{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:15:58Z","timestamp":1787508958068,"version":"build-2736575974"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Hjerteforeningen,Denmark"},{"DOI":"10.13039\/501100003491","name":"Herlev Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003491","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Candys Foundation,Liechtenstein"},{"DOI":"10.13039\/100009584","name":"Toyota Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009584","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Royal Library, Copenhagen University Library"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ventricular septal defects (VSD) represent the most common congenital heart defect in newborns. We assessed the electrocardiographic characteristics of newborns with VSDs in a general population sample. The Copenhagen Baby Heart Study is a prospective population\u2013based cohort study offering cardiac evaluation of newborns. Echocardiograms and electrocardiograms were obtained within 30\u00a0days after birth and systematically analysed. A VSD was identified in 530 newborns (mean age 11\u2009\u00b1\u20097\u00a0days, 42% boys). Newborns with VSDs had a more left-shifted\n                    <jats:italic>QRS<\/jats:italic>\n                    axis (116\u2009\u00b1\u200934 vs. 120\u2009\u00b1\u20093\u00b0,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02), and a higher\n                    <jats:italic>S<\/jats:italic>\n                    -wave amplitude in V1 (721\u2009\u00b1\u2009584 vs. 636\u2009\u00b1\u2009549\u00a0\u00b5V,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) than controls. The largest differences were found in newborns with large or perimembraneous VSDs with a higher frequency of left axis deviation, higher\n                    <jats:italic>S<\/jats:italic>\n                    -wave amplitudes in V1, and higher\n                    <jats:italic>R<\/jats:italic>\n                    - and\n                    <jats:italic>S<\/jats:italic>\n                    -wave amplitudes in V6 compared with controls.\n                    <jats:italic>R<\/jats:italic>\n                    -waves in V1 and V6 were significantly associated to left ventricular mass, whereas\n                    <jats:italic>S<\/jats:italic>\n                    -waves in V1 and V6 were dependent on left ventricular end-diastolic diameter on echocardiography.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:italic>\u00a0 Conclusion<\/jats:italic>\n                    : Newborns with VSDs showed significant differences in\n                    <jats:italic>QRS<\/jats:italic>\n                    axis, and\n                    <jats:italic>R<\/jats:italic>\n                    - and\n                    <jats:italic>S<\/jats:italic>\n                    -wave precordial amplitudes compared to matched controls. Perimembranous and large VSDs had the greatest effect on the neonatal ECG.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 Ventricular septal defects in newborns are prevalent and may affect cardiac function and structure.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 The Copenhagen Baby Heart Study is the largest study including a cohort of unselected newborns undergoing postnatal cardiac examination.<\/jats:italic>\n                              <jats:italic>\u2022 We found that newborns with VSD showed significant electrocardiographic differences depending on size and type of VSD compared with healthy newborns.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-023-05187-7","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T03:02:38Z","timestamp":1694401358000},"page":"5149-5158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Electrocardiographic characteristics of newborns with ventricular septal defects: a Copenhagen Baby Heart Study"],"prefix":"10.1007","volume":"182","author":[{"given":"Christian","family":"Pihl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Munk","family":"P\u00e6rregaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Sillesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Ottilia B","family":"V\u00f8gg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Pietersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Axelsson","family":"Raja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper Karmark","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Bundgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex H\u00f8rby","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,11]]},"reference":[{"issue":"123","key":"5187_CR1","first-page":"841","volume":"2011","author":"Dolk H, Loane M, Garne E, European Surveillance of Congenital Anomalies (EUROCAT) Working Group. 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HGH-2016\u201353). Written informed consent was provided by parents.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written consent was given by all parents or legal guardians.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent statement"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}