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The objective of this study was to evaluate the association between iron parameters and lipid, glycemic and blood pressure alterations in the pediatric population. This was a cross-sectional study of 1954 children between 9 and 10\u00a0years of age in Madrid (Spain), participants in a longitudinal study of childhood obesity. Iron metabolism parameters, i.e., serum iron (<jats:italic>Is<\/jats:italic>), ferritin (<jats:italic>Fs<\/jats:italic>), transferrin (<jats:italic>Tf<\/jats:italic>) and transferrin saturation (<jats:italic>STf<\/jats:italic>) and lipid, glycemic and blood pressure profiles were evaluated. Odds ratios (ORs) were estimated using logistic regression models adjusted for sociodemographic characteristics, diet, physical activity, C-reactive protein and body mass index. Compared with the participants in the low <jats:italic>Is<\/jats:italic> and <jats:italic>STf<\/jats:italic> tertiles, those in the upper tertiles had a lower risk of low HDL-Chol (OR: 0.34; 95%CI: 0.17; 0.67) and OR: 0.44 (95%CI: 0.23<jats:bold>;<\/jats:bold> 0.84), respectively, and children in the upper <jats:italic>Fs<\/jats:italic> tertile had an OR of 2.07 (95%CI: 1.16<jats:bold>;<\/jats:bold> 3.68) for low HDL-Chol. Children in the highest <jats:italic>Is<\/jats:italic> and <jats:italic>STf<\/jats:italic> tertiles had a lower risk of prediabetes [OR: 0.63 (95%CI: 0.41<jats:bold>;<\/jats:bold> 0.97) and OR: 0.53 (95%CI: 0.34; 0.82)] and insulin resistance (IR) (OR: 0.37; 95%CI: 0.22<jats:bold>;<\/jats:bold> 0.64), and those in the upper <jats:italic>Tf<\/jats:italic> tertile had a higher risk of IR (OR: 1.90; 95%CI: 1.16; 3.12). An increased risk of hypertension was found only in children in the upper <jats:italic>Fs<\/jats:italic> tertile (OR: 1.46; 95%CI: 1.01; 2.13).<\/jats:p><jats:p><jats:italic>  Conclusions<\/jats:italic>: Biomarkers of iron metabolism are associated with cardiometabolic alterations in the pediatric population, with a variable direction and magnitude depending on the indicators used.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Iron metabolism is related to important cardiometabolic alterations such as metabolic syndrome and its components.<\/jats:italic><jats:italic>\u2022 Association between biomarkers of iron status and cardiometabolic risk have been less explored in children.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Biomarkers of iron metabolism are associated with cardiometabolic alterations in the pediatric population.<\/jats:italic><jats:italic>\u2022 Iron parameters in the pediatric population could be of great help to detect and prevent cardiometabolic abnormalities early.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-023-05244-1","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T14:03:12Z","timestamp":1697032992000},"page":"5649-5659","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between biomarkers of iron status and cardiometabolic risk in Spanish children aged 9\u201310\u00a0years. 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