/10.1542\/peds.2008-1055e","journal-title":"Pediatrics"},{"key":"5036_CR8","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1001\/archpedi.161.6.578","volume":"161","author":"RW Smith","year":"2007","unstructured":"Smith RW, Shah V, Goldman RD, Taddio A (2007) Caregivers\u2019 responses to pain in their children in the emergency department. Arch Pediatr Adolesc Med 161:578\u2013582. https:\/\/doi.org\/10.1001\/archpedi.161.6.578","journal-title":"Arch Pediatr Adolesc Med"},{"key":"5036_CR9","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1080\/00207144.2019.1612669","volume":"67","author":"AM Cyna","year":"2019","unstructured":"Cyna AM (2019) The Laurs of Hypnotic Communication and the \u201cLived in Imagination\u201d Technique in Medical Practice. Int J Clin Exp Hypn 67:247\u2013261. https:\/\/doi.org\/10.1080\/00207144.2019.1612669","journal-title":"Int J Clin Exp Hypn"},{"key":"5036_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.pain.2006.06.035","volume":"126","author":"EV Lang","year":"2006","unstructured":"Lang EV, Berbaum KS, Faintuch S, Hatsiopoulou O, Halsey N, Li X, Berbaum ML, Laser E, Baum J (2006) Adjunctive self-hypnotic relaxation for outpatient medical procedures: a prospective randomized trial with women undergoing large core breast biopsy. Pain 126:155\u2013164. https:\/\/doi.org\/10.1016\/j.pain.2006.06.035","journal-title":"Pain"},{"key":"5036_CR11","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jradnu.2012.08.001","volume":"31","author":"EV Lang","year":"2012","unstructured":"Lang EV (2012) A better patient experience through better communication. J Radiol Nurs 31:114\u2013119. https:\/\/doi.org\/10.1016\/j.jradnu.2012.08.001","journal-title":"J Radiol Nurs"},{"key":"5036_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/s0010-440x(66)80065-2","volume":"7","author":"M Bowen","year":"1966","unstructured":"Bowen M (1966) The use of family theory in clinical practice. Compr Psychiatry 7:345\u2013374. https:\/\/doi.org\/10.1016\/s0010-440x(66)80065-2","journal-title":"Compr psychiatry"},{"key":"5036_CR13","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/jpepsy\/jss041","volume":"37","author":"DJ Bearden","year":"2012","unstructured":"Bearden DJ, Feinstein A, Cohen LL (2012) The influence of parent preprocedural anxiety on child procedural pain: mediation by child procedural anxiety. J Pediatr Psychol 37:680\u2013686. https:\/\/doi.org\/10.1093\/jpepsy\/jss041","journal-title":"J Pediatr Psychol"},{"key":"5036_CR14","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s10880-006-9027-6","volume":"13","author":"RS Bernard","year":"2006","unstructured":"Bernard RS, Cohen LL (2006) Parent anxiety and infant pain during pediatric immunizations. J Clin Psychol Med Settings 13:282\u2013287. https:\/\/doi.org\/10.1007\/s10880-006-9027-6","journal-title":"J Clin Psychol Med Settings"},{"key":"5036_CR15","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/jpepsy\/jsj038","volume":"31","author":"TA Lipani","year":"2006","unstructured":"Lipani TA, Walker LS (2006) Children\u2019s appraisal and coping with pain: Relation to maternal ratings of worry and restriction in family activities. J Ped Psychol 31:667\u2013673. https:\/\/doi.org\/10.1093\/jpepsy\/jsj038","journal-title":"J Ped Psychol"},{"key":"5036_CR16","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1037\/\/0022-006x.67.6.826","volume":"67","author":"SE Whaley","year":"1999","unstructured":"Whaley SE, Pinto A, Sigman M (1999) Characterizing interactions between anxious mothers and their children. J Consult Clin Psychol 67:826\u2013836. https:\/\/doi.org\/10.1037\/\/0022-006x.67.6.826","journal-title":"J Consult Clin Psychol"},{"key":"5036_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jradnu.2016.11.005","volume":"36","author":"EV Lang","year":"2017","unstructured":"Lang EV, Viegas J, Bleeker C, Bruhn J, van Geffen G-J (2017) Helping children cope with medical tests and interventions. J Radiol Nurs 36:44\u201350. https:\/\/doi.org\/10.1016\/j.jradnu.2016.11.005","journal-title":"J Radiol Nurs"},{"key":"5036_CR18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1177\/0310057X20914909","volume":"48","author":"AM Cyna","year":"2020","unstructured":"Cyna AM (2020) Little words BIG impact: Perioperative communication for children with burns. Anaesth Intensive Care 48:123\u2013128. https:\/\/doi.org\/10.1177\/0310057X20914909","journal-title":"Anaesth Intensive Care"},{"key":"5036_CR19","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1097\/DBP.0b013e3182245b09","volume":"32","author":"CJ Davit","year":"2011","unstructured":"Davit CJ, Hundley RJ, Bacic JD, Hanson EM (2011) A pilot study to improve venipuncture compliance in children and adolescents with autism spectrum disorders. J Dev Behav Pediatr 32:521\u2013525. https:\/\/doi.org\/10.1097\/DBP.0b013e3182245b09","journal-title":"J Dev Behav Pediatr"},{"key":"5036_CR20","unstructured":"Van der Ploeg HM, Defares PB, Spielberger CD (1980) Handleiding bij de Zelf-Analyse Vragenlijst, ZAV [Manual for the Self-Analysis Questionnaire, ZAV]"},{"key":"5036_CR21","doi-asserted-by":"publisher","unstructured":"Hicks CL, von Baeyer CL, Spafford PA, van Korlaar I, Goodenough B (2001) The Faces Pain Scale\u2013Revised: toward a common metric in pediatric pain measurement. Pain 93\u2013173\u2013183. https:\/\/doi.org\/10.1016\/S0304-3959(01)00314-1","DOI":"10.1016\/S0304-3959(01)00314-1"},{"key":"5036_CR22","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.jpain.2008.04.007","volume":"9","author":"PJ McGrath","year":"2008","unstructured":"McGrath PJ, Walco GA, Turk DC, Dworkin RH, Brown MT, Davidson K, Eccleston C, Finley A, Goldschneider K, Haverkos, et al (2008) Core outcome domains and measures for pediatric acute and chronic\/recurrent pain clinical trials: PedIMMPACT recommendations. J Pain 9:771\u2013783. https:\/\/doi.org\/10.1016\/j.jpain.2008.04.007","journal-title":"J Pain"},{"key":"5036_CR23","doi-asserted-by":"publisher","first-page":"e1168","DOI":"10.1542\/peds.2010-1609","volume":"126","author":"D Tomlinson","year":"2010","unstructured":"Tomlinson D, von Baeyer CL, Stinson JN, Sung L (2010) A systematic review of faces scales for the self-report of pain intensity in children. Pediatrics 126:e1168\u2013e1198. https:\/\/doi.org\/10.1542\/peds.2010-1609","journal-title":"Pediatrics"},{"key":"5036_CR24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/PEC.0000000000000791","volume":"34","author":"DS Tsze","year":"2018","unstructured":"Tsze DS, Hirschfeld G, Dayan PS, Bulloch B, von Baeyer CL (2018) Defining no pain, mild, moderate, and severe pain based on the Faces Pain Scale-Revised and Color Analog Scale in children with acute pain. Pediatr Emerg Care 34:537\u2013544. https:\/\/doi.org\/10.1097\/PEC.0000000000000791","journal-title":"Pediatr Emerg Care"},{"key":"5036_CR25","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3758\/bf03206553","volume":"36","author":"KJ Preacher","year":"2004","unstructured":"Preacher KJ, Hayes AF (2004) SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods 36:717\u2013731. https:\/\/doi.org\/10.3758\/bf03206553","journal-title":"Behav Res Methods"},{"key":"5036_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjopen-2019-033336","volume":"10","author":"C Wensley","year":"2020","unstructured":"Wensley C, Botti M, McKillop A, Merry AF (2020) Maximising comfort: how do patients describe the care that matters? A two-stage qualitative descriptive study to develop a quality improvement framework for comfort-related care in inpatient settings. BMJ Open 10:1\u201318. https:\/\/doi.org\/10.1136\/bmjopen-2019-033336","journal-title":"BMJ Open"},{"key":"5036_CR27","doi-asserted-by":"publisher","unstructured":"Miu MW, Martin A, Cyna AM. Postoperative pain and comfort scores: Do they correlate? Anaesthes Intensive Care 47:435\u2013441. https:\/\/doi.org\/10.1177\/0310057X19861985","DOI":"10.1177\/0310057X19861985"},{"key":"5036_CR28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/nop2.399","volume":"7","author":"L Hed\u00e9n","year":"2019","unstructured":"Hed\u00e9n L, von Essen L, Ljungman G (2019) Children\u2019s self-reports of fear and pain levels during needle procedures. Nurs Open 7:376\u2013382. https:\/\/doi.org\/10.1002\/nop2.399","journal-title":"Nurs Open"},{"key":"5036_CR29","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/acem.12620","volume":"22","author":"DS Tsze","year":"2015","unstructured":"Tsze DS, Hirschfeld G, von Baeyer CL, Bulloch B, Dayan PS (2015) Clinically significant differences in acute pain measured on self-report pain scales in children. Acad Emerg Med 22:415\u2013422. https:\/\/doi.org\/10.1111\/acem.12620","journal-title":"Acad Emerg Med"},{"key":"5036_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pedn.2003.09.005","volume":"19","author":"TL Rogers","year":"2004","unstructured":"Rogers TL, Ostrow CL (2004) The use of EMLA cream to decrease venipuncture pain in children. J Pediatr Nurs 19:33\u201339. https:\/\/doi.org\/10.1016\/j.pedn.2003.09.005","journal-title":"J Pediatr Nurs"},{"key":"5036_CR31","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/j.1365-2214.2006.00578.x","volume":"32","author":"J Tak","year":"2006","unstructured":"Tak J, Van Bon W (2006) Pain-and distress-reducing interventions for venepuncture in children. Child Care Health Dev 32:257\u2013268. https:\/\/doi.org\/10.1111\/j.1365-2214.2006.00578.x","journal-title":"Child Care Health Dev"},{"key":"5036_CR32","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1207\/S15326888CHC2902_2","volume":"29","author":"D Fanurik","year":"2000","unstructured":"Fanurik D, Koh JL, Schmitz ML (2000) Distraction techniques combined with EMLA: Effects on IV insertion pain and distress in children. Child Health Care 29:87\u2013101. https:\/\/doi.org\/10.1207\/S15326888CHC2902_2","journal-title":"Child Health Care"},{"key":"5036_CR33","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.bja.2019.11.020","volume":"124","author":"N Fusco","year":"2020","unstructured":"Fusco N, Bernard F, Roelants F, Watremez C, Musellec H, Laviolle B, Beloeil H (2020) Hypnosis and communication reduce pain and anxiety in peripheral intravenous cannulation: Effect of Language and Confusion on Pain During Peripheral Intravenous Catheterization (KTHYPE), a multicentre randomised trial. Br J Anaesth 124:292\u2013298. https:\/\/doi.org\/10.1016\/j.bja.2019.11.020","journal-title":"Br J Anaesth"},{"key":"5036_CR34","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.pain.2009.01.017","volume":"14","author":"C Liossi","year":"2009","unstructured":"Liossi C, White P, Hatira P (2009) A randomized clinical trial of a brief hypnosis intervention to control venepuncture-related pain of paediatric cancer patients. Pain 14:255\u2013263. https:\/\/doi.org\/10.1016\/j.pain.2009.01.017","journal-title":"Pain"},{"key":"5036_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/RMR.0000000000000242","volume":"29","author":"AA Ajam","year":"2020","unstructured":"Ajam AA, Tahir A, Makary MS, Longworth S, Lang EV, Krishna NG, Mayr NA, Nguen XV (2020) Communication and team interactions to improve patient experiences, quality of care, and throughput in MRI. Top Magn Reson Imaging 29:131\u2013134. https:\/\/doi.org\/10.1097\/RMR.0000000000000242","journal-title":"Top Magn Reson Imaging"},{"key":"5036_CR36","volume-title":"Econometric foundations pack with CD-ROM","author":"RC Mittelhammer","year":"2000","unstructured":"Mittelhammer RC, Judge GG, Miller DJ (2000) Econometric foundations pack with CD-ROM. Cambridge University Press, Cambridge"},{"key":"5036_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10578-004-3619-x","volume":"36","author":"DW Evans","year":"2005","unstructured":"Evans DW, Canavera K, Maccubbin E, Taga K (2005) The fears, phobias and anxieties of children with autism spectrum disorders and down syndrome: Comparisons with developmentally and chronologically age matched children. Child Psychiatry Hum Dev 36:3\u201326. https:\/\/doi.org\/10.1007\/s10578-004-3619-x","journal-title":"Child Psychiatry Hum Dev"},{"key":"5036_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.rasd.2008.06.001","volume":"3","author":"BM MacNeil","year":"2009","unstructured":"MacNeil BM, Lopes VA, Minnes PM (2009) Anxiety in children and adolescents with autism spectrum disorders. Res Autism Spectr Disord 3:1\u201321. https:\/\/doi.org\/10.1016\/j.rasd.2008.06.001","journal-title":"Res Autism Spectr Disord"},{"key":"5036_CR39","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cpr.2009.01.003","volume":"29","author":"SW White","year":"2009","unstructured":"White SW, Oswald D, Ollendick T, Scahill L (2009) Anxiety in children and adolescents with autism spectrum disorders. Clin Psych Rev 29:216\u2013229. https:\/\/doi.org\/10.1016\/j.cpr.2009.01.003","journal-title":"Clin Psych Rev"}],"container-title":["European Journal of Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-05036-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00431-023-05036-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00431-023-05036-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T03:31:43Z","timestamp":1697167903000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00431-023-05036-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,17]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["5036"],"URL":"https:\/\/doi.org\/10.1007\/s00431-023-05036-7","relation":{},"ISSN":["1432-1076"],"issn-type":[{"value":"1432-1076","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,17]]},"assertion":[{"value":"17 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the medical ethical committee CMO region Arnhem-Nijmegen (May 24, 2019\/N0 2019-5488).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Subject, code and patient identification were saved in an identification log. A key file with password for the identifying personal data, linked to the study code, was saved on a separate file and was only accessible for the researchers. On the Case Report Form and in the database (Castor EDC) only coded data was used, no personal identification data. Data was saved for 15 years.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Storage of data"}}]}}