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A literature review was performed to synthesize information from clinical studies, expert opinions, and guidelines. PASC also termed Long COVID\u00a0\u2014\u00a0at any age comprise a plethora of unspecific symptoms present later than 4\u00a0weeks after confirmed or probable infection with severe respiratory syndrome corona virus type 2 (SARS-CoV-2), without another medical explanation. PCC in children and adolescents was defined by the WHO as PASC occurring within 3\u00a0months of acute coronavirus disease 2019 (COVID-19), lasting at least 2\u00a0months, and limiting daily activities. Pediatric PASC mostly manifest after mild courses of COVID-19 and in the majority of cases remit after few months. However, symptoms can last for more than 1\u00a0year and may result in significant disability. Frequent symptoms include fatigue, exertion intolerance, and anxiety. Some patients present with postural tachycardia syndrome (PoTS), and a small number of cases fulfill the clinical criteria of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS). To date, no diagnostic marker has been established, and differential diagnostics remains challenging. Therapeutic approaches include appropriate self-management as well as the palliation of symptoms by non-pharmaceutical and pharmaceutical strategies.<\/jats:p>\n                  <jats:p>\n                    \u00a0 \u00a0\n                    <jats:italic>Conclusion<\/jats:italic>\n                    : PASC in pediatrics present with heterogenous severity and duration. A stepped, interdisciplinary, and individualized approach is essential for appropriate clinical management. Current health care structures have to be adapted, and research was extended to meet the medical and psychosocial needs of young people with PASC or similar conditions.\n                    <jats:table-wrap>\n                      <jats:table>\n                        <jats:tbody>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is Known:<\/jats:bold>\n                              <jats:italic>\u2022 Post-acute sequelae of coronavirus 2019 (COVID-19) (PASC)\u00a0\u2014\u00a0also termed Long COVID\u00a0\u2014\u00a0in children and adolescents can lead to activity limitation and reduced quality of life.<\/jats:italic>\n                              <jats:italic>\u2022 PASC belongs to a large group of similar post-acute infection syndromes (PAIS).\u00a0Specific biomarkers and causal treatment options are not yet available.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                          <jats:tr>\n                            <jats:td colspan=\"2\">\n                              <jats:bold>What is New:<\/jats:bold>\n                              <jats:italic>\u2022 In February 2023, a case definition for post COVID-19 condition (PCC) in children and adolescents was provided by the World Health Organization (WHO), indicating PASC with duration of at least 2\u00a0months and limitation of daily activities.\u00a0<\/jats:italic>\n                              <jats:italic>PCC can present as myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS).<\/jats:italic>\n                              <jats:italic>\u2022 Interdisciplinary collaborations are necessary and have been established worldwide to offer harmonized, multimodal approaches to diagnosis and management of PASC\/PCC in children and adolescents.<\/jats:italic>\n                            <\/jats:td>\n                          <\/jats:tr>\n                        <\/jats:tbody>\n                      <\/jats:table>\n                    <\/jats:table-wrap>\n                  <\/jats:p>","DOI":"10.1007\/s00431-023-05360-y","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T23:31:11Z","timestamp":1706311871000},"page":"1543-1553","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Long COVID in pediatrics\u2014epidemiology, diagnosis, and management"],"prefix":"10.1007","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9693-4419","authenticated-orcid":false,"given":"Nicole","family":"Toepfner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Folke","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Augustin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Stojanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Behrends","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"5360_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/d41586-020-02335-z","volume":"584","author":"NA Alwan","year":"2020","unstructured":"Alwan NA (2020) A negative COVID-19 test does not mean recovery. 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