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This study aims to evaluate heart rate variability and electrocardiography findings in patients with HUS by comparing a healthy group. Patients who are diagnosed with HUS at a university hospital from December 2020 to June 2022 are screened by electrocardiography (ECG), echocardiography, and 24-h Holter ECG. A healthy control group, compatible in age and gender with the patient group, was selected from healthy subjects. HRV parameters, laboratory values, and ECG findings were analyzed and compared with the healthy group and each other. There were 25 patients with HUS and 51 participants in the healthy control group. Statistically significant differences were found in some HRV parameters: standard deviation of normal to normal intervals, the mean of the 5-min RR interval standard deviations, the standard deviation of 5-min RR interval means, the triangular interpolation of normal to normal interval, and very-low-frequency power. HUS patients had impaired and declined HRV values compared to the healthy group. There was a significant decrease in the PR distance, while a significant increase in the corrected QT and QT dispersion values was detected in the electrocardiographic findings of the patient group. HRV values impaired as renal failure parameters increased.<\/jats:p><jats:p><jats:italic>\u00a0 Conclusion:<\/jats:italic> Patients with HUS may have autonomic nervous system dysfunction. HRV measurement is a non-invasive method that can evaluate this. It can be thought that there may be an increased risk of cardiovascular events and arrhythmias in some patients with HUS. ECG should be also considered to detect arrhythmia.\n<jats:table-wrap><jats:table><jats:tbody>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is Known:<\/jats:bold><jats:italic>\u2022 Hemolytic uremic syndrome (HUS) primarily effects the hematologic parameters and kidney.<\/jats:italic><jats:italic>\u2022 Secondary cardiomyopathy with hypertension and renal failure could be observed in these patients.<\/jats:italic><jats:italic>\u2022 Rhythm problems are not expected primarily in these patients.<\/jats:italic><jats:italic>\u2022 There is very limited data in evaluating autonomic function and arrhythmia risk for these patients.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                    <jats:tr>\n                      <jats:td colspan=\"2\"><jats:bold>What is New:<\/jats:bold><jats:italic>\u2022 Patients with HUS may have autonomic nervous system dysfunction.<\/jats:italic><jats:italic>\u2022 HRV measurement is a non-invasive method that can evaluate this.<\/jats:italic><jats:italic>\u2022 Cardiovascular events and arrhythmias due to the deterioration of the balance between the sympathetic and parasympathetic systems could manifest in patients with HUS.<\/jats:italic><jats:italic>\u2022 An ECG and screening patients for cardiac events, and monitoring them closely should be considered.<\/jats:italic><\/jats:td>\n                    <\/jats:tr>\n                  <\/jats:tbody><\/jats:table><\/jats:table-wrap><\/jats:p>","DOI":"10.1007\/s00431-024-05420-x","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T06:02:32Z","timestamp":1705644152000},"page":"1447-1454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autonomic activity and cardiovascular system risk assessment in pediatric patients with hemolytic uremic syndrome"],"prefix":"10.1007","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-1709","authenticated-orcid":false,"given":"Derya","family":"Duman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9109-859X","authenticated-orcid":false,"given":"Serra","family":"S\u00fcrmeli D\u00f6ven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-1403","authenticated-orcid":false,"given":"Derya","family":"Karpuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-1131","authenticated-orcid":false,"given":"Esra","family":"Danac\u0131 Vatansever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8146-4912","authenticated-orcid":false,"given":"Bahar","family":"Ta\u015fdelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-9276","authenticated-orcid":false,"given":"Ali","family":"Deliba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"issue":"1","key":"5420_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.pcl.2018.09.011","volume":"66","author":"EM Cody","year":"2019","unstructured":"Cody EM, Dixon BP (2019) Hemolytic uremic syndrome. 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